The histone methyltransferase SETDB1 is recurrently amplified in melanoma and accelerates its onset View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-03

AUTHORS

Craig J. Ceol, Yariv Houvras, Judit Jane-Valbuena, Steve Bilodeau, David A. Orlando, Valentine Battisti, Lauriane Fritsch, William M. Lin, Travis J. Hollmann, Fabrizio Ferré, Caitlin Bourque, Christopher J. Burke, Laura Turner, Audrey Uong, Laura A. Johnson, Rameen Beroukhim, Craig H. Mermel, Massimo Loda, Slimane Ait-Si-Ali, Levi A. Garraway, Richard A. Young, Leonard I. Zon

ABSTRACT

The most common mutation in human melanoma, BRAF(V600E), activates the serine/threonine kinase BRAF and causes excessive activity in the mitogen-activated protein kinase pathway. BRAF(V600E) mutations are also present in benign melanocytic naevi, highlighting the importance of additional genetic alterations in the genesis of malignant tumours. Such changes include recurrent copy number variations that result in the amplification of oncogenes. For certain amplifications, the large number of genes in the interval has precluded an understanding of the cooperating oncogenic events. Here we have used a zebrafish melanoma model to test genes in a recurrently amplified region of chromosome 1 for the ability to cooperate with BRAF(V600E) and accelerate melanoma. SETDB1, an enzyme that methylates histone H3 on lysine 9 (H3K9), was found to accelerate melanoma formation significantly in zebrafish. Chromatin immunoprecipitation coupled with massively parallel DNA sequencing and gene expression analyses uncovered genes, including HOX genes, that are transcriptionally dysregulated in response to increased levels of SETDB1. Our studies establish SETDB1 as an oncogene in melanoma and underscore the role of chromatin factors in regulating tumorigenesis. More... »

