Image-based genome-wide siRNA screen identifies selective autophagy factors View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-10-23

AUTHORS

Anthony Orvedahl, Rhea Sumpter, Guanghua Xiao, Aylwin Ng, Zhongju Zou, Yi Tang, Masahiro Narimatsu, Christopher Gilpin, Qihua Sun, Michael Roth, Christian V. Forst, Jeffrey L. Wrana, Ying E. Zhang, Katherine Luby-Phelps, Ramnik J. Xavier, Yang Xie, Beth Levine

ABSTRACT

Selective autophagy involves the recognition and targeting of specific cargo, such as damaged organelles, misfolded proteins, or invading pathogens for lysosomal destruction. Yeast genetic screens have identified proteins required for different forms of selective autophagy, including cytoplasm-to-vacuole targeting, pexophagy and mitophagy, and mammalian genetic screens have identified proteins required for autophagy regulation. However, there have been no systematic approaches to identify molecular determinants of selective autophagy in mammalian cells. Here, to identify mammalian genes required for selective autophagy, we performed a high-content, image-based, genome-wide small interfering RNA screen to detect genes required for the colocalization of Sindbis virus capsid protein with autophagolysosomes. We identified 141 candidate genes required for viral autophagy, which were enriched for cellular pathways related to messenger RNA processing, interferon signalling, vesicle trafficking, cytoskeletal motor function and metabolism. Ninety-six of these genes were also required for Parkin-mediated mitophagy, indicating that common molecular determinants may be involved in autophagic targeting of viral nucleocapsids and autophagic targeting of damaged mitochondria. Murine embryonic fibroblasts lacking one of these gene products, the C2-domain containing protein, SMURF1, are deficient in the autophagosomal targeting of Sindbis and herpes simplex viruses and in the clearance of damaged mitochondria. Moreover, SMURF1-deficient mice accumulate damaged mitochondria in the heart, brain and liver. Thus, our study identifies candidate determinants of selective autophagy, and defines SMURF1 as a newly recognized mediator of both viral autophagy and mitophagy. More... »

