Heart regeneration View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-05

AUTHORS

Michael A. Laflamme, Charles E. Murry

ABSTRACT

Heart failure plagues industrialized nations, killing more people than any other disease. It usually results from a deficiency of specialized cardiac muscle cells known as cardiomyocytes, and a robust therapy to regenerate lost myocardium could help millions of patients every year. Heart regeneration is well documented in amphibia and fish and in developing mammals. After birth, however, human heart regeneration becomes limited to very slow cardiomyocyte replacement. Several experimental strategies to remuscularize the injured heart using adult stem cells and pluripotent stem cells, cellular reprogramming and tissue engineering are in progress. Although many challenges remain, these interventions may eventually lead to better approaches to treat or prevent heart failure. More... »

PAGES

326

References to SciGraph publications

  • 2004-04. Haematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial infarcts in NATURE
  • 2010-03. Primary contribution to zebrafish heart regeneration by gata4+ cardiomyocytes in NATURE
  • 2008-05-22. Human cardiovascular progenitor cells develop from a KDR+ embryonic-stem-cell-derived population in NATURE
  • 2011-03. Conversion of mouse fibroblasts into cardiomyocytes using a direct reprogramming strategy in NATURE CELL BIOLOGY
  • 2010-07. C-kit+ CD45− cells found in the adult human heart represent a population of endothelial progenitor cells in BASIC RESEARCH IN CARDIOLOGY
  • 1992-12. Variability of the cardiomyocyte ploidy in normal human hearts in VIRCHOWS ARCHIV B CELL PATHOLOGY
  • 2006-04. Engineered heart tissue grafts improve systolic and diastolic function in infarcted rat hearts in NATURE MEDICINE
  • 2007-09. Cardiomyocytes derived from human embryonic stem cells in pro-survival factors enhance function of infarcted rat hearts in NATURE BIOTECHNOLOGY
  • 2007-08. Evidence from a genetic fate-mapping study that stem cells refresh adult mammalian cardiomyocytes after injury in NATURE MEDICINE
  • 2008-05-15. Stem-cell-based therapy and lessons from the heart in NATURE
  • 2010-03. Zebrafish heart regeneration occurs by cardiomyocyte dedifferentiation and proliferation in NATURE
  • 2004-04. Haematopoietic stem cells adopt mature haematopoietic fates in ischaemic myocardium in NATURE
  • 2008-02. Stem-cell therapy for cardiac disease in NATURE
  • 2007-08. Periostin induces proliferation of differentiated cardiomyocytes and promotes cardiac repair in NATURE MEDICINE
  • 2001-04. Bone marrow cells regenerate infarcted myocardium in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nature10147

