Acetylation-dependent regulation of endothelial Notch signalling by the SIRT1 deacetylase View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-04-17

AUTHORS

Virginia Guarani, Gianluca Deflorian, Claudio A. Franco, Marcus Krüger, Li-Kun Phng, Katie Bentley, Louise Toussaint, Franck Dequiedt, Raul Mostoslavsky, Mirko H. H. Schmidt, Barbara Zimmermann, Ralf P. Brandes, Marina Mione, Christoph H. Westphal, Thomas Braun, Andreas M. Zeiher, Holger Gerhardt, Stefanie Dimmeler, Michael Potente

ABSTRACT

Notch signalling in angiogenesisNotch signalling coordinates angiogenesis by controlling the specification of endothelial cells into tip cells that lead the way in growing blood vessels and the stalk cells that follow. Michael Potente and colleagues have identified a previously unknown component in Notch signalling regulation in endothelial cells that may provide a mechanism for fine-tuning angiogenesis in response to metabolic requirements and angiogenic stress. They show that the metabolism- and redox-sensing deacetylase SIRT1 deacetylates the Notch1 intracellular domain directly, thereby controlling its stability and turnover and negatively modulating Notch signalling. Inactivation of SIRT1 impairs angiogenesis in zebrafish and mice. More... »

PAGES

234-238

Journal

TITLE

Nature

ISSUE

7346

VOLUME

473

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature09917

DOI

http://dx.doi.org/10.1038/nature09917

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1041823426

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21499261


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365 Molecular Signal Transduction, Institute of Neurology (Edinger Institute), Goethe University, D-60590 Frankfurt, Germany
366 Vascular Research Centre, Institute for Cardiovascular Physiology, Goethe University, D-60590 Frankfurt, Germany
367 rdf:type schema:Organization
 




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