PAGES

513

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature09806

DOI

http://dx.doi.org/10.1038/nature09806

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1037092980

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21430779


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Age of Onset", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Amino Acid Substitution", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals, Genetically Modified", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Transformation, Neoplastic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromatin Immunoprecipitation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromosomes, Human, Pair 1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Copy Number Variations", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Models, Animal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Amplification", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Profiling", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation, Neoplastic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genes, Homeobox", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Histone-Lysine N-Methyltransferase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Melanocytes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Melanoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nevus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Oncogenes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Methyltransferases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proto-Oncogene Proteins B-raf", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Zebrafish", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "name": [
            "Stem Cell Program and Hematology/Oncology, Children\u2019s Hospital Boston, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School, Boston, Massachusetts 02115, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ceol", 
        "givenName": "Craig J.", 
        "id": "sg:person.01054223656.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01054223656.64"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Stem Cell Program and Hematology/Oncology, Children\u2019s Hospital Boston, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School, Boston, Massachusetts 02115, USA", 
            "Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts 02114, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Houvras", 
        "givenName": "Yariv", 
        "id": "sg:person.01124440503.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01124440503.77"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Broad Institute", 
          "id": "https://www.grid.ac/institutes/grid.66859.34", 
          "name": [
            "Departments of Medical Oncology, Cancer Biology, and Center for Cancer Genome Discovery, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA", 
            "The Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jane-Valbuena", 
        "givenName": "Judit", 
        "id": "sg:person.01224766415.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01224766415.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Massachusetts Institute of Technology", 
          "id": "https://www.grid.ac/institutes/grid.116068.8", 
          "name": [
            "Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bilodeau", 
        "givenName": "Steve", 
        "id": "sg:person.01312501443.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01312501443.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Massachusetts Institute of Technology", 
          "id": "https://www.grid.ac/institutes/grid.116068.8", 
          "name": [
            "Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Orlando", 
        "givenName": "David A.", 
        "id": "sg:person.0671254772.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0671254772.98"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "French National Centre for Scientific Research", 
          "id": "https://www.grid.ac/institutes/grid.4444.0", 
          "name": [
            "UMR7216 Epig\u00e9n\u00e9tique et Destin Cellulaire, CNRS, Universit\u00e9 Paris-Diderot, 35 rue H\u00e9l\u00e8ne Brion, 75013 Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Battisti", 
        "givenName": "Valentine", 
        "id": "sg:person.01047207203.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01047207203.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "French National Centre for Scientific Research", 
          "id": "https://www.grid.ac/institutes/grid.4444.0", 
          "name": [
            "UMR7216 Epig\u00e9n\u00e9tique et Destin Cellulaire, CNRS, Universit\u00e9 Paris-Diderot, 35 rue H\u00e9l\u00e8ne Brion, 75013 Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fritsch", 
        "givenName": "Lauriane", 
        "id": "sg:person.01267277456.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01267277456.70"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Broad Institute", 
          "id": "https://www.grid.ac/institutes/grid.66859.34", 
          "name": [
            "Departments of Medical Oncology, Cancer Biology, and Center for Cancer Genome Discovery, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA", 
            "The Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lin", 
        "givenName": "William M.", 
        "id": "sg:person.01223112477.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01223112477.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Center for Molecular Oncologic Pathology, Brigham and Women\u2019s Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hollmann", 
        "givenName": "Travis J.", 
        "id": "sg:person.01172403162.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01172403162.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sapienza University of Rome", 
          "id": "https://www.grid.ac/institutes/grid.7841.a", 
          "name": [
            "A. Rossi Fanelli Biochemical Sciences Department, Sapienza University of Rome, Rome 00185, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ferr\u00e9", 
        "givenName": "Fabrizio", 
        "id": "sg:person.01070373430.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01070373430.02"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Stem Cell Program and Hematology/Oncology, Children\u2019s Hospital Boston, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School, Boston, Massachusetts 02115, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bourque", 
        "givenName": "Caitlin", 
        "id": "sg:person.0753463017.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0753463017.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Stem Cell Program and Hematology/Oncology, Children\u2019s Hospital Boston, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School, Boston, Massachusetts 02115, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Burke", 
        "givenName": "Christopher J.", 
        "id": "sg:person.01064050317.67", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01064050317.67"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Stem Cell Program and Hematology/Oncology, Children\u2019s Hospital Boston, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School, Boston, Massachusetts 02115, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Turner", 
        "givenName": "Laura", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Stem Cell Program and Hematology/Oncology, Children\u2019s Hospital Boston, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School, Boston, Massachusetts 02115, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Uong", 
        "givenName": "Audrey", 
        "id": "sg:person.01225111030.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01225111030.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Broad Institute", 
          "id": "https://www.grid.ac/institutes/grid.66859.34", 
          "name": [
            "Departments of Medical Oncology, Cancer Biology, and Center for Cancer Genome Discovery, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA", 
            "The Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Johnson", 
        "givenName": "Laura A.", 
        "id": "sg:person.01034152552.92", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01034152552.92"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Broad Institute", 
          "id": "https://www.grid.ac/institutes/grid.66859.34", 
          "name": [
            "Departments of Medical Oncology, Cancer Biology, and Center for Cancer Genome Discovery, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA", 
            "The Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Beroukhim", 
        "givenName": "Rameen", 
        "id": "sg:person.01310170137.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01310170137.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Broad Institute", 
          "id": "https://www.grid.ac/institutes/grid.66859.34", 
          "name": [
            "Departments of Medical Oncology, Cancer Biology, and Center for Cancer Genome Discovery, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA", 
            "The Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mermel", 
        "givenName": "Craig H.", 
        "id": "sg:person.01066471003.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01066471003.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Center for Molecular Oncologic Pathology, Brigham and Women\u2019s Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Loda", 
        "givenName": "Massimo", 
        "id": "sg:person.01170002671.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01170002671.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "French National Centre for Scientific Research", 
          "id": "https://www.grid.ac/institutes/grid.4444.0", 
          "name": [
            "UMR7216 Epig\u00e9n\u00e9tique et Destin Cellulaire, CNRS, Universit\u00e9 Paris-Diderot, 35 rue H\u00e9l\u00e8ne Brion, 75013 Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ait-Si-Ali", 
        "givenName": "Slimane", 
        "id": "sg:person.0703764143.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0703764143.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Broad Institute", 
