Telomere shortening and loss of self-renewal in dyskeratosis congenita induced pluripotent stem cells View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-06

AUTHORS

Luis F. Z. Batista, Matthew F. Pech, Franklin L. Zhong, Ha Nam Nguyen, Kathleen T. Xie, Arthur J. Zaug, Sharon M. Crary, Jinkuk Choi, Vittorio Sebastiano, Athena Cherry, Neelam Giri, Marius Wernig, Blanche P. Alter, Thomas R. Cech, Sharon A. Savage, Renee A. Reijo Pera, Steven E. Artandi

ABSTRACT

The differentiation of patient-derived induced pluripotent stem cells (iPSCs) to committed fates such as neurons, muscle and liver is a powerful approach for understanding key parameters of human development and disease. Whether undifferentiated iPSCs themselves can be used to probe disease mechanisms is uncertain. Dyskeratosis congenita is characterized by defective maintenance of blood, pulmonary tissue and epidermal tissues and is caused by mutations in genes controlling telomere homeostasis. Short telomeres, a hallmark of dyskeratosis congenita, impair tissue stem cell function in mouse models, indicating that a tissue stem cell defect may underlie the pathophysiology of dyskeratosis congenita. Here we show that even in the undifferentiated state, iPSCs from dyskeratosis congenita patients harbour the precise biochemical defects characteristic of each form of the disease and that the magnitude of the telomere maintenance defect in iPSCs correlates with clinical severity. In iPSCs from patients with heterozygous mutations in TERT, the telomerase reverse transcriptase, a 50% reduction in telomerase levels blunts the natural telomere elongation that accompanies reprogramming. In contrast, mutation of dyskerin (DKC1) in X-linked dyskeratosis congenita severely impairs telomerase activity by blocking telomerase assembly and disrupts telomere elongation during reprogramming. In iPSCs from a form of dyskeratosis congenita caused by mutations in TCAB1 (also known as WRAP53), telomerase catalytic activity is unperturbed, yet the ability of telomerase to lengthen telomeres is abrogated, because telomerase mislocalizes from Cajal bodies to nucleoli within the iPSCs. Extended culture of DKC1-mutant iPSCs leads to progressive telomere shortening and eventual loss of self-renewal, indicating that a similar process occurs in tissue stem cells in dyskeratosis congenita patients. These findings in iPSCs from dyskeratosis congenita patients reveal that undifferentiated iPSCs accurately recapitulate features of a human stem cell disease and may serve as a cell-culture-based system for the development of targeted therapeutics. More... »

