Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2011-08

AUTHORS

Wim de Lau, Nick Barker, Teck Y. Low, Bon-Kyoung Koo, Vivian S. W. Li, Hans Teunissen, Pekka Kujala, Andrea Haegebarth, Peter J. Peters, Marc van de Wetering, D. E. Stange, J. van Es, Daniele Guardavaccaro, Richard B. M. Schasfoort, Yasuaki Mohri, Katsuhiko Nishimori, Shabaz Mohammed, Albert J. R. Heck, Hans Clevers

ABSTRACT

The adult stem cell marker Lgr5 and its relative Lgr4 are often co-expressed in Wnt-driven proliferative compartments. We find that conditional deletion of both genes in the mouse gut impairs Wnt target gene expression and results in the rapid demise of intestinal crypts, thus phenocopying Wnt pathway inhibition. Mass spectrometry demonstrates that Lgr4 and Lgr5 associate with the Frizzled/Lrp Wnt receptor complex. Each of the four R-spondins, secreted Wnt pathway agonists, can bind to Lgr4, -5 and -6. In HEK293 cells, RSPO1 enhances canonical WNT signals initiated by WNT3A. Removal of LGR4 does not affect WNT3A signalling, but abrogates the RSPO1-mediated signal enhancement, a phenomenon rescued by re-expression of LGR4, -5 or -6. Genetic deletion of Lgr4/5 in mouse intestinal crypt cultures phenocopies withdrawal of Rspo1 and can be rescued by Wnt pathway activation. Lgr5 homologues are facultative Wnt receptor components that mediate Wnt signal enhancement by soluble R-spondin proteins. These results will guide future studies towards the application of R-spondins for regenerative purposes of tissues expressing Lgr5 homologues. More... »

PAGES

293

Journal

TITLE

Nature

ISSUE

7360

VOLUME

476

From Grant

  • Related Patents

  • Rsv G Protein Specific Antibodies
  • Notch Pathway Inhibition
  • Compositions And Methods For Treating And Diagnosing Cancer
  • Methods Of Treating Cancer By Administering Anti-Gpr49 Antibodies
  • Anti-Lgr5 Antibodies And Immunoconjugates
  • Compositions And Methods Relating To Induction Of Intestinal Stem Cell Homeogenesis And/Or Regeneration
  • Anti-Gpr49 Monoclonal Antibodies
  • Anti-Rspo2 Antibodies And Uses Thereof
  • A Rapid Quantitative Assay To Measure Cftr Function In A Primary Intestinal Culture Model
  • Methods Of Blocking Cancer Stem Cell Growth
  • Liver Organoid, Uses Thereof And Culture Method For Obtaining Them
  • Treatment Of Dermal Fibrosis
  • Anti-Lgr5 Antibodies And Immunoconjugates
  • Method For Preparing Induced Paraxial Mesoderm Progenitor (Ipam) Cells And Their Use
  • Method For Identifying, Expanding, And Removing Adult Stem Cells And Cancer Stem Cells
  • Methods Of Inhibiting Solid Tumor Growth By Administering Gpr49 Antibodies
  • Culture Medium For Epithelial Stem Cells And Organoids Comprising The Stem Cells
  • Method For Identifying, Expanding And Removing Adult Stem Cells And Cancer Stem Cells
  • A Rapid Quantitative Assay To Measure Cftr Function In A Primary Intestinal Culture Model
  • Compositions And Methods For Treating And Diagnosing Cancer
  • Methods For Establishing And Improving The Survival Of A Population Of Pancreatic Progenitor Or Stem Cells
  • Rapid Quantitative Assay To Measure Cftr Function In A Primary Intestinal Culture Model
  • Rspo3 Binding Agents And Uses Thereof
  • Humanized Antibodies That Bind Lgr5
  • Methods Of Blocking Cancer Stem Cell Growth
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nature10337