          "id": "https://www.grid.ac/institutes/grid.66859.34", 
          "name": [
            "Departments of Medical Oncology, Cancer Biology, and Center for Cancer Genome Discovery, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA", 
            "The Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Garraway", 
        "givenName": "Levi A.", 
        "id": "sg:person.01354065210.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354065210.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Massachusetts Institute of Technology", 
          "id": "https://www.grid.ac/institutes/grid.116068.8", 
          "name": [
            "Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Young", 
        "givenName": "Richard A.", 
        "id": "sg:person.011705017367.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011705017367.87"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Stem Cell Program and Hematology/Oncology, Children\u2019s Hospital Boston, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School, Boston, Massachusetts 02115, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zon", 
        "givenName": "Leonard I.", 
        "id": "sg:person.015341736157.56", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015341736157.56"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/ng.349", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001520036", 
          "https://doi.org/10.1038/ng.349"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03890", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003324113", 
          "https://doi.org/10.1038/nature03890"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03890", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003324113", 
          "https://doi.org/10.1038/nature03890"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03890", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003324113", 
          "https://doi.org/10.1038/nature03890"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/humrep/14.11.2844", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007010269"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa050092", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007050226"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa050092", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007050226"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1593/neo.07878", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007078703"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2009.12.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008826917"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2003.08.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010087489"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2003.08.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010087489"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08822", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010635813", 
          "https://doi.org/10.1038/nature08822"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08822", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010635813", 
          "https://doi.org/10.1038/nature08822"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-07-2615", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012217489"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1180", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014377811", 
          "https://doi.org/10.1038/ng1180"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1180", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014377811", 
          "https://doi.org/10.1038/ng1180"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/dmm.001016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016071771"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03664", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016552205", 
          "https://doi.org/10.1038/nature03664"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03664", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016552205", 
          "https://doi.org/10.1038/nature03664"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03664", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016552205", 
          "https://doi.org/10.1038/nature03664"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(04)00215-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019563286"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.92.20.9363", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021293422"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2004.06.043", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023397499"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2004.06.043", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023397499"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2004.06.043", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023397499"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2004.06.043", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023397499"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature00766", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023536940", 
          "https://doi.org/10.1038/nature00766"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature00766", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023536940", 
          "https://doi.org/10.1038/nature00766"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08672", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032969139", 
          "https://doi.org/10.1038/nature08672"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08672", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032969139", 
          "https://doi.org/10.1038/nature08672"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0710052104", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034562854"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/dvdy.21343", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035734715"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1054", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035969538", 
          "https://doi.org/10.1038/ng1054"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1054", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035969538", 
          "https://doi.org/10.1038/ng1054"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0506580102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037705714"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0506580102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037705714"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.1837309", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045357547"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cub.2005.01.031", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046159905"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2011-03", 
    "datePublishedReg": "2011-03-01", 
    "description": "The most common mutation in human melanoma, BRAF(V600E), activates the serine/threonine kinase BRAF and causes excessive activity in the mitogen-activated protein kinase pathway. BRAF(V600E) mutations are also present in benign melanocytic naevi, highlighting the importance of additional genetic alterations in the genesis of malignant tumours. Such changes include recurrent copy number variations that result in the amplification of oncogenes. For certain amplifications, the large number of genes in the interval has precluded an understanding of the cooperating oncogenic events. Here we have used a zebrafish melanoma model to test genes in a recurrently amplified region of chromosome 1 for the ability to cooperate with BRAF(V600E) and accelerate melanoma. SETDB1, an enzyme that methylates histone H3 on lysine 9 (H3K9), was found to accelerate melanoma formation significantly in zebrafish. Chromatin immunoprecipitation coupled with massively parallel DNA sequencing and gene expression analyses uncovered genes, including HOX genes, that are transcriptionally dysregulated in response to increased levels of SETDB1. Our studies establish SETDB1 as an oncogene in melanoma and underscore the role of chromatin factors in regulating tumorigenesis.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/nature09806", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2529142", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2421986", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2477011", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2441455", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2634850", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2496063", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2683815", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2480778", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2412284", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2496531", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0090-0028", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "7339", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "471"
      }
    ], 
    "name": "The histone methyltransferase SETDB1 is recurrently amplified in melanoma and accelerates its onset", 
    "pagination": "513", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "b0b28b2caec95b92edacf2abba1553fcf15eefcd64dc71bba7c687971b9b08a5"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "21430779"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0410462"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/nature09806"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1037092980"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/nature09806", 
      "https://app.dimensions.ai/details/publication/pub.1037092980"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T18:57", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8678_00000434.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/nature09806"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nature09806'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nature09806'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nature09806'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nature09806'