PAGES

113

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature10546

DOI

http://dx.doi.org/10.1038/nature10546

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1010217088

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22020285


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Autophagy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Capsid Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genome-Wide Association Study", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "HeLa Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lysosomes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mitochondria", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Transport", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Small Interfering", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sindbis Virus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ubiquitin-Protein Ligases", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "The University of Texas Southwestern Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.267313.2", 
          "name": [
            "Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9113, USA", 
            "Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9113, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Orvedahl", 
        "givenName": "Anthony", 
        "id": "sg:person.01322141226.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01322141226.83"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas Southwestern Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.267313.2", 
          "name": [
            "Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9113, USA", 
            "Center for Autophagy Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9113, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sumpter", 
        "givenName": "Rhea", 
        "id": "sg:person.01370254426.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01370254426.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas Southwestern Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.267313.2", 
          "name": [
            "Department of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9113, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Xiao", 
        "givenName": "Guanghua", 
        "id": "sg:person.0774370033.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774370033.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Broad Institute", 
          "id": "https://www.grid.ac/institutes/grid.66859.34", 
          "name": [
            "Center for Computational and Integrative Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA", 
            "Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA", 
            "Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ng", 
        "givenName": "Aylwin", 
        "id": "sg:person.0645153566.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0645153566.99"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas Southwestern Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.267313.2", 
          "name": [
            "Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9113, USA", 
            "Center for Autophagy Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9113, USA", 
            "Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9113, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zou", 
        "givenName": "Zhongju", 
        "id": "sg:person.01150235102.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01150235102.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institutes of Health", 
          "id": "https://www.grid.ac/institutes/grid.94365.3d", 
          "name": [
            "Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tang", 
        "givenName": "Yi", 
        "id": "sg:person.01253457142.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01253457142.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Center for Systems Biology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Narimatsu", 
        "givenName": "Masahiro", 
        "id": "sg:person.0721077273.68", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721077273.68"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas Southwestern Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.267313.2", 
          "name": [
            "Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9113, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gilpin", 
        "givenName": "Christopher", 
        "id": "sg:person.01075630566.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01075630566.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas Southwestern Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.267313.2", 
          "name": [
            "Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9113, USA", 
            "Center for Autophagy Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9113, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sun", 
        "givenName": "Qihua", 
        "id": "sg:person.01143743766.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01143743766.74"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas Southwestern Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.267313.2", 
          "name": [
            "Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9113, USA", 
            "Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9113, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Roth", 
        "givenName": "Michael", 
        "id": "sg:person.015054511340.97", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015054511340.97"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas Southwestern Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.267313.2", 
          "name": [
            "Department of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9113, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Forst", 
        "givenName": "Christian V.", 
        "id": "sg:person.0624557664.95", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0624557664.95"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Toronto", 
          "id": "https://www.grid.ac/institutes/grid.17063.33", 
          "name": [
            "Center for Systems Biology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada", 
            "Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 3E1, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wrana", 
        "givenName": "Jeffrey L.", 
        "id": "sg:person.01242174727.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242174727.43"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institutes of Health", 
          "id": "https://www.grid.ac/institutes/grid.94365.3d", 
          "name": [
            "Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhang", 
        "givenName": "Ying E.", 
        "id": "sg:person.0630076533.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630076533.75"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas Southwestern Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.267313.2", 
          "name": [
            "Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9113, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Luby-Phelps", 
        "givenName": "Katherine", 
        "id": "sg:person.01172572170.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01172572170.99"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Broad Institute", 
          "id": "https://www.grid.ac/institutes/grid.66859.34", 
          "name": [
            "Center for Computational and Integrative Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA", 
            "Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA", 
            "Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Xavier", 
        "givenName": "Ramnik J.", 
        "id": "sg:person.0717130066.82", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0717130066.82"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas Southwestern Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.267313.2", 
          "name": [
            "Department of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9113, USA", 
            "Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9113, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Xie", 
        "givenName": "Yang", 
        "id": "sg:person.015050220024.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015050220024.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas Southwestern Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.267313.2", 
          "name": [
            "Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9113, USA", 
            "Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9113, USA", 
            "Center for Autophagy Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9113, USA", 
            "Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9113, USA", 