    DOI

    http://dx.doi.org/10.1038/nature10337

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1053455836

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/21727895


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biochemistry and Cell Biology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adult Stem Cells", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cells, Cultured", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Epithelial Cells", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Frizzled Receptors", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Deletion", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "HEK293 Cells", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Protein Binding", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Protein Structure, Tertiary", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Receptors, G-Protein-Coupled", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Regeneration", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Signal Transduction", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Thrombospondins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Wnt Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Wnt3 Protein", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Wnt3A Protein", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "name": [
                "Hubrecht Institute and University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "de Lau", 
            "givenName": "Wim", 
            "id": "sg:person.01213722537.34", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01213722537.34"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Hubrecht Institute and University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Barker", 
            "givenName": "Nick", 
            "id": "sg:person.01307053755.26", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01307053755.26"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Utrecht University", 
              "id": "https://www.grid.ac/institutes/grid.5477.1", 
              "name": [
                "Biomolecular Mass Spectrometry and Proteomics Group, Bijvoet Center, Utrecht University, 3584 CH Utrecht, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Low", 
            "givenName": "Teck Y.", 
            "id": "sg:person.01313245325.38", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01313245325.38"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Hubrecht Institute and University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Koo", 
            "givenName": "Bon-Kyoung", 
            "id": "sg:person.01352156370.23", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01352156370.23"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Hubrecht Institute and University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Li", 
            "givenName": "Vivian S. W.", 
            "id": "sg:person.012054747172.33", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012054747172.33"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Hubrecht Institute and University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Teunissen", 
            "givenName": "Hans", 
            "id": "sg:person.0677136307.17", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677136307.17"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Antoni van Leeuwenhoek Hospital Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kujala", 
            "givenName": "Pekka", 
            "id": "sg:person.0616060543.03", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0616060543.03"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Hubrecht Institute and University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Haegebarth", 
            "givenName": "Andrea", 
            "id": "sg:person.01273351443.89", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01273351443.89"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Antoni van Leeuwenhoek Hospital Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Peters", 
            "givenName": "Peter J.", 
            "id": "sg:person.01132006272.03", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01132006272.03"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Hubrecht Institute and University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "van de Wetering", 
            "givenName": "Marc", 
            "id": "sg:person.0750240753.37", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0750240753.37"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Hubrecht Institute and University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Stange", 
            "givenName": "D. E.", 
            "id": "sg:person.0643614125.13", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0643614125.13"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Hubrecht Institute and University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "van Es", 
            "givenName": "J.", 
            "id": "sg:person.01064467353.67", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01064467353.67"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Hubrecht Institute and University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Guardavaccaro", 
            "givenName": "Daniele", 
            "id": "sg:person.0666067727.95", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0666067727.95"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Twente", 
              "id": "https://www.grid.ac/institutes/grid.6214.1", 
              "name": [
                "Medical Cell Biophysics, MIRA institute, University of Twente, 7500 AE Enschede, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Schasfoort", 
            "givenName": "Richard B. M.", 
            "id": "sg:person.015536155047.43", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015536155047.43"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Tohoku University", 
              "id": "https://www.grid.ac/institutes/grid.69566.3a", 
              "name": [
                "Tohoku University, 981-8555 Sendai, Miyagi, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mohri", 
            "givenName": "Yasuaki", 
            "id": "sg:person.0735472007.92", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0735472007.92"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Tohoku University", 
              "id": "https://www.grid.ac/institutes/grid.69566.3a", 
              "name": [
                "Tohoku University, 981-8555 Sendai, Miyagi, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nishimori", 
            "givenName": "Katsuhiko", 
            "id": "sg:person.01151605507.23", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01151605507.23"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Utrecht University", 
              "id": "https://www.grid.ac/institutes/grid.5477.1", 
              "name": [
                "Biomolecular Mass Spectrometry and Proteomics Group, Bijvoet Center, Utrecht University, 3584 CH Utrecht, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mohammed", 
            "givenName": "Shabaz", 
            "id": "sg:person.01237336020.34", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01237336020.34"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Utrecht University", 
              "id": "https://www.grid.ac/institutes/grid.5477.1", 
              "name": [
                "Biomolecular Mass Spectrometry and Proteomics Group, Bijvoet Center, Utrecht University, 3584 CH Utrecht, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Heck", 
            "givenName": "Albert J. R.", 
            "id": "sg:person.07502404177.84", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07502404177.84"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Hubrecht Institute and University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Clevers", 
            "givenName": "Hans", 
            "id": "sg:person.0662243670.45", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0662243670.45"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1053/j.gastro.2009.05.035", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001779262"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/1270", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002695839", 
              "https://doi.org/10.1038/1270"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/1270", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002695839", 
              "https://doi.org/10.1038/1270"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature05674", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002848303", 
