Recapitulation of premature ageing with iPSCs from Hutchinson–Gilford progeria syndrome View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-04

AUTHORS

Guang-Hui Liu, Basam Z. Barkho, Sergio Ruiz, Dinh Diep, Jing Qu, Sheng-Lian Yang, Athanasia D. Panopoulos, Keiichiro Suzuki, Leo Kurian, Christopher Walsh, James Thompson, Stephanie Boue, Ho Lim Fung, Ignacio Sancho-Martinez, Kun Zhang, John Yates, Juan Carlos Izpisua Belmonte

ABSTRACT

Hutchinson-Gilford progeria syndrome (HGPS) is a rare and fatal human premature ageing disease, characterized by premature arteriosclerosis and degeneration of vascular smooth muscle cells (SMCs). HGPS is caused by a single point mutation in the lamin A (LMNA) gene, resulting in the generation of progerin, a truncated splicing mutant of lamin A. Accumulation of progerin leads to various ageing-associated nuclear defects including disorganization of nuclear lamina and loss of heterochromatin. Here we report the generation of induced pluripotent stem cells (iPSCs) from fibroblasts obtained from patients with HGPS. HGPS-iPSCs show absence of progerin, and more importantly, lack the nuclear envelope and epigenetic alterations normally associated with premature ageing. Upon differentiation of HGPS-iPSCs, progerin and its ageing-associated phenotypic consequences are restored. Specifically, directed differentiation of HGPS-iPSCs to SMCs leads to the appearance of premature senescence phenotypes associated with vascular ageing. Additionally, our studies identify DNA-dependent protein kinase catalytic subunit (DNAPKcs, also known as PRKDC) as a downstream target of progerin. The absence of nuclear DNAPK holoenzyme correlates with premature as well as physiological ageing. Because progerin also accumulates during physiological ageing, our results provide an in vitro iPSC-based model to study the pathogenesis of human premature and physiological vascular ageing. More... »