            "Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9113, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Levine", 
        "givenName": "Beth", 
        "id": "sg:person.015037702577.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015037702577.87"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.4161/auto.6.8.13426", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001792419"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1205405", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003415329"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1205405", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003415329"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.chom.2010.01.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004871829"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jcb.22586", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006750515"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jcb.22586", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006750515"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.chom.2006.12.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007784854"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature07976", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010869485", 
          "https://doi.org/10.1038/nature07976"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature07976", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010869485", 
          "https://doi.org/10.1038/nature07976"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/cdd.2009.39", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011447374", 
          "https://doi.org/10.1038/cdd.2009.39"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/cdd.2009.39", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011447374", 
          "https://doi.org/10.1038/cdd.2009.39"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2008.06.016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015565368"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature09204", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016097032", 
          "https://doi.org/10.1038/nature09204"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature09204", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016097032", 
          "https://doi.org/10.1038/nature09204"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.febslet.2010.01.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017310539"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.012485299", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018705762"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb2012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021281910", 
          "https://doi.org/10.1038/ncb2012"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb2012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021281910", 
          "https://doi.org/10.1038/ncb2012"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature09782", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021726704", 
          "https://doi.org/10.1038/nature09782"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbalip.2006.06.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022692022"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.devcel.2010.05.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023221604"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/emboj.2009.405", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028270097"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/emboj.2009.405", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028270097"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2005.01.035", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031782545"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m110.211979", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031873253"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2011.06.022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033124985"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1469-185x.2009.00082.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036344993"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1469-185x.2009.00082.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036344993"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.200809125", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039514804"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2443.2010.01433.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047472205"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb0910-823", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051165995", 
          "https://doi.org/10.1038/ncb0910-823"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb0910-823", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051165995", 
          "https://doi.org/10.1038/ncb0910-823"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ceb.2009.12.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052193092"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/auto.2176", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072289610"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2011-10-23", 
    "datePublishedReg": "2011-10-23", 
    "description": "Selective autophagy involves the recognition and targeting of specific cargo, such as damaged organelles, misfolded proteins, or invading pathogens for lysosomal destruction. Yeast genetic screens have identified proteins required for different forms of selective autophagy, including cytoplasm-to-vacuole targeting, pexophagy and mitophagy, and mammalian genetic screens have identified proteins required for autophagy regulation. However, there have been no systematic approaches to identify molecular determinants of selective autophagy in mammalian cells. Here, to identify mammalian genes required for selective autophagy, we performed a high-content, image-based, genome-wide small interfering RNA screen to detect genes required for the colocalization of Sindbis virus capsid protein with autophagolysosomes. We identified 141 candidate genes required for viral autophagy, which were enriched for cellular pathways related to messenger RNA processing, interferon signalling, vesicle trafficking, cytoskeletal motor function and metabolism. Ninety-six of these genes were also required for Parkin-mediated mitophagy, indicating that common molecular determinants may be involved in autophagic targeting of viral nucleocapsids and autophagic targeting of damaged mitochondria. Murine embryonic fibroblasts lacking one of these gene products, the C2-domain containing protein, SMURF1, are deficient in the autophagosomal targeting of Sindbis and herpes simplex viruses and in the clearance of damaged mitochondria. Moreover, SMURF1-deficient mice accumulate damaged mitochondria in the heart, brain and liver. Thus, our study identifies candidate determinants of selective autophagy, and defines SMURF1 as a newly recognized mediator of both viral autophagy and mitophagy.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/nature10546", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2439002", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.3100457", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2455747", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2438997", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2474644", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2499878", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2705137", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2456929", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2724092", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2668586", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0090-0028", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "7375", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "480"
      }
    ], 
    "name": "Image-based genome-wide siRNA screen identifies selective autophagy factors", 
    "pagination": "113", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "30aceffc9d277c9834ce456cb6381a890464cfbf914471716474055af4c9e62d"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "22020285"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0410462"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/nature10546"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1010217088"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/nature10546", 
      "https://app.dimensions.ai/details/publication/pub.1010217088"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T00:05", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8695_00000434.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/nature10546"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nature10546'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nature10546'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nature10546'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nature10546'


