The wMel Wolbachia strain blocks dengue and invades caged Aedes aegypti populations View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2011-08

AUTHORS

T. Walker, P. H. Johnson, L. A. Moreira, I. Iturbe-Ormaetxe, F. D. Frentiu, C. J. McMeniman, Y. S. Leong, Y. Dong, J. Axford, P. Kriesner, A. L. Lloyd, S. A. Ritchie, S. L. O’Neill, A. A. Hoffmann

ABSTRACT

Dengue fever is the most important mosquito-borne viral disease of humans with more than 50 million cases estimated annually in more than 100 countries. Disturbingly, the geographic range of dengue is currently expanding and the severity of outbreaks is increasing. Control options for dengue are very limited and currently focus on reducing population abundance of the major mosquito vector, Aedes aegypti. These strategies are failing to reduce dengue incidence in tropical communities and there is an urgent need for effective alternatives. It has been proposed that endosymbiotic bacterial Wolbachia infections of insects might be used in novel strategies for dengue control. For example, the wMelPop-CLA Wolbachia strain reduces the lifespan of adult A. aegypti mosquitoes in stably transinfected lines. This life-shortening phenotype was predicted to reduce the potential for dengue transmission. The recent discovery that several Wolbachia infections, including wMelPop-CLA, can also directly influence the susceptibility of insects to infection with a range of insect and human pathogens has markedly changed the potential for Wolbachia infections to control human diseases. Here we describe the successful transinfection of A. aegypti with the avirulent wMel strain of Wolbachia, which induces the reproductive phenotype cytoplasmic incompatibility with minimal apparent fitness costs and high maternal transmission, providing optimal phenotypic effects for invasion. Under semi-field conditions, the wMel strain increased from an initial starting frequency of 0.65 to near fixation within a few generations, invading A. aegypti populations at an accelerated rate relative to trials with the wMelPop-CLA strain. We also show that wMel and wMelPop-CLA strains block transmission of dengue serotype 2 (DENV-2) in A. aegypti, forming the basis of a practical approach to dengue suppression. More... »