PAGES

221

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature09879

DOI

http://dx.doi.org/10.1038/nature09879

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1032027822

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21346760


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aging", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aging, Premature", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Calcium-Binding Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Differentiation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cellular Reprogramming", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cellular Senescence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA-Activated Protein Kinase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Epigenesis, Genetic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fibroblasts", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Holoenzymes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Induced Pluripotent Stem Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lamin Type A", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Microfilament Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Models, Biological", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Muscle, Smooth, Vascular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nuclear Envelope", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nuclear Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phenotype", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Progeria", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Precursors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Substrate Specificity", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Salk Institute for Biological Studies", 
          "id": "https://www.grid.ac/institutes/grid.250671.7", 
          "name": [
            "Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Liu", 
        "givenName": "Guang-Hui", 
        "id": "sg:person.014311705137.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014311705137.80"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Salk Institute for Biological Studies", 
          "id": "https://www.grid.ac/institutes/grid.250671.7", 
          "name": [
            "Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Barkho", 
        "givenName": "Basam Z.", 
        "id": "sg:person.0577375446.84", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577375446.84"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Salk Institute for Biological Studies", 
          "id": "https://www.grid.ac/institutes/grid.250671.7", 
          "name": [
            "Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ruiz", 
        "givenName": "Sergio", 
        "id": "sg:person.01333604123.60", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01333604123.60"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of California, San Diego", 
          "id": "https://www.grid.ac/institutes/grid.266100.3", 
          "name": [
            "Department of Bioengineering, University of California at San Diego, La Jolla, California 92093, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Diep", 
        "givenName": "Dinh", 
        "id": "sg:person.0666643624.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0666643624.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Salk Institute for Biological Studies", 
          "id": "https://www.grid.ac/institutes/grid.250671.7", 
          "name": [
            "Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Qu", 
        "givenName": "Jing", 
        "id": "sg:person.0754746042.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0754746042.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Salk Institute for Biological Studies", 
          "id": "https://www.grid.ac/institutes/grid.250671.7", 
          "name": [
            "Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yang", 
        "givenName": "Sheng-Lian", 
        "id": "sg:person.0613236700.68", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0613236700.68"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Salk Institute for Biological Studies", 
          "id": "https://www.grid.ac/institutes/grid.250671.7", 
          "name": [
            "Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Panopoulos", 
        "givenName": "Athanasia D.", 
        "id": "sg:person.01116675610.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01116675610.86"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Salk Institute for Biological Studies", 
          "id": "https://www.grid.ac/institutes/grid.250671.7", 
          "name": [
            "Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Suzuki", 
        "givenName": "Keiichiro", 
        "id": "sg:person.01051045643.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01051045643.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Salk Institute for Biological Studies", 
          "id": "https://www.grid.ac/institutes/grid.250671.7", 
          "name": [
            "Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kurian", 
        "givenName": "Leo", 
        "id": "sg:person.01007145436.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01007145436.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Salk Institute for Biological Studies", 
          "id": "https://www.grid.ac/institutes/grid.250671.7", 
          "name": [
            "Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Walsh", 
        "givenName": "Christopher", 
        "id": "sg:person.01313060355.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01313060355.66"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Scripps Research Institute", 
          "id": "https://www.grid.ac/institutes/grid.214007.0", 
          "name": [
            "Department of Cell Biology, Scripps Research Institute, La Jolla, California 92037, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Thompson", 
        "givenName": "James", 
        "id": "sg:person.01225244766.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01225244766.88"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Center of Regenerative Medicine in Barcelona", 
          "id": "https://www.grid.ac/institutes/grid.434617.3", 
          "name": [
            "Center for Regenerative Medicine in Barcelona, Dr. Aiguader 88, 08003 Barcelona, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Boue", 
        "givenName": "Stephanie", 
        "id": "sg:person.01077255356.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01077255356.91"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of California, San Diego", 
          "id": "https://www.grid.ac/institutes/grid.266100.3", 
          "name": [
            "Department of Bioengineering, University of California at San Diego, La Jolla, California 92093, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fung", 
        "givenName": "Ho Lim", 
        "id": "sg:person.0576305537.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0576305537.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Salk Institute for Biological Studies", 
          "id": "https://www.grid.ac/institutes/grid.250671.7", 
          "name": [
            "Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sancho-Martinez", 
        "givenName": "Ignacio", 
        "id": "sg:person.01110454126.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01110454126.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of California, San Diego", 
          "id": "https://www.grid.ac/institutes/grid.266100.3", 
          "name": [
            "Department of Bioengineering, University of California at San Diego, La Jolla, California 92093, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhang", 
        "givenName": "Kun", 
        "id": "sg:person.010125337727.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010125337727.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Scripps Research Institute", 
          "id": "https://www.grid.ac/institutes/grid.214007.0", 
          "name": [
            "Department of Cell Biology, Scripps Research Institute, La Jolla, California 92037, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yates", 
        "givenName": "John", 
        "id": "sg:person.01104567247.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104567247.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Center of Regenerative Medicine in Barcelona", 
          "id": "https://www.grid.ac/institutes/grid.434617.3", 
          "name": [
            "Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA", 
            "Center for Regenerative Medicine in Barcelona, Dr. Aiguader 88, 08003 Barcelona, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Belmonte", 
        "givenName": "Juan Carlos Izpisua", 
        "id": "sg:person.014010175255.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014010175255.22"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s00439-005-0051-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000128047", 
          "https://doi.org/10.1007/s00439-005-0051-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00439-005-0051-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000128047", 
          "https://doi.org/10.1007/s00439-005-0051-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00439-005-0051-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000128047", 