 

This table displays all metadata directly associated to this object as RDF triples.

429 TRIPLES      21 PREDICATES      74 URIs      43 LITERALS      31 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/nature09806 schema:about N17c607ed9ad344ac91c55351204958ff
2 N240081026d8346f294af3ad7620477f0
3 N26bd13198bb44e7897a4bd04b26472a8
4 N2b1a2b665d014f59897dc178a0bc26d2
5 N2de5d2b817df4a9aacf640bf5718fdf5
6 N3783d7ff283a49a9ab396ae5efef4831
7 N43455ab5e700432d8d1f47d727dc80f9
8 N4af96716c78641719500849858bbe9d2
9 N56c3994ade10422493f716a362643480
10 N5947eb2beb3847edb45a61731c75dc59
11 N62d75e1e4ab54bd1b0629f1a59e4c1a3
12 N67cbd6617bae470db5ff16f7e8b4cc8d
13 N69afebd268384d4bac5022876ea027a0
14 N6acbe31532fd4726b9ebc785c2779a7e
15 N82cfa301cf48424c83c8c52db87eecdc
16 N8532a70a96024a8d9185078b9c7196c1
17 Nb34009754558421284196d8a662a88d2
18 Nb4f9a39ab7e14a4296e8c5ace4797a5f
19 Neb789e8070e741c4a85653150b901c29
20 Nef409f15f6614a25b348820bfbf1907b
21 Nf0bae5c58f8d4016a43ff1c930ef3e5e
22 Nfc3017e653dd49a19d5d331c81db86ed
23 anzsrc-for:06
24 anzsrc-for:0604
25 schema:author N35f1a8008a8942829a4b57af070e083e
26 schema:citation sg:pub.10.1038/nature00766
27 sg:pub.10.1038/nature03664
28 sg:pub.10.1038/nature03890
29 sg:pub.10.1038/nature08672
30 sg:pub.10.1038/nature08822
31 sg:pub.10.1038/ng.349
32 sg:pub.10.1038/ng1054
33 sg:pub.10.1038/ng1180
34 https://doi.org/10.1002/dvdy.21343
35 https://doi.org/10.1016/j.cub.2005.01.031
36 https://doi.org/10.1016/j.molcel.2003.08.007
37 https://doi.org/10.1016/j.molcel.2004.06.043
38 https://doi.org/10.1016/j.molcel.2009.12.017
39 https://doi.org/10.1016/s0092-8674(04)00215-6
40 https://doi.org/10.1056/nejmoa050092
41 https://doi.org/10.1073/pnas.0506580102
42 https://doi.org/10.1073/pnas.0710052104
43 https://doi.org/10.1073/pnas.92.20.9363
44 https://doi.org/10.1093/humrep/14.11.2844
45 https://doi.org/10.1101/gad.1837309
46 https://doi.org/10.1158/0008-5472.can-07-2615
47 https://doi.org/10.1242/dmm.001016
48 https://doi.org/10.1593/neo.07878
49 schema:datePublished 2011-03
50 schema:datePublishedReg 2011-03-01
51 schema:description The most common mutation in human melanoma, BRAF(V600E), activates the serine/threonine kinase BRAF and causes excessive activity in the mitogen-activated protein kinase pathway. BRAF(V600E) mutations are also present in benign melanocytic naevi, highlighting the importance of additional genetic alterations in the genesis of malignant tumours. Such changes include recurrent copy number variations that result in the amplification of oncogenes. For certain amplifications, the large number of genes in the interval has precluded an understanding of the cooperating oncogenic events. Here we have used a zebrafish melanoma model to test genes in a recurrently amplified region of chromosome 1 for the ability to cooperate with BRAF(V600E) and accelerate melanoma. SETDB1, an enzyme that methylates histone H3 on lysine 9 (H3K9), was found to accelerate melanoma formation significantly in zebrafish. Chromatin immunoprecipitation coupled with massively parallel DNA sequencing and gene expression analyses uncovered genes, including HOX genes, that are transcriptionally dysregulated in response to increased levels of SETDB1. Our studies establish SETDB1 as an oncogene in melanoma and underscore the role of chromatin factors in regulating tumorigenesis.
52 schema:genre research_article
53 schema:inLanguage en
54 schema:isAccessibleForFree true
55 schema:isPartOf N92f4537b1fba4cbb8569b6a53aaa2265
56 N9b357aa230ec4c28bb21b59384c559a4
57 sg:journal.1018957
58 schema:name The histone methyltransferase SETDB1 is recurrently amplified in melanoma and accelerates its onset
59 schema:pagination 513
60 schema:productId N339ef1b36a894393828d61b4a1495068
61 N38e5dfe94734448a82b81a59a9a94cdc
62 N8f477436cc004327bf623476e12ac33b
63 Naf970df791d94a24adc3aa4153667fd6
64 Ne67d79f45c9d412b81d2e6e7821fc145
65 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037092980
66 https://doi.org/10.1038/nature09806
67 schema:sdDatePublished 2019-04-10T18:57
68 schema:sdLicense https://scigraph.springernature.com/explorer/license/
69 schema:sdPublisher Nc0849c93fcd54766b470c3e04c9a4503
70 schema:url https://www.nature.com/articles/nature09806
71 sgo:license sg:explorer/license/
72 sgo:sdDataset articles
73 rdf:type schema:ScholarlyArticle
74 N17c607ed9ad344ac91c55351204958ff schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
75 schema:name Amino Acid Substitution
76 rdf:type schema:DefinedTerm
77 N1f1b9989052e4d2ea084819a2bb61ed7 rdf:first sg:person.01034152552.92
78 rdf:rest Ne1182b84e33746a093f211e3c2d089c7
79 N240081026d8346f294af3ad7620477f0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
80 schema:name Animals, Genetically Modified
81 rdf:type schema:DefinedTerm
82 N26bd13198bb44e7897a4bd04b26472a8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
83 schema:name Chromatin Immunoprecipitation
