Transgenerational epigenetic inheritance of longevity in Caenorhabditis elegans View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-11

AUTHORS

Eric L. Greer, Travis J. Maures, Duygu Ucar, Anna G. Hauswirth, Elena Mancini, Jana P. Lim, Bérénice A. Benayoun, Yang Shi, Anne Brunet

ABSTRACT

Chromatin modifiers regulate lifespan in several organisms, raising the question of whether changes in chromatin states in the parental generation could be incompletely reprogrammed in the next generation and thereby affect the lifespan of descendants. The histone H3 lysine 4 trimethylation (H3K4me3) complex, composed of ASH-2, WDR-5 and the histone methyltransferase SET-2, regulates Caenorhabditis elegans lifespan. Here we show that deficiencies in the H3K4me3 chromatin modifiers ASH-2, WDR-5 or SET-2 in the parental generation extend the lifespan of descendants up until the third generation. The transgenerational inheritance of lifespan extension by members of the ASH-2 complex is dependent on the H3K4me3 demethylase RBR-2, and requires the presence of a functioning germline in the descendants. Transgenerational inheritance of lifespan is specific for the H3K4me3 methylation complex and is associated with epigenetic changes in gene expression. Thus, manipulation of specific chromatin modifiers only in parents can induce an epigenetic memory of longevity in descendants. More... »

PAGES

365

References to SciGraph publications

  • 2003-07. Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans in NATURE
  • 2010-09. Active DNA demethylation: many roads lead to Rome in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2006-05. RNA-mediated non-mendelian inheritance of an epigenetic change in the mouse in NATURE
  • 2010-12. Trans-generational epigenetic regulation of C. elegans primordial germ cells in EPIGENETICS & CHROMATIN
  • 1999-09. An epigenetic mutation responsible for natural variation in floral symmetry in NATURE
  • 1993-12. A C. elegans mutant that lives twice as long as wild type in NATURE
  • 2006-05. Glucose metabolism is altered in the adequately-nourished grand-offspring (F3 generation) of rats malnourished during gestation and perinatal life in DIABETOLOGIA
  • 2005-11. ChIPOTle: a user-friendly tool for the analysis of ChIP-chip data in GENOME BIOLOGY
  • 2010-07. Members of the H3K4 trimethylation complex regulate lifespan in a germline-dependent manner in C. elegans in NATURE
  • 2007-07. Transgenerational response to nutrition, early life circumstances and longevity in EUROPEAN JOURNAL OF HUMAN GENETICS
  • 2006-08. Regulation of MLL1 H3K4 methyltransferase activity by its core components in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2009-06. Histone H4 lysine 16 acetylation regulates cellular lifespan in NATURE
  • 1999-11. Epigenetic inheritance at the agouti locus in the mouse in NATURE GENETICS
  • 2003-01. A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity in NATURE GENETICS
  • 2006-09. Molecular regulation of H3K4 trimethylation by ASH2L, a shared subunit of MLL complexes in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2010-10. Chronic high-fat diet in fathers programs β-cell dysfunction in female rat offspring in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nature10572

    DOI

    http://dx.doi.org/10.1038/nature10572

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1044259768

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/22012258


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