    DOI

    http://dx.doi.org/10.1038/nature10147

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1005736924

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/21593865


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Cardiorespiratory Medicine and Haematology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cellular Reprogramming", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Heart", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Heart Failure", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Myocytes, Cardiac", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Regeneration", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Regenerative Medicine", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Stem Cell Transplantation", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "University of Washington", 
              "id": "https://www.grid.ac/institutes/grid.34477.33", 
              "name": [
                "Department of Pathology, Center for Cardiovascular Biology, Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, Washington 98109, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Laflamme", 
            "givenName": "Michael A.", 
            "id": "sg:person.01133245377.56", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01133245377.56"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Washington", 
              "id": "https://www.grid.ac/institutes/grid.34477.33", 
              "name": [
                "Department of Pathology, Center for Cardiovascular Biology, Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, Washington 98109, USA.", 
                "Deparment of Bioengineering, Center for Cardiovascular Biology, Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, Washington 98109, USA.", 
                "Department of Medicine/Cardiology, Center for Cardiovascular Biology, Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, Washington 98109, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Murry", 
            "givenName": "Charles E.", 
            "id": "sg:person.013672502277.92", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013672502277.92"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1371/journal.pone.0005407", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000801305"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1006442107", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001617489"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jez.1401870208", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002443585"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jez.1401870208", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002443585"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0011134", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003517824"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.stem.2008.06.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003587066"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.yjmcc.2010.09.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004450831"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm1394", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004554673", 
              "https://doi.org/10.1038/nm1394"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm1394", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004554673", 
              "https://doi.org/10.1038/nm1394"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0908381106", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004771540"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.res.0000257776.05673.ff", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005428950"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.res.0000257776.05673.ff", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005428950"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0610024104", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005938799"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf02890430", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006065714", 
              "https://doi.org/10.1007/bf02890430"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf02890430", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006065714", 
              "https://doi.org/10.1007/bf02890430"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2009.04.060", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006772073"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature07040", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007829432", 
              "https://doi.org/10.1038/nature07040"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2006.08.052", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009514940"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.yexcr.2010.08.017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010683934"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci119030", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010761648"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1077857", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010826141"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2007.11.019", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010904856"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circulationaha.109.868885", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011009143"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1586/erc.10.99", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011571107"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4330/wjc.v2.i5.107", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011706008"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circresaha.108.175505", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011957551"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circresaha.108.175505", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011957551"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature02446", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012041829", 
              "https://doi.org/10.1038/nature02446"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature02446", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012041829", 
              "https://doi.org/10.1038/nature02446"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08804", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012430772", 
              "https://doi.org/10.1038/nature08804"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08804", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012430772", 
              "https://doi.org/10.1038/nature08804"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/cvr/cvq027", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013683799"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circresaha.110.223917", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013907142"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circresaha.110.223917", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013907142"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circresaha.110.223917", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013907142"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.res.68.6.1560", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013925871"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/jmcc.1996.0163", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013968309"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.physiol.010908.163111", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014048380"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2006.07.024", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014573758"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2006.10.028", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015577984"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/jmcc.1996.0137", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015870620"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circulationaha.106.655209", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016179858"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt1327", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018175651", 
              "https://doi.org/10.1038/nbt1327"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.res.0000080317.92718.99", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021380512"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.res.0000080317.92718.99", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021380512"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0702859104", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021549969"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circresaha.109.210682", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021588712"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circresaha.109.210682", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021588712"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08899", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021886040", 
              "https://doi.org/10.1038/nature08899"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08899", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021886040", 
              "https://doi.org/10.1038/nature08899"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0360-3016(84)90414-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022861369"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2010.07.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022964788"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.amjcard.2004.03.034", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025466555"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1432-0436.2008.00284.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027321413"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0607382103", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027358785"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.stem.2010.08.012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027563924"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/hc0102.101442", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027646277"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jacc.2006.02.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028831583"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.282.5391.1145", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028898955"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.cir.97.10.971", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029627153"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm1619", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031766978", 