84 rdf:type schema:DefinedTerm
85 N2b1a2b665d014f59897dc178a0bc26d2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
86 schema:name Histone-Lysine N-Methyltransferase
87 rdf:type schema:DefinedTerm
88 N2de5d2b817df4a9aacf640bf5718fdf5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
89 schema:name Melanocytes
90 rdf:type schema:DefinedTerm
91 N317f032295fe421fbdd9d5ea30237703 rdf:first sg:person.0703764143.17
92 rdf:rest Na6925f2e24b642a1bf50136b75ce2c4c
93 N339ef1b36a894393828d61b4a1495068 schema:name pubmed_id
94 schema:value 21430779
95 rdf:type schema:PropertyValue
96 N35f1a8008a8942829a4b57af070e083e rdf:first sg:person.01054223656.64
97 rdf:rest N4589cd22fd674625a6fbe96a10dc1ff4
98 N37440e43df35427aa5ee6ace1444012b schema:affiliation Nd35de6250bec426f80b7b5d21be19f99
99 schema:familyName Turner
100 schema:givenName Laura
101 rdf:type schema:Person
102 N3783d7ff283a49a9ab396ae5efef4831 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Animals
104 rdf:type schema:DefinedTerm
105 N38e5dfe94734448a82b81a59a9a94cdc schema:name readcube_id
106 schema:value b0b28b2caec95b92edacf2abba1553fcf15eefcd64dc71bba7c687971b9b08a5
107 rdf:type schema:PropertyValue
108 N3fc0a3a0a50649fa9dbf115dc9eccfe7 rdf:first sg:person.01224766415.14
109 rdf:rest N654f81495dcd4c409e1577c63589a551
110 N43455ab5e700432d8d1f47d727dc80f9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Gene Amplification
112 rdf:type schema:DefinedTerm
113 N449eb276997f44b4b290c11bbdc920c8 schema:name Center for Molecular Oncologic Pathology, Brigham and Women’s Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
114 rdf:type schema:Organization
115 N4589cd22fd674625a6fbe96a10dc1ff4 rdf:first sg:person.01124440503.77
116 rdf:rest N3fc0a3a0a50649fa9dbf115dc9eccfe7
117 N4af96716c78641719500849858bbe9d2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Melanoma
119 rdf:type schema:DefinedTerm
120 N4e17ac172171430d9d7413e29ea59436 rdf:first sg:person.01170002671.44
121 rdf:rest N317f032295fe421fbdd9d5ea30237703
122 N4f752f472280457d82dd7ed73146a70f rdf:first sg:person.01172403162.27
123 rdf:rest Nefc4c07e961c4e2d94ad3d2f2fc4c65a
124 N501e0885665b48bcb4426df0f971c238 rdf:first sg:person.015341736157.56
125 rdf:rest rdf:nil
126 N50dae589eeb24eb195d8e772807f3eed schema:name Stem Cell Program and Hematology/Oncology, Children’s Hospital Boston, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
127 rdf:type schema:Organization
128 N51272e043e6240f28eaeabcbf44d19d7 rdf:first sg:person.01225111030.28
129 rdf:rest N1f1b9989052e4d2ea084819a2bb61ed7
130 N549e650047104382a6752e12100053ca rdf:first sg:person.01223112477.28
131 rdf:rest N4f752f472280457d82dd7ed73146a70f
132 N56c3994ade10422493f716a362643480 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Nevus
134 rdf:type schema:DefinedTerm
135 N5947eb2beb3847edb45a61731c75dc59 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Zebrafish
137 rdf:type schema:DefinedTerm
138 N62d75e1e4ab54bd1b0629f1a59e4c1a3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Gene Expression Regulation, Neoplastic
140 rdf:type schema:DefinedTerm
141 N654f81495dcd4c409e1577c63589a551 rdf:first sg:person.01312501443.55
142 rdf:rest Nce6835b33ed94c5cae3fcb052e7290ab
143 N67cbd6617bae470db5ff16f7e8b4cc8d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Humans
145 rdf:type schema:DefinedTerm
146 N69afebd268384d4bac5022876ea027a0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Proto-Oncogene Proteins B-raf
148 rdf:type schema:DefinedTerm
149 N6aadd4493daf40859384e8aa2860f5f3 schema:name Stem Cell Program and Hematology/Oncology, Children’s Hospital Boston, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
150 rdf:type schema:Organization
151 N6acbe31532fd4726b9ebc785c2779a7e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Protein Methyltransferases
153 rdf:type schema:DefinedTerm
154 N7991b7e8eb5d424c92c9a295c794ab13 rdf:first sg:person.01267277456.70
155 rdf:rest N549e650047104382a6752e12100053ca
156 N7f8d10eaa5b846beb2bca2a5b9081c40 rdf:first sg:person.01047207203.53
157 rdf:rest N7991b7e8eb5d424c92c9a295c794ab13
158 N80424bde5df949ea98a77deedec6c190 schema:name Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts 02114, USA
159 Stem Cell Program and Hematology/Oncology, Children’s Hospital Boston, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
160 rdf:type schema:Organization
161 N80c6d20893544cf4839271e1a4909b48 schema:name Center for Molecular Oncologic Pathology, Brigham and Women’s Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
162 rdf:type schema:Organization
163 N82cfa301cf48424c83c8c52db87eecdc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Gene Expression Profiling
165 rdf:type schema:DefinedTerm
166 N8532a70a96024a8d9185078b9c7196c1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name DNA Copy Number Variations
168 rdf:type schema:DefinedTerm
169 N8f477436cc004327bf623476e12ac33b schema:name doi
