Enterotypes of the human gut microbiome View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-04-20

AUTHORS

Manimozhiyan Arumugam, Jeroen Raes, Eric Pelletier, Denis Le Paslier, Takuji Yamada, Daniel R. Mende, Gabriel R. Fernandes, Julien Tap, Thomas Bruls, Jean-Michel Batto, Marcelo Bertalan, Natalia Borruel, Francesc Casellas, Leyden Fernandez, Laurent Gautier, Torben Hansen, Masahira Hattori, Tetsuya Hayashi, Michiel Kleerebezem, Ken Kurokawa, Marion Leclerc, Florence Levenez, Chaysavanh Manichanh, H. Bjørn Nielsen, Trine Nielsen, Nicolas Pons, Julie Poulain, Junjie Qin, Thomas Sicheritz-Ponten, Sebastian Tims, David Torrents, Edgardo Ugarte, Erwin G. Zoetendal, Jun Wang, Francisco Guarner, Oluf Pedersen, Willem M. de Vos, Søren Brunak, Joel Doré, Jean Weissenbach, S. Dusko Ehrlich, Peer Bork

ABSTRACT

Our knowledge of species and functional composition of the human gut microbiome is rapidly increasing, but it is still based on very few cohorts and little is known about variation across the world. By combining 22 newly sequenced faecal metagenomes of individuals from four countries with previously published data sets, here we identify three robust clusters (referred to as enterotypes hereafter) that are not nation or continent specific. We also confirmed the enterotypes in two published, larger cohorts, indicating that intestinal microbiota variation is generally stratified, not continuous. This indicates further the existence of a limited number of well-balanced host–microbial symbiotic states that might respond differently to diet and drug intake. The enterotypes are mostly driven by species composition, but abundant molecular functions are not necessarily provided by abundant species, highlighting the importance of a functional analysis to understand microbial communities. Although individual host properties such as body mass index, age, or gender cannot explain the observed enterotypes, data-driven marker genes or functional modules can be identified for each of these host properties. For example, twelve genes significantly correlate with age and three functional modules with the body mass index, hinting at a diagnostic potential of microbial markers. More... »

PAGES

174-180

Journal

TITLE

Nature

ISSUE

7346

VOLUME

473

Author Affiliations

  • European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
  • VIB—Vrije Universiteit Brussel, 1050 Brussels, Belgium
  • Université d'Evry Val d'Essone 91000 Evry, France
  • Department of Biochemistry and Immunology, Universidade Federal de Minas Gerais, Av. Antônio Carlos 6627, 31270-901 Belo Horizonte, Minas Gerais, Brazil
  • Institut National de la Recherche Agronomique, 78350 Jouy en Josas, France
  • Center for Biological Sequence Analysis, Technical University of Denmark, DK-2800 Lyngby, Denmark
  • Digestive System Research Unit, University Hospital Vall d’Hebron, Ciberehd, 08035 Barcelona, Spain
  • Barcelona Supercomputing Center, Jordi Girona 31, 08034 Barcelona, Spain
  • Faculty of Health Sciences, University of Southern Denmark, DK-5000 Odense, Denmark
  • Computational Biology Laboratory Bld, The University of Tokyo Kashiwa Campus, Kashiwa-no-ha 5-1-5, Kashiwa, Chiba, 277-8561, Japan
  • Division of Bioenvironmental Science, Frontier Science Research Center, University of Miyazaki, 5200 Kiyotake, Miyazaki 889-1692, Japan
  • Laboratory of Microbiology, Wageningen University, 6710BA Ede, The Netherlands
  • Department of Biological Information, Tokyo Institute of Technology, Graduate School of Bioscience and Biotechnology, 4259 Nagatsuta-cho, Midori-ku, Yokohama-shi, Kanagawa Pref. 226-8501, Japan
  • Marie Krogh Center for Metabolic Research, Section of Metabolic Genetics, Faculty of Health Sciences, University of Copenhagen, DK-2100 Copenhagen, Denmark
  • Commissariat à l’Energie Atomique, Genoscope, 91000 Evry, France
  • BGI-Shenzhen, 518083, Shenzhen, China
  • Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, DK-2800 Lyngby, Denmark
  • Institució Catalana de Recerca i Estudis Avançats (ICREA), Pg. Lluís Companys 23, 08010 Barcelona, Spain
  • Department of Biology, University of Copenhagen, DK-2200 Copenhagen, Denmark
  • Faculty of Health Sciences, University of Aarhus, DK-8000 Aarhus, Denmark
  • University of Helsinki, FI-00014 Helsinki, Finland
  • Max Delbrück Centre for Molecular Medicine, D-13092 Berlin, Germany
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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nature09944

    DOI

    http://dx.doi.org/10.1038/nature09944

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1026204536

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/21508958


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