              "https://doi.org/10.1038/nature05674"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1184733", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002969630"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.24.22.9736-9743.2004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003545217"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2009.01.031", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003917776"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/j.gastro.2007.02.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004526083"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m701927200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007327575"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.267103", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011480346"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.267103", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011480346"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ydbio.2009.04.020", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013884866"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.febslet.2007.08.064", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016812609"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m508324200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017083954"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m109.078261", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018759398"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1091/mbc.e08-02-0187", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022351840"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.239", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023194186", 
              "https://doi.org/10.1038/ng.239"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature07935", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024082069", 
              "https://doi.org/10.1038/nature07935"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature07935", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024082069", 
              "https://doi.org/10.1038/nature07935"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.devcel.2004.07.019", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024994615"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/j.gastro.2010.03.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025461503"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/embor.2011.52", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028716824"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09637", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030684957", 
              "https://doi.org/10.1038/nature09637"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/mcp.m800093-mcp200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031511342"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1124/mol.105.014183", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031657105"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/dvdy.20446", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031742698"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/dvdy.20446", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031742698"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0076-6879(03)70037-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035247640"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.93.16.8455", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035953957"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0506580102", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037705714"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0506580102", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037705714"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.devcel.2011.01.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038585487"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/pr1011729", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039087538"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.stem.2009.11.013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039362335"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.00821-06", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040375340"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00418-005-0002-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044478492", 
              "https://doi.org/10.1007/s00418-005-0002-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00418-005-0002-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044478492", 
              "https://doi.org/10.1007/s00418-005-0002-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0702305104", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045150931"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03659", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046707660", 
              "https://doi.org/10.1038/nature03659"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03659", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046707660", 
              "https://doi.org/10.1038/nature03659"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.1511", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049469421", 
              "https://doi.org/10.1038/nbt.1511"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature06196", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050225537", 
              "https://doi.org/10.1038/nature06196"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.2536800100", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050279034"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.2536800100", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050279034"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1112521", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050697196"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/34848", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051110109", 
              "https://doi.org/10.1038/34848"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/34848", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051110109", 
              "https://doi.org/10.1038/34848"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/34848", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051110109", 
              "https://doi.org/10.1038/34848"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ac950914h", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055072376"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ac950914h", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055072376"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.275.5307.1784", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062556119"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2144/03342mt01", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1075245738"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082831306", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2011-08", 
        "datePublishedReg": "2011-08-01", 
        "description": "The adult stem cell marker Lgr5 and its relative Lgr4 are often co-expressed in Wnt-driven proliferative compartments. We find that conditional deletion of both genes in the mouse gut impairs Wnt target gene expression and results in the rapid demise of intestinal crypts, thus phenocopying Wnt pathway inhibition. Mass spectrometry demonstrates that Lgr4 and Lgr5 associate with the Frizzled/Lrp Wnt receptor complex. Each of the four R-spondins, secreted Wnt pathway agonists, can bind to Lgr4, -5 and -6. In HEK293 cells, RSPO1 enhances canonical WNT signals initiated by WNT3A. Removal of LGR4 does not affect WNT3A signalling, but abrogates the RSPO1-mediated signal enhancement, a phenomenon rescued by re-expression of LGR4, -5 or -6. Genetic deletion of Lgr4/5 in mouse intestinal crypt cultures phenocopies withdrawal of Rspo1 and can be rescued by Wnt pathway activation. Lgr5 homologues are facultative Wnt receptor components that mediate Wnt signal enhancement by soluble R-spondin proteins. These results will guide future studies towards the application of R-spondins for regenerative purposes of tissues expressing Lgr5 homologues.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/nature10337", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.6058394", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.6047570", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1018957", 
            "issn": [
              "0090-0028", 
              "1476-4687"
            ], 
            "name": "Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "7360", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "476"
          }
        ], 
        "name": "Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling", 
        "pagination": "293", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "fe9de5c111a1cf3076e8fe425b2dc5c3def58db135207348b2f7c594f28bc3fe"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "21727895"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "0410462"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/nature10337"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1053455836"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/nature10337", 
          "https://app.dimensions.ai/details/publication/pub.1053455836"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T16:30", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8669_00000434.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/nature10337"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nature10337'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nature10337'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nature10337'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nature10337'


