Antibiotic resistance is ancient View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2011-08-31

AUTHORS

Vanessa M. D’Costa, Christine E. King, Lindsay Kalan, Mariya Morar, Wilson W. L. Sung, Carsten Schwarz, Duane Froese, Grant Zazula, Fabrice Calmels, Regis Debruyne, G. Brian Golding, Hendrik N. Poinar, Gerard D. Wright

ABSTRACT

The roots of antibiotic resistanceAntibiotic resistance is thought to have evolved long before naturally occurring antibiotics and their derivatives were used to treat human disease, but direct evidence for genes that encode resistance has been lacking. Now, an ancient vancomycin-resistance gene has been recovered from 30,000-year-old samples of Siberian permafrost, and the three-dimensional structure of its product has been compared with that of its modern counterpart. There are minor structural differences between the ancient and modern versions, but the differences are not reflected in enzyme function. More... »

PAGES

457-461

References to SciGraph publications

Journal

TITLE

Nature

ISSUE

7365

VOLUME

477

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature10388

DOI

http://dx.doi.org/10.1038/nature10388

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1004674718

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21881561


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