PAGES

399

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature10084

DOI

http://dx.doi.org/10.1038/nature10084

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1005531889

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21602826


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Cycle Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Division", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cellular Reprogramming", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dyskeratosis Congenita", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fibroblasts", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Induced Pluripotent Stem Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nuclear Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Telomerase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Telomere", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Stanford University", 
          "id": "https://www.grid.ac/institutes/grid.168010.e", 
          "name": [
            "Department of Medicine, Stanford University School of Medicine, Stanford, California 94305, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Batista", 
        "givenName": "Luis F. Z.", 
        "id": "sg:person.016346162622.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016346162622.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Stanford University", 
          "id": "https://www.grid.ac/institutes/grid.168010.e", 
          "name": [
            "Department of Medicine, Stanford University School of Medicine, Stanford, California 94305, USA", 
            "Cancer Biology Program, Stanford University School of Medicine, Stanford, California 94305, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pech", 
        "givenName": "Matthew F.", 
        "id": "sg:person.01063254723.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01063254723.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Stanford University", 
          "id": "https://www.grid.ac/institutes/grid.168010.e", 
          "name": [
            "Department of Medicine, Stanford University School of Medicine, Stanford, California 94305, USA", 
            "Cancer Biology Program, Stanford University School of Medicine, Stanford, California 94305, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhong", 
        "givenName": "Franklin L.", 
        "id": "sg:person.01037641115.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01037641115.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Stanford University", 
          "id": "https://www.grid.ac/institutes/grid.168010.e", 
          "name": [
            "Institute for Stem Cell Biology & Regenerative Medicine, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, California 94305, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nguyen", 
        "givenName": "Ha Nam", 
        "id": "sg:person.0644144002.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0644144002.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Stanford University", 
          "id": "https://www.grid.ac/institutes/grid.168010.e", 
          "name": [
            "Department of Biochemistry, Stanford University School of Medicine, Stanford, California 94305, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Xie", 
        "givenName": "Kathleen T.", 
        "id": "sg:person.01230266744.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230266744.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Colorado Boulder", 
          "id": "https://www.grid.ac/institutes/grid.266190.a", 
          "name": [
            "Department of Chemistry and Biochemistry, Howard Hughes Medical Institute, University of Colorado, Boulder, Colorado 80309, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zaug", 
        "givenName": "Arthur J.", 
        "id": "sg:person.0630722557.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630722557.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Colorado Boulder", 
          "id": "https://www.grid.ac/institutes/grid.266190.a", 
          "name": [
            "Department of Chemistry and Biochemistry, Howard Hughes Medical Institute, University of Colorado, Boulder, Colorado 80309, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Crary", 
        "givenName": "Sharon M.", 
        "id": "sg:person.01165426624.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01165426624.87"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Stanford University", 
          "id": "https://www.grid.ac/institutes/grid.168010.e", 
          "name": [
            "Department of Medicine, Stanford University School of Medicine, Stanford, California 94305, USA", 
            "Cancer Biology Program, Stanford University School of Medicine, Stanford, California 94305, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Choi", 
        "givenName": "Jinkuk", 
        "id": "sg:person.0734134653.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0734134653.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Stanford University", 
          "id": "https://www.grid.ac/institutes/grid.168010.e", 
          "name": [
            "Institute for Stem Cell Biology & Regenerative Medicine, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, California 94305, USA", 
            "Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sebastiano", 
        "givenName": "Vittorio", 
        "id": "sg:person.01125163710.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01125163710.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Stanford University", 
          "id": "https://www.grid.ac/institutes/grid.168010.e", 
          "name": [
            "Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cherry", 
        "givenName": "Athena", 
        "id": "sg:person.0641222446.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0641222446.43"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institutes of Health", 
          "id": "https://www.grid.ac/institutes/grid.94365.3d", 
          "name": [
            "Clinical Genetics Branch, Division of Cancer Epidemiology & Genetics, National Cancer Institute, National Institutes of Health, Department of Health & Human Services, Bethesda, Maryland 20852, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Giri", 
        "givenName": "Neelam", 
        "id": "sg:person.01213242400.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01213242400.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Stanford University", 
          "id": "https://www.grid.ac/institutes/grid.168010.e", 
          "name": [
            "Institute for Stem Cell Biology & Regenerative Medicine, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, California 94305, USA", 
            "Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wernig", 
        "givenName": "Marius", 
        "id": "sg:person.01256420377.73", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256420377.73"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institutes of Health", 
          "id": "https://www.grid.ac/institutes/grid.94365.3d", 
          "name": [
            "Clinical Genetics Branch, Division of Cancer Epidemiology & Genetics, National Cancer Institute, National Institutes of Health, Department of Health & Human Services, Bethesda, Maryland 20852, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Alter", 
        "givenName": "Blanche P.", 
        "id": "sg:person.01145461404.61", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145461404.61"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Colorado Boulder", 
          "id": "https://www.grid.ac/institutes/grid.266190.a", 
          "name": [
            "Department of Chemistry and Biochemistry, Howard Hughes Medical Institute, University of Colorado, Boulder, Colorado 80309, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cech", 
        "givenName": "Thomas R.", 
        "id": "sg:person.01211064044.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01211064044.70"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institutes of Health", 
          "id": "https://www.grid.ac/institutes/grid.94365.3d", 
          "name": [
            "Clinical Genetics Branch, Division of Cancer Epidemiology & Genetics, National Cancer Institute, National Institutes of Health, Department of Health & Human Services, Bethesda, Maryland 20852, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Savage", 
        "givenName": "Sharon A.", 
        "id": "sg:person.01014331770.94", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014331770.94"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Stanford University", 
          "id": "https://www.grid.ac/institutes/grid.168010.e", 
          "name": [
            "Cancer Biology Program, Stanford University School of Medicine, Stanford, California 94305, USA", 
            "Institute for Stem Cell Biology & Regenerative Medicine, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, California 94305, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pera", 
        "givenName": "Renee A. Reijo", 
        "id": "sg:person.013377035207.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013377035207.86"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Stanford University", 
          "id": "https://www.grid.ac/institutes/grid.168010.e", 
          "name": [
            "Department of Medicine, Stanford University School of Medicine, Stanford, California 94305, USA", 
            "Cancer Biology Program, Stanford University School of Medicine, Stanford, California 94305, USA", 
            "The Glenn Laboratories for the Biology of Aging, Stanford University School of Medicine, Stanford, California 94305, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Artandi", 
        "givenName": "Steven E.", 
        "id": "sg:person.01171267724.61", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01171267724.61"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.stem.2008.12.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000438832"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0007118", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000574059"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0402560101", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000761717"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2009.02.020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005196665"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08792", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005411330", 