 

This table displays all metadata directly associated to this object as RDF triples.

355 TRIPLES      21 PREDICATES      66 URIs      33 LITERALS      22 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/nature10546 schema:about N1d2999fe935e41ae9f5e10d9e36121a3
2 N3e7defac45b7432cb89e610d8395f6c5
3 N440a818034c6449fbe48b8927d10d85d
4 N47f4feb6c4a1494ca302834a76b6c19a
5 N5679183566834c959c33c4dff075d2c1
6 N67b468dac42b4d96907ccaa1748003be
7 N6e29d1aa8c1141fd972a35021f03def6
8 N6edd23c922fb46a4b3c58fa0057364f4
9 N723824317bf940c1a755903a25353d4b
10 N97ad4af0564847419bb22bd6e330b8fd
11 Nc224c612bafe495fadcb94821e275ebd
12 Nd0280568ff0e4736b26c3e2473a8950d
13 Ned9f5d68d35b4ea6871022e68b53dad5
14 anzsrc-for:06
15 anzsrc-for:0601
16 schema:author Nd01249937b814611928624049cfa4077
17 schema:citation sg:pub.10.1038/cdd.2009.39
18 sg:pub.10.1038/nature07976
19 sg:pub.10.1038/nature09204
20 sg:pub.10.1038/nature09782
21 sg:pub.10.1038/ncb0910-823
22 sg:pub.10.1038/ncb2012
23 https://doi.org/10.1002/jcb.22586
24 https://doi.org/10.1016/j.bbalip.2006.06.014
25 https://doi.org/10.1016/j.ceb.2009.12.004
26 https://doi.org/10.1016/j.cell.2005.01.035
27 https://doi.org/10.1016/j.cell.2008.06.016
28 https://doi.org/10.1016/j.cell.2011.06.022
29 https://doi.org/10.1016/j.chom.2006.12.001
30 https://doi.org/10.1016/j.chom.2010.01.007
31 https://doi.org/10.1016/j.devcel.2010.05.005
32 https://doi.org/10.1016/j.febslet.2010.01.018
33 https://doi.org/10.1038/emboj.2009.405
34 https://doi.org/10.1073/pnas.012485299
35 https://doi.org/10.1074/jbc.m110.211979
36 https://doi.org/10.1083/jcb.200809125
37 https://doi.org/10.1111/j.1365-2443.2010.01433.x
38 https://doi.org/10.1111/j.1469-185x.2009.00082.x
39 https://doi.org/10.1126/science.1205405
40 https://doi.org/10.4161/auto.2176
41 https://doi.org/10.4161/auto.6.8.13426
42 schema:datePublished 2011-10-23
43 schema:datePublishedReg 2011-10-23
44 schema:description Selective autophagy involves the recognition and targeting of specific cargo, such as damaged organelles, misfolded proteins, or invading pathogens for lysosomal destruction. Yeast genetic screens have identified proteins required for different forms of selective autophagy, including cytoplasm-to-vacuole targeting, pexophagy and mitophagy, and mammalian genetic screens have identified proteins required for autophagy regulation. However, there have been no systematic approaches to identify molecular determinants of selective autophagy in mammalian cells. Here, to identify mammalian genes required for selective autophagy, we performed a high-content, image-based, genome-wide small interfering RNA screen to detect genes required for the colocalization of Sindbis virus capsid protein with autophagolysosomes. We identified 141 candidate genes required for viral autophagy, which were enriched for cellular pathways related to messenger RNA processing, interferon signalling, vesicle trafficking, cytoskeletal motor function and metabolism. Ninety-six of these genes were also required for Parkin-mediated mitophagy, indicating that common molecular determinants may be involved in autophagic targeting of viral nucleocapsids and autophagic targeting of damaged mitochondria. Murine embryonic fibroblasts lacking one of these gene products, the C2-domain containing protein, SMURF1, are deficient in the autophagosomal targeting of Sindbis and herpes simplex viruses and in the clearance of damaged mitochondria. Moreover, SMURF1-deficient mice accumulate damaged mitochondria in the heart, brain and liver. Thus, our study identifies candidate determinants of selective autophagy, and defines SMURF1 as a newly recognized mediator of both viral autophagy and mitophagy.
45 schema:genre research_article
46 schema:inLanguage en
47 schema:isAccessibleForFree true
48 schema:isPartOf N19e7bd8574cf4f98bee42a9e555d5e6c
49 Nc861828b81b6449886463da017f62f72
50 sg:journal.1018957
51 schema:name Image-based genome-wide siRNA screen identifies selective autophagy factors
52 schema:pagination 113
53 schema:productId N0c4a2004f5d2446a8938f44d29aab48c
54 N71ffdc7a17144673965ce3cc2bed78f5
55 N940eadd670904bb085508d8190209639
56 N97c083a5deb24ad393358abd9e9b2139
57 Nd1fc4ee509264ed4acebe8b1c7ef3289
58 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010217088
59 https://doi.org/10.1038/nature10546
60 schema:sdDatePublished 2019-04-11T00:05
61 schema:sdLicense https://scigraph.springernature.com/explorer/license/
62 schema:sdPublisher N33c4151af01a4c1db05916f5da09bb61
63 schema:url https://www.nature.com/articles/nature10546
64 sgo:license sg:explorer/license/
65 sgo:sdDataset articles
66 rdf:type schema:ScholarlyArticle
67 N0c4a2004f5d2446a8938f44d29aab48c schema:name doi
68 schema:value 10.1038/nature10546
69 rdf:type schema:PropertyValue
70 N19e7bd8574cf4f98bee42a9e555d5e6c schema:issueNumber 7375
71 rdf:type schema:PublicationIssue
72 N1c7e7de653b04e05be97aba4231180b3 rdf:first sg:person.0717130066.82
73 rdf:rest N8c03b8eaf4a1444aa3a9116a4c2c6041
74 N1d2999fe935e41ae9f5e10d9e36121a3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
75 schema:name Autophagy
76 rdf:type schema:DefinedTerm