PAGES

450

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature10355

DOI

http://dx.doi.org/10.1038/nature10355

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1018779060

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21866159


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1108", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical Microbiology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aedes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dengue", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dengue Virus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Fitness", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Insect Vectors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pest Control, Biological", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Reproduction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Saliva", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Wolbachia", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Queensland", 
          "id": "https://www.grid.ac/institutes/grid.1003.2", 
          "name": [
            "School of Biological Sciences, The University of Queensland, Brisbane, Queensland 4072, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Walker", 
        "givenName": "T.", 
        "id": "sg:person.01252247006.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01252247006.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "James Cook University", 
          "id": "https://www.grid.ac/institutes/grid.1011.1", 
          "name": [
            "School of Public Health and Tropical Medicine and Rehabilitative Sciences, James Cook University, Cairns, Queensland 4870, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Johnson", 
        "givenName": "P. H.", 
        "id": "sg:person.01137467515.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01137467515.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Queensland", 
          "id": "https://www.grid.ac/institutes/grid.1003.2", 
          "name": [
            "School of Biological Sciences, The University of Queensland, Brisbane, Queensland 4072, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Moreira", 
        "givenName": "L. A.", 
        "id": "sg:person.011752236112.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011752236112.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Queensland", 
          "id": "https://www.grid.ac/institutes/grid.1003.2", 
          "name": [
            "School of Biological Sciences, The University of Queensland, Brisbane, Queensland 4072, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Iturbe-Ormaetxe", 
        "givenName": "I.", 
        "id": "sg:person.01015613267.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01015613267.65"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Queensland", 
          "id": "https://www.grid.ac/institutes/grid.1003.2", 
          "name": [
            "School of Biological Sciences, The University of Queensland, Brisbane, Queensland 4072, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Frentiu", 
        "givenName": "F. D.", 
        "id": "sg:person.0756213143.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0756213143.77"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Queensland", 
          "id": "https://www.grid.ac/institutes/grid.1003.2", 
          "name": [
            "School of Biological Sciences, The University of Queensland, Brisbane, Queensland 4072, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "McMeniman", 
        "givenName": "C. J.", 
        "id": "sg:person.01355552111.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355552111.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Queensland", 
          "id": "https://www.grid.ac/institutes/grid.1003.2", 
          "name": [
            "School of Biological Sciences, The University of Queensland, Brisbane, Queensland 4072, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Leong", 
        "givenName": "Y. S.", 
        "id": "sg:person.01214332336.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01214332336.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Queensland", 
          "id": "https://www.grid.ac/institutes/grid.1003.2", 
          "name": [
            "School of Biological Sciences, The University of Queensland, Brisbane, Queensland 4072, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dong", 
        "givenName": "Y.", 
        "id": "sg:person.01262445536.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01262445536.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Melbourne", 
          "id": "https://www.grid.ac/institutes/grid.1008.9", 
          "name": [
            "Bio21 Institute, Department of Genetics, The University of Melbourne, Victoria 3010, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Axford", 
        "givenName": "J.", 
        "id": "sg:person.01330560736.93", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01330560736.93"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Melbourne", 
          "id": "https://www.grid.ac/institutes/grid.1008.9", 
          "name": [
            "Bio21 Institute, Department of Genetics, The University of Melbourne, Victoria 3010, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kriesner", 
        "givenName": "P.", 
        "id": "sg:person.0605154636.71", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0605154636.71"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Fogarty International Center", 
          "id": "https://www.grid.ac/institutes/grid.453035.4", 
          "name": [
            "Biomathematics Graduate Program and Department of Mathematics, North Carolina State University, Raleigh, North Carolina 27695, USA", 
            "Fogarty International Center, National Institutes of Health, Bethesda, Maryland 20892, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lloyd", 
        "givenName": "A. L.", 
        "id": "sg:person.01302207740.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01302207740.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "James Cook University", 
          "id": "https://www.grid.ac/institutes/grid.1011.1", 
          "name": [
            "School of Public Health and Tropical Medicine and Rehabilitative Sciences, James Cook University, Cairns, Queensland 4870, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ritchie", 
        "givenName": "S. A.", 
        "id": "sg:person.01255441224.67", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255441224.67"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Monash University", 
          "id": "https://www.grid.ac/institutes/grid.1002.3", 
          "name": [
            "School of Biological Sciences, The University of Queensland, Brisbane, Queensland 4072, Australia", 
            "School of Biological Sciences, Monash University, Victoria 3800, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "O\u2019Neill", 
        "givenName": "S. L.", 
        "id": "sg:person.01247137464.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01247137464.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Melbourne", 
          "id": "https://www.grid.ac/institutes/grid.1008.9", 
          "name": [
            "Bio21 Institute, Department of Genetics, The University of Melbourne, Victoria 3010, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hoffmann", 
        "givenName": "A. A.", 
        "id": "sg:person.01367151252.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01367151252.10"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/nature10356", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006803239", 
          "https://doi.org/10.1038/nature10356"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrmicro2460", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007647905", 
          "https://doi.org/10.1038/nrmicro2460"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2180-7-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008140138", 