          "https://doi.org/10.1038/nature08792"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08792", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005411330", 
          "https://doi.org/10.1038/nature08792"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.c400479200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007614091"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.emboj.7600952", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007634214"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.emboj.7600952", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007634214"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(89)90132-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007901925"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.stem.2008.02.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008490443"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature05454", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009193256", 
          "https://doi.org/10.1038/nature05454"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature05454", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009193256", 
          "https://doi.org/10.1038/nature05454"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2007.11.019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010904856"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.stem.2009.08.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011286553"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0508124102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012543371"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0508124102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012543371"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1346", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015472949", 
          "https://doi.org/10.1038/ng1346"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1346", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015472949", 
          "https://doi.org/10.1038/ng1346"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/33345", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017086815", 
          "https://doi.org/10.1038/33345"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/33345", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017086815", 
          "https://doi.org/10.1038/33345"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2009.02.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019496424"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2008.01.019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021714687"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2141.2009.07598.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022677780"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m502212200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023145429"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2007-02-075598", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023916083"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.febslet.2010.05.019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024181730"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrm2124", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024336069", 
          "https://doi.org/10.1038/nrm2124"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci43122", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024382505"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci43122", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024382505"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2141.2010.08212.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031893912"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2141.2010.08212.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031893912"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature09879", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032027822", 
          "https://doi.org/10.1038/nature09879"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0906894106", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033541298"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0906894106", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033541298"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.1476206", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036605766"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2002-07-2334", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037762638"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.1881810", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038670018"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1158799", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039463429"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(71)90287-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043749520"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.2006411", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045292796"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/990141", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047096543", 
          "https://doi.org/10.1038/990141"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/990141", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047096543", 
          "https://doi.org/10.1038/990141"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.26.6.2146-2159.2006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049798074"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1634/stemcells.2008-1075", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049957596"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1091/mbc.e08-02-0184", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052025435"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1165357", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062458971"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2011-06", 
    "datePublishedReg": "2011-06-01", 
    "description": "The differentiation of patient-derived induced pluripotent stem cells (iPSCs) to committed fates such as neurons, muscle and liver is a powerful approach for understanding key parameters of human development and disease. Whether undifferentiated iPSCs themselves can be used to probe disease mechanisms is uncertain. Dyskeratosis congenita is characterized by defective maintenance of blood, pulmonary tissue and epidermal tissues and is caused by mutations in genes controlling telomere homeostasis. Short telomeres, a hallmark of dyskeratosis congenita, impair tissue stem cell function in mouse models, indicating that a tissue stem cell defect may underlie the pathophysiology of dyskeratosis congenita. Here we show that even in the undifferentiated state, iPSCs from dyskeratosis congenita patients harbour the precise biochemical defects characteristic of each form of the disease and that the magnitude of the telomere maintenance defect in iPSCs correlates with clinical severity. In iPSCs from patients with heterozygous mutations in TERT, the telomerase reverse transcriptase, a 50% reduction in telomerase levels blunts the natural telomere elongation that accompanies reprogramming. In contrast, mutation of dyskerin (DKC1) in X-linked dyskeratosis congenita severely impairs telomerase activity by blocking telomerase assembly and disrupts telomere elongation during reprogramming. In iPSCs from a form of dyskeratosis congenita caused by mutations in TCAB1 (also known as WRAP53), telomerase catalytic activity is unperturbed, yet the ability of telomerase to lengthen telomeres is abrogated, because telomerase mislocalizes from Cajal bodies to nucleoli within the iPSCs. Extended culture of DKC1-mutant iPSCs leads to progressive telomere shortening and eventual loss of self-renewal, indicating that a similar process occurs in tissue stem cells in dyskeratosis congenita patients. These findings in iPSCs from dyskeratosis congenita patients reveal that undifferentiated iPSCs accurately recapitulate features of a human stem cell disease and may serve as a cell-culture-based system for the development of targeted therapeutics.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/nature10084", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2724421", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2682529", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2477790", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2479149", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2448563", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2668884", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2691994", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0090-0028", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "7351", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "474"
      }
    ], 
    "name": "Telomere shortening and loss of self-renewal in dyskeratosis congenita induced pluripotent stem cells", 
    "pagination": "399", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "1a5bac628b5009cb4adf9410f347247f1a6b1e13e6dc49446e5bf4dfd064411e"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "21602826"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0410462"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/nature10084"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1005531889"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/nature10084", 
      "https://app.dimensions.ai/details/publication/pub.1005531889"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T13:57", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8660_00000435.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/nature10084"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nature10084'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nature10084'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nature10084'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nature10084'