     

    This table displays all metadata directly associated to this object as RDF triples.

    438 TRIPLES      21 PREDICATES      89 URIs      39 LITERALS      27 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/nature10337 schema:about N02609acc848f4b64bc123167c700b1d2
    2 N0d9adb6e5804449e992feecc2742b20e
    3 N1640d80ddac04ea0be1771ec0b1d816f
    4 N1708d0a1010740f3bbe300f9254805b3
    5 N190c6f1293f243cd9fd89c8ccd80c339
    6 N3859f1ea814d4bf19c1343c95822bf9f
    7 N3e1b0155f60a4694862189c70a68a485
    8 N4bcd0902691a4af7bb477fb4cd02996c
    9 N4fc9477a0b3a48a0b5ede0dd1147b325
    10 N5de98dfc181542f2bba8b239ea8c44db
    11 N6731a0758f834726a29ab4bb83056c86
    12 N7c8b50420cdc4d51aa0a00297fd363cb
    13 N8dd83e9d7ece40708cb98229f8e1ae44
    14 N9891ca03286f4178929acaa30369a971
    15 N9a92c1cc2f60431e83b2201ea7685e99
    16 Nca54ad95d8f045fc9c0738c352329735
    17 Ncd2304148aa8431c9f021b7cefe0dec4
    18 Ne4b94dbbd8a34cee9de53d3eaa5ed54c
    19 anzsrc-for:06
    20 anzsrc-for:0601
    21 schema:author N80f3cc9bec9d4c94a448d7b85abebd81
    22 schema:citation sg:pub.10.1007/s00418-005-0002-3
    23 sg:pub.10.1038/1270
    24 sg:pub.10.1038/34848
    25 sg:pub.10.1038/nature03659
    26 sg:pub.10.1038/nature05674
    27 sg:pub.10.1038/nature06196
    28 sg:pub.10.1038/nature07935
    29 sg:pub.10.1038/nature09637
    30 sg:pub.10.1038/nbt.1511
    31 sg:pub.10.1038/ng.239
    32 https://app.dimensions.ai/details/publication/pub.1082831306
    33 https://doi.org/10.1002/dvdy.20446
    34 https://doi.org/10.1016/j.cell.2009.01.031
    35 https://doi.org/10.1016/j.devcel.2004.07.019
    36 https://doi.org/10.1016/j.devcel.2011.01.006
    37 https://doi.org/10.1016/j.febslet.2007.08.064
    38 https://doi.org/10.1016/j.stem.2009.11.013
    39 https://doi.org/10.1016/j.ydbio.2009.04.020
    40 https://doi.org/10.1016/s0076-6879(03)70037-8
    41 https://doi.org/10.1021/ac950914h
    42 https://doi.org/10.1021/pr1011729
    43 https://doi.org/10.1038/embor.2011.52
    44 https://doi.org/10.1053/j.gastro.2007.02.001
    45 https://doi.org/10.1053/j.gastro.2009.05.035
    46 https://doi.org/10.1053/j.gastro.2010.03.002
    47 https://doi.org/10.1073/pnas.0506580102
    48 https://doi.org/10.1073/pnas.0702305104
    49 https://doi.org/10.1073/pnas.2536800100
    50 https://doi.org/10.1073/pnas.93.16.8455
    51 https://doi.org/10.1074/jbc.m109.078261
    52 https://doi.org/10.1074/jbc.m508324200
    53 https://doi.org/10.1074/jbc.m701927200
    54 https://doi.org/10.1074/mcp.m800093-mcp200
    55 https://doi.org/10.1091/mbc.e08-02-0187
    56 https://doi.org/10.1101/gad.267103
    57 https://doi.org/10.1124/mol.105.014183
    58 https://doi.org/10.1126/science.1112521
    59 https://doi.org/10.1126/science.1184733
    60 https://doi.org/10.1126/science.275.5307.1784
    61 https://doi.org/10.1128/mcb.00821-06
    62 https://doi.org/10.1128/mcb.24.22.9736-9743.2004
    63 https://doi.org/10.2144/03342mt01
    64 schema:datePublished 2011-08
    65 schema:datePublishedReg 2011-08-01
    66 schema:description The adult stem cell marker Lgr5 and its relative Lgr4 are often co-expressed in Wnt-driven proliferative compartments. We find that conditional deletion of both genes in the mouse gut impairs Wnt target gene expression and results in the rapid demise of intestinal crypts, thus phenocopying Wnt pathway inhibition. Mass spectrometry demonstrates that Lgr4 and Lgr5 associate with the Frizzled/Lrp Wnt receptor complex. Each of the four R-spondins, secreted Wnt pathway agonists, can bind to Lgr4, -5 and -6. In HEK293 cells, RSPO1 enhances canonical WNT signals initiated by WNT3A. Removal of LGR4 does not affect WNT3A signalling, but abrogates the RSPO1-mediated signal enhancement, a phenomenon rescued by re-expression of LGR4, -5 or -6. Genetic deletion of Lgr4/5 in mouse intestinal crypt cultures phenocopies withdrawal of Rspo1 and can be rescued by Wnt pathway activation. Lgr5 homologues are facultative Wnt receptor components that mediate Wnt signal enhancement by soluble R-spondin proteins. These results will guide future studies towards the application of R-spondins for regenerative purposes of tissues expressing Lgr5 homologues.
    67 schema:genre research_article
    68 schema:inLanguage en
    69 schema:isAccessibleForFree false
    70 schema:isPartOf Nb572de26e5d54abc8e6a5f2f96a8191f
    71 Ndef947c8e66246c8ab71382a0bb6f2f1
    72 sg:journal.1018957
    73 schema:name Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling
    74 schema:pagination 293
    75 schema:productId N0879122b08964963a370d1e7f286107d
    76 N3b653056c7d54863b5f3cbcbb8679fe9
    77 N86cbf7da0f4d485eaa3670ea3a0725b8
    78 N8cebae34176443c6ae5f02f6435c04e8
    79 Ncd87b4352bbd441c956931c8e5b18535
    80 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053455836
    81 https://doi.org/10.1038/nature10337
    82 schema:sdDatePublished 2019-04-10T16:30
    83 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    84 schema:sdPublisher Nb4d9b700e720419d8f459b1152df27b4
    85 schema:url https://www.nature.com/articles/nature10337
    86 sgo:license sg:explorer/license/
    87 sgo:sdDataset articles
    88 rdf:type schema:ScholarlyArticle
    89 N02609acc848f4b64bc123167c700b1d2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    90 schema:name Wnt3 Protein
    91 rdf:type schema:DefinedTerm