77 N29e307b8a5534e0c98346ebb3d332f9e rdf:first sg:person.01150235102.06
78 rdf:rest Ne983f4cf22684dac97f1c8638f47cb9e
79 N33c4151af01a4c1db05916f5da09bb61 schema:name Springer Nature - SN SciGraph project
80 rdf:type schema:Organization
81 N3b947410dbd4498582b07964b267ba7f rdf:first sg:person.01143743766.74
82 rdf:rest Ned871434da2947c387fba495fa7f0a08
83 N3e7defac45b7432cb89e610d8395f6c5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
84 schema:name Mice
85 rdf:type schema:DefinedTerm
86 N440a818034c6449fbe48b8927d10d85d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name Genome-Wide Association Study
88 rdf:type schema:DefinedTerm
89 N47f4feb6c4a1494ca302834a76b6c19a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Mitochondria
91 rdf:type schema:DefinedTerm
92 N4b2cd3d9df334275bb518bca44850905 rdf:first sg:person.0645153566.99
93 rdf:rest N29e307b8a5534e0c98346ebb3d332f9e
94 N515d5d4a5f814af9abefcbc2be67cd09 rdf:first sg:person.0721077273.68
95 rdf:rest Nb434c90ddb28469480e1e26fc04d9296
96 N5679183566834c959c33c4dff075d2c1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name HeLa Cells
98 rdf:type schema:DefinedTerm
99 N67b468dac42b4d96907ccaa1748003be schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Animals
101 rdf:type schema:DefinedTerm
102 N6db1ed3d2d4a42c19a45487cc59e89df rdf:first sg:person.01370254426.42
103 rdf:rest Nce1249eed1cb402f8820fe5164a17158
104 N6e29d1aa8c1141fd972a35021f03def6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Protein Transport
106 rdf:type schema:DefinedTerm
107 N6edd23c922fb46a4b3c58fa0057364f4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Lysosomes
109 rdf:type schema:DefinedTerm
110 N71ffdc7a17144673965ce3cc2bed78f5 schema:name dimensions_id
111 schema:value pub.1010217088
112 rdf:type schema:PropertyValue
113 N723824317bf940c1a755903a25353d4b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Capsid Proteins
115 rdf:type schema:DefinedTerm
116 N743ec7275848449eb0c5506fa4847afa rdf:first sg:person.01172572170.99
117 rdf:rest N1c7e7de653b04e05be97aba4231180b3
118 N8c03b8eaf4a1444aa3a9116a4c2c6041 rdf:first sg:person.015050220024.04
119 rdf:rest Na737b26cf0634644b2727970faefb5be
120 N940eadd670904bb085508d8190209639 schema:name nlm_unique_id
121 schema:value 0410462
122 rdf:type schema:PropertyValue
123 N97ad4af0564847419bb22bd6e330b8fd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name RNA, Small Interfering
125 rdf:type schema:DefinedTerm
126 N97c083a5deb24ad393358abd9e9b2139 schema:name pubmed_id
127 schema:value 22020285
128 rdf:type schema:PropertyValue
129 Na737b26cf0634644b2727970faefb5be rdf:first sg:person.015037702577.87
130 rdf:rest rdf:nil
131 Nad0e0623ff574dc581fa3886534cdc2c rdf:first sg:person.0624557664.95
132 rdf:rest Ndb06d2c7c3db462db948122f5b8eb215
133 Nb434c90ddb28469480e1e26fc04d9296 rdf:first sg:person.01075630566.22
134 rdf:rest N3b947410dbd4498582b07964b267ba7f
135 Nc224c612bafe495fadcb94821e275ebd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Humans
137 rdf:type schema:DefinedTerm
138 Nc30bc0a564fd4d6ea9d90015d2493aaa rdf:first sg:person.0630076533.75
139 rdf:rest N743ec7275848449eb0c5506fa4847afa
140 Nc4a0d920babb4279bdf7482f9bf89c99 schema:name Center for Systems Biology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada
141 rdf:type schema:Organization
142 Nc861828b81b6449886463da017f62f72 schema:volumeNumber 480
143 rdf:type schema:PublicationVolume
144 Nce1249eed1cb402f8820fe5164a17158 rdf:first sg:person.0774370033.55
145 rdf:rest N4b2cd3d9df334275bb518bca44850905
146 Nd01249937b814611928624049cfa4077 rdf:first sg:person.01322141226.83
147 rdf:rest N6db1ed3d2d4a42c19a45487cc59e89df
148 Nd0280568ff0e4736b26c3e2473a8950d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Sindbis Virus
150 rdf:type schema:DefinedTerm
151 Nd1fc4ee509264ed4acebe8b1c7ef3289 schema:name readcube_id
152 schema:value 30aceffc9d277c9834ce456cb6381a890464cfbf914471716474055af4c9e62d
153 rdf:type schema:PropertyValue
154 Ndb06d2c7c3db462db948122f5b8eb215 rdf:first sg:person.01242174727.43
155 rdf:rest Nc30bc0a564fd4d6ea9d90015d2493aaa
156 Ne983f4cf22684dac97f1c8638f47cb9e rdf:first sg:person.01253457142.11
157 rdf:rest N515d5d4a5f814af9abefcbc2be67cd09
158 Ned871434da2947c387fba495fa7f0a08 rdf:first sg:person.015054511340.97
159 rdf:rest Nad0e0623ff574dc581fa3886534cdc2c
160 Ned9f5d68d35b4ea6871022e68b53dad5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Ubiquitin-Protein Ligases
162 rdf:type schema:DefinedTerm
163 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
164 schema:name Biological Sciences
165 rdf:type schema:DefinedTerm
166 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
167 schema:name Biochemistry and Cell Biology
168 rdf:type schema:DefinedTerm
169 sg:grant.2438997 http://pending.schema.org/fundedItem sg:pub.10.1038/nature10546
170 rdf:type schema:MonetaryGrant
171 sg:grant.2439002 http://pending.schema.org/fundedItem sg:pub.10.1038/nature10546
172 rdf:type schema:MonetaryGrant
173 sg:grant.2455747 http://pending.schema.org/fundedItem sg:pub.10.1038/nature10546
174 rdf:type schema:MonetaryGrant
175 sg:grant.2456929 http://pending.schema.org/fundedItem sg:pub.10.1038/nature10546