          "https://doi.org/10.1007/s00439-005-0051-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2010.03.016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004413613"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.res.0000256837.40544.4a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006165478"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.res.0000256837.40544.4a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006165478"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0511133103", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011787076"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1634/stemcells.2004-0159", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013167626"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1634/stemcells.2004-0159", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013167626"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1016/1044-0305(94)80016-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018629105", 
          "https://doi.org/10.1016/1044-0305(94)80016-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1016/1044-0305(94)80016-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018629105", 
          "https://doi.org/10.1016/1044-0305(94)80016-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1091/mbc.e07-01-0029", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018776426"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.00355-08", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020485197"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/gb-2003-4-5-p3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021292424", 
          "https://doi.org/10.1186/gb-2003-4-5-p3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.embor.7400127", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022880128"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev-genom-082908-150150", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023517205"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circulationaha.109.902056", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024233813"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrm2944", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025973418", 
          "https://doi.org/10.1038/nrm2944"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cardiores.2006.06.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028615153"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/cshperspect.a000760", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029164617"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.stem.2010.12.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031328210"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt.1530", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031583743", 
          "https://doi.org/10.1038/nbt.1530"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb1792", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032211996", 
          "https://doi.org/10.1038/ncb1792"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.298", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032369744", 
          "https://doi.org/10.1038/ng.298"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa0706898", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033012132"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb1971", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034778622", 
          "https://doi.org/10.1038/ncb1971"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bioinformatics/bth947", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035690890"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2004-04-1649", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037158040"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/atvbaha.110.209460", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038589392"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/atvbaha.110.209460", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038589392"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.1652708", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039212754"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nprot.2008.211", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039987283", 
          "https://doi.org/10.1038/nprot.2008.211"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.stem.2008.08.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040008680"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08311", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040491383", 
          "https://doi.org/10.1038/nature08311"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08311", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040491383", 
          "https://doi.org/10.1038/nature08311"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/gb-2003-4-9-r60", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041539408", 
          "https://doi.org/10.1186/gb-2003-4-9-r60"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.00684-09", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041925845"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.yexcr.2010.10.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042148046"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nprot.2009.191", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042227432", 
          "https://doi.org/10.1038/nprot.2009.191"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.00785-07", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042770896"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/pr025556v", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045717219"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm1204", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045731227", 
          "https://doi.org/10.1038/nm1204"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm1204", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045731227", 
          "https://doi.org/10.1038/nm1204"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrm2161", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046582123", 
          "https://doi.org/10.1038/nrm2161"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0001269", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050421154"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/85686", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050637706", 
          "https://doi.org/10.1038/85686"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/85686", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050637706", 
          "https://doi.org/10.1038/85686"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2217/17460751.4.1.37", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051645139"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0600012103", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053658631"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/pr015514r", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056290133"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1127168", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062453753"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2011-04", 
    "datePublishedReg": "2011-04-01", 
    "description": "Hutchinson-Gilford progeria syndrome (HGPS) is a rare and fatal human premature ageing disease, characterized by premature arteriosclerosis and degeneration of vascular smooth muscle cells (SMCs). HGPS is caused by a single point mutation in the lamin A (LMNA) gene, resulting in the generation of progerin, a truncated splicing mutant of lamin A. Accumulation of progerin leads to various ageing-associated nuclear defects including disorganization of nuclear lamina and loss of heterochromatin. Here we report the generation of induced pluripotent stem cells (iPSCs) from fibroblasts obtained from patients with HGPS. HGPS-iPSCs show absence of progerin, and more importantly, lack the nuclear envelope and epigenetic alterations normally associated with premature ageing. Upon differentiation of HGPS-iPSCs, progerin and its ageing-associated phenotypic consequences are restored. Specifically, directed differentiation of HGPS-iPSCs to SMCs leads to the appearance of premature senescence phenotypes associated with vascular ageing. Additionally, our studies identify DNA-dependent protein kinase catalytic subunit (DNAPKcs, also known as PRKDC) as a downstream target of progerin. The absence of nuclear DNAPK holoenzyme correlates with premature as well as physiological ageing. Because progerin also accumulates during physiological ageing, our results provide an in vitro iPSC-based model to study the pathogenesis of human premature and physiological vascular ageing.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/nature09879", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2682551", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2486664", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2439911", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0090-0028", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "7342", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "472"
      }
    ], 
    "name": "Recapitulation of premature ageing with iPSCs from Hutchinson\u2013Gilford progeria syndrome", 
    "pagination": "221", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "98935557961dac137201456ed07e87216e8e841766a97455f68974ea2f1075e8"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "21346760"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0410462"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/nature09879"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1032027822"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/nature09879", 
      "https://app.dimensions.ai/details/publication/pub.1032027822"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T00:23", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8695_00000550.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/nature09879"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nature09879'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nature09879'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nature09879'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nature09879'