    92 N0334269aa9004b169a94c5f18eec1be1 rdf:first sg:person.0735472007.92
    93 rdf:rest N6c077f6d200f45eebae408a165f71533
    94 N0879122b08964963a370d1e7f286107d schema:name dimensions_id
    95 schema:value pub.1053455836
    96 rdf:type schema:PropertyValue
    97 N0d9adb6e5804449e992feecc2742b20e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    98 schema:name Humans
    99 rdf:type schema:DefinedTerm
    100 N149c88250a8e44cea7a4692a7c229bd2 schema:name Hubrecht Institute and University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands
    101 rdf:type schema:Organization
    102 N1640d80ddac04ea0be1771ec0b1d816f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    103 schema:name Cells, Cultured
    104 rdf:type schema:DefinedTerm
    105 N1708d0a1010740f3bbe300f9254805b3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    106 schema:name Receptors, G-Protein-Coupled
    107 rdf:type schema:DefinedTerm
    108 N190c6f1293f243cd9fd89c8ccd80c339 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    109 schema:name Wnt3A Protein
    110 rdf:type schema:DefinedTerm
    111 N1a7e4a0e03df4f6591e0b73e92b99285 schema:name Hubrecht Institute and University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands
    112 rdf:type schema:Organization
    113 N246c984efa5a43a794191b2b277cc326 schema:name Hubrecht Institute and University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands
    114 rdf:type schema:Organization
    115 N30a19c9a17fa48869f4125de3495ba22 schema:name Hubrecht Institute and University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands
    116 rdf:type schema:Organization
    117 N35ccb972c2ed4ada8ad161edec4d5f5b schema:name Antoni van Leeuwenhoek Hospital Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands
    118 rdf:type schema:Organization
    119 N3859f1ea814d4bf19c1343c95822bf9f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    120 schema:name Animals
    121 rdf:type schema:DefinedTerm
    122 N38e1ea1238a54be4a18cc69d033fb477 rdf:first sg:person.01237336020.34
    123 rdf:rest Nfb09ebd509d74fee875a169524d942c7
    124 N3b653056c7d54863b5f3cbcbb8679fe9 schema:name nlm_unique_id
    125 schema:value 0410462
    126 rdf:type schema:PropertyValue
    127 N3e1b0155f60a4694862189c70a68a485 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    128 schema:name Adult Stem Cells
    129 rdf:type schema:DefinedTerm
    130 N3f333c5407034ef0920635a4fa4a359c rdf:first sg:person.01352156370.23
    131 rdf:rest Nba04c164bf854693b220a2952bae507f
    132 N468e76043dab4c98b7ed11e978d3dcce rdf:first sg:person.0616060543.03
    133 rdf:rest N86e0a2e2c6004a1daecb1dad0e530ee0
    134 N46d27c09c05041df88b06c2bae8467c2 rdf:first sg:person.0677136307.17
    135 rdf:rest N468e76043dab4c98b7ed11e978d3dcce
    136 N4bcd0902691a4af7bb477fb4cd02996c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    137 schema:name Frizzled Receptors
    138 rdf:type schema:DefinedTerm
    139 N4fc9477a0b3a48a0b5ede0dd1147b325 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    140 schema:name Gene Deletion
    141 rdf:type schema:DefinedTerm
    142 N5de98dfc181542f2bba8b239ea8c44db schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    143 schema:name Wnt Proteins
    144 rdf:type schema:DefinedTerm
    145 N6201c2f1596548c58a985528b2e44a81 rdf:first sg:person.0662243670.45
    146 rdf:rest rdf:nil
    147 N6731a0758f834726a29ab4bb83056c86 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    148 schema:name Signal Transduction
    149 rdf:type schema:DefinedTerm
    150 N69b594c9db214af7b480e15eb543b8b1 schema:name Hubrecht Institute and University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands
    151 rdf:type schema:Organization
    152 N6c077f6d200f45eebae408a165f71533 rdf:first sg:person.01151605507.23
    153 rdf:rest N38e1ea1238a54be4a18cc69d033fb477
    154 N7c8b50420cdc4d51aa0a00297fd363cb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    155 schema:name Protein Structure, Tertiary
    156 rdf:type schema:DefinedTerm
    157 N7e8381f084cc4f86941d75775eae7754 rdf:first sg:person.01064467353.67
    158 rdf:rest N86d7d1de41d241049ebff8c8111a4b19
    159 N80f3cc9bec9d4c94a448d7b85abebd81 rdf:first sg:person.01213722537.34
    160 rdf:rest Naaf78e11ee87423bacef3af63d2c5227
    161 N821f1bb2ca3a4eec986838b3b77829d7 rdf:first sg:person.01132006272.03
    162 rdf:rest Ne4e1d165100d4a23bda1ab10c311162b
    163 N847d868650cc44ab872fd8934af989e7 schema:name Hubrecht Institute and University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands
    164 rdf:type schema:Organization
    165 N86cbf7da0f4d485eaa3670ea3a0725b8 schema:name doi
    166 schema:value 10.1038/nature10337
    167 rdf:type schema:PropertyValue
    168 N86d7d1de41d241049ebff8c8111a4b19 rdf:first sg:person.0666067727.95
    169 rdf:rest N9cac7f94579143e4bd525cf2e76e8504
    170 N86e0a2e2c6004a1daecb1dad0e530ee0 rdf:first sg:person.01273351443.89
    171 rdf:rest N821f1bb2ca3a4eec986838b3b77829d7
    172 N8cebae34176443c6ae5f02f6435c04e8 schema:name pubmed_id
    173 schema:value 21727895
    174 rdf:type schema:PropertyValue
    175 N8dd83e9d7ece40708cb98229f8e1ae44 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    176 schema:name Epithelial Cells
    177 rdf:type schema:DefinedTerm