              "https://doi.org/10.1038/nm1619"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0808920106", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032486217"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2006.10.029", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032600395"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.res.0000147315.71699.51", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033809756"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.res.0000147315.71699.51", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033809756"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb2164", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034013325", 
              "https://doi.org/10.1038/ncb2164"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circresaha.110.222703", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034139929"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circresaha.110.222703", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034139929"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circulationaha.109.871905", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034267444"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1200708", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034294546"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circresaha.108.192237", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037272431"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circresaha.108.192237", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037272431"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.cir.100.2.193", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038002862"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1634/stemcells.2006-0466", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038580241"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.bioeng.6.040803.140027", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038622770"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature06800", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039041937", 
              "https://doi.org/10.1038/nature06800"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature02460", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039639626", 
              "https://doi.org/10.1038/nature02460"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature02460", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039639626", 
              "https://doi.org/10.1038/nature02460"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circulationaha.109.909093", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039835484"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0407817101", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040754704"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.pathol.2.010506.092038", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041638875"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejm200106073442303", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042194700"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1096/fj.06-6769com", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042505672"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.stem.2008.10.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043032196"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature06894", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043777271", 
              "https://doi.org/10.1038/nature06894"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm1618", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043954874", 
              "https://doi.org/10.1038/nm1618"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jacc.2009.06.055", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044707993"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jacc.2007.07.054", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044771138"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0812242106", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045972011"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35070587", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046093021", 
              "https://doi.org/10.1038/35070587"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35070587", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046093021", 
              "https://doi.org/10.1038/35070587"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/physrev.00032.2006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047131206"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0706760104", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047345653"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circresaha.110.223024", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047380069"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circresaha.110.223024", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047380069"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/cvr/cvm101", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048667988"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1151526", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048905674"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circresaha.108.188649", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050102150"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circresaha.108.188649", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050102150"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0022-2828(86)80981-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050802790"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00395-010-0088-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051119404", 
              "https://doi.org/10.1007/s00395-010-0088-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00395-010-0088-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051119404", 
              "https://doi.org/10.1007/s00395-010-0088-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circulationaha.107.761031", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052151571"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/stem.72", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053030064"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/stem.72", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053030064"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.res.83.1.15", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053057757"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circresaha.108.174615", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053127886"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circresaha.108.174615", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053127886"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0008-6363(97)00140-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1054579789"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/eurheartj/14.1.40", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059574226"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1164680", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062458925"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1177350", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062460426"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci12131", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063416054"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1075301159", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1075355378", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077996242", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1078384481", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/ajpheart.1997.272.1.h220", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083048484"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2011-05", 
        "datePublishedReg": "2011-05-01", 
        "description": "Heart failure plagues industrialized nations, killing more people than any other disease. It usually results from a deficiency of specialized cardiac muscle cells known as cardiomyocytes, and a robust therapy to regenerate lost myocardium could help millions of patients every year. Heart regeneration is well documented in amphibia and fish and in developing mammals. After birth, however, human heart regeneration becomes limited to very slow cardiomyocyte replacement. Several experimental strategies to remuscularize the injured heart using adult stem cells and pluripotent stem cells, cellular reprogramming and tissue engineering are in progress. Although many challenges remain, these interventions may eventually lead to better approaches to treat or prevent heart failure.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/nature10147", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2437071", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2541038", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2705146", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1018957", 
            "issn": [
              "0090-0028", 
              "1476-4687"
            ], 
            "name": "Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "7347", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "473"
          }
        ], 
        "name": "Heart regeneration", 
        "pagination": "326", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "1b55464aeac398b23b8e6539b27f0c524540067a600e04735e3998254f9d6018"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "21593865"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "0410462"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/nature10147"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1005736924"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/nature10147", 
          "https://app.dimensions.ai/details/publication/pub.1005736924"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T00:14", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8695_00000503.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/nature10147"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nature10147'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nature10147'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nature10147'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nature10147'