 

This table displays all metadata directly associated to this object as RDF triples.

430 TRIPLES      21 PREDICATES      94 URIs      44 LITERALS      32 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/nature09879 schema:about N0fc87937de5a4f289c1ce912679daf30
2 N18b3978b10b14440b6a9673cfceb9232
3 N212b3a79f9e140c9aa79f408d7676f3d
4 N228829a7565044fe9e064781bf244c91
5 N23748642d8c44bfd8c2c1f2155d95bc2
6 N2d3e908fc34d47b18d9f3d097ab4d70d
7 N2d5547740271433dbf4dd16de4438879
8 N2dbf8dfdad574c56b47a7333d0305e76
9 N3910fb3a134442aab52b718a1c0a5f59
10 N5112d0298fd748c99f37a291b43c2104
11 N55ee008f463742e299f530243b93b5b5
12 N6f3157ea0e9c49179a028be481c118d1
13 N702cf24c58e541e285ba1add312c785b
14 N76265494adbe44d9952a6b0cf9f9091c
15 N912b83089e5d4b1b870348ede7e503b2
16 Na22ba554aebd43c3a5e0353c38581b64
17 Nb371055be1224ae7ae25c6c3d4d0af25
18 Nbe05f488db304b75af513bfde98321df
19 Nc5a9cdbcd864416ca380b68099528f75
20 Nc8fc131360624b7cb59f24f7b5319737
21 Nd3fc40e6684841b9a449b95c8bd81b1b
22 Ne3e21eb3d33046cd888aaae08e57f047
23 Nf9b50f144e8344e48459df31b20bb846
24 anzsrc-for:06
25 anzsrc-for:0601
26 schema:author Ncf02f0bbafac48a79ecb2bd83c99f084
27 schema:citation sg:pub.10.1007/s00439-005-0051-7
28 sg:pub.10.1016/1044-0305(94)80016-2
29 sg:pub.10.1038/85686
30 sg:pub.10.1038/nature08311
31 sg:pub.10.1038/nbt.1530
32 sg:pub.10.1038/ncb1792
33 sg:pub.10.1038/ncb1971
34 sg:pub.10.1038/ng.298
35 sg:pub.10.1038/nm1204
36 sg:pub.10.1038/nprot.2008.211
37 sg:pub.10.1038/nprot.2009.191
38 sg:pub.10.1038/nrm2161
39 sg:pub.10.1038/nrm2944
40 sg:pub.10.1186/gb-2003-4-5-p3
41 sg:pub.10.1186/gb-2003-4-9-r60
42 https://doi.org/10.1016/j.cardiores.2006.06.004
43 https://doi.org/10.1016/j.molcel.2010.03.016
44 https://doi.org/10.1016/j.stem.2008.08.014
45 https://doi.org/10.1016/j.stem.2010.12.002
46 https://doi.org/10.1016/j.yexcr.2010.10.014
47 https://doi.org/10.1021/pr015514r
48 https://doi.org/10.1021/pr025556v
49 https://doi.org/10.1038/sj.embor.7400127
50 https://doi.org/10.1056/nejmoa0706898
51 https://doi.org/10.1073/pnas.0511133103
52 https://doi.org/10.1073/pnas.0600012103
53 https://doi.org/10.1091/mbc.e07-01-0029
54 https://doi.org/10.1093/bioinformatics/bth947
55 https://doi.org/10.1101/cshperspect.a000760
56 https://doi.org/10.1101/gad.1652708
57 https://doi.org/10.1126/science.1127168
58 https://doi.org/10.1128/mcb.00355-08
59 https://doi.org/10.1128/mcb.00684-09
60 https://doi.org/10.1128/mcb.00785-07
61 https://doi.org/10.1146/annurev-genom-082908-150150
62 https://doi.org/10.1161/01.res.0000256837.40544.4a
63 https://doi.org/10.1161/atvbaha.110.209460
64 https://doi.org/10.1161/circulationaha.109.902056
65 https://doi.org/10.1182/blood-2004-04-1649
66 https://doi.org/10.1371/journal.pone.0001269
67 https://doi.org/10.1634/stemcells.2004-0159
68 https://doi.org/10.2217/17460751.4.1.37
69 schema:datePublished 2011-04
70 schema:datePublishedReg 2011-04-01
71 schema:description Hutchinson-Gilford progeria syndrome (HGPS) is a rare and fatal human premature ageing disease, characterized by premature arteriosclerosis and degeneration of vascular smooth muscle cells (SMCs). HGPS is caused by a single point mutation in the lamin A (LMNA) gene, resulting in the generation of progerin, a truncated splicing mutant of lamin A. Accumulation of progerin leads to various ageing-associated nuclear defects including disorganization of nuclear lamina and loss of heterochromatin. Here we report the generation of induced pluripotent stem cells (iPSCs) from fibroblasts obtained from patients with HGPS. HGPS-iPSCs show absence of progerin, and more importantly, lack the nuclear envelope and epigenetic alterations normally associated with premature ageing. Upon differentiation of HGPS-iPSCs, progerin and its ageing-associated phenotypic consequences are restored. Specifically, directed differentiation of HGPS-iPSCs to SMCs leads to the appearance of premature senescence phenotypes associated with vascular ageing. Additionally, our studies identify DNA-dependent protein kinase catalytic subunit (DNAPKcs, also known as PRKDC) as a downstream target of progerin. The absence of nuclear DNAPK holoenzyme correlates with premature as well as physiological ageing. Because progerin also accumulates during physiological ageing, our results provide an in vitro iPSC-based model to study the pathogenesis of human premature and physiological vascular ageing.
72 schema:genre research_article
73 schema:inLanguage en
74 schema:isAccessibleForFree true
75 schema:isPartOf N2e4e29b2181948f297745de6dda5ede2
76 N5750b56406084246949695867a74c5a1
77 sg:journal.1018957
78 schema:name Recapitulation of premature ageing with iPSCs from Hutchinson–Gilford progeria syndrome
79 schema:pagination 221
80 schema:productId N1de81e4b2e1b4db7b1ba89f0057e2855
81 N3fc6f49d186d4cd082a50193764da646
