The genomic complexity of primary human prostate cancer View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-02-09

AUTHORS

Michael F. Berger, Michael S. Lawrence, Francesca Demichelis, Yotam Drier, Kristian Cibulskis, Andrey Y. Sivachenko, Andrea Sboner, Raquel Esgueva, Dorothee Pflueger, Carrie Sougnez, Robert Onofrio, Scott L. Carter, Kyung Park, Lukas Habegger, Lauren Ambrogio, Timothy Fennell, Melissa Parkin, Gordon Saksena, Douglas Voet, Alex H. Ramos, Trevor J. Pugh, Jane Wilkinson, Sheila Fisher, Wendy Winckler, Scott Mahan, Kristin Ardlie, Jennifer Baldwin, Jonathan W. Simons, Naoki Kitabayashi, Theresa Y. MacDonald, Philip W. Kantoff, Lynda Chin, Stacey B. Gabriel, Mark B. Gerstein, Todd R. Golub, Matthew Meyerson, Ashutosh Tewari, Eric S. Lander, Gad Getz, Mark A. Rubin, Levi A. Garraway

ABSTRACT

Prostate cancer is the second most common cause of male cancer deaths in the United States. However, the full range of prostate cancer genomic alterations is incompletely characterized. Here we present the complete sequence of seven primary human prostate cancers and their paired normal counterparts. Several tumours contained complex chains of balanced (that is, ‘copy-neutral’) rearrangements that occurred within or adjacent to known cancer genes. Rearrangement breakpoints were enriched near open chromatin, androgen receptor and ERG DNA binding sites in the setting of the ETS gene fusion TMPRSS2–ERG, but inversely correlated with these regions in tumours lacking ETS fusions. This observation suggests a link between chromatin or transcriptional regulation and the genesis of genomic aberrations. Three tumours contained rearrangements that disrupted CADM2, and four harboured events disrupting either PTEN (unbalanced events), a prostate tumour suppressor, or MAGI2 (balanced events), a PTEN interacting protein not previously implicated in prostate tumorigenesis. Thus, genomic rearrangements may arise from transcriptional or chromatin aberrancies and engage prostate tumorigenic mechanisms. More... »

PAGES

214-220

References to SciGraph publications

  • 2010-04. Genome remodelling in a basal-like breast cancer metastasis and xenograft in NATURE
  • 2009-07-08. Chd1 regulates open chromatin and pluripotency of embryonic stem cells in NATURE
  • 2008-11. DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome in NATURE
  • 2010-07-04. Androgen-induced TOP2B-mediated double-strand breaks and prostate cancer gene rearrangements in NATURE GENETICS
  • 2009-10-21. Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1 in NATURE
  • 2009-12-16. A comprehensive catalogue of somatic mutations from a human cancer genome in NATURE
  • 1995-04. In vivo amplification of the androgen receptor gene and progression of human prostate cancer in NATURE GENETICS
  • 2007-08-02. Distinct classes of chromosomal rearrangements create oncogenic ETS gene fusions in prostate cancer in NATURE
  • 2010-05. The mutation spectrum revealed by paired genome sequences from a lung cancer patient in NATURE
  • 2010-06-06. Rearrangements of the RAF kinase pathway in prostate cancer, gastric cancer and melanoma in NATURE MEDICINE
  • 2009-10. Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution in NATURE
  • 2010-02. The landscape of somatic copy-number alteration across human cancers in NATURE
  • 2007-06. Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project in NATURE
  • 2009-04-26. Cooperativity of TMPRSS2-ERG with PI3-kinase pathway activation in prostate oncogenesis in NATURE GENETICS
  • 2009-04-26. Aberrant ERG expression cooperates with loss of PTEN to promote cancer progression in the prostate in NATURE GENETICS
  • 2009-12. Complex landscapes of somatic rearrangement in human breast cancer genomes in NATURE
  • 2004-09-07. Active genes dynamically colocalize to shared sites of ongoing transcription in NATURE GENETICS
  • 2010-07-28. Diverse somatic mutation patterns and pathway alterations in human cancers in NATURE
  • 2008-09-04. Comprehensive genomic characterization defines human glioblastoma genes and core pathways in NATURE
  • 2010-02. Signatures of mutation and selection in the cancer genome in NATURE
  • 2009-12-16. A small-cell lung cancer genome with complex signatures of tobacco exposure in NATURE
  • 2009-05-01. Fluorescence in situ hybridization study shows association of PTEN deletion with ERG rearrangement during prostate cancer progression in MODERN PATHOLOGY
  • Journal