170 schema:value 10.1038/nature09806
171 rdf:type schema:PropertyValue
172 N92f4537b1fba4cbb8569b6a53aaa2265 schema:volumeNumber 471
173 rdf:type schema:PublicationVolume
174 N9808523fadf04616ace77a376d187a99 rdf:first sg:person.0753463017.41
175 rdf:rest Ne13059370ad94d1394baeacbd23fe7b4
176 N9b357aa230ec4c28bb21b59384c559a4 schema:issueNumber 7339
177 rdf:type schema:PublicationIssue
178 Na6925f2e24b642a1bf50136b75ce2c4c rdf:first sg:person.01354065210.34
179 rdf:rest Nd0ae685e87e04e439d87a153b1aa719e
180 Naf970df791d94a24adc3aa4153667fd6 schema:name dimensions_id
181 schema:value pub.1037092980
182 rdf:type schema:PropertyValue
183 Nb34009754558421284196d8a662a88d2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
184 schema:name Disease Models, Animal
185 rdf:type schema:DefinedTerm
186 Nb4f9a39ab7e14a4296e8c5ace4797a5f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
187 schema:name Age of Onset
188 rdf:type schema:DefinedTerm
189 Nb8c980ca748b4883a732da59801c0824 rdf:first sg:person.01066471003.08
190 rdf:rest N4e17ac172171430d9d7413e29ea59436
191 Nc0849c93fcd54766b470c3e04c9a4503 schema:name Springer Nature - SN SciGraph project
192 rdf:type schema:Organization
193 Nce6835b33ed94c5cae3fcb052e7290ab rdf:first sg:person.0671254772.98
194 rdf:rest N7f8d10eaa5b846beb2bca2a5b9081c40
195 Nd0ae685e87e04e439d87a153b1aa719e rdf:first sg:person.011705017367.87
196 rdf:rest N501e0885665b48bcb4426df0f971c238
197 Nd35de6250bec426f80b7b5d21be19f99 schema:name Stem Cell Program and Hematology/Oncology, Children’s Hospital Boston, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
198 rdf:type schema:Organization
199 Nd792defc290e4626a5e9bd418fbd56d7 schema:name Stem Cell Program and Hematology/Oncology, Children’s Hospital Boston, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
200 rdf:type schema:Organization
201 Ne1182b84e33746a093f211e3c2d089c7 rdf:first sg:person.01310170137.53
202 rdf:rest Nb8c980ca748b4883a732da59801c0824
203 Ne13059370ad94d1394baeacbd23fe7b4 rdf:first sg:person.01064050317.67
204 rdf:rest Ne92acc1b097b40cf99f387886a97b408
205 Ne67d79f45c9d412b81d2e6e7821fc145 schema:name nlm_unique_id
206 schema:value 0410462
207 rdf:type schema:PropertyValue
208 Ne92acc1b097b40cf99f387886a97b408 rdf:first N37440e43df35427aa5ee6ace1444012b
209 rdf:rest N51272e043e6240f28eaeabcbf44d19d7
210 Neb789e8070e741c4a85653150b901c29 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
211 schema:name Chromosomes, Human, Pair 1
212 rdf:type schema:DefinedTerm
213 Nef409f15f6614a25b348820bfbf1907b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
214 schema:name Cell Transformation, Neoplastic
215 rdf:type schema:DefinedTerm
216 Nefc4c07e961c4e2d94ad3d2f2fc4c65a rdf:first sg:person.01070373430.02
217 rdf:rest N9808523fadf04616ace77a376d187a99
218 Nf0bae5c58f8d4016a43ff1c930ef3e5e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
219 schema:name Oncogenes
220 rdf:type schema:DefinedTerm
221 Nf2fe6a41cfdc409eb3f39c8be9c8601a schema:name Stem Cell Program and Hematology/Oncology, Children’s Hospital Boston, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
222 rdf:type schema:Organization
223 Nf6c60ba8abc84a5296255bda6bd1cb4b schema:name Stem Cell Program and Hematology/Oncology, Children’s Hospital Boston, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
224 rdf:type schema:Organization
225 Nfc3017e653dd49a19d5d331c81db86ed schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
226 schema:name Genes, Homeobox
227 rdf:type schema:DefinedTerm
228 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
229 schema:name Biological Sciences
230 rdf:type schema:DefinedTerm
231 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
232 schema:name Genetics
233 rdf:type schema:DefinedTerm
234 sg:grant.2412284 http://pending.schema.org/fundedItem sg:pub.10.1038/nature09806
235 rdf:type schema:MonetaryGrant
236 sg:grant.2421986 http://pending.schema.org/fundedItem sg:pub.10.1038/nature09806
237 rdf:type schema:MonetaryGrant
238 sg:grant.2441455 http://pending.schema.org/fundedItem sg:pub.10.1038/nature09806
239 rdf:type schema:MonetaryGrant
240 sg:grant.2477011 http://pending.schema.org/fundedItem sg:pub.10.1038/nature09806
241 rdf:type schema:MonetaryGrant
242 sg:grant.2480778 http://pending.schema.org/fundedItem sg:pub.10.1038/nature09806
243 rdf:type schema:MonetaryGrant
244 sg:grant.2496063 http://pending.schema.org/fundedItem sg:pub.10.1038/nature09806
245 rdf:type schema:MonetaryGrant
246 sg:grant.2496531 http://pending.schema.org/fundedItem sg:pub.10.1038/nature09806
247 rdf:type schema:MonetaryGrant
248 sg:grant.2529142 http://pending.schema.org/fundedItem sg:pub.10.1038/nature09806
249 rdf:type schema:MonetaryGrant
250 sg:grant.2634850 http://pending.schema.org/fundedItem sg:pub.10.1038/nature09806
251 rdf:type schema:MonetaryGrant
252 sg:grant.2683815 http://pending.schema.org/fundedItem sg:pub.10.1038/nature09806