82 N6a7bbbc7b7494044a32b354e4db80ad3
83 N913c2eba8c104c1683d2482039cdc5b9
84 Nec4eb0ee3d824755b75d12aa80a727be
85 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032027822
86 https://doi.org/10.1038/nature09879
87 schema:sdDatePublished 2019-04-11T00:23
88 schema:sdLicense https://scigraph.springernature.com/explorer/license/
89 schema:sdPublisher N7c1a5d9f0d0b4440b2ee3f15a8f74081
90 schema:url https://www.nature.com/articles/nature09879
91 sgo:license sg:explorer/license/
92 sgo:sdDataset articles
93 rdf:type schema:ScholarlyArticle
94 N0b084dfb779d4dfba64afa54d4664fe5 rdf:first sg:person.010125337727.46
95 rdf:rest N69d0a87d84b540d5b8a2509944ea0269
96 N0fc87937de5a4f289c1ce912679daf30 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Cell Line
98 rdf:type schema:DefinedTerm
99 N131cd5a11a33430d90a5e23c8efd4b66 rdf:first sg:person.0613236700.68
100 rdf:rest Na999e56024104da286a549fa32fe1b09
101 N18b3978b10b14440b6a9673cfceb9232 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Substrate Specificity
103 rdf:type schema:DefinedTerm
104 N1de81e4b2e1b4db7b1ba89f0057e2855 schema:name readcube_id
105 schema:value 98935557961dac137201456ed07e87216e8e841766a97455f68974ea2f1075e8
106 rdf:type schema:PropertyValue
107 N20fb8a5efb84434d9f881efd2f09799b rdf:first sg:person.01051045643.14
108 rdf:rest N7eeef59a4a664a8aa330edd751c9ba68
109 N212b3a79f9e140c9aa79f408d7676f3d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Humans
111 rdf:type schema:DefinedTerm
112 N228829a7565044fe9e064781bf244c91 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Phenotype
114 rdf:type schema:DefinedTerm
115 N23748642d8c44bfd8c2c1f2155d95bc2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Holoenzymes
117 rdf:type schema:DefinedTerm
118 N269a00f4ebc24f7a88968b8132838003 rdf:first sg:person.0666643624.45
119 rdf:rest N5f6d6fd45b5944c8a9d2bc15cfcd6f1d
120 N28c34505490d4d2fb68b9144d283841a rdf:first sg:person.014010175255.22
121 rdf:rest rdf:nil
122 N2cf47e0e4d11418abd33a42f3d696dc6 rdf:first sg:person.01313060355.66
123 rdf:rest Nb59f11f2b007475dbcd9103acfe968ae
124 N2d3e908fc34d47b18d9f3d097ab4d70d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Calcium-Binding Proteins
126 rdf:type schema:DefinedTerm
127 N2d5547740271433dbf4dd16de4438879 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Aging, Premature
129 rdf:type schema:DefinedTerm
130 N2dbf8dfdad574c56b47a7333d0305e76 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Models, Biological
132 rdf:type schema:DefinedTerm
133 N2e4e29b2181948f297745de6dda5ede2 schema:volumeNumber 472
134 rdf:type schema:PublicationVolume
135 N3910fb3a134442aab52b718a1c0a5f59 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Cellular Reprogramming
137 rdf:type schema:DefinedTerm
138 N3fc6f49d186d4cd082a50193764da646 schema:name dimensions_id
139 schema:value pub.1032027822
140 rdf:type schema:PropertyValue
141 N4b1caef7414f4e73a10ea174679b94cf rdf:first sg:person.0577375446.84
142 rdf:rest N7f70a70c030c4f0b8658fe8e2be6379d
143 N5112d0298fd748c99f37a291b43c2104 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Epigenesis, Genetic
145 rdf:type schema:DefinedTerm
146 N55ee008f463742e299f530243b93b5b5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Nuclear Proteins
148 rdf:type schema:DefinedTerm
149 N5750b56406084246949695867a74c5a1 schema:issueNumber 7342
150 rdf:type schema:PublicationIssue
151 N5f6d6fd45b5944c8a9d2bc15cfcd6f1d rdf:first sg:person.0754746042.08
152 rdf:rest N131cd5a11a33430d90a5e23c8efd4b66
153 N69d0a87d84b540d5b8a2509944ea0269 rdf:first sg:person.01104567247.41
154 rdf:rest N28c34505490d4d2fb68b9144d283841a
155 N6a7bbbc7b7494044a32b354e4db80ad3 schema:name nlm_unique_id
156 schema:value 0410462
157 rdf:type schema:PropertyValue
158 N6f3157ea0e9c49179a028be481c118d1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Induced Pluripotent Stem Cells
160 rdf:type schema:DefinedTerm
161 N702cf24c58e541e285ba1add312c785b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Lamin Type A
163 rdf:type schema:DefinedTerm
164 N76265494adbe44d9952a6b0cf9f9091c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Cell Differentiation
166 rdf:type schema:DefinedTerm
167 N7c1a5d9f0d0b4440b2ee3f15a8f74081 schema:name Springer Nature - SN SciGraph project
168 rdf:type schema:Organization
169 N7eeef59a4a664a8aa330edd751c9ba68 rdf:first sg:person.01007145436.31
170 rdf:rest N2cf47e0e4d11418abd33a42f3d696dc6
171 N7f70a70c030c4f0b8658fe8e2be6379d rdf:first sg:person.01333604123.60
172 rdf:rest N269a00f4ebc24f7a88968b8132838003
173 N85797903eefa4a84ae15839ec5ba652d rdf:first sg:person.01110454126.31
174 rdf:rest N0b084dfb779d4dfba64afa54d4664fe5
175 N883bae024ba340e28f64e287f16094e2 rdf:first sg:person.0576305537.04
176 rdf:rest N85797903eefa4a84ae15839ec5ba652d