176 rdf:type schema:MonetaryGrant
177 sg:grant.2474644 http://pending.schema.org/fundedItem sg:pub.10.1038/nature10546
178 rdf:type schema:MonetaryGrant
179 sg:grant.2499878 http://pending.schema.org/fundedItem sg:pub.10.1038/nature10546
180 rdf:type schema:MonetaryGrant
181 sg:grant.2668586 http://pending.schema.org/fundedItem sg:pub.10.1038/nature10546
182 rdf:type schema:MonetaryGrant
183 sg:grant.2705137 http://pending.schema.org/fundedItem sg:pub.10.1038/nature10546
184 rdf:type schema:MonetaryGrant
185 sg:grant.2724092 http://pending.schema.org/fundedItem sg:pub.10.1038/nature10546
186 rdf:type schema:MonetaryGrant
187 sg:grant.3100457 http://pending.schema.org/fundedItem sg:pub.10.1038/nature10546
188 rdf:type schema:MonetaryGrant
189 sg:journal.1018957 schema:issn 0090-0028
190 1476-4687
191 schema:name Nature
192 rdf:type schema:Periodical
193 sg:person.01075630566.22 schema:affiliation https://www.grid.ac/institutes/grid.267313.2
194 schema:familyName Gilpin
195 schema:givenName Christopher
196 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01075630566.22
197 rdf:type schema:Person
198 sg:person.01143743766.74 schema:affiliation https://www.grid.ac/institutes/grid.267313.2
199 schema:familyName Sun
200 schema:givenName Qihua
201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01143743766.74
202 rdf:type schema:Person
203 sg:person.01150235102.06 schema:affiliation https://www.grid.ac/institutes/grid.267313.2
204 schema:familyName Zou
205 schema:givenName Zhongju
206 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01150235102.06
207 rdf:type schema:Person
208 sg:person.01172572170.99 schema:affiliation https://www.grid.ac/institutes/grid.267313.2
209 schema:familyName Luby-Phelps
210 schema:givenName Katherine
211 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01172572170.99
212 rdf:type schema:Person
213 sg:person.01242174727.43 schema:affiliation https://www.grid.ac/institutes/grid.17063.33
214 schema:familyName Wrana
215 schema:givenName Jeffrey L.
216 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242174727.43
217 rdf:type schema:Person
218 sg:person.01253457142.11 schema:affiliation https://www.grid.ac/institutes/grid.94365.3d
219 schema:familyName Tang
220 schema:givenName Yi
221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01253457142.11
222 rdf:type schema:Person
223 sg:person.01322141226.83 schema:affiliation https://www.grid.ac/institutes/grid.267313.2
224 schema:familyName Orvedahl
225 schema:givenName Anthony
226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01322141226.83
227 rdf:type schema:Person
228 sg:person.01370254426.42 schema:affiliation https://www.grid.ac/institutes/grid.267313.2
229 schema:familyName Sumpter
230 schema:givenName Rhea
231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01370254426.42
232 rdf:type schema:Person
233 sg:person.015037702577.87 schema:affiliation https://www.grid.ac/institutes/grid.267313.2
234 schema:familyName Levine
235 schema:givenName Beth
236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015037702577.87
237 rdf:type schema:Person
238 sg:person.015050220024.04 schema:affiliation https://www.grid.ac/institutes/grid.267313.2
239 schema:familyName Xie
240 schema:givenName Yang
241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015050220024.04
242 rdf:type schema:Person
243 sg:person.015054511340.97 schema:affiliation https://www.grid.ac/institutes/grid.267313.2
244 schema:familyName Roth
245 schema:givenName Michael
246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015054511340.97
247 rdf:type schema:Person
248 sg:person.0624557664.95 schema:affiliation https://www.grid.ac/institutes/grid.267313.2
249 schema:familyName Forst
250 schema:givenName Christian V.
251 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0624557664.95
252 rdf:type schema:Person
253 sg:person.0630076533.75 schema:affiliation https://www.grid.ac/institutes/grid.94365.3d
254 schema:familyName Zhang
255 schema:givenName Ying E.
256 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630076533.75
257 rdf:type schema:Person
258 sg:person.0645153566.99 schema:affiliation https://www.grid.ac/institutes/grid.66859.34
259 schema:familyName Ng
260 schema:givenName Aylwin
261 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0645153566.99
262 rdf:type schema:Person
263 sg:person.0717130066.82 schema:affiliation https://www.grid.ac/institutes/grid.66859.34
264 schema:familyName Xavier
265 schema:givenName Ramnik J.
266 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0717130066.82
267 rdf:type schema:Person
268 sg:person.0721077273.68 schema:affiliation Nc4a0d920babb4279bdf7482f9bf89c99
269 schema:familyName Narimatsu
270 schema:givenName Masahiro
271 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721077273.68
272 rdf:type schema:Person
273 sg:person.0774370033.55 schema:affiliation https://www.grid.ac/institutes/grid.267313.2
274 schema:familyName Xiao
275 schema:givenName Guanghua
276 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774370033.55
277 rdf:type schema:Person
278 sg:pub.10.1038/cdd.2009.39 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011447374