    TITLE

    Nature

    ISSUE

    7333

    VOLUME

    470

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nature09744

    DOI

    http://dx.doi.org/10.1038/nature09744

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1026944448

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/21307934


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biochemistry and Cell Biology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Genetics", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adaptor Proteins, Signal Transducing", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Carrier Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Case-Control Studies", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Adhesion Molecules", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Chromatin", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Chromosome Aberrations", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Chromosome Breakpoints", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Epigenesis, Genetic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Expression Regulation, Neoplastic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genome, Human", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Guanylate Kinases", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "PTEN Phosphohydrolase", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Prostatic Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Recombination, Genetic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Signal Transduction", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Transcription, Genetic", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Present address: Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA.", 
              "id": "http://www.grid.ac/institutes/grid.51462.34", 
              "name": [
                "The Broad Institute of Harvard and MIT, 02142, Cambridge, Massachusetts, USA", 
                "Present address: Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Berger", 
            "givenName": "Michael F.", 
            "id": "sg:person.0653777340.46", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0653777340.46"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The Broad Institute of Harvard and MIT, 02142, Cambridge, Massachusetts, USA", 
              "id": "http://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "The Broad Institute of Harvard and MIT, 02142, Cambridge, Massachusetts, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lawrence", 
            "givenName": "Michael S.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institute for Computational Biomedicine, Weill Cornell Medical College, 10021, New York, New York, USA", 
              "id": "http://www.grid.ac/institutes/grid.5386.8", 
              "name": [
                "Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, 10065, New York, New York, USA", 
                "Institute for Computational Biomedicine, Weill Cornell Medical College, 10021, New York, New York, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Demichelis", 
            "givenName": "Francesca", 
            "id": "sg:person.01155160665.19", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01155160665.19"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Physics of Complex Systems, Weizmann Institute of Science, 76100, Rehovot, Israel", 
              "id": "http://www.grid.ac/institutes/grid.13992.30", 
              "name": [
                "Department of Physics of Complex Systems, Weizmann Institute of Science, 76100, Rehovot, Israel"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Drier", 
            "givenName": "Yotam", 
            "id": "sg:person.01113243415.98", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01113243415.98"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The Broad Institute of Harvard and MIT, 02142, Cambridge, Massachusetts, USA", 
              "id": "http://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "The Broad Institute of Harvard and MIT, 02142, Cambridge, Massachusetts, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Cibulskis", 
            "givenName": "Kristian", 
            "id": "sg:person.01340751121.56", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01340751121.56"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The Broad Institute of Harvard and MIT, 02142, Cambridge, Massachusetts, USA", 
              "id": "http://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "The Broad Institute of Harvard and MIT, 02142, Cambridge, Massachusetts, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sivachenko", 
            "givenName": "Andrey Y.", 
            "id": "sg:person.0715340031.86", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0715340031.86"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Program in Computational Biology and Bioinformatics, Yale University, 06520, New Haven, Connecticut, USA", 
              "id": "http://www.grid.ac/institutes/grid.47100.32", 
              "name": [
                "Department of Molecular Biophysics and Biochemistry, Yale University, 06520, New Haven, Connecticut, USA", 
                "Program in Computational Biology and Bioinformatics, Yale University, 06520, New Haven, Connecticut, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sboner", 
            "givenName": "Andrea", 
            "id": "sg:person.01243371302.09", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01243371302.09"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, 10065, New York, New York, USA", 
              "id": "http://www.grid.ac/institutes/grid.5386.8", 
              "name": [
                "Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, 10065, New York, New York, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Esgueva", 
            "givenName": "Raquel", 
            "id": "sg:person.01274645753.56", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274645753.56"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, 10065, New York, New York, USA", 
              "id": "http://www.grid.ac/institutes/grid.5386.8", 
              "name": [
                "Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, 10065, New York, New York, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Pflueger", 
            "givenName": "Dorothee", 
            "id": "sg:person.0650274766.39", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0650274766.39"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The Broad Institute of Harvard and MIT, 02142, Cambridge, Massachusetts, USA", 