177 N912b83089e5d4b1b870348ede7e503b2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
178 schema:name Fibroblasts
179 rdf:type schema:DefinedTerm
180 N913c2eba8c104c1683d2482039cdc5b9 schema:name doi
181 schema:value 10.1038/nature09879
182 rdf:type schema:PropertyValue
183 Na22ba554aebd43c3a5e0353c38581b64 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
184 schema:name DNA-Activated Protein Kinase
185 rdf:type schema:DefinedTerm
186 Na999e56024104da286a549fa32fe1b09 rdf:first sg:person.01116675610.86
187 rdf:rest N20fb8a5efb84434d9f881efd2f09799b
188 Nb371055be1224ae7ae25c6c3d4d0af25 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
189 schema:name Nuclear Envelope
190 rdf:type schema:DefinedTerm
191 Nb59f11f2b007475dbcd9103acfe968ae rdf:first sg:person.01225244766.88
192 rdf:rest Ndcfafe12c5ea4e06a0e058a19f85a5f0
193 Nbe05f488db304b75af513bfde98321df schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
194 schema:name Microfilament Proteins
195 rdf:type schema:DefinedTerm
196 Nc5a9cdbcd864416ca380b68099528f75 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
197 schema:name Aging
198 rdf:type schema:DefinedTerm
199 Nc8fc131360624b7cb59f24f7b5319737 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
200 schema:name Progeria
201 rdf:type schema:DefinedTerm
202 Ncf02f0bbafac48a79ecb2bd83c99f084 rdf:first sg:person.014311705137.80
203 rdf:rest N4b1caef7414f4e73a10ea174679b94cf
204 Nd3fc40e6684841b9a449b95c8bd81b1b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
205 schema:name Muscle, Smooth, Vascular
206 rdf:type schema:DefinedTerm
207 Ndcfafe12c5ea4e06a0e058a19f85a5f0 rdf:first sg:person.01077255356.91
208 rdf:rest N883bae024ba340e28f64e287f16094e2
209 Ne3e21eb3d33046cd888aaae08e57f047 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
210 schema:name Protein Precursors
211 rdf:type schema:DefinedTerm
212 Nec4eb0ee3d824755b75d12aa80a727be schema:name pubmed_id
213 schema:value 21346760
214 rdf:type schema:PropertyValue
215 Nf9b50f144e8344e48459df31b20bb846 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
216 schema:name Cellular Senescence
217 rdf:type schema:DefinedTerm
218 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
219 schema:name Biological Sciences
220 rdf:type schema:DefinedTerm
221 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
222 schema:name Biochemistry and Cell Biology
223 rdf:type schema:DefinedTerm
224 sg:grant.2439911 http://pending.schema.org/fundedItem sg:pub.10.1038/nature09879
225 rdf:type schema:MonetaryGrant
226 sg:grant.2486664 http://pending.schema.org/fundedItem sg:pub.10.1038/nature09879
227 rdf:type schema:MonetaryGrant
228 sg:grant.2682551 http://pending.schema.org/fundedItem sg:pub.10.1038/nature09879
229 rdf:type schema:MonetaryGrant
230 sg:journal.1018957 schema:issn 0090-0028
231 1476-4687
232 schema:name Nature
233 rdf:type schema:Periodical
234 sg:person.01007145436.31 schema:affiliation https://www.grid.ac/institutes/grid.250671.7
235 schema:familyName Kurian
236 schema:givenName Leo
237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01007145436.31
238 rdf:type schema:Person
239 sg:person.010125337727.46 schema:affiliation https://www.grid.ac/institutes/grid.266100.3
240 schema:familyName Zhang
241 schema:givenName Kun
242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010125337727.46
243 rdf:type schema:Person
244 sg:person.01051045643.14 schema:affiliation https://www.grid.ac/institutes/grid.250671.7
245 schema:familyName Suzuki
246 schema:givenName Keiichiro
247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01051045643.14
248 rdf:type schema:Person
249 sg:person.01077255356.91 schema:affiliation https://www.grid.ac/institutes/grid.434617.3
250 schema:familyName Boue
251 schema:givenName Stephanie
252 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01077255356.91
253 rdf:type schema:Person
254 sg:person.01104567247.41 schema:affiliation https://www.grid.ac/institutes/grid.214007.0
255 schema:familyName Yates
256 schema:givenName John
257 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104567247.41
258 rdf:type schema:Person
259 sg:person.01110454126.31 schema:affiliation https://www.grid.ac/institutes/grid.250671.7
260 schema:familyName Sancho-Martinez
261 schema:givenName Ignacio
262 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01110454126.31
263 rdf:type schema:Person
264 sg:person.01116675610.86 schema:affiliation https://www.grid.ac/institutes/grid.250671.7
265 schema:familyName Panopoulos
266 schema:givenName Athanasia D.
267 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01116675610.86
268 rdf:type schema:Person
269 sg:person.01225244766.88 schema:affiliation https://www.grid.ac/institutes/grid.214007.0
270 schema:familyName Thompson
271 schema:givenName James
272 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01225244766.88