     

    This table displays all metadata directly associated to this object as RDF triples.

    419 TRIPLES      21 PREDICATES      134 URIs      30 LITERALS      18 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/nature10147 schema:about N0569b942c2ae419595ddd5a3867fd713
    2 N0e808dee51094d2a89c4cf95e13870d8
    3 N53547b0c13b640b3aa93dd1a31c19e99
    4 N57441615714e446db52956c1966141d5
    5 N8d3253ab85b74ee8b68af54f9d52ab5e
    6 Na3eb9958bbd14858a71d13cece36a06a
    7 Nb15e0b66bbab4b2f93e89440e3a20949
    8 Nb6c479d14c0546f888b421be8b114823
    9 Ne6088dc4af2546a69dc39d1ef4ed0cea
    10 anzsrc-for:11
    11 anzsrc-for:1102
    12 schema:author N506fbf16bc8c48b7b6c0d87dc08f2c11
    13 schema:citation sg:pub.10.1007/bf02890430
    14 sg:pub.10.1007/s00395-010-0088-1
    15 sg:pub.10.1038/35070587
    16 sg:pub.10.1038/nature02446
    17 sg:pub.10.1038/nature02460
    18 sg:pub.10.1038/nature06800
    19 sg:pub.10.1038/nature06894
    20 sg:pub.10.1038/nature07040
    21 sg:pub.10.1038/nature08804
    22 sg:pub.10.1038/nature08899
    23 sg:pub.10.1038/nbt1327
    24 sg:pub.10.1038/ncb2164
    25 sg:pub.10.1038/nm1394
    26 sg:pub.10.1038/nm1618
    27 sg:pub.10.1038/nm1619
    28 https://app.dimensions.ai/details/publication/pub.1075301159
    29 https://app.dimensions.ai/details/publication/pub.1075355378
    30 https://app.dimensions.ai/details/publication/pub.1077996242
    31 https://app.dimensions.ai/details/publication/pub.1078384481
    32 https://doi.org/10.1002/jez.1401870208
    33 https://doi.org/10.1002/stem.72
    34 https://doi.org/10.1006/jmcc.1996.0137
    35 https://doi.org/10.1006/jmcc.1996.0163
    36 https://doi.org/10.1016/0360-3016(84)90414-0
    37 https://doi.org/10.1016/j.amjcard.2004.03.034
    38 https://doi.org/10.1016/j.cell.2006.07.024
    39 https://doi.org/10.1016/j.cell.2006.08.052
    40 https://doi.org/10.1016/j.cell.2006.10.028
    41 https://doi.org/10.1016/j.cell.2006.10.029
    42 https://doi.org/10.1016/j.cell.2007.11.019
    43 https://doi.org/10.1016/j.cell.2009.04.060
    44 https://doi.org/10.1016/j.cell.2010.07.002
    45 https://doi.org/10.1016/j.jacc.2006.02.002
    46 https://doi.org/10.1016/j.jacc.2007.07.054
    47 https://doi.org/10.1016/j.jacc.2009.06.055
    48 https://doi.org/10.1016/j.stem.2008.06.009
    49 https://doi.org/10.1016/j.stem.2008.10.004
    50 https://doi.org/10.1016/j.stem.2010.08.012
    51 https://doi.org/10.1016/j.yexcr.2010.08.017
    52 https://doi.org/10.1016/j.yjmcc.2010.09.008
    53 https://doi.org/10.1016/s0008-6363(97)00140-5
    54 https://doi.org/10.1016/s0022-2828(86)80981-6
    55 https://doi.org/10.1056/nejm200106073442303
    56 https://doi.org/10.1073/pnas.0407817101
    57 https://doi.org/10.1073/pnas.0607382103
    58 https://doi.org/10.1073/pnas.0610024104
    59 https://doi.org/10.1073/pnas.0702859104
    60 https://doi.org/10.1073/pnas.0706760104
    61 https://doi.org/10.1073/pnas.0808920106
    62 https://doi.org/10.1073/pnas.0812242106
    63 https://doi.org/10.1073/pnas.0908381106
    64 https://doi.org/10.1073/pnas.1006442107
    65 https://doi.org/10.1093/cvr/cvm101
    66 https://doi.org/10.1093/cvr/cvq027
    67 https://doi.org/10.1093/eurheartj/14.1.40
    68 https://doi.org/10.1096/fj.06-6769com
    69 https://doi.org/10.1111/j.1432-0436.2008.00284.x
    70 https://doi.org/10.1126/science.1077857
    71 https://doi.org/10.1126/science.1151526
    72 https://doi.org/10.1126/science.1164680
    73 https://doi.org/10.1126/science.1177350
    74 https://doi.org/10.1126/science.1200708
    75 https://doi.org/10.1126/science.282.5391.1145
    76 https://doi.org/10.1146/annurev.bioeng.6.040803.140027
    77 https://doi.org/10.1146/annurev.pathol.2.010506.092038
    78 https://doi.org/10.1146/annurev.physiol.010908.163111
    79 https://doi.org/10.1152/ajpheart.1997.272.1.h220
    80 https://doi.org/10.1152/physrev.00032.2006
    81 https://doi.org/10.1161/01.cir.100.2.193
    82 https://doi.org/10.1161/01.cir.97.10.971
    83 https://doi.org/10.1161/01.res.0000080317.92718.99
    84 https://doi.org/10.1161/01.res.0000147315.71699.51
    85 https://doi.org/10.1161/01.res.0000257776.05673.ff
    86 https://doi.org/10.1161/01.res.68.6.1560
    87 https://doi.org/10.1161/01.res.83.1.15
    88 https://doi.org/10.1161/circresaha.108.174615
    89 https://doi.org/10.1161/circresaha.108.175505
    90 https://doi.org/10.1161/circresaha.108.188649
    91 https://doi.org/10.1161/circresaha.108.192237
    92 https://doi.org/10.1161/circresaha.109.210682
    93 https://doi.org/10.1161/circresaha.110.222703
    94 https://doi.org/10.1161/circresaha.110.223024
    95 https://doi.org/10.1161/circresaha.110.223917
    96 https://doi.org/10.1161/circulationaha.106.655209
    97 https://doi.org/10.1161/circulationaha.107.761031
    98 https://doi.org/10.1161/circulationaha.109.868885
    99 https://doi.org/10.1161/circulationaha.109.871905
    100 https://doi.org/10.1161/circulationaha.109.909093
    101 https://doi.org/10.1161/hc0102.101442
    102 https://doi.org/10.1172/jci119030
    103 https://doi.org/10.1172/jci12131
    104 https://doi.org/10.1371/journal.pone.0005407
    105 https://doi.org/10.1371/journal.pone.0011134
    106 https://doi.org/10.1586/erc.10.99
    107 https://doi.org/10.1634/stemcells.2006-0466