              "id": "http://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "The Broad Institute of Harvard and MIT, 02142, Cambridge, Massachusetts, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sougnez", 
            "givenName": "Carrie", 
            "id": "sg:person.0727475244.45", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0727475244.45"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The Broad Institute of Harvard and MIT, 02142, Cambridge, Massachusetts, USA", 
              "id": "http://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "The Broad Institute of Harvard and MIT, 02142, Cambridge, Massachusetts, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Onofrio", 
            "givenName": "Robert", 
            "id": "sg:person.01234470615.07", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01234470615.07"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The Broad Institute of Harvard and MIT, 02142, Cambridge, Massachusetts, USA", 
              "id": "http://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "The Broad Institute of Harvard and MIT, 02142, Cambridge, Massachusetts, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Carter", 
            "givenName": "Scott L.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, 10065, New York, New York, USA", 
              "id": "http://www.grid.ac/institutes/grid.5386.8", 
              "name": [
                "Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, 10065, New York, New York, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Park", 
            "givenName": "Kyung", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Program in Computational Biology and Bioinformatics, Yale University, 06520, New Haven, Connecticut, USA", 
              "id": "http://www.grid.ac/institutes/grid.47100.32", 
              "name": [
                "Program in Computational Biology and Bioinformatics, Yale University, 06520, New Haven, Connecticut, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Habegger", 
            "givenName": "Lukas", 
            "id": "sg:person.0577023315.83", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577023315.83"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The Broad Institute of Harvard and MIT, 02142, Cambridge, Massachusetts, USA", 
              "id": "http://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "The Broad Institute of Harvard and MIT, 02142, Cambridge, Massachusetts, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ambrogio", 
            "givenName": "Lauren", 
            "id": "sg:person.01011536500.23", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01011536500.23"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The Broad Institute of Harvard and MIT, 02142, Cambridge, Massachusetts, USA", 
              "id": "http://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "The Broad Institute of Harvard and MIT, 02142, Cambridge, Massachusetts, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fennell", 
            "givenName": "Timothy", 
            "id": "sg:person.016012720777.47", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016012720777.47"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The Broad Institute of Harvard and MIT, 02142, Cambridge, Massachusetts, USA", 
              "id": "http://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "The Broad Institute of Harvard and MIT, 02142, Cambridge, Massachusetts, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Parkin", 
            "givenName": "Melissa", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The Broad Institute of Harvard and MIT, 02142, Cambridge, Massachusetts, USA", 
              "id": "http://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "The Broad Institute of Harvard and MIT, 02142, Cambridge, Massachusetts, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Saksena", 
            "givenName": "Gordon", 
            "id": "sg:person.01027152075.90", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01027152075.90"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The Broad Institute of Harvard and MIT, 02142, Cambridge, Massachusetts, USA", 
              "id": "http://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "The Broad Institute of Harvard and MIT, 02142, Cambridge, Massachusetts, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Voet", 
            "givenName": "Douglas", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Harvard Medical School, 02115, Boston, Massachusetts, USA", 
              "id": "http://www.grid.ac/institutes/grid.38142.3c", 
              "name": [
                "The Broad Institute of Harvard and MIT, 02142, Cambridge, Massachusetts, USA", 
                "Harvard Medical School, 02115, Boston, Massachusetts, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ramos", 
            "givenName": "Alex H.", 
            "id": "sg:person.01260766452.93", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01260766452.93"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Medical Oncology, Dana-Farber Cancer Institute, 02115, Boston, Massachusetts, USA", 
              "id": "http://www.grid.ac/institutes/grid.65499.37", 
              "name": [
                "The Broad Institute of Harvard and MIT, 02142, Cambridge, Massachusetts, USA", 
                "Harvard Medical School, 02115, Boston, Massachusetts, USA", 
                "Department of Medical Oncology, Dana-Farber Cancer Institute, 02115, Boston, Massachusetts, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Pugh", 
            "givenName": "Trevor J.", 
            "id": "sg:person.011314310445.23", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011314310445.23"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The Broad Institute of Harvard and MIT, 02142, Cambridge, Massachusetts, USA", 
              "id": "http://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "The Broad Institute of Harvard and MIT, 02142, Cambridge, Massachusetts, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wilkinson", 
            "givenName": "Jane", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The Broad Institute of Harvard and MIT, 02142, Cambridge, Massachusetts, USA", 
              "id": "http://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "The Broad Institute of Harvard and MIT, 02142, Cambridge, Massachusetts, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fisher", 