273 rdf:type schema:Person
274 sg:person.01313060355.66 schema:affiliation https://www.grid.ac/institutes/grid.250671.7
275 schema:familyName Walsh
276 schema:givenName Christopher
277 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01313060355.66
278 rdf:type schema:Person
279 sg:person.01333604123.60 schema:affiliation https://www.grid.ac/institutes/grid.250671.7
280 schema:familyName Ruiz
281 schema:givenName Sergio
282 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01333604123.60
283 rdf:type schema:Person
284 sg:person.014010175255.22 schema:affiliation https://www.grid.ac/institutes/grid.434617.3
285 schema:familyName Belmonte
286 schema:givenName Juan Carlos Izpisua
287 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014010175255.22
288 rdf:type schema:Person
289 sg:person.014311705137.80 schema:affiliation https://www.grid.ac/institutes/grid.250671.7
290 schema:familyName Liu
291 schema:givenName Guang-Hui
292 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014311705137.80
293 rdf:type schema:Person
294 sg:person.0576305537.04 schema:affiliation https://www.grid.ac/institutes/grid.266100.3
295 schema:familyName Fung
296 schema:givenName Ho Lim
297 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0576305537.04
298 rdf:type schema:Person
299 sg:person.0577375446.84 schema:affiliation https://www.grid.ac/institutes/grid.250671.7
300 schema:familyName Barkho
301 schema:givenName Basam Z.
302 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577375446.84
303 rdf:type schema:Person
304 sg:person.0613236700.68 schema:affiliation https://www.grid.ac/institutes/grid.250671.7
305 schema:familyName Yang
306 schema:givenName Sheng-Lian
307 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0613236700.68
308 rdf:type schema:Person
309 sg:person.0666643624.45 schema:affiliation https://www.grid.ac/institutes/grid.266100.3
310 schema:familyName Diep
311 schema:givenName Dinh
312 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0666643624.45
313 rdf:type schema:Person
314 sg:person.0754746042.08 schema:affiliation https://www.grid.ac/institutes/grid.250671.7
315 schema:familyName Qu
316 schema:givenName Jing
317 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0754746042.08
318 rdf:type schema:Person
319 sg:pub.10.1007/s00439-005-0051-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000128047
320 https://doi.org/10.1007/s00439-005-0051-7
321 rdf:type schema:CreativeWork
322 sg:pub.10.1016/1044-0305(94)80016-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018629105
323 https://doi.org/10.1016/1044-0305(94)80016-2
324 rdf:type schema:CreativeWork
325 sg:pub.10.1038/85686 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050637706
326 https://doi.org/10.1038/85686
327 rdf:type schema:CreativeWork
328 sg:pub.10.1038/nature08311 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040491383
329 https://doi.org/10.1038/nature08311
330 rdf:type schema:CreativeWork
331 sg:pub.10.1038/nbt.1530 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031583743
332 https://doi.org/10.1038/nbt.1530
333 rdf:type schema:CreativeWork
334 sg:pub.10.1038/ncb1792 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032211996
335 https://doi.org/10.1038/ncb1792
336 rdf:type schema:CreativeWork
337 sg:pub.10.1038/ncb1971 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034778622
338 https://doi.org/10.1038/ncb1971
339 rdf:type schema:CreativeWork
340 sg:pub.10.1038/ng.298 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032369744
341 https://doi.org/10.1038/ng.298
342 rdf:type schema:CreativeWork
343 sg:pub.10.1038/nm1204 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045731227
344 https://doi.org/10.1038/nm1204
345 rdf:type schema:CreativeWork
346 sg:pub.10.1038/nprot.2008.211 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039987283
347 https://doi.org/10.1038/nprot.2008.211
348 rdf:type schema:CreativeWork
349 sg:pub.10.1038/nprot.2009.191 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042227432
350 https://doi.org/10.1038/nprot.2009.191
351 rdf:type schema:CreativeWork
352 sg:pub.10.1038/nrm2161 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046582123
353 https://doi.org/10.1038/nrm2161
354 rdf:type schema:CreativeWork
355 sg:pub.10.1038/nrm2944 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025973418
356 https://doi.org/10.1038/nrm2944
357 rdf:type schema:CreativeWork
358 sg:pub.10.1186/gb-2003-4-5-p3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021292424
359 https://doi.org/10.1186/gb-2003-4-5-p3
360 rdf:type schema:CreativeWork
361 sg:pub.10.1186/gb-2003-4-9-r60 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041539408
362 https://doi.org/10.1186/gb-2003-4-9-r60
363 rdf:type schema:CreativeWork
364 https://doi.org/10.1016/j.cardiores.2006.06.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028615153