    178 N9891ca03286f4178929acaa30369a971 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    179 schema:name Protein Binding
    180 rdf:type schema:DefinedTerm
    181 N98bb838e4f654501aad51e32be7ecc06 schema:name Hubrecht Institute and University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands
    182 rdf:type schema:Organization
    183 N99abecbab4da4850bc05a2d778662000 schema:name Hubrecht Institute and University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands
    184 rdf:type schema:Organization
    185 N9a92c1cc2f60431e83b2201ea7685e99 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    186 schema:name HEK293 Cells
    187 rdf:type schema:DefinedTerm
    188 N9cac7f94579143e4bd525cf2e76e8504 rdf:first sg:person.015536155047.43
    189 rdf:rest N0334269aa9004b169a94c5f18eec1be1
    190 Naaf78e11ee87423bacef3af63d2c5227 rdf:first sg:person.01307053755.26
    191 rdf:rest Nf3e8e341a2634a37a44c5ad4a112b943
    192 Nae5fe01c72af4d6f90c13187d26a252b schema:name Hubrecht Institute and University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands
    193 rdf:type schema:Organization
    194 Naf7bc9321fd44680981159ca9f68ead7 schema:name Hubrecht Institute and University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands
    195 rdf:type schema:Organization
    196 Nb4d9b700e720419d8f459b1152df27b4 schema:name Springer Nature - SN SciGraph project
    197 rdf:type schema:Organization
    198 Nb572de26e5d54abc8e6a5f2f96a8191f schema:issueNumber 7360
    199 rdf:type schema:PublicationIssue
    200 Nb7ed56a355a94f329d3255f8a67fa51c rdf:first sg:person.0643614125.13
    201 rdf:rest N7e8381f084cc4f86941d75775eae7754
    202 Nba04c164bf854693b220a2952bae507f rdf:first sg:person.012054747172.33
    203 rdf:rest N46d27c09c05041df88b06c2bae8467c2
    204 Nca54ad95d8f045fc9c0738c352329735 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    205 schema:name Thrombospondins
    206 rdf:type schema:DefinedTerm
    207 Ncd2304148aa8431c9f021b7cefe0dec4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    208 schema:name Regeneration
    209 rdf:type schema:DefinedTerm
    210 Ncd87b4352bbd441c956931c8e5b18535 schema:name readcube_id
    211 schema:value fe9de5c111a1cf3076e8fe425b2dc5c3def58db135207348b2f7c594f28bc3fe
    212 rdf:type schema:PropertyValue
    213 Nd8874e308a6a42738ce1b741801b1596 schema:name Antoni van Leeuwenhoek Hospital Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands
    214 rdf:type schema:Organization
    215 Ndef947c8e66246c8ab71382a0bb6f2f1 schema:volumeNumber 476
    216 rdf:type schema:PublicationVolume
    217 Ne4b94dbbd8a34cee9de53d3eaa5ed54c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    218 schema:name Mice
    219 rdf:type schema:DefinedTerm
    220 Ne4e1d165100d4a23bda1ab10c311162b rdf:first sg:person.0750240753.37
    221 rdf:rest Nb7ed56a355a94f329d3255f8a67fa51c
    222 Ne70d286ee7b048dfbd783bb9d806b957 schema:name Hubrecht Institute and University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands
    223 rdf:type schema:Organization
    224 Nf3e8e341a2634a37a44c5ad4a112b943 rdf:first sg:person.01313245325.38
    225 rdf:rest N3f333c5407034ef0920635a4fa4a359c
    226 Nfb09ebd509d74fee875a169524d942c7 rdf:first sg:person.07502404177.84
    227 rdf:rest N6201c2f1596548c58a985528b2e44a81
    228 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    229 schema:name Biological Sciences
    230 rdf:type schema:DefinedTerm
    231 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
    232 schema:name Biochemistry and Cell Biology
    233 rdf:type schema:DefinedTerm
    234 sg:grant.6047570 http://pending.schema.org/fundedItem sg:pub.10.1038/nature10337
    235 rdf:type schema:MonetaryGrant
    236 sg:grant.6058394 http://pending.schema.org/fundedItem sg:pub.10.1038/nature10337
    237 rdf:type schema:MonetaryGrant
    238 sg:journal.1018957 schema:issn 0090-0028
    239 1476-4687
    240 schema:name Nature
    241 rdf:type schema:Periodical
    242 sg:person.01064467353.67 schema:affiliation Ne70d286ee7b048dfbd783bb9d806b957
    243 schema:familyName van Es
    244 schema:givenName J.
    245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01064467353.67
    246 rdf:type schema:Person
    247 sg:person.01132006272.03 schema:affiliation Nd8874e308a6a42738ce1b741801b1596
    248 schema:familyName Peters
    249 schema:givenName Peter J.
    250 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01132006272.03
    251 rdf:type schema:Person
    252 sg:person.01151605507.23 schema:affiliation https://www.grid.ac/institutes/grid.69566.3a
    253 schema:familyName Nishimori
    254 schema:givenName Katsuhiko
    255 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01151605507.23
    256 rdf:type schema:Person
    257 sg:person.012054747172.33 schema:affiliation N30a19c9a17fa48869f4125de3495ba22
    258 schema:familyName Li
    259 schema:givenName Vivian S. W.
    260 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012054747172.33
    261 rdf:type schema:Person
    262 sg:person.01213722537.34 schema:affiliation N149c88250a8e44cea7a4692a7c229bd2
    263 schema:familyName de Lau
    264 schema:givenName Wim
    265 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01213722537.34
    266 rdf:type schema:Person
    267 sg:person.01237336020.34 schema:affiliation https://www.grid.ac/institutes/grid.5477.1