            "givenName": "Sheila", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The Broad Institute of Harvard and MIT, 02142, Cambridge, Massachusetts, USA", 
              "id": "http://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "The Broad Institute of Harvard and MIT, 02142, Cambridge, Massachusetts, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Winckler", 
            "givenName": "Wendy", 
            "id": "sg:person.01346637410.20", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01346637410.20"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The Broad Institute of Harvard and MIT, 02142, Cambridge, Massachusetts, USA", 
              "id": "http://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "The Broad Institute of Harvard and MIT, 02142, Cambridge, Massachusetts, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mahan", 
            "givenName": "Scott", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The Broad Institute of Harvard and MIT, 02142, Cambridge, Massachusetts, USA", 
              "id": "http://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "The Broad Institute of Harvard and MIT, 02142, Cambridge, Massachusetts, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ardlie", 
            "givenName": "Kristin", 
            "id": "sg:person.01131126727.99", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01131126727.99"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The Broad Institute of Harvard and MIT, 02142, Cambridge, Massachusetts, USA", 
              "id": "http://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "The Broad Institute of Harvard and MIT, 02142, Cambridge, Massachusetts, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Baldwin", 
            "givenName": "Jennifer", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The Prostate Cancer Foundation, 90401, Santa Monica, California, USA", 
              "id": "http://www.grid.ac/institutes/grid.453146.1", 
              "name": [
                "The Prostate Cancer Foundation, 90401, Santa Monica, California, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Simons", 
            "givenName": "Jonathan W.", 
            "id": "sg:person.016002575237.78", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016002575237.78"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, 10065, New York, New York, USA", 
              "id": "http://www.grid.ac/institutes/grid.5386.8", 
              "name": [
                "Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, 10065, New York, New York, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kitabayashi", 
            "givenName": "Naoki", 
            "id": "sg:person.0665470253.21", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0665470253.21"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, 10065, New York, New York, USA", 
              "id": "http://www.grid.ac/institutes/grid.5386.8", 
              "name": [
                "Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, 10065, New York, New York, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "MacDonald", 
            "givenName": "Theresa Y.", 
            "id": "sg:person.01143726715.14", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01143726715.14"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Medical Oncology, Dana-Farber Cancer Institute, 02115, Boston, Massachusetts, USA", 
              "id": "http://www.grid.ac/institutes/grid.65499.37", 
              "name": [
                "Harvard Medical School, 02115, Boston, Massachusetts, USA", 
                "Department of Medical Oncology, Dana-Farber Cancer Institute, 02115, Boston, Massachusetts, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kantoff", 
            "givenName": "Philip W.", 
            "id": "sg:person.010572036137.03", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010572036137.03"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Belfer Institute for Applied Cancer Science, Dana-Farber Cancer Institute, 02115, Boston, Massachusetts, USA", 
              "id": "http://www.grid.ac/institutes/grid.65499.37", 
              "name": [
                "The Broad Institute of Harvard and MIT, 02142, Cambridge, Massachusetts, USA", 
                "Harvard Medical School, 02115, Boston, Massachusetts, USA", 
                "Department of Medical Oncology, Dana-Farber Cancer Institute, 02115, Boston, Massachusetts, USA", 
                "Belfer Institute for Applied Cancer Science, Dana-Farber Cancer Institute, 02115, Boston, Massachusetts, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Chin", 
            "givenName": "Lynda", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The Broad Institute of Harvard and MIT, 02142, Cambridge, Massachusetts, USA", 
              "id": "http://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "The Broad Institute of Harvard and MIT, 02142, Cambridge, Massachusetts, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gabriel", 
            "givenName": "Stacey B.", 
            "id": "sg:person.012151177437.05", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012151177437.05"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Computer Science, Yale University, 06520, New Haven, Connecticut, USA", 
              "id": "http://www.grid.ac/institutes/grid.47100.32", 
              "name": [
                "Department of Molecular Biophysics and Biochemistry, Yale University, 06520, New Haven, Connecticut, USA", 
                "Program in Computational Biology and Bioinformatics, Yale University, 06520, New Haven, Connecticut, USA", 
                "Department of Computer Science, Yale University, 06520, New Haven, Connecticut, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gerstein", 
            "givenName": "Mark B.", 
            "id": "sg:person.011677655217.83", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011677655217.83"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Center for Cancer Genome Discovery, Dana-Farber Cancer Institute, 02115, Boston, Massachusetts, USA", 
              "id": "http://www.grid.ac/institutes/grid.65499.37", 
              "name": [
                "The Broad Institute of Harvard and MIT, 02142, Cambridge, Massachusetts, USA", 
                "Department of Pediatric Oncology, Dana-Farber Cancer Institute, 02115, Boston, Massachusetts, USA", 