365 rdf:type schema:CreativeWork
366 https://doi.org/10.1016/j.molcel.2010.03.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004413613
367 rdf:type schema:CreativeWork
368 https://doi.org/10.1016/j.stem.2008.08.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040008680
369 rdf:type schema:CreativeWork
370 https://doi.org/10.1016/j.stem.2010.12.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031328210
371 rdf:type schema:CreativeWork
372 https://doi.org/10.1016/j.yexcr.2010.10.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042148046
373 rdf:type schema:CreativeWork
374 https://doi.org/10.1021/pr015514r schema:sameAs https://app.dimensions.ai/details/publication/pub.1056290133
375 rdf:type schema:CreativeWork
376 https://doi.org/10.1021/pr025556v schema:sameAs https://app.dimensions.ai/details/publication/pub.1045717219
377 rdf:type schema:CreativeWork
378 https://doi.org/10.1038/sj.embor.7400127 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022880128
379 rdf:type schema:CreativeWork
380 https://doi.org/10.1056/nejmoa0706898 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033012132
381 rdf:type schema:CreativeWork
382 https://doi.org/10.1073/pnas.0511133103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011787076
383 rdf:type schema:CreativeWork
384 https://doi.org/10.1073/pnas.0600012103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053658631
385 rdf:type schema:CreativeWork
386 https://doi.org/10.1091/mbc.e07-01-0029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018776426
387 rdf:type schema:CreativeWork
388 https://doi.org/10.1093/bioinformatics/bth947 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035690890
389 rdf:type schema:CreativeWork
390 https://doi.org/10.1101/cshperspect.a000760 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029164617
391 rdf:type schema:CreativeWork
392 https://doi.org/10.1101/gad.1652708 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039212754
393 rdf:type schema:CreativeWork
394 https://doi.org/10.1126/science.1127168 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062453753
395 rdf:type schema:CreativeWork
396 https://doi.org/10.1128/mcb.00355-08 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020485197
397 rdf:type schema:CreativeWork
398 https://doi.org/10.1128/mcb.00684-09 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041925845
399 rdf:type schema:CreativeWork
400 https://doi.org/10.1128/mcb.00785-07 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042770896
401 rdf:type schema:CreativeWork
402 https://doi.org/10.1146/annurev-genom-082908-150150 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023517205
403 rdf:type schema:CreativeWork
404 https://doi.org/10.1161/01.res.0000256837.40544.4a schema:sameAs https://app.dimensions.ai/details/publication/pub.1006165478
405 rdf:type schema:CreativeWork
406 https://doi.org/10.1161/atvbaha.110.209460 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038589392
407 rdf:type schema:CreativeWork
408 https://doi.org/10.1161/circulationaha.109.902056 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024233813
409 rdf:type schema:CreativeWork
410 https://doi.org/10.1182/blood-2004-04-1649 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037158040
411 rdf:type schema:CreativeWork
412 https://doi.org/10.1371/journal.pone.0001269 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050421154
413 rdf:type schema:CreativeWork
414 https://doi.org/10.1634/stemcells.2004-0159 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013167626
415 rdf:type schema:CreativeWork
416 https://doi.org/10.2217/17460751.4.1.37 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051645139
417 rdf:type schema:CreativeWork
418 https://www.grid.ac/institutes/grid.214007.0 schema:alternateName Scripps Research Institute
419 schema:name Department of Cell Biology, Scripps Research Institute, La Jolla, California 92037, USA
420 rdf:type schema:Organization
421 https://www.grid.ac/institutes/grid.250671.7 schema:alternateName Salk Institute for Biological Studies
422 schema:name Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
423 rdf:type schema:Organization
424 https://www.grid.ac/institutes/grid.266100.3 schema:alternateName University of California, San Diego
425 schema:name Department of Bioengineering, University of California at San Diego, La Jolla, California 92093, USA
426 rdf:type schema:Organization
427 https://www.grid.ac/institutes/grid.434617.3 schema:alternateName Center of Regenerative Medicine in Barcelona
428 schema:name Center for Regenerative Medicine in Barcelona, Dr. Aiguader 88, 08003 Barcelona, Spain
429 Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
430 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...