    268 schema:familyName Mohammed
    269 schema:givenName Shabaz
    270 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01237336020.34
    271 rdf:type schema:Person
    272 sg:person.01273351443.89 schema:affiliation N99abecbab4da4850bc05a2d778662000
    273 schema:familyName Haegebarth
    274 schema:givenName Andrea
    275 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01273351443.89
    276 rdf:type schema:Person
    277 sg:person.01307053755.26 schema:affiliation Nae5fe01c72af4d6f90c13187d26a252b
    278 schema:familyName Barker
    279 schema:givenName Nick
    280 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01307053755.26
    281 rdf:type schema:Person
    282 sg:person.01313245325.38 schema:affiliation https://www.grid.ac/institutes/grid.5477.1
    283 schema:familyName Low
    284 schema:givenName Teck Y.
    285 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01313245325.38
    286 rdf:type schema:Person
    287 sg:person.01352156370.23 schema:affiliation N1a7e4a0e03df4f6591e0b73e92b99285
    288 schema:familyName Koo
    289 schema:givenName Bon-Kyoung
    290 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01352156370.23
    291 rdf:type schema:Person
    292 sg:person.015536155047.43 schema:affiliation https://www.grid.ac/institutes/grid.6214.1
    293 schema:familyName Schasfoort
    294 schema:givenName Richard B. M.
    295 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015536155047.43
    296 rdf:type schema:Person
    297 sg:person.0616060543.03 schema:affiliation N35ccb972c2ed4ada8ad161edec4d5f5b
    298 schema:familyName Kujala
    299 schema:givenName Pekka
    300 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0616060543.03
    301 rdf:type schema:Person
    302 sg:person.0643614125.13 schema:affiliation N69b594c9db214af7b480e15eb543b8b1
    303 schema:familyName Stange
    304 schema:givenName D. E.
    305 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0643614125.13
    306 rdf:type schema:Person
    307 sg:person.0662243670.45 schema:affiliation N98bb838e4f654501aad51e32be7ecc06
    308 schema:familyName Clevers
    309 schema:givenName Hans
    310 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0662243670.45
    311 rdf:type schema:Person
    312 sg:person.0666067727.95 schema:affiliation Naf7bc9321fd44680981159ca9f68ead7
    313 schema:familyName Guardavaccaro
    314 schema:givenName Daniele
    315 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0666067727.95
    316 rdf:type schema:Person
    317 sg:person.0677136307.17 schema:affiliation N847d868650cc44ab872fd8934af989e7
    318 schema:familyName Teunissen
    319 schema:givenName Hans
    320 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677136307.17
    321 rdf:type schema:Person
    322 sg:person.0735472007.92 schema:affiliation https://www.grid.ac/institutes/grid.69566.3a
    323 schema:familyName Mohri
    324 schema:givenName Yasuaki
    325 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0735472007.92
    326 rdf:type schema:Person
    327 sg:person.07502404177.84 schema:affiliation https://www.grid.ac/institutes/grid.5477.1
    328 schema:familyName Heck
    329 schema:givenName Albert J. R.
    330 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07502404177.84
    331 rdf:type schema:Person
    332 sg:person.0750240753.37 schema:affiliation N246c984efa5a43a794191b2b277cc326
    333 schema:familyName van de Wetering
    334 schema:givenName Marc
    335 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0750240753.37
    336 rdf:type schema:Person
    337 sg:pub.10.1007/s00418-005-0002-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044478492
    338 https://doi.org/10.1007/s00418-005-0002-3
    339 rdf:type schema:CreativeWork
    340 sg:pub.10.1038/1270 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002695839
    341 https://doi.org/10.1038/1270
    342 rdf:type schema:CreativeWork
    343 sg:pub.10.1038/34848 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051110109
    344 https://doi.org/10.1038/34848
    345 rdf:type schema:CreativeWork
    346 sg:pub.10.1038/nature03659 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046707660
    347 https://doi.org/10.1038/nature03659
    348 rdf:type schema:CreativeWork
    349 sg:pub.10.1038/nature05674 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002848303
    350 https://doi.org/10.1038/nature05674
    351 rdf:type schema:CreativeWork
    352 sg:pub.10.1038/nature06196 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050225537
    353 https://doi.org/10.1038/nature06196
    354 rdf:type schema:CreativeWork
    355 sg:pub.10.1038/nature07935 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024082069
    356 https://doi.org/10.1038/nature07935
    357 rdf:type schema:CreativeWork
    358 sg:pub.10.1038/nature09637 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030684957
    359 https://doi.org/10.1038/nature09637
    360 rdf:type schema:CreativeWork
    361 sg:pub.10.1038/nbt.1511 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049469421
    362 https://doi.org/10.1038/nbt.1511
    363 rdf:type schema:CreativeWork
    364 sg:pub.10.1038/ng.239 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023194186
    365 https://doi.org/10.1038/ng.239
    366 rdf:type schema:CreativeWork
    367 https://app.dimensions.ai/details/publication/pub.1082831306 schema:CreativeWork