 

This table displays all metadata directly associated to this object as RDF triples.

372 TRIPLES      21 PREDICATES      78 URIs      33 LITERALS      21 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/nature10084 schema:about N122716cae70b4188be5fedf5e6099123
2 N1976311be5644a55ade23b43c255691d
3 N2a611be184ee493aa13dfa45f9b28e59
4 N3c5e6170d8044bb697e79423dbf3e4b8
5 N4a9ad32397fa425d9dcd7142fbbc4984
6 N656e6524ee3d42848044951d8f6386ba
7 N7086c5426de34fc280f7aa544d081370
8 N73a6fc08b79d420ea5b961c870063919
9 Na45c104c2d78488098ae5083378c4752
10 Nb361bbdd310b4938b2f9f619657da968
11 Nb46f32a4c17c419398034611302f5be0
12 Ned3f64714bad4de58748721163973571
13 anzsrc-for:06
14 anzsrc-for:0601
15 schema:author N32c8bea0af504b32a0624114e307a728
16 schema:citation sg:pub.10.1038/33345
17 sg:pub.10.1038/990141
18 sg:pub.10.1038/nature05454
19 sg:pub.10.1038/nature08792
20 sg:pub.10.1038/nature09879
21 sg:pub.10.1038/ng1346
22 sg:pub.10.1038/nrm2124
23 https://doi.org/10.1016/0092-8674(89)90132-3
24 https://doi.org/10.1016/j.cell.2007.11.019
25 https://doi.org/10.1016/j.cell.2008.01.019
26 https://doi.org/10.1016/j.cell.2009.02.013
27 https://doi.org/10.1016/j.febslet.2010.05.019
28 https://doi.org/10.1016/j.molcel.2009.02.020
29 https://doi.org/10.1016/j.stem.2008.02.001
30 https://doi.org/10.1016/j.stem.2008.12.010
31 https://doi.org/10.1016/j.stem.2009.08.001
32 https://doi.org/10.1016/s0140-6736(71)90287-x
33 https://doi.org/10.1038/sj.emboj.7600952
34 https://doi.org/10.1073/pnas.0402560101
35 https://doi.org/10.1073/pnas.0508124102
36 https://doi.org/10.1073/pnas.0906894106
37 https://doi.org/10.1074/jbc.c400479200
38 https://doi.org/10.1074/jbc.m502212200
39 https://doi.org/10.1091/mbc.e08-02-0184
40 https://doi.org/10.1101/gad.1476206
41 https://doi.org/10.1101/gad.1881810
42 https://doi.org/10.1101/gad.2006411
43 https://doi.org/10.1111/j.1365-2141.2009.07598.x
44 https://doi.org/10.1111/j.1365-2141.2010.08212.x
45 https://doi.org/10.1126/science.1158799
46 https://doi.org/10.1126/science.1165357
47 https://doi.org/10.1128/mcb.26.6.2146-2159.2006
48 https://doi.org/10.1172/jci43122
49 https://doi.org/10.1182/blood-2002-07-2334
50 https://doi.org/10.1182/blood-2007-02-075598
51 https://doi.org/10.1371/journal.pone.0007118
52 https://doi.org/10.1634/stemcells.2008-1075
53 schema:datePublished 2011-06
54 schema:datePublishedReg 2011-06-01
55 schema:description The differentiation of patient-derived induced pluripotent stem cells (iPSCs) to committed fates such as neurons, muscle and liver is a powerful approach for understanding key parameters of human development and disease. Whether undifferentiated iPSCs themselves can be used to probe disease mechanisms is uncertain. Dyskeratosis congenita is characterized by defective maintenance of blood, pulmonary tissue and epidermal tissues and is caused by mutations in genes controlling telomere homeostasis. Short telomeres, a hallmark of dyskeratosis congenita, impair tissue stem cell function in mouse models, indicating that a tissue stem cell defect may underlie the pathophysiology of dyskeratosis congenita. Here we show that even in the undifferentiated state, iPSCs from dyskeratosis congenita patients harbour the precise biochemical defects characteristic of each form of the disease and that the magnitude of the telomere maintenance defect in iPSCs correlates with clinical severity. In iPSCs from patients with heterozygous mutations in TERT, the telomerase reverse transcriptase, a 50% reduction in telomerase levels blunts the natural telomere elongation that accompanies reprogramming. In contrast, mutation of dyskerin (DKC1) in X-linked dyskeratosis congenita severely impairs telomerase activity by blocking telomerase assembly and disrupts telomere elongation during reprogramming. In iPSCs from a form of dyskeratosis congenita caused by mutations in TCAB1 (also known as WRAP53), telomerase catalytic activity is unperturbed, yet the ability of telomerase to lengthen telomeres is abrogated, because telomerase mislocalizes from Cajal bodies to nucleoli within the iPSCs. Extended culture of DKC1-mutant iPSCs leads to progressive telomere shortening and eventual loss of self-renewal, indicating that a similar process occurs in tissue stem cells in dyskeratosis congenita patients. These findings in iPSCs from dyskeratosis congenita patients reveal that undifferentiated iPSCs accurately recapitulate features of a human stem cell disease and may serve as a cell-culture-based system for the development of targeted therapeutics.