253 rdf:type schema:MonetaryGrant
254 sg:journal.1018957 schema:issn 0090-0028
255 1476-4687
256 schema:name Nature
257 rdf:type schema:Periodical
258 sg:person.01034152552.92 schema:affiliation https://www.grid.ac/institutes/grid.66859.34
259 schema:familyName Johnson
260 schema:givenName Laura A.
261 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01034152552.92
262 rdf:type schema:Person
263 sg:person.01047207203.53 schema:affiliation https://www.grid.ac/institutes/grid.4444.0
264 schema:familyName Battisti
265 schema:givenName Valentine
266 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01047207203.53
267 rdf:type schema:Person
268 sg:person.01054223656.64 schema:affiliation Nf6c60ba8abc84a5296255bda6bd1cb4b
269 schema:familyName Ceol
270 schema:givenName Craig J.
271 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01054223656.64
272 rdf:type schema:Person
273 sg:person.01064050317.67 schema:affiliation Nd792defc290e4626a5e9bd418fbd56d7
274 schema:familyName Burke
275 schema:givenName Christopher J.
276 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01064050317.67
277 rdf:type schema:Person
278 sg:person.01066471003.08 schema:affiliation https://www.grid.ac/institutes/grid.66859.34
279 schema:familyName Mermel
280 schema:givenName Craig H.
281 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01066471003.08
282 rdf:type schema:Person
283 sg:person.01070373430.02 schema:affiliation https://www.grid.ac/institutes/grid.7841.a
284 schema:familyName Ferré
285 schema:givenName Fabrizio
286 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01070373430.02
287 rdf:type schema:Person
288 sg:person.01124440503.77 schema:affiliation N80424bde5df949ea98a77deedec6c190
289 schema:familyName Houvras
290 schema:givenName Yariv
291 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01124440503.77
292 rdf:type schema:Person
293 sg:person.01170002671.44 schema:affiliation N449eb276997f44b4b290c11bbdc920c8
294 schema:familyName Loda
295 schema:givenName Massimo
296 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01170002671.44
297 rdf:type schema:Person
298 sg:person.011705017367.87 schema:affiliation https://www.grid.ac/institutes/grid.116068.8
299 schema:familyName Young
300 schema:givenName Richard A.
301 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011705017367.87
302 rdf:type schema:Person
303 sg:person.01172403162.27 schema:affiliation N80c6d20893544cf4839271e1a4909b48
304 schema:familyName Hollmann
305 schema:givenName Travis J.
306 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01172403162.27
307 rdf:type schema:Person
308 sg:person.01223112477.28 schema:affiliation https://www.grid.ac/institutes/grid.66859.34
309 schema:familyName Lin
310 schema:givenName William M.
311 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01223112477.28
312 rdf:type schema:Person
313 sg:person.01224766415.14 schema:affiliation https://www.grid.ac/institutes/grid.66859.34
314 schema:familyName Jane-Valbuena
315 schema:givenName Judit
316 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01224766415.14
317 rdf:type schema:Person
318 sg:person.01225111030.28 schema:affiliation Nf2fe6a41cfdc409eb3f39c8be9c8601a
319 schema:familyName Uong
320 schema:givenName Audrey
321 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01225111030.28
322 rdf:type schema:Person
323 sg:person.01267277456.70 schema:affiliation https://www.grid.ac/institutes/grid.4444.0
324 schema:familyName Fritsch
325 schema:givenName Lauriane
326 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01267277456.70
327 rdf:type schema:Person
328 sg:person.01310170137.53 schema:affiliation https://www.grid.ac/institutes/grid.66859.34
329 schema:familyName Beroukhim
330 schema:givenName Rameen
331 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01310170137.53
332 rdf:type schema:Person
333 sg:person.01312501443.55 schema:affiliation https://www.grid.ac/institutes/grid.116068.8
334 schema:familyName Bilodeau
335 schema:givenName Steve
336 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01312501443.55
337 rdf:type schema:Person
338 sg:person.01354065210.34 schema:affiliation https://www.grid.ac/institutes/grid.66859.34
339 schema:familyName Garraway
340 schema:givenName Levi A.
341 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354065210.34
342 rdf:type schema:Person
343 sg:person.015341736157.56 schema:affiliation N6aadd4493daf40859384e8aa2860f5f3
344 schema:familyName Zon
345 schema:givenName Leonard I.
346 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015341736157.56
347 rdf:type schema:Person
348 sg:person.0671254772.98 schema:affiliation https://www.grid.ac/institutes/grid.116068.8
349 schema:familyName Orlando
350 schema:givenName David A.
351 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0671254772.98
352 rdf:type schema:Person
353 sg:person.0703764143.17 schema:affiliation https://www.grid.ac/institutes/grid.4444.0