          "https://doi.org/10.1186/1471-2180-7-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1558-5646.2009.00822.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010666723"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1558-5646.2009.00822.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010666723"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1603/0022-2585(2008)45[1173:reoaap]2.0.co;2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011189300"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pntd.0000748", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013735805"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrmicro1690", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014054283", 
          "https://doi.org/10.1038/nrmicro1690"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0011977", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016830058"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cub.2005.06.069", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018163230"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1603/0022-2585-38.4.537", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018452333"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pbio.0060002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019920791"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1534/genetics.110.122390", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022074646"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1534/genetics.110.122390", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022074646"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/aem.68.2.656-660.2002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023297799"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.ppat.1000833", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023532374"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jmedent/45.6.1173", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023632304"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0013398", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023982749"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pbio.0020069", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027888170"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/aem.01038-08", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028149791"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.micro.62.081307.163005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029615197"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pbio.1000002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032857555"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2435.2008.01538.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032930031"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/bsp.2010.0032", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032962535"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-0-387-78225-6_11", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033462010", 
          "https://doi.org/10.1007/978-0-387-78225-6_11"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jinsphys.2004.05.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034614003"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pntd.0000988", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034885671"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/353440a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040408142", 
          "https://doi.org/10.1038/353440a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3201/eid1105.050195", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045931384"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1162418", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048146906"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2009.11.042", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048590141"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.trstmh.2006.08.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054751366"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/658121", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058845019"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1165326", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062458968"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1603/0022-2585(2008)45[1173:reoaap]2.0.co;2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068118004"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3376/1081-1710(2006)31[371:dipoaa]2.0.co;2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071230126"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4269/ajtmh.2002.67.85", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1075170573"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4269/ajtmh.2002.67.244", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1075183308"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4269/ajtmh.2006.74.132", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077173872"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4269/ajtmh.1987.36.143", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079966055"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4269/ajtmh.1979.28.1045", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1080790376"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2011-08", 
    "datePublishedReg": "2011-08-01", 
    "description": "Dengue fever is the most important mosquito-borne viral disease of humans with more than 50 million cases estimated annually in more than 100 countries. Disturbingly, the geographic range of dengue is currently expanding and the severity of outbreaks is increasing. Control options for dengue are very limited and currently focus on reducing population abundance of the major mosquito vector, Aedes aegypti. These strategies are failing to reduce dengue incidence in tropical communities and there is an urgent need for effective alternatives. It has been proposed that endosymbiotic bacterial Wolbachia infections of insects might be used in novel strategies for dengue control. For example, the wMelPop-CLA Wolbachia strain reduces the lifespan of adult A. aegypti mosquitoes in stably transinfected lines. This life-shortening phenotype was predicted to reduce the potential for dengue transmission. The recent discovery that several Wolbachia infections, including wMelPop-CLA, can also directly influence the susceptibility of insects to infection with a range of insect and human pathogens has markedly changed the potential for Wolbachia infections to control human diseases. Here we describe the successful transinfection of A. aegypti with the avirulent wMel strain of Wolbachia, which induces the reproductive phenotype cytoplasmic incompatibility with minimal apparent fitness costs and high maternal transmission, providing optimal phenotypic effects for invasion. Under semi-field conditions, the wMel strain increased from an initial starting frequency of 0.65 to near fixation within a few generations, invading A. aegypti populations at an accelerated rate relative to trials with the wMelPop-CLA strain. We also show that wMel and wMelPop-CLA strains block transmission of dengue serotype 2 (DENV-2) in A. aegypti, forming the basis of a practical approach to dengue suppression.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/nature10355", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0090-0028", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "7361", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "476"
      }
    ], 
    "name": "The wMel Wolbachia strain blocks dengue and invades caged Aedes aegypti populations", 
    "pagination": "450", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "5979a633bda4f6e702030d3191a1fe0c2a9c664d9590f33a530071734e45f39c"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "21866159"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0410462"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/nature10355"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1018779060"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/nature10355", 
      "https://app.dimensions.ai/details/publication/pub.1018779060"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T20:35", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8684_00000435.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/nature10355"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nature10355'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nature10355'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nature10355'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nature10355'