56 schema:genre research_article
57 schema:inLanguage en
58 schema:isAccessibleForFree true
59 schema:isPartOf N53932fd8ac9b45c2bd5d15311c1279d4
60 N7ba14ee5fc1d4537b8a6809ae472d7c7
61 sg:journal.1018957
62 schema:name Telomere shortening and loss of self-renewal in dyskeratosis congenita induced pluripotent stem cells
63 schema:pagination 399
64 schema:productId N0694363646c24e3eac92fc89ffbafe02
65 N13254f240b1c4e7d95f8e66182ecb792
66 N732a34b9ff9a48bdbdc7d40d554f991e
67 Nbaf8d291e1fb449fa08682ad67a7daea
68 Nfe914cbe49bf4a6a86806850f2954e82
69 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005531889
70 https://doi.org/10.1038/nature10084
71 schema:sdDatePublished 2019-04-10T13:57
72 schema:sdLicense https://scigraph.springernature.com/explorer/license/
73 schema:sdPublisher Naee48d9827474edb86edf0723a6ae0ff
74 schema:url https://www.nature.com/articles/nature10084
75 sgo:license sg:explorer/license/
76 sgo:sdDataset articles
77 rdf:type schema:ScholarlyArticle
78 N0694363646c24e3eac92fc89ffbafe02 schema:name doi
79 schema:value 10.1038/nature10084
80 rdf:type schema:PropertyValue
81 N086f3e5112f948e4880d49a5efedeb48 rdf:first sg:person.01063254723.07
82 rdf:rest N5950c8fae62f42c8995d51b9860b5357
83 N122716cae70b4188be5fedf5e6099123 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
84 schema:name Fibroblasts
85 rdf:type schema:DefinedTerm
86 N13254f240b1c4e7d95f8e66182ecb792 schema:name readcube_id
87 schema:value 1a5bac628b5009cb4adf9410f347247f1a6b1e13e6dc49446e5bf4dfd064411e
88 rdf:type schema:PropertyValue
89 N17275b3bc4514028a5b54f6af17bfd94 rdf:first sg:person.01230266744.22
90 rdf:rest N98899eebe1ef4524ba4830aab92562a2
91 N1976311be5644a55ade23b43c255691d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Nuclear Proteins
93 rdf:type schema:DefinedTerm
94 N1b87b91d78eb452fa9652e49d1ebec92 rdf:first sg:person.0641222446.43
95 rdf:rest Nf9793dd510c3465fb9afe32bd8c91e97
96 N206c2525b0ad4f1d9a908aed5d81d5bd rdf:first sg:person.01171267724.61
97 rdf:rest rdf:nil
98 N2a611be184ee493aa13dfa45f9b28e59 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name RNA
100 rdf:type schema:DefinedTerm
101 N32c8bea0af504b32a0624114e307a728 rdf:first sg:person.016346162622.39
102 rdf:rest N086f3e5112f948e4880d49a5efedeb48
103 N3c5e6170d8044bb697e79423dbf3e4b8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Humans
105 rdf:type schema:DefinedTerm
106 N4a9ad32397fa425d9dcd7142fbbc4984 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Gene Expression Regulation
108 rdf:type schema:DefinedTerm
109 N53932fd8ac9b45c2bd5d15311c1279d4 schema:volumeNumber 474
110 rdf:type schema:PublicationVolume
111 N5950c8fae62f42c8995d51b9860b5357 rdf:first sg:person.01037641115.07
112 rdf:rest Na7360ff9e5914422a3346dfaef04295a
113 N656e6524ee3d42848044951d8f6386ba schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Induced Pluripotent Stem Cells
115 rdf:type schema:DefinedTerm
116 N7086c5426de34fc280f7aa544d081370 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Telomere
118 rdf:type schema:DefinedTerm
119 N732a34b9ff9a48bdbdc7d40d554f991e schema:name pubmed_id
120 schema:value 21602826
121 rdf:type schema:PropertyValue
122 N73a6fc08b79d420ea5b961c870063919 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Telomerase
124 rdf:type schema:DefinedTerm
125 N75f574276a65480287abb86279acbf89 rdf:first sg:person.01014331770.94
126 rdf:rest Ne95957262b5b4d2e9d3236de6442aa1d
127 N7ba14ee5fc1d4537b8a6809ae472d7c7 schema:issueNumber 7351
128 rdf:type schema:PublicationIssue
129 N98899eebe1ef4524ba4830aab92562a2 rdf:first sg:person.0630722557.23
130 rdf:rest Nf91de8a3fdb8442d9584f1d144e7c82e
131 Na45c104c2d78488098ae5083378c4752 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Cellular Reprogramming
133 rdf:type schema:DefinedTerm
134 Na490b3bc807d4948b5eaaf93c097473d rdf:first sg:person.01125163710.09
135 rdf:rest N1b87b91d78eb452fa9652e49d1ebec92
136 Na7360ff9e5914422a3346dfaef04295a rdf:first sg:person.0644144002.36
137 rdf:rest N17275b3bc4514028a5b54f6af17bfd94
138 Naee48d9827474edb86edf0723a6ae0ff schema:name Springer Nature - SN SciGraph project
139 rdf:type schema:Organization
140 Nb361bbdd310b4938b2f9f619657da968 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Dyskeratosis Congenita
142 rdf:type schema:DefinedTerm
143 Nb46f32a4c17c419398034611302f5be0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Cell Division