354 schema:familyName Ait-Si-Ali
355 schema:givenName Slimane
356 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0703764143.17
357 rdf:type schema:Person
358 sg:person.0753463017.41 schema:affiliation N50dae589eeb24eb195d8e772807f3eed
359 schema:familyName Bourque
360 schema:givenName Caitlin
361 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0753463017.41
362 rdf:type schema:Person
363 sg:pub.10.1038/nature00766 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023536940
364 https://doi.org/10.1038/nature00766
365 rdf:type schema:CreativeWork
366 sg:pub.10.1038/nature03664 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016552205
367 https://doi.org/10.1038/nature03664
368 rdf:type schema:CreativeWork
369 sg:pub.10.1038/nature03890 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003324113
370 https://doi.org/10.1038/nature03890
371 rdf:type schema:CreativeWork
372 sg:pub.10.1038/nature08672 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032969139
373 https://doi.org/10.1038/nature08672
374 rdf:type schema:CreativeWork
375 sg:pub.10.1038/nature08822 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010635813
376 https://doi.org/10.1038/nature08822
377 rdf:type schema:CreativeWork
378 sg:pub.10.1038/ng.349 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001520036
379 https://doi.org/10.1038/ng.349
380 rdf:type schema:CreativeWork
381 sg:pub.10.1038/ng1054 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035969538
382 https://doi.org/10.1038/ng1054
383 rdf:type schema:CreativeWork
384 sg:pub.10.1038/ng1180 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014377811
385 https://doi.org/10.1038/ng1180
386 rdf:type schema:CreativeWork
387 https://doi.org/10.1002/dvdy.21343 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035734715
388 rdf:type schema:CreativeWork
389 https://doi.org/10.1016/j.cub.2005.01.031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046159905
390 rdf:type schema:CreativeWork
391 https://doi.org/10.1016/j.molcel.2003.08.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010087489
392 rdf:type schema:CreativeWork
393 https://doi.org/10.1016/j.molcel.2004.06.043 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023397499
394 rdf:type schema:CreativeWork
395 https://doi.org/10.1016/j.molcel.2009.12.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008826917
396 rdf:type schema:CreativeWork
397 https://doi.org/10.1016/s0092-8674(04)00215-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019563286
398 rdf:type schema:CreativeWork
399 https://doi.org/10.1056/nejmoa050092 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007050226
400 rdf:type schema:CreativeWork
401 https://doi.org/10.1073/pnas.0506580102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037705714
402 rdf:type schema:CreativeWork
403 https://doi.org/10.1073/pnas.0710052104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034562854
404 rdf:type schema:CreativeWork
405 https://doi.org/10.1073/pnas.92.20.9363 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021293422
406 rdf:type schema:CreativeWork
407 https://doi.org/10.1093/humrep/14.11.2844 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007010269
408 rdf:type schema:CreativeWork
409 https://doi.org/10.1101/gad.1837309 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045357547
410 rdf:type schema:CreativeWork
411 https://doi.org/10.1158/0008-5472.can-07-2615 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012217489
412 rdf:type schema:CreativeWork
413 https://doi.org/10.1242/dmm.001016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016071771
414 rdf:type schema:CreativeWork
415 https://doi.org/10.1593/neo.07878 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007078703
416 rdf:type schema:CreativeWork
417 https://www.grid.ac/institutes/grid.116068.8 schema:alternateName Massachusetts Institute of Technology
418 schema:name Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
419 rdf:type schema:Organization
420 https://www.grid.ac/institutes/grid.4444.0 schema:alternateName French National Centre for Scientific Research
421 schema:name UMR7216 Epigénétique et Destin Cellulaire, CNRS, Université Paris-Diderot, 35 rue Hélène Brion, 75013 Paris, France
422 rdf:type schema:Organization
423 https://www.grid.ac/institutes/grid.66859.34 schema:alternateName Broad Institute
424 schema:name Departments of Medical Oncology, Cancer Biology, and Center for Cancer Genome Discovery, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
425 The Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
426 rdf:type schema:Organization
427 https://www.grid.ac/institutes/grid.7841.a schema:alternateName Sapienza University of Rome
428 schema:name A. Rossi Fanelli Biochemical Sciences Department, Sapienza University of Rome, Rome 00185, Italy
429 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...