 

This table displays all metadata directly associated to this object as RDF triples.

347 TRIPLES      21 PREDICATES      80 URIs      34 LITERALS      22 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/nature10355 schema:about N05ec13f1b02d4217a7823d4fbfcc224f
2 N1314ca3b6f9a439b9becbee07aa2c7ad
3 N1cd27a83d2494cd5a2a5d3f5107e92f3
4 N308032b60d7048dd9409bc18833e2aeb
5 N31ab0a0bb582467c89d8449910283485
6 N4c89d8fda6954b2b8ef0e98d4e9f2897
7 N4dfa77f93f664130988519f6e790a805
8 N611ee4495592409f9edd4c4401849223
9 N8ffd6920181c43308431e37f477e8b02
10 Nce757ddfeb54426289220b1d3a2554b4
11 Ndd037d8c1b0c472d8bf37dfd29d810ba
12 Ne828e3bc86f94b1e975d6ac406ef490f
13 Nf9134bfa61a24a2c9f0cde664e56f318
14 anzsrc-for:11
15 anzsrc-for:1108
16 schema:author Na4a295dfe687468c89fa34291b6e5e44
17 schema:citation sg:pub.10.1007/978-0-387-78225-6_11
18 sg:pub.10.1038/353440a0
19 sg:pub.10.1038/nature10356
20 sg:pub.10.1038/nrmicro1690
21 sg:pub.10.1038/nrmicro2460
22 sg:pub.10.1186/1471-2180-7-9
23 https://doi.org/10.1016/j.cell.2009.11.042
24 https://doi.org/10.1016/j.cub.2005.06.069
25 https://doi.org/10.1016/j.jinsphys.2004.05.001
26 https://doi.org/10.1016/j.trstmh.2006.08.007
27 https://doi.org/10.1086/658121
28 https://doi.org/10.1089/bsp.2010.0032
29 https://doi.org/10.1093/jmedent/45.6.1173
30 https://doi.org/10.1111/j.1365-2435.2008.01538.x
31 https://doi.org/10.1111/j.1558-5646.2009.00822.x
32 https://doi.org/10.1126/science.1162418
33 https://doi.org/10.1126/science.1165326
34 https://doi.org/10.1128/aem.01038-08
35 https://doi.org/10.1128/aem.68.2.656-660.2002
36 https://doi.org/10.1146/annurev.micro.62.081307.163005
37 https://doi.org/10.1371/journal.pbio.0020069
38 https://doi.org/10.1371/journal.pbio.0060002
39 https://doi.org/10.1371/journal.pbio.1000002
40 https://doi.org/10.1371/journal.pntd.0000748
41 https://doi.org/10.1371/journal.pntd.0000988
42 https://doi.org/10.1371/journal.pone.0011977
43 https://doi.org/10.1371/journal.pone.0013398
44 https://doi.org/10.1371/journal.ppat.1000833
45 https://doi.org/10.1534/genetics.110.122390
46 https://doi.org/10.1603/0022-2585(2008)45[1173:reoaap]2.0.co;2
47 https://doi.org/10.1603/0022-2585-38.4.537
48 https://doi.org/10.3201/eid1105.050195
49 https://doi.org/10.3376/1081-1710(2006)31[371:dipoaa]2.0.co;2
50 https://doi.org/10.4269/ajtmh.1979.28.1045
51 https://doi.org/10.4269/ajtmh.1987.36.143
52 https://doi.org/10.4269/ajtmh.2002.67.244
53 https://doi.org/10.4269/ajtmh.2002.67.85
54 https://doi.org/10.4269/ajtmh.2006.74.132
55 schema:datePublished 2011-08
56 schema:datePublishedReg 2011-08-01
57 schema:description Dengue fever is the most important mosquito-borne viral disease of humans with more than 50 million cases estimated annually in more than 100 countries. Disturbingly, the geographic range of dengue is currently expanding and the severity of outbreaks is increasing. Control options for dengue are very limited and currently focus on reducing population abundance of the major mosquito vector, Aedes aegypti. These strategies are failing to reduce dengue incidence in tropical communities and there is an urgent need for effective alternatives. It has been proposed that endosymbiotic bacterial Wolbachia infections of insects might be used in novel strategies for dengue control. For example, the wMelPop-CLA Wolbachia strain reduces the lifespan of adult A. aegypti mosquitoes in stably transinfected lines. This life-shortening phenotype was predicted to reduce the potential for dengue transmission. The recent discovery that several Wolbachia infections, including wMelPop-CLA, can also directly influence the susceptibility of insects to infection with a range of insect and human pathogens has markedly changed the potential for Wolbachia infections to control human diseases. Here we describe the successful transinfection of A. aegypti with the avirulent wMel strain of Wolbachia, which induces the reproductive phenotype cytoplasmic incompatibility with minimal apparent fitness costs and high maternal transmission, providing optimal phenotypic effects for invasion. Under semi-field conditions, the wMel strain increased from an initial starting frequency of 0.65 to near fixation within a few generations, invading A. aegypti populations at an accelerated rate relative to trials with the wMelPop-CLA strain. We also show that wMel and wMelPop-CLA strains block transmission of dengue serotype 2 (DENV-2) in A. aegypti, forming the basis of a practical approach to dengue suppression.
