Initial genome sequencing and analysis of multiple myeloma View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-03

AUTHORS

Michael A. Chapman, Michael S. Lawrence, Jonathan J. Keats, Kristian Cibulskis, Carrie Sougnez, Anna C. Schinzel, Christina L. Harview, Jean-Philippe Brunet, Gregory J. Ahmann, Mazhar Adli, Kenneth C. Anderson, Kristin G. Ardlie, Daniel Auclair, Angela Baker, P. Leif Bergsagel, Bradley E. Bernstein, Yotam Drier, Rafael Fonseca, Stacey B. Gabriel, Craig C. Hofmeister, Sundar Jagannath, Andrzej J. Jakubowiak, Amrita Krishnan, Joan Levy, Ted Liefeld, Sagar Lonial, Scott Mahan, Bunmi Mfuko, Stefano Monti, Louise M. Perkins, Robb Onofrio, Trevor J. Pugh, S. Vincent Rajkumar, Alex H. Ramos, David S. Siegel, Andrey Sivachenko, A. Keith Stewart, Suzanne Trudel, Ravi Vij, Douglas Voet, Wendy Winckler, Todd Zimmerman, John Carpten, Jeff Trent, William C. Hahn, Levi A. Garraway, Matthew Meyerson, Eric S. Lander, Gad Getz, Todd R. Golub

ABSTRACT

Multiple myeloma is an incurable malignancy of plasma cells, and its pathogenesis is poorly understood. Here we report the massively parallel sequencing of 38 tumour genomes and their comparison to matched normal DNAs. Several new and unexpected oncogenic mechanisms were suggested by the pattern of somatic mutation across the data set. These include the mutation of genes involved in protein translation (seen in nearly half of the patients), genes involved in histone methylation, and genes involved in blood coagulation. In addition, a broader than anticipated role of NF-κB signalling was indicated by mutations in 11 members of the NF-κB pathway. Of potential immediate clinical relevance, activating mutations of the kinase BRAF were observed in 4% of patients, suggesting the evaluation of BRAF inhibitors in multiple myeloma clinical trials. These results indicate that cancer genome sequencing of large collections of samples will yield new insights into cancer not anticipated by existing knowledge. More... »

PAGES

467

References to SciGraph publications

  • 2010-04-15. Genome remodelling in a basal-like breast cancer metastasis and xenograft in NATURE
  • 2009-10-08. Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution in NATURE
  • 2007-01. A single subunit, Dis3, is essentially responsible for yeast exosome core activity in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2008-07. IRF4 addiction in multiple myeloma in NATURE
  • 2009-05. Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer in NATURE GENETICS
  • 2008-11. DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome in NATURE
  • 2008-09. The endoplasmic reticulum stress response in immunity and autoimmunity in NATURE REVIEWS IMMUNOLOGY
  • 2010-05. The mutation spectrum revealed by paired genome sequences from a lung cancer patient in NATURE
  • 2003-07. PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes in NATURE GENETICS
  • 2010-01. A comprehensive catalogue of somatic mutations from a human cancer genome in NATURE
  • 2010-01. A small-cell lung cancer genome with complex signatures of tobacco exposure in NATURE
  • 2008-06. Identification of somatically acquired rearrangements in cancer using genome-wide massively parallel paired-end sequencing in NATURE GENETICS
  • 2002-06. Mutations of the BRAF gene in human cancer in NATURE
  • 2007-12. Unravelling the hidden heterogeneities of diffuse large B-cell lymphoma based on coupled two-way clustering in BMC GENOMICS
  • 2007-11. Determinants of protein function revealed by combinatorial entropy optimization in GENOME BIOLOGY
  • Journal

    TITLE

    Nature

    ISSUE

    7339

    VOLUME

    471

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nature09837

    DOI

    http://dx.doi.org/10.1038/nature09837

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1007161398

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/21430775


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