                "Howard Hughes Medical Institute, 20815, Chevy Chase, Maryland, USA", 
                "Center for Cancer Genome Discovery, Dana-Farber Cancer Institute, 02115, Boston, Massachusetts, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Golub", 
            "givenName": "Todd R.", 
            "id": "sg:person.01152644406.14", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01152644406.14"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Center for Cancer Genome Discovery, Dana-Farber Cancer Institute, 02115, Boston, Massachusetts, USA", 
              "id": "http://www.grid.ac/institutes/grid.65499.37", 
              "name": [
                "The Broad Institute of Harvard and MIT, 02142, Cambridge, Massachusetts, USA", 
                "Harvard Medical School, 02115, Boston, Massachusetts, USA", 
                "Department of Medical Oncology, Dana-Farber Cancer Institute, 02115, Boston, Massachusetts, USA", 
                "Center for Cancer Genome Discovery, Dana-Farber Cancer Institute, 02115, Boston, Massachusetts, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Meyerson", 
            "givenName": "Matthew", 
            "id": "sg:person.0707456775.47", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0707456775.47"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Urology, Institute of Prostate Cancer and Lefrak Center of Robotic Surgery, Weill Cornell Medical College and New York Presbyterian Hospitals, 10065, New York, New York, USA", 
              "id": "http://www.grid.ac/institutes/grid.413734.6", 
              "name": [
                "Department of Urology, Institute of Prostate Cancer and Lefrak Center of Robotic Surgery, Weill Cornell Medical College and New York Presbyterian Hospitals, 10065, New York, New York, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tewari", 
            "givenName": "Ashutosh", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Whitehead Institute for Biomedical Research, 9 Cambridge Center, 02142, Cambridge, Massachusetts, USA", 
              "id": "http://www.grid.ac/institutes/grid.270301.7", 
              "name": [
                "The Broad Institute of Harvard and MIT, 02142, Cambridge, Massachusetts, USA", 
                "Harvard Medical School, 02115, Boston, Massachusetts, USA", 
                "Whitehead Institute for Biomedical Research, 9 Cambridge Center, 02142, Cambridge, Massachusetts, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lander", 
            "givenName": "Eric S.", 
            "id": "sg:person.01260666165.62", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01260666165.62"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The Broad Institute of Harvard and MIT, 02142, Cambridge, Massachusetts, USA", 
              "id": "http://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "The Broad Institute of Harvard and MIT, 02142, Cambridge, Massachusetts, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Getz", 
            "givenName": "Gad", 
            "id": "sg:person.01316313531.32", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01316313531.32"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, 10065, New York, New York, USA", 
              "id": "http://www.grid.ac/institutes/grid.5386.8", 
              "name": [
                "Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, 10065, New York, New York, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rubin", 
            "givenName": "Mark A.", 
            "id": "sg:person.01012625411.99", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01012625411.99"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Center for Cancer Genome Discovery, Dana-Farber Cancer Institute, 02115, Boston, Massachusetts, USA", 
              "id": "http://www.grid.ac/institutes/grid.65499.37", 
              "name": [
                "The Broad Institute of Harvard and MIT, 02142, Cambridge, Massachusetts, USA", 
                "Harvard Medical School, 02115, Boston, Massachusetts, USA", 
                "Department of Medical Oncology, Dana-Farber Cancer Institute, 02115, Boston, Massachusetts, USA", 
                "Center for Cancer Genome Discovery, Dana-Farber Cancer Institute, 02115, Boston, Massachusetts, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Garraway", 
            "givenName": "Levi A.", 
            "id": "sg:person.01354065210.34", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354065210.34"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/nature08629", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041012667", 
              "https://doi.org/10.1038/nature08629"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.371", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010653128", 
              "https://doi.org/10.1038/ng.371"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08460", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002209653", 
              "https://doi.org/10.1038/nature08460"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature07385", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039570773", 
              "https://doi.org/10.1038/nature07385"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1423", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013569568", 
              "https://doi.org/10.1038/ng1423"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.613", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017624697", 
              "https://doi.org/10.1038/ng.613"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature05874", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005913886", 
              "https://doi.org/10.1038/nature05874"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08645", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050729897", 
              "https://doi.org/10.1038/nature08645"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08989", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051657357", 
              "https://doi.org/10.1038/nature08989"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08489", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006711248", 
              "https://doi.org/10.1038/nature08489"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.2166", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038009239", 
              "https://doi.org/10.1038/nm.2166"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature06024", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027447235", 