58 schema:genre research_article
59 schema:inLanguage en
60 schema:isAccessibleForFree false
61 schema:isPartOf N102fbff1da924e1e8a688d9350633609
62 N1d75851f823944749e512df93214fe25
63 sg:journal.1018957
64 schema:name The wMel Wolbachia strain blocks dengue and invades caged Aedes aegypti populations
65 schema:pagination 450
66 schema:productId N16cf3f382f75413f9de991a8ce2cb6e8
67 N3c6c498cde924274900259abf23a0c56
68 N4c7e5926932e42b9b39598544c3b7f2c
69 N72728e53d10e4625b86384264b52fd94
70 Na9c06c069df74720a605ab25e104fb74
71 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018779060
72 https://doi.org/10.1038/nature10355
73 schema:sdDatePublished 2019-04-10T20:35
74 schema:sdLicense https://scigraph.springernature.com/explorer/license/
75 schema:sdPublisher N31978bc6f2fd4626a2b1411ed91d197c
76 schema:url https://www.nature.com/articles/nature10355
77 sgo:license sg:explorer/license/
78 sgo:sdDataset articles
79 rdf:type schema:ScholarlyArticle
80 N05ec13f1b02d4217a7823d4fbfcc224f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
81 schema:name Humans
82 rdf:type schema:DefinedTerm
83 N102fbff1da924e1e8a688d9350633609 schema:volumeNumber 476
84 rdf:type schema:PublicationVolume
85 N1314ca3b6f9a439b9becbee07aa2c7ad schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
86 schema:name Saliva
87 rdf:type schema:DefinedTerm
88 N15fc644ad7b345a8afe1442a78b5ea3d rdf:first sg:person.01302207740.54
89 rdf:rest N9335d3781ada49c0923a8d2f58c70bca
90 N16cf3f382f75413f9de991a8ce2cb6e8 schema:name nlm_unique_id
91 schema:value 0410462
92 rdf:type schema:PropertyValue
93 N1cd27a83d2494cd5a2a5d3f5107e92f3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name Female
95 rdf:type schema:DefinedTerm
96 N1d75851f823944749e512df93214fe25 schema:issueNumber 7361
97 rdf:type schema:PublicationIssue
98 N20c1a4e5dc7a451cb49b799b0913cbb6 rdf:first sg:person.0756213143.77
99 rdf:rest N316e538e110f4a78bd2907304ced9df3
100 N308032b60d7048dd9409bc18833e2aeb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Animals
102 rdf:type schema:DefinedTerm
103 N30bc072195e84b9fb0642fae3671d626 rdf:first sg:person.0605154636.71
104 rdf:rest N15fc644ad7b345a8afe1442a78b5ea3d
105 N316e538e110f4a78bd2907304ced9df3 rdf:first sg:person.01355552111.50
106 rdf:rest N6d20c30c76c64cddaacbf2875099a482
107 N31978bc6f2fd4626a2b1411ed91d197c schema:name Springer Nature - SN SciGraph project
108 rdf:type schema:Organization
109 N31ab0a0bb582467c89d8449910283485 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Reproduction
111 rdf:type schema:DefinedTerm
112 N34965a33e06c49e0ae421bfa4ff51b17 rdf:first sg:person.01015613267.65
113 rdf:rest N20c1a4e5dc7a451cb49b799b0913cbb6
114 N3c6c498cde924274900259abf23a0c56 schema:name dimensions_id
115 schema:value pub.1018779060
116 rdf:type schema:PropertyValue
117 N4c7e5926932e42b9b39598544c3b7f2c schema:name readcube_id
118 schema:value 5979a633bda4f6e702030d3191a1fe0c2a9c664d9590f33a530071734e45f39c
119 rdf:type schema:PropertyValue
120 N4c89d8fda6954b2b8ef0e98d4e9f2897 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Dengue
122 rdf:type schema:DefinedTerm
123 N4dfa77f93f664130988519f6e790a805 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Insect Vectors
125 rdf:type schema:DefinedTerm
126 N4f41bf9913db42b2b6e69d1366df1f4a rdf:first sg:person.01247137464.00
127 rdf:rest Nd2bbd74560bd49fea1de82a14f57e06b
128 N5541ab67638344389cba877fbd57eba2 rdf:first sg:person.01137467515.31
129 rdf:rest Nd5f9c5a9256049328bdf9c5eecef3777
130 N611ee4495592409f9edd4c4401849223 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Genetic Fitness
132 rdf:type schema:DefinedTerm
133 N6b2c12333a8c47d08007abfd96ed3b59 rdf:first sg:person.01330560736.93
134 rdf:rest N30bc072195e84b9fb0642fae3671d626
135 N6d20c30c76c64cddaacbf2875099a482 rdf:first sg:person.01214332336.25