279 https://doi.org/10.1038/cdd.2009.39
280 rdf:type schema:CreativeWork
281 sg:pub.10.1038/nature07976 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010869485
282 https://doi.org/10.1038/nature07976
283 rdf:type schema:CreativeWork
284 sg:pub.10.1038/nature09204 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016097032
285 https://doi.org/10.1038/nature09204
286 rdf:type schema:CreativeWork
287 sg:pub.10.1038/nature09782 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021726704
288 https://doi.org/10.1038/nature09782
289 rdf:type schema:CreativeWork
290 sg:pub.10.1038/ncb0910-823 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051165995
291 https://doi.org/10.1038/ncb0910-823
292 rdf:type schema:CreativeWork
293 sg:pub.10.1038/ncb2012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021281910
294 https://doi.org/10.1038/ncb2012
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1002/jcb.22586 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006750515
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1016/j.bbalip.2006.06.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022692022
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1016/j.ceb.2009.12.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052193092
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1016/j.cell.2005.01.035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031782545
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1016/j.cell.2008.06.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015565368
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1016/j.cell.2011.06.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033124985
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1016/j.chom.2006.12.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007784854
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1016/j.chom.2010.01.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004871829
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1016/j.devcel.2010.05.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023221604
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1016/j.febslet.2010.01.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017310539
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1038/emboj.2009.405 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028270097
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1073/pnas.012485299 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018705762
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1074/jbc.m110.211979 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031873253
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1083/jcb.200809125 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039514804
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1111/j.1365-2443.2010.01433.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1047472205
325 rdf:type schema:CreativeWork
326 https://doi.org/10.1111/j.1469-185x.2009.00082.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1036344993
327 rdf:type schema:CreativeWork
328 https://doi.org/10.1126/science.1205405 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003415329
329 rdf:type schema:CreativeWork
330 https://doi.org/10.4161/auto.2176 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072289610
331 rdf:type schema:CreativeWork
332 https://doi.org/10.4161/auto.6.8.13426 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001792419
333 rdf:type schema:CreativeWork
334 https://www.grid.ac/institutes/grid.17063.33 schema:alternateName University of Toronto
335 schema:name Center for Systems Biology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada
336 Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 3E1, Canada
337 rdf:type schema:Organization
338 https://www.grid.ac/institutes/grid.267313.2 schema:alternateName The University of Texas Southwestern Medical Center
339 schema:name Center for Autophagy Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9113, USA
340 Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9113, USA
341 Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9113, USA
342 Department of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9113, USA
343 Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9113, USA
344 Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9113, USA
345 Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9113, USA
346 Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9113, USA
347 rdf:type schema:Organization
348 https://www.grid.ac/institutes/grid.66859.34 schema:alternateName Broad Institute
349 schema:name Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
350 Center for Computational and Integrative Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
351 Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
352 rdf:type schema:Organization
353 https://www.grid.ac/institutes/grid.94365.3d schema:alternateName National Institutes of Health
354 schema:name Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
355 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...