    108 https://doi.org/10.4330/wjc.v2.i5.107
    109 schema:datePublished 2011-05
    110 schema:datePublishedReg 2011-05-01
    111 schema:description Heart failure plagues industrialized nations, killing more people than any other disease. It usually results from a deficiency of specialized cardiac muscle cells known as cardiomyocytes, and a robust therapy to regenerate lost myocardium could help millions of patients every year. Heart regeneration is well documented in amphibia and fish and in developing mammals. After birth, however, human heart regeneration becomes limited to very slow cardiomyocyte replacement. Several experimental strategies to remuscularize the injured heart using adult stem cells and pluripotent stem cells, cellular reprogramming and tissue engineering are in progress. Although many challenges remain, these interventions may eventually lead to better approaches to treat or prevent heart failure.
    112 schema:genre research_article
    113 schema:inLanguage en
    114 schema:isAccessibleForFree true
    115 schema:isPartOf N3996e919a0d046f5947f3981a25227be
    116 N7d65ca486012480fa37ef96296c51585
    117 sg:journal.1018957
    118 schema:name Heart regeneration
    119 schema:pagination 326
    120 schema:productId N4fb3522ef7974f2196294d682f72b624
    121 N73f6b301ce9d42ac990ee22d578667a4
    122 Nbb223567ad434683a6c2554363b4f25a
    123 Nc78409adb8324eeb833c70d59baef695
    124 Nee25fad9f0184e0e99bc4de3e1513144
    125 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005736924
    126 https://doi.org/10.1038/nature10147
    127 schema:sdDatePublished 2019-04-11T00:14
    128 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    129 schema:sdPublisher N3fed454109d64d20a67e8bab10dfc3d6
    130 schema:url https://www.nature.com/articles/nature10147
    131 sgo:license sg:explorer/license/
    132 sgo:sdDataset articles
    133 rdf:type schema:ScholarlyArticle
    134 N0569b942c2ae419595ddd5a3867fd713 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    135 schema:name Animals
    136 rdf:type schema:DefinedTerm
    137 N0e808dee51094d2a89c4cf95e13870d8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    138 schema:name Heart Failure
    139 rdf:type schema:DefinedTerm
    140 N3996e919a0d046f5947f3981a25227be schema:issueNumber 7347
    141 rdf:type schema:PublicationIssue
    142 N3fed454109d64d20a67e8bab10dfc3d6 schema:name Springer Nature - SN SciGraph project
    143 rdf:type schema:Organization
    144 N4fb3522ef7974f2196294d682f72b624 schema:name readcube_id
    145 schema:value 1b55464aeac398b23b8e6539b27f0c524540067a600e04735e3998254f9d6018
    146 rdf:type schema:PropertyValue
    147 N506fbf16bc8c48b7b6c0d87dc08f2c11 rdf:first sg:person.01133245377.56
    148 rdf:rest N7f02573f9c814e2ba488783ae6915f08
    149 N53547b0c13b640b3aa93dd1a31c19e99 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    150 schema:name Myocytes, Cardiac
    151 rdf:type schema:DefinedTerm
    152 N57441615714e446db52956c1966141d5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    153 schema:name Heart
    154 rdf:type schema:DefinedTerm
    155 N73f6b301ce9d42ac990ee22d578667a4 schema:name doi
    156 schema:value 10.1038/nature10147
    157 rdf:type schema:PropertyValue
    158 N7d65ca486012480fa37ef96296c51585 schema:volumeNumber 473
    159 rdf:type schema:PublicationVolume
    160 N7f02573f9c814e2ba488783ae6915f08 rdf:first sg:person.013672502277.92
    161 rdf:rest rdf:nil
    162 N8d3253ab85b74ee8b68af54f9d52ab5e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    163 schema:name Regeneration
    164 rdf:type schema:DefinedTerm
    165 Na3eb9958bbd14858a71d13cece36a06a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    166 schema:name Regenerative Medicine
    167 rdf:type schema:DefinedTerm
    168 Nb15e0b66bbab4b2f93e89440e3a20949 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    169 schema:name Stem Cell Transplantation
    170 rdf:type schema:DefinedTerm
    171 Nb6c479d14c0546f888b421be8b114823 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    172 schema:name Cellular Reprogramming
    173 rdf:type schema:DefinedTerm
    174 Nbb223567ad434683a6c2554363b4f25a schema:name dimensions_id
    175 schema:value pub.1005736924
    176 rdf:type schema:PropertyValue
    177 Nc78409adb8324eeb833c70d59baef695 schema:name pubmed_id
    178 schema:value 21593865
    179 rdf:type schema:PropertyValue
    180 Ne6088dc4af2546a69dc39d1ef4ed0cea schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    181 schema:name Humans
    182 rdf:type schema:DefinedTerm
    183 Nee25fad9f0184e0e99bc4de3e1513144 schema:name nlm_unique_id
    184 schema:value 0410462
    185 rdf:type schema:PropertyValue
    186 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    187 schema:name Medical and Health Sciences
    188 rdf:type schema:DefinedTerm
    189 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
    190 schema:name Cardiorespiratory Medicine and Haematology
    191 rdf:type schema:DefinedTerm
    192 sg:grant.2437071 http://pending.schema.org/fundedItem sg:pub.10.1038/nature10147
    193 rdf:type schema:MonetaryGrant
    194 sg:grant.2541038 http://pending.schema.org/fundedItem sg:pub.10.1038/nature10147
    195 rdf:type schema:MonetaryGrant
    196 sg:grant.2705146 http://pending.schema.org/fundedItem sg:pub.10.1038/nature10147