              "https://doi.org/10.1038/nature06024"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08658", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014288207", 
              "https://doi.org/10.1038/nature08658"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08768", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002735811", 
              "https://doi.org/10.1038/nature08768"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08212", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021803949", 
              "https://doi.org/10.1038/nature08212"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09208", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048324405", 
              "https://doi.org/10.1038/nature09208"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.370", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049961568", 
              "https://doi.org/10.1038/ng.370"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/modpathol.2009.69", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032303147", 
              "https://doi.org/10.1038/modpathol.2009.69"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042375369", 
              "https://doi.org/10.1038/nature09004"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08822", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010635813", 
              "https://doi.org/10.1038/nature08822"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature07485", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034796960", 
              "https://doi.org/10.1038/nature07485"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng0495-401", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021884717", 
              "https://doi.org/10.1038/ng0495-401"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2011-02-09", 
        "datePublishedReg": "2011-02-09", 
        "description": "Prostate cancer is the second most common cause of male cancer deaths in the United States. However, the full range of prostate cancer genomic alterations is incompletely characterized. Here we present the complete sequence of seven primary human prostate cancers and their paired normal counterparts. Several tumours contained complex chains of balanced (that is, \u2018copy-neutral\u2019) rearrangements that occurred within or adjacent to known cancer genes. Rearrangement breakpoints were enriched near open chromatin, androgen receptor and ERG DNA binding sites in the setting of the ETS gene fusion TMPRSS2\u2013ERG, but inversely correlated with these regions in tumours lacking ETS fusions. This observation suggests a link between chromatin or transcriptional regulation and the genesis of genomic aberrations. Three tumours contained rearrangements that disrupted CADM2, and four harboured events disrupting either PTEN (unbalanced events), a prostate tumour suppressor, or MAGI2 (balanced events), a PTEN interacting protein not previously implicated in prostate tumorigenesis. Thus, genomic rearrangements may arise from transcriptional or chromatin aberrancies and engage prostate tumorigenic mechanisms.", 
        "genre": "article", 
        "id": "sg:pub.10.1038/nature09744", 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2699326", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2355258", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.7144153", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2440165", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2631831", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1018957", 
            "issn": [
              "0028-0836", 
              "1476-4687"
            ], 
            "name": "Nature", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "7333", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "470"
          }
        ], 
        "keywords": [
          "primary human prostate cancers", 
          "human prostate cancer", 
          "cancer genomic alterations", 
          "prostate tumor suppressor", 
          "open chromatin", 
          "transcriptional regulation", 
          "genomic rearrangements", 
          "complete sequence", 
          "rearrangement breakpoints", 
          "genomic complexity", 
          "tumor suppressor", 
          "cancer genes", 
          "tumorigenic mechanisms", 
          "ETS fusions", 
          "genomic aberrations", 
          "prostate tumorigenesis", 
          "genomic alterations", 
          "balanced rearrangements", 
          "chromatin", 
          "normal counterparts", 
          "PTEN", 
          "TMPRSS2-ERG", 
          "rearrangement", 
          "genes", 
          "suppressor", 
          "CADM2", 
          "MAGI2", 
          "protein", 
          "DNA", 
          "tumorigenesis", 
          "regulation", 
          "male cancer deaths", 
          "sequence", 
          "complex chain", 
          "prostate cancer", 
          "breakpoints", 
          "cancer", 
          "receptors", 
          "androgen receptor", 
          "fusion", 
          "alterations", 
          "sites", 
          "aberrations", 
          "aberrancies", 
          "mechanism", 
          "region", 
          "tumors", 
          "death", 
          "chain", 
          "events", 
          "cancer death", 
          "counterparts", 
          "full range", 
          "link", 
          "observations", 
          "genesis", 
          "range", 
          "complexity", 
          "United States", 
          "cause", 
          "common cause", 
          "state", 
          "setting"
        ], 
        "name": "The genomic complexity of primary human prostate cancer", 
        "pagination": "214-220", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1026944448"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/nature09744"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "21307934"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/nature09744", 
          "https://app.dimensions.ai/details/publication/pub.1026944448"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-11-24T20:56", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20221124/entities/gbq_results/article/article_541.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1038/nature09744"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nature09744'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nature09744'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nature09744'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nature09744'