136 rdf:rest Ncf17ae535f074a6a8a7a9e325307f7c4
137 N72728e53d10e4625b86384264b52fd94 schema:name pubmed_id
138 schema:value 21866159
139 rdf:type schema:PropertyValue
140 N8ffd6920181c43308431e37f477e8b02 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Dengue Virus
142 rdf:type schema:DefinedTerm
143 N9335d3781ada49c0923a8d2f58c70bca rdf:first sg:person.01255441224.67
144 rdf:rest N4f41bf9913db42b2b6e69d1366df1f4a
145 Na4a295dfe687468c89fa34291b6e5e44 rdf:first sg:person.01252247006.45
146 rdf:rest N5541ab67638344389cba877fbd57eba2
147 Na9c06c069df74720a605ab25e104fb74 schema:name doi
148 schema:value 10.1038/nature10355
149 rdf:type schema:PropertyValue
150 Nce757ddfeb54426289220b1d3a2554b4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Aedes
152 rdf:type schema:DefinedTerm
153 Ncf17ae535f074a6a8a7a9e325307f7c4 rdf:first sg:person.01262445536.15
154 rdf:rest N6b2c12333a8c47d08007abfd96ed3b59
155 Nd2bbd74560bd49fea1de82a14f57e06b rdf:first sg:person.01367151252.10
156 rdf:rest rdf:nil
157 Nd5f9c5a9256049328bdf9c5eecef3777 rdf:first sg:person.011752236112.03
158 rdf:rest N34965a33e06c49e0ae421bfa4ff51b17
159 Ndd037d8c1b0c472d8bf37dfd29d810ba schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Wolbachia
161 rdf:type schema:DefinedTerm
162 Ne828e3bc86f94b1e975d6ac406ef490f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Male
164 rdf:type schema:DefinedTerm
165 Nf9134bfa61a24a2c9f0cde664e56f318 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Pest Control, Biological
167 rdf:type schema:DefinedTerm
168 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
169 schema:name Medical and Health Sciences
170 rdf:type schema:DefinedTerm
171 anzsrc-for:1108 schema:inDefinedTermSet anzsrc-for:
172 schema:name Medical Microbiology
173 rdf:type schema:DefinedTerm
174 sg:journal.1018957 schema:issn 0090-0028
175 1476-4687
176 schema:name Nature
177 rdf:type schema:Periodical
178 sg:person.01015613267.65 schema:affiliation https://www.grid.ac/institutes/grid.1003.2
179 schema:familyName Iturbe-Ormaetxe
180 schema:givenName I.
181 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01015613267.65
182 rdf:type schema:Person
183 sg:person.01137467515.31 schema:affiliation https://www.grid.ac/institutes/grid.1011.1
184 schema:familyName Johnson
185 schema:givenName P. H.
186 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01137467515.31
187 rdf:type schema:Person
188 sg:person.011752236112.03 schema:affiliation https://www.grid.ac/institutes/grid.1003.2
189 schema:familyName Moreira
190 schema:givenName L. A.
191 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011752236112.03
192 rdf:type schema:Person
193 sg:person.01214332336.25 schema:affiliation https://www.grid.ac/institutes/grid.1003.2
194 schema:familyName Leong
195 schema:givenName Y. S.
196 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01214332336.25
197 rdf:type schema:Person
198 sg:person.01247137464.00 schema:affiliation https://www.grid.ac/institutes/grid.1002.3
199 schema:familyName O’Neill
200 schema:givenName S. L.
201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01247137464.00
202 rdf:type schema:Person
203 sg:person.01252247006.45 schema:affiliation https://www.grid.ac/institutes/grid.1003.2
204 schema:familyName Walker
205 schema:givenName T.
206 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01252247006.45
207 rdf:type schema:Person
208 sg:person.01255441224.67 schema:affiliation https://www.grid.ac/institutes/grid.1011.1
209 schema:familyName Ritchie
210 schema:givenName S. A.
211 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255441224.67
212 rdf:type schema:Person
213 sg:person.01262445536.15 schema:affiliation https://www.grid.ac/institutes/grid.1003.2
214 schema:familyName Dong
215 schema:givenName Y.
216 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01262445536.15
217 rdf:type schema:Person
218 sg:person.01302207740.54 schema:affiliation https://www.grid.ac/institutes/grid.453035.4
219 schema:familyName Lloyd
220 schema:givenName A. L.
221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01302207740.54
222 rdf:type schema:Person