    197 rdf:type schema:MonetaryGrant
    198 sg:journal.1018957 schema:issn 0090-0028
    199 1476-4687
    200 schema:name Nature
    201 rdf:type schema:Periodical
    202 sg:person.01133245377.56 schema:affiliation https://www.grid.ac/institutes/grid.34477.33
    203 schema:familyName Laflamme
    204 schema:givenName Michael A.
    205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01133245377.56
    206 rdf:type schema:Person
    207 sg:person.013672502277.92 schema:affiliation https://www.grid.ac/institutes/grid.34477.33
    208 schema:familyName Murry
    209 schema:givenName Charles E.
    210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013672502277.92
    211 rdf:type schema:Person
    212 sg:pub.10.1007/bf02890430 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006065714
    213 https://doi.org/10.1007/bf02890430
    214 rdf:type schema:CreativeWork
    215 sg:pub.10.1007/s00395-010-0088-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051119404
    216 https://doi.org/10.1007/s00395-010-0088-1
    217 rdf:type schema:CreativeWork
    218 sg:pub.10.1038/35070587 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046093021
    219 https://doi.org/10.1038/35070587
    220 rdf:type schema:CreativeWork
    221 sg:pub.10.1038/nature02446 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012041829
    222 https://doi.org/10.1038/nature02446
    223 rdf:type schema:CreativeWork
    224 sg:pub.10.1038/nature02460 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039639626
    225 https://doi.org/10.1038/nature02460
    226 rdf:type schema:CreativeWork
    227 sg:pub.10.1038/nature06800 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039041937
    228 https://doi.org/10.1038/nature06800
    229 rdf:type schema:CreativeWork
    230 sg:pub.10.1038/nature06894 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043777271
    231 https://doi.org/10.1038/nature06894
    232 rdf:type schema:CreativeWork
    233 sg:pub.10.1038/nature07040 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007829432
    234 https://doi.org/10.1038/nature07040
    235 rdf:type schema:CreativeWork
    236 sg:pub.10.1038/nature08804 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012430772
    237 https://doi.org/10.1038/nature08804
    238 rdf:type schema:CreativeWork
    239 sg:pub.10.1038/nature08899 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021886040
    240 https://doi.org/10.1038/nature08899
    241 rdf:type schema:CreativeWork
    242 sg:pub.10.1038/nbt1327 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018175651
    243 https://doi.org/10.1038/nbt1327
    244 rdf:type schema:CreativeWork
    245 sg:pub.10.1038/ncb2164 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034013325
    246 https://doi.org/10.1038/ncb2164
    247 rdf:type schema:CreativeWork
    248 sg:pub.10.1038/nm1394 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004554673
    249 https://doi.org/10.1038/nm1394
    250 rdf:type schema:CreativeWork
    251 sg:pub.10.1038/nm1618 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043954874
    252 https://doi.org/10.1038/nm1618
    253 rdf:type schema:CreativeWork
    254 sg:pub.10.1038/nm1619 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031766978
    255 https://doi.org/10.1038/nm1619
    256 rdf:type schema:CreativeWork
    257 https://app.dimensions.ai/details/publication/pub.1075301159 schema:CreativeWork
    258 https://app.dimensions.ai/details/publication/pub.1075355378 schema:CreativeWork
    259 https://app.dimensions.ai/details/publication/pub.1077996242 schema:CreativeWork
    260 https://app.dimensions.ai/details/publication/pub.1078384481 schema:CreativeWork
    261 https://doi.org/10.1002/jez.1401870208 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002443585
    262 rdf:type schema:CreativeWork
    263 https://doi.org/10.1002/stem.72 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053030064
    264 rdf:type schema:CreativeWork
    265 https://doi.org/10.1006/jmcc.1996.0137 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015870620
    266 rdf:type schema:CreativeWork
    267 https://doi.org/10.1006/jmcc.1996.0163 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013968309
    268 rdf:type schema:CreativeWork
    269 https://doi.org/10.1016/0360-3016(84)90414-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022861369
    270 rdf:type schema:CreativeWork
    271 https://doi.org/10.1016/j.amjcard.2004.03.034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025466555
    272 rdf:type schema:CreativeWork
    273 https://doi.org/10.1016/j.cell.2006.07.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014573758
    274 rdf:type schema:CreativeWork
    275 https://doi.org/10.1016/j.cell.2006.08.052 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009514940
    276 rdf:type schema:CreativeWork
    277 https://doi.org/10.1016/j.cell.2006.10.028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015577984
    278 rdf:type schema:CreativeWork
    279 https://doi.org/10.1016/j.cell.2006.10.029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032600395
    280 rdf:type schema:CreativeWork
    281 https://doi.org/10.1016/j.cell.2007.11.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010904856