145 rdf:type schema:DefinedTerm
146 Nbaf8d291e1fb449fa08682ad67a7daea schema:name nlm_unique_id
147 schema:value 0410462
148 rdf:type schema:PropertyValue
149 Nbc85bdd4b68443f897c6ad25e9ed6ed2 rdf:first sg:person.01211064044.70
150 rdf:rest N75f574276a65480287abb86279acbf89
151 Nbd7db9dab3f548f88d109eff5a497be4 rdf:first sg:person.0734134653.11
152 rdf:rest Na490b3bc807d4948b5eaaf93c097473d
153 Ndedc7294676f40309093221576c36a9b rdf:first sg:person.01256420377.73
154 rdf:rest Nee08fdb1479e41ee8affd6901fe6f2bc
155 Ne95957262b5b4d2e9d3236de6442aa1d rdf:first sg:person.013377035207.86
156 rdf:rest N206c2525b0ad4f1d9a908aed5d81d5bd
157 Ned3f64714bad4de58748721163973571 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Cell Cycle Proteins
159 rdf:type schema:DefinedTerm
160 Nee08fdb1479e41ee8affd6901fe6f2bc rdf:first sg:person.01145461404.61
161 rdf:rest Nbc85bdd4b68443f897c6ad25e9ed6ed2
162 Nf91de8a3fdb8442d9584f1d144e7c82e rdf:first sg:person.01165426624.87
163 rdf:rest Nbd7db9dab3f548f88d109eff5a497be4
164 Nf9793dd510c3465fb9afe32bd8c91e97 rdf:first sg:person.01213242400.04
165 rdf:rest Ndedc7294676f40309093221576c36a9b
166 Nfe914cbe49bf4a6a86806850f2954e82 schema:name dimensions_id
167 schema:value pub.1005531889
168 rdf:type schema:PropertyValue
169 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
170 schema:name Biological Sciences
171 rdf:type schema:DefinedTerm
172 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
173 schema:name Biochemistry and Cell Biology
174 rdf:type schema:DefinedTerm
175 sg:grant.2448563 http://pending.schema.org/fundedItem sg:pub.10.1038/nature10084
176 rdf:type schema:MonetaryGrant
177 sg:grant.2477790 http://pending.schema.org/fundedItem sg:pub.10.1038/nature10084
178 rdf:type schema:MonetaryGrant
179 sg:grant.2479149 http://pending.schema.org/fundedItem sg:pub.10.1038/nature10084
180 rdf:type schema:MonetaryGrant
181 sg:grant.2668884 http://pending.schema.org/fundedItem sg:pub.10.1038/nature10084
182 rdf:type schema:MonetaryGrant
183 sg:grant.2682529 http://pending.schema.org/fundedItem sg:pub.10.1038/nature10084
184 rdf:type schema:MonetaryGrant
185 sg:grant.2691994 http://pending.schema.org/fundedItem sg:pub.10.1038/nature10084
186 rdf:type schema:MonetaryGrant
187 sg:grant.2724421 http://pending.schema.org/fundedItem sg:pub.10.1038/nature10084
188 rdf:type schema:MonetaryGrant
189 sg:journal.1018957 schema:issn 0090-0028
190 1476-4687
191 schema:name Nature
192 rdf:type schema:Periodical
193 sg:person.01014331770.94 schema:affiliation https://www.grid.ac/institutes/grid.94365.3d
194 schema:familyName Savage
195 schema:givenName Sharon A.
196 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014331770.94
197 rdf:type schema:Person
198 sg:person.01037641115.07 schema:affiliation https://www.grid.ac/institutes/grid.168010.e
199 schema:familyName Zhong
200 schema:givenName Franklin L.
201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01037641115.07
202 rdf:type schema:Person
203 sg:person.01063254723.07 schema:affiliation https://www.grid.ac/institutes/grid.168010.e
204 schema:familyName Pech
205 schema:givenName Matthew F.
206 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01063254723.07
207 rdf:type schema:Person
208 sg:person.01125163710.09 schema:affiliation https://www.grid.ac/institutes/grid.168010.e
209 schema:familyName Sebastiano
210 schema:givenName Vittorio
211 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01125163710.09
212 rdf:type schema:Person
213 sg:person.01145461404.61 schema:affiliation https://www.grid.ac/institutes/grid.94365.3d
214 schema:familyName Alter
215 schema:givenName Blanche P.
216 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145461404.61
217 rdf:type schema:Person
218 sg:person.01165426624.87 schema:affiliation https://www.grid.ac/institutes/grid.266190.a
219 schema:familyName Crary
220 schema:givenName Sharon M.
221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01165426624.87
222 rdf:type schema:Person
223 sg:person.01171267724.61 schema:affiliation https://www.grid.ac/institutes/grid.168010.e
224 schema:familyName Artandi
225 schema:givenName Steven E.
226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01171267724.61
227 rdf:type schema:Person
228 sg:person.01211064044.70 schema:affiliation https://www.grid.ac/institutes/grid.266190.a
229 schema:familyName Cech
230 schema:givenName Thomas R.
231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01211064044.70