223 sg:person.01330560736.93 schema:affiliation https://www.grid.ac/institutes/grid.1008.9
224 schema:familyName Axford
225 schema:givenName J.
226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01330560736.93
227 rdf:type schema:Person
228 sg:person.01355552111.50 schema:affiliation https://www.grid.ac/institutes/grid.1003.2
229 schema:familyName McMeniman
230 schema:givenName C. J.
231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355552111.50
232 rdf:type schema:Person
233 sg:person.01367151252.10 schema:affiliation https://www.grid.ac/institutes/grid.1008.9
234 schema:familyName Hoffmann
235 schema:givenName A. A.
236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01367151252.10
237 rdf:type schema:Person
238 sg:person.0605154636.71 schema:affiliation https://www.grid.ac/institutes/grid.1008.9
239 schema:familyName Kriesner
240 schema:givenName P.
241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0605154636.71
242 rdf:type schema:Person
243 sg:person.0756213143.77 schema:affiliation https://www.grid.ac/institutes/grid.1003.2
244 schema:familyName Frentiu
245 schema:givenName F. D.
246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0756213143.77
247 rdf:type schema:Person
248 sg:pub.10.1007/978-0-387-78225-6_11 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033462010
249 https://doi.org/10.1007/978-0-387-78225-6_11
250 rdf:type schema:CreativeWork
251 sg:pub.10.1038/353440a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040408142
252 https://doi.org/10.1038/353440a0
253 rdf:type schema:CreativeWork
254 sg:pub.10.1038/nature10356 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006803239
255 https://doi.org/10.1038/nature10356
256 rdf:type schema:CreativeWork
257 sg:pub.10.1038/nrmicro1690 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014054283
258 https://doi.org/10.1038/nrmicro1690
259 rdf:type schema:CreativeWork
260 sg:pub.10.1038/nrmicro2460 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007647905
261 https://doi.org/10.1038/nrmicro2460
262 rdf:type schema:CreativeWork
263 sg:pub.10.1186/1471-2180-7-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008140138
264 https://doi.org/10.1186/1471-2180-7-9
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1016/j.cell.2009.11.042 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048590141
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1016/j.cub.2005.06.069 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018163230
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1016/j.jinsphys.2004.05.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034614003
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1016/j.trstmh.2006.08.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054751366
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1086/658121 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058845019
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1089/bsp.2010.0032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032962535
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1093/jmedent/45.6.1173 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023632304
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1111/j.1365-2435.2008.01538.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1032930031
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1111/j.1558-5646.2009.00822.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1010666723
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1126/science.1162418 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048146906
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1126/science.1165326 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062458968
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1128/aem.01038-08 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028149791
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1128/aem.68.2.656-660.2002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023297799
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1146/annurev.micro.62.081307.163005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029615197