    282 rdf:type schema:CreativeWork
    283 https://doi.org/10.1016/j.cell.2009.04.060 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006772073
    284 rdf:type schema:CreativeWork
    285 https://doi.org/10.1016/j.cell.2010.07.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022964788
    286 rdf:type schema:CreativeWork
    287 https://doi.org/10.1016/j.jacc.2006.02.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028831583
    288 rdf:type schema:CreativeWork
    289 https://doi.org/10.1016/j.jacc.2007.07.054 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044771138
    290 rdf:type schema:CreativeWork
    291 https://doi.org/10.1016/j.jacc.2009.06.055 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044707993
    292 rdf:type schema:CreativeWork
    293 https://doi.org/10.1016/j.stem.2008.06.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003587066
    294 rdf:type schema:CreativeWork
    295 https://doi.org/10.1016/j.stem.2008.10.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043032196
    296 rdf:type schema:CreativeWork
    297 https://doi.org/10.1016/j.stem.2010.08.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027563924
    298 rdf:type schema:CreativeWork
    299 https://doi.org/10.1016/j.yexcr.2010.08.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010683934
    300 rdf:type schema:CreativeWork
    301 https://doi.org/10.1016/j.yjmcc.2010.09.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004450831
    302 rdf:type schema:CreativeWork
    303 https://doi.org/10.1016/s0008-6363(97)00140-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054579789
    304 rdf:type schema:CreativeWork
    305 https://doi.org/10.1016/s0022-2828(86)80981-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050802790
    306 rdf:type schema:CreativeWork
    307 https://doi.org/10.1056/nejm200106073442303 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042194700
    308 rdf:type schema:CreativeWork
    309 https://doi.org/10.1073/pnas.0407817101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040754704
    310 rdf:type schema:CreativeWork
    311 https://doi.org/10.1073/pnas.0607382103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027358785
    312 rdf:type schema:CreativeWork
    313 https://doi.org/10.1073/pnas.0610024104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005938799
    314 rdf:type schema:CreativeWork
    315 https://doi.org/10.1073/pnas.0702859104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021549969
    316 rdf:type schema:CreativeWork
    317 https://doi.org/10.1073/pnas.0706760104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047345653
    318 rdf:type schema:CreativeWork
    319 https://doi.org/10.1073/pnas.0808920106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032486217
    320 rdf:type schema:CreativeWork
    321 https://doi.org/10.1073/pnas.0812242106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045972011
    322 rdf:type schema:CreativeWork
    323 https://doi.org/10.1073/pnas.0908381106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004771540
    324 rdf:type schema:CreativeWork
    325 https://doi.org/10.1073/pnas.1006442107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001617489
    326 rdf:type schema:CreativeWork
    327 https://doi.org/10.1093/cvr/cvm101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048667988
    328 rdf:type schema:CreativeWork
    329 https://doi.org/10.1093/cvr/cvq027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013683799
    330 rdf:type schema:CreativeWork
    331 https://doi.org/10.1093/eurheartj/14.1.40 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059574226
    332 rdf:type schema:CreativeWork
    333 https://doi.org/10.1096/fj.06-6769com schema:sameAs https://app.dimensions.ai/details/publication/pub.1042505672
    334 rdf:type schema:CreativeWork
    335 https://doi.org/10.1111/j.1432-0436.2008.00284.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1027321413
    336 rdf:type schema:CreativeWork
    337 https://doi.org/10.1126/science.1077857 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010826141
    338 rdf:type schema:CreativeWork
    339 https://doi.org/10.1126/science.1151526 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048905674
    340 rdf:type schema:CreativeWork
    341 https://doi.org/10.1126/science.1164680 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062458925
    342 rdf:type schema:CreativeWork
    343 https://doi.org/10.1126/science.1177350 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062460426
    344 rdf:type schema:CreativeWork
    345 https://doi.org/10.1126/science.1200708 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034294546
    346 rdf:type schema:CreativeWork
    347 https://doi.org/10.1126/science.282.5391.1145 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028898955
    348 rdf:type schema:CreativeWork
    349 https://doi.org/10.1146/annurev.bioeng.6.040803.140027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038622770
    350 rdf:type schema:CreativeWork
    351 https://doi.org/10.1146/annurev.pathol.2.010506.092038 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041638875
    352 rdf:type schema:CreativeWork