232 rdf:type schema:Person
233 sg:person.01213242400.04 schema:affiliation https://www.grid.ac/institutes/grid.94365.3d
234 schema:familyName Giri
235 schema:givenName Neelam
236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01213242400.04
237 rdf:type schema:Person
238 sg:person.01230266744.22 schema:affiliation https://www.grid.ac/institutes/grid.168010.e
239 schema:familyName Xie
240 schema:givenName Kathleen T.
241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230266744.22
242 rdf:type schema:Person
243 sg:person.01256420377.73 schema:affiliation https://www.grid.ac/institutes/grid.168010.e
244 schema:familyName Wernig
245 schema:givenName Marius
246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256420377.73
247 rdf:type schema:Person
248 sg:person.013377035207.86 schema:affiliation https://www.grid.ac/institutes/grid.168010.e
249 schema:familyName Pera
250 schema:givenName Renee A. Reijo
251 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013377035207.86
252 rdf:type schema:Person
253 sg:person.016346162622.39 schema:affiliation https://www.grid.ac/institutes/grid.168010.e
254 schema:familyName Batista
255 schema:givenName Luis F. Z.
256 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016346162622.39
257 rdf:type schema:Person
258 sg:person.0630722557.23 schema:affiliation https://www.grid.ac/institutes/grid.266190.a
259 schema:familyName Zaug
260 schema:givenName Arthur J.
261 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630722557.23
262 rdf:type schema:Person
263 sg:person.0641222446.43 schema:affiliation https://www.grid.ac/institutes/grid.168010.e
264 schema:familyName Cherry
265 schema:givenName Athena
266 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0641222446.43
267 rdf:type schema:Person
268 sg:person.0644144002.36 schema:affiliation https://www.grid.ac/institutes/grid.168010.e
269 schema:familyName Nguyen
270 schema:givenName Ha Nam
271 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0644144002.36
272 rdf:type schema:Person
273 sg:person.0734134653.11 schema:affiliation https://www.grid.ac/institutes/grid.168010.e
274 schema:familyName Choi
275 schema:givenName Jinkuk
276 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0734134653.11
277 rdf:type schema:Person
278 sg:pub.10.1038/33345 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017086815
279 https://doi.org/10.1038/33345
280 rdf:type schema:CreativeWork
281 sg:pub.10.1038/990141 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047096543
282 https://doi.org/10.1038/990141
283 rdf:type schema:CreativeWork
284 sg:pub.10.1038/nature05454 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009193256
285 https://doi.org/10.1038/nature05454
286 rdf:type schema:CreativeWork
287 sg:pub.10.1038/nature08792 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005411330
288 https://doi.org/10.1038/nature08792
289 rdf:type schema:CreativeWork
290 sg:pub.10.1038/nature09879 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032027822
291 https://doi.org/10.1038/nature09879
292 rdf:type schema:CreativeWork
293 sg:pub.10.1038/ng1346 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015472949
294 https://doi.org/10.1038/ng1346
295 rdf:type schema:CreativeWork
296 sg:pub.10.1038/nrm2124 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024336069
297 https://doi.org/10.1038/nrm2124
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1016/0092-8674(89)90132-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007901925
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1016/j.cell.2007.11.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010904856
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1016/j.cell.2008.01.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021714687
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1016/j.cell.2009.02.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019496424
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1016/j.febslet.2010.05.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024181730
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1016/j.molcel.2009.02.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005196665
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1016/j.stem.2008.02.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008490443
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1016/j.stem.2008.12.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000438832
