Molecular chaperones in protein folding and proteostasis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2011-07

AUTHORS

F. Ulrich Hartl, Andreas Bracher, Manajit Hayer-Hartl

ABSTRACT

Most proteins must fold into defined three-dimensional structures to gain functional activity. But in the cellular environment, newly synthesized proteins are at great risk of aberrant folding and aggregation, potentially forming toxic species. To avoid these dangers, cells invest in a complex network of molecular chaperones, which use ingenious mechanisms to prevent aggregation and promote efficient folding. Because protein molecules are highly dynamic, constant chaperone surveillance is required to ensure protein homeostasis (proteostasis). Recent advances suggest that an age-related decline in proteostasis capacity allows the manifestation of various protein-aggregation diseases, including Alzheimer's disease and Parkinson's disease. Interventions in these and numerous other pathological states may spring from a detailed understanding of the pathways underlying proteome maintenance. More... »

PAGES

324

References to SciGraph publications

  • 2010-03. The genetics of ageing in NATURE
  • 2007-05. Essential function of the built-in lid in the allosteric regulation of eukaryotic and archaeal chaperonins in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2006-10. Cytosolic chaperonin prevents polyglutamine toxicity with altering the aggregation state in NATURE CELL BIOLOGY
  • 2010-07. HSP90 at the hub of protein homeostasis: emerging mechanistic insights in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 1996-06. Molecular chaperones in cellular protein folding in NATURE
  • 2006-10. The chaperonin TRiC controls polyglutamine aggregation and toxicity through subunit-specific interactions in NATURE CELL BIOLOGY
  • 2010-12. The kinetic parameters and energy cost of the Hsp70 chaperone as a polypeptide unfoldase in NATURE CHEMICAL BIOLOGY
  • 2010-01. Coupled chaperone action in folding and assembly of hexadecameric Rubisco in NATURE
  • 2011-01. Crystal structure of the open conformation of the mammalian chaperonin CCT in complex with tubulin in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2008-03. GroEL stimulates protein folding through forced unfolding in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 1997-05. Interaction of Hsp70 chaperones with substrates in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2005-12. Folding zones inside the ribosomal exit tunnel in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2008-08. Misfolded proteins partition between two distinct quality control compartments in NATURE
  • 2009-06. Cellular mechanisms of membrane protein folding in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2008-08. The structure of CCT–Hsc70NBD suggests a mechanism for Hsp70 delivery of substrates to the chaperonin in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2010-09-09. Enhancement of proteasome activity by a small-molecule inhibitor of USP14 in NATURE
  • 1992-04. Successive action of DnaK, DnaJ and GroEL along the pathway of chaperone-mediated protein folding in NATURE
  • 2006-11. Real-time observation of trigger factor function on translating ribosomes in NATURE
  • 1998-11. Hsp90 as a capacitor for morphological evolution in NATURE
  • 2011-05. Gain of function of mutant p53 by coaggregation with multiple tumor suppressors in NATURE CHEMICAL BIOLOGY
  • 1994-07. Folding of nascent polypeptide chains in a high molecular mass assembly with molecular chaperones in NATURE
  • 1999-07-01. Co-translational domain folding as the structural basis for the rapid de novo folding of firefly luciferase in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 1997-08. The crystal structure of the asymmetric GroEL–GroES–(ADP)7 chaperonin complex in NATURE
  • 2010-08. The HSP70 chaperone machinery: J proteins as drivers of functional specificity in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2009-06. Chaperonin overexpression promotes genetic variation and enzyme evolution in NATURE
  • 2007-04. Heat shock protein 90: The cancer chaperone in JOURNAL OF BIOSCIENCES
  • 2004-09. Trigger factor in complex with the ribosome forms a molecular cradle for nascent proteins in NATURE
  • 2009-06. An expanding arsenal of experimental methods yields an explosion of insights into protein folding mechanisms in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2009-06. Converging concepts of protein folding in vitro and in vivo in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 1997-07. Recombination of protein domains facilitated by co-translational folding in eukaryotes in NATURE
  • 2006-04. Crystal structure of an Hsp90–nucleotide–p23/Sba1 closed chaperone complex in NATURE
  • 2007-10. To be, or not to be — molecular chaperones in protein degradation in CELLULAR AND MOLECULAR LIFE SCIENCES
  • Identifiers

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    http://scigraph.springernature.com/pub.10.1038/nature10317

    DOI

    http://dx.doi.org/10.1038/nature10317

    DIMENSIONS

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/21776078


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