    353 https://doi.org/10.1146/annurev.physiol.010908.163111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014048380
    354 rdf:type schema:CreativeWork
    355 https://doi.org/10.1152/ajpheart.1997.272.1.h220 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083048484
    356 rdf:type schema:CreativeWork
    357 https://doi.org/10.1152/physrev.00032.2006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047131206
    358 rdf:type schema:CreativeWork
    359 https://doi.org/10.1161/01.cir.100.2.193 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038002862
    360 rdf:type schema:CreativeWork
    361 https://doi.org/10.1161/01.cir.97.10.971 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029627153
    362 rdf:type schema:CreativeWork
    363 https://doi.org/10.1161/01.res.0000080317.92718.99 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021380512
    364 rdf:type schema:CreativeWork
    365 https://doi.org/10.1161/01.res.0000147315.71699.51 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033809756
    366 rdf:type schema:CreativeWork
    367 https://doi.org/10.1161/01.res.0000257776.05673.ff schema:sameAs https://app.dimensions.ai/details/publication/pub.1005428950
    368 rdf:type schema:CreativeWork
    369 https://doi.org/10.1161/01.res.68.6.1560 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013925871
    370 rdf:type schema:CreativeWork
    371 https://doi.org/10.1161/01.res.83.1.15 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053057757
    372 rdf:type schema:CreativeWork
    373 https://doi.org/10.1161/circresaha.108.174615 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053127886
    374 rdf:type schema:CreativeWork
    375 https://doi.org/10.1161/circresaha.108.175505 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011957551
    376 rdf:type schema:CreativeWork
    377 https://doi.org/10.1161/circresaha.108.188649 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050102150
    378 rdf:type schema:CreativeWork
    379 https://doi.org/10.1161/circresaha.108.192237 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037272431
    380 rdf:type schema:CreativeWork
    381 https://doi.org/10.1161/circresaha.109.210682 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021588712
    382 rdf:type schema:CreativeWork
    383 https://doi.org/10.1161/circresaha.110.222703 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034139929
    384 rdf:type schema:CreativeWork
    385 https://doi.org/10.1161/circresaha.110.223024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047380069
    386 rdf:type schema:CreativeWork
    387 https://doi.org/10.1161/circresaha.110.223917 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013907142
    388 rdf:type schema:CreativeWork
    389 https://doi.org/10.1161/circulationaha.106.655209 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016179858
    390 rdf:type schema:CreativeWork
    391 https://doi.org/10.1161/circulationaha.107.761031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052151571
    392 rdf:type schema:CreativeWork
    393 https://doi.org/10.1161/circulationaha.109.868885 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011009143
    394 rdf:type schema:CreativeWork
    395 https://doi.org/10.1161/circulationaha.109.871905 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034267444
    396 rdf:type schema:CreativeWork
    397 https://doi.org/10.1161/circulationaha.109.909093 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039835484
    398 rdf:type schema:CreativeWork
    399 https://doi.org/10.1161/hc0102.101442 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027646277
    400 rdf:type schema:CreativeWork
    401 https://doi.org/10.1172/jci119030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010761648
    402 rdf:type schema:CreativeWork
    403 https://doi.org/10.1172/jci12131 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063416054
    404 rdf:type schema:CreativeWork
    405 https://doi.org/10.1371/journal.pone.0005407 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000801305
    406 rdf:type schema:CreativeWork
    407 https://doi.org/10.1371/journal.pone.0011134 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003517824
    408 rdf:type schema:CreativeWork
    409 https://doi.org/10.1586/erc.10.99 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011571107
    410 rdf:type schema:CreativeWork
    411 https://doi.org/10.1634/stemcells.2006-0466 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038580241
    412 rdf:type schema:CreativeWork
    413 https://doi.org/10.4330/wjc.v2.i5.107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011706008
    414 rdf:type schema:CreativeWork
    415 https://www.grid.ac/institutes/grid.34477.33 schema:alternateName University of Washington
    416 schema:name Deparment of Bioengineering, Center for Cardiovascular Biology, Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, Washington 98109, USA.
    417 Department of Medicine/Cardiology, Center for Cardiovascular Biology, Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, Washington 98109, USA.
    418 Department of Pathology, Center for Cardiovascular Biology, Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, Washington 98109, USA.
    419 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...