    368 https://doi.org/10.1002/dvdy.20446 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031742698
    369 rdf:type schema:CreativeWork
    370 https://doi.org/10.1016/j.cell.2009.01.031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003917776
    371 rdf:type schema:CreativeWork
    372 https://doi.org/10.1016/j.devcel.2004.07.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024994615
    373 rdf:type schema:CreativeWork
    374 https://doi.org/10.1016/j.devcel.2011.01.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038585487
    375 rdf:type schema:CreativeWork
    376 https://doi.org/10.1016/j.febslet.2007.08.064 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016812609
    377 rdf:type schema:CreativeWork
    378 https://doi.org/10.1016/j.stem.2009.11.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039362335
    379 rdf:type schema:CreativeWork
    380 https://doi.org/10.1016/j.ydbio.2009.04.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013884866
    381 rdf:type schema:CreativeWork
    382 https://doi.org/10.1016/s0076-6879(03)70037-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035247640
    383 rdf:type schema:CreativeWork
    384 https://doi.org/10.1021/ac950914h schema:sameAs https://app.dimensions.ai/details/publication/pub.1055072376
    385 rdf:type schema:CreativeWork
    386 https://doi.org/10.1021/pr1011729 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039087538
    387 rdf:type schema:CreativeWork
    388 https://doi.org/10.1038/embor.2011.52 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028716824
    389 rdf:type schema:CreativeWork
    390 https://doi.org/10.1053/j.gastro.2007.02.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004526083
    391 rdf:type schema:CreativeWork
    392 https://doi.org/10.1053/j.gastro.2009.05.035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001779262
    393 rdf:type schema:CreativeWork
    394 https://doi.org/10.1053/j.gastro.2010.03.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025461503
    395 rdf:type schema:CreativeWork
    396 https://doi.org/10.1073/pnas.0506580102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037705714
    397 rdf:type schema:CreativeWork
    398 https://doi.org/10.1073/pnas.0702305104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045150931
    399 rdf:type schema:CreativeWork
    400 https://doi.org/10.1073/pnas.2536800100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050279034
    401 rdf:type schema:CreativeWork
    402 https://doi.org/10.1073/pnas.93.16.8455 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035953957
    403 rdf:type schema:CreativeWork
    404 https://doi.org/10.1074/jbc.m109.078261 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018759398
    405 rdf:type schema:CreativeWork
    406 https://doi.org/10.1074/jbc.m508324200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017083954
    407 rdf:type schema:CreativeWork
    408 https://doi.org/10.1074/jbc.m701927200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007327575
    409 rdf:type schema:CreativeWork
    410 https://doi.org/10.1074/mcp.m800093-mcp200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031511342
    411 rdf:type schema:CreativeWork
    412 https://doi.org/10.1091/mbc.e08-02-0187 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022351840
    413 rdf:type schema:CreativeWork
    414 https://doi.org/10.1101/gad.267103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011480346
    415 rdf:type schema:CreativeWork
    416 https://doi.org/10.1124/mol.105.014183 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031657105
    417 rdf:type schema:CreativeWork
    418 https://doi.org/10.1126/science.1112521 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050697196
    419 rdf:type schema:CreativeWork
    420 https://doi.org/10.1126/science.1184733 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002969630
    421 rdf:type schema:CreativeWork
    422 https://doi.org/10.1126/science.275.5307.1784 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062556119
    423 rdf:type schema:CreativeWork
    424 https://doi.org/10.1128/mcb.00821-06 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040375340
    425 rdf:type schema:CreativeWork
    426 https://doi.org/10.1128/mcb.24.22.9736-9743.2004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003545217
    427 rdf:type schema:CreativeWork
    428 https://doi.org/10.2144/03342mt01 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075245738
    429 rdf:type schema:CreativeWork
    430 https://www.grid.ac/institutes/grid.5477.1 schema:alternateName Utrecht University
    431 schema:name Biomolecular Mass Spectrometry and Proteomics Group, Bijvoet Center, Utrecht University, 3584 CH Utrecht, The Netherlands
    432 rdf:type schema:Organization
    433 https://www.grid.ac/institutes/grid.6214.1 schema:alternateName University of Twente
    434 schema:name Medical Cell Biophysics, MIRA institute, University of Twente, 7500 AE Enschede, The Netherlands
    435 rdf:type schema:Organization
    436 https://www.grid.ac/institutes/grid.69566.3a schema:alternateName Tohoku University
    437 schema:name Tohoku University, 981-8555 Sendai, Miyagi, Japan
    438 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...