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1371/journal.pbio.0020069 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027888170
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1371/journal.pbio.0060002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019920791
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1371/journal.pbio.1000002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032857555
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1371/journal.pntd.0000748 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013735805
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1371/journal.pntd.0000988 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034885671
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1371/journal.pone.0011977 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016830058
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1371/journal.pone.0013398 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023982749
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1371/journal.ppat.1000833 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023532374
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1534/genetics.110.122390 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022074646
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1603/0022-2585(2008)45[1173:reoaap]2.0.co;2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011189300
313 https://app.dimensions.ai/details/publication/pub.1068118004
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1603/0022-2585-38.4.537 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018452333
316 rdf:type schema:CreativeWork
317 https://doi.org/10.3201/eid1105.050195 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045931384
318 rdf:type schema:CreativeWork
319 https://doi.org/10.3376/1081-1710(2006)31[371:dipoaa]2.0.co;2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071230126
320 rdf:type schema:CreativeWork
321 https://doi.org/10.4269/ajtmh.1979.28.1045 schema:sameAs https://app.dimensions.ai/details/publication/pub.1080790376
322 rdf:type schema:CreativeWork
323 https://doi.org/10.4269/ajtmh.1987.36.143 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079966055
324 rdf:type schema:CreativeWork
325 https://doi.org/10.4269/ajtmh.2002.67.244 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075183308
326 rdf:type schema:CreativeWork
327 https://doi.org/10.4269/ajtmh.2002.67.85 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075170573
328 rdf:type schema:CreativeWork
329 https://doi.org/10.4269/ajtmh.2006.74.132 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077173872
330 rdf:type schema:CreativeWork
331 https://www.grid.ac/institutes/grid.1002.3 schema:alternateName Monash University
332 schema:name School of Biological Sciences, Monash University, Victoria 3800, Australia
333 School of Biological Sciences, The University of Queensland, Brisbane, Queensland 4072, Australia
334 rdf:type schema:Organization
335 https://www.grid.ac/institutes/grid.1003.2 schema:alternateName University of Queensland
336 schema:name School of Biological Sciences, The University of Queensland, Brisbane, Queensland 4072, Australia
337 rdf:type schema:Organization
338 https://www.grid.ac/institutes/grid.1008.9 schema:alternateName University of Melbourne
339 schema:name Bio21 Institute, Department of Genetics, The University of Melbourne, Victoria 3010, Australia
340 rdf:type schema:Organization
341 https://www.grid.ac/institutes/grid.1011.1 schema:alternateName James Cook University
342 schema:name School of Public Health and Tropical Medicine and Rehabilitative Sciences, James Cook University, Cairns, Queensland 4870, Australia
343 rdf:type schema:Organization
344 https://www.grid.ac/institutes/grid.453035.4 schema:alternateName Fogarty International Center
345 schema:name Biomathematics Graduate Program and Department of Mathematics, North Carolina State University, Raleigh, North Carolina 27695, USA
346 Fogarty International Center, National Institutes of Health, Bethesda, Maryland 20892, USA
347 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...