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1016/j.stem.2009.08.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011286553
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1016/s0140-6736(71)90287-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1043749520
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1038/sj.emboj.7600952 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007634214
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1073/pnas.0402560101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000761717
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1073/pnas.0508124102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012543371
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1073/pnas.0906894106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033541298
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1074/jbc.c400479200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007614091
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1074/jbc.m502212200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023145429
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1091/mbc.e08-02-0184 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052025435
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1101/gad.1476206 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036605766
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1101/gad.1881810 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038670018
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1101/gad.2006411 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045292796
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1111/j.1365-2141.2009.07598.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1022677780
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1111/j.1365-2141.2010.08212.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1031893912
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1126/science.1158799 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039463429
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1126/science.1165357 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062458971
346 rdf:type schema:CreativeWork
347 https://doi.org/10.1128/mcb.26.6.2146-2159.2006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049798074
348 rdf:type schema:CreativeWork
349 https://doi.org/10.1172/jci43122 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024382505
350 rdf:type schema:CreativeWork
351 https://doi.org/10.1182/blood-2002-07-2334 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037762638
352 rdf:type schema:CreativeWork
353 https://doi.org/10.1182/blood-2007-02-075598 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023916083
354 rdf:type schema:CreativeWork
355 https://doi.org/10.1371/journal.pone.0007118 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000574059
356 rdf:type schema:CreativeWork
357 https://doi.org/10.1634/stemcells.2008-1075 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049957596
358 rdf:type schema:CreativeWork
359 https://www.grid.ac/institutes/grid.168010.e schema:alternateName Stanford University
360 schema:name Cancer Biology Program, Stanford University School of Medicine, Stanford, California 94305, USA
361 Department of Biochemistry, Stanford University School of Medicine, Stanford, California 94305, USA
362 Department of Medicine, Stanford University School of Medicine, Stanford, California 94305, USA
363 Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
364 Institute for Stem Cell Biology & Regenerative Medicine, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, California 94305, USA
365 The Glenn Laboratories for the Biology of Aging, Stanford University School of Medicine, Stanford, California 94305, USA
366 rdf:type schema:Organization
367 https://www.grid.ac/institutes/grid.266190.a schema:alternateName University of Colorado Boulder
368 schema:name Department of Chemistry and Biochemistry, Howard Hughes Medical Institute, University of Colorado, Boulder, Colorado 80309, USA
369 rdf:type schema:Organization
370 https://www.grid.ac/institutes/grid.94365.3d schema:alternateName National Institutes of Health
371 schema:name Clinical Genetics Branch, Division of Cancer Epidemiology & Genetics, National Cancer Institute, National Institutes of Health, Department of Health & Human Services, Bethesda, Maryland 20852, USA
372 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...