     

    This table displays all metadata directly associated to this object as RDF triples.

    619 TRIPLES      21 PREDICATES      131 URIs      98 LITERALS      25 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/nature09744 schema:about N0fd23c4553b341bf9ce37090b7cf3768
    2 N17693054c22a48c19f12050488e4b824
    3 N2575a5653b804108968de647e4d635a7
    4 N2c11696e2c714434a2f4fb43b2998577
    5 N31e38f1b108642dfb4845a095d70007f
    6 N3407f2b1d5644e6a93953ce68da65b93
    7 N3558a67cbf254a7399906b88ac0cef6b
    8 N419f77746e8743e5a54fecc3cacf08fb
    9 N465c7e22fbde440aa84d41582da748b4
    10 N6dfe1175c7a74d8eb1a9aaf497c2743a
    11 N72935a2d95c1407bae74b8ac1434f598
    12 N82393db979564cd9af0aa703c23552b8
    13 N8654cec226dd4ccab41268046b21a30f
    14 Naac726f5ffa64fb985ef920c9e6eaa38
    15 Nb52be36de4fc4f03ae737b58e0c50d1a
    16 Nd437c10767094307a8765bbe86b8ccc2
    17 Nd55b5fa466a14a64974596e13c282657
    18 Ndbed37a515fd43d99a3989c9e711cc8d
    19 anzsrc-for:06
    20 anzsrc-for:0601
    21 anzsrc-for:0604
    22 anzsrc-for:11
    23 anzsrc-for:1112
    24 schema:author N1df777aecbc144ffb09c4293acbcab8a
    25 schema:citation sg:pub.10.1038/modpathol.2009.69
    26 sg:pub.10.1038/nature05874
    27 sg:pub.10.1038/nature06024
    28 sg:pub.10.1038/nature07385
    29 sg:pub.10.1038/nature07485
    30 sg:pub.10.1038/nature08212
    31 sg:pub.10.1038/nature08460
    32 sg:pub.10.1038/nature08489
    33 sg:pub.10.1038/nature08629
    34 sg:pub.10.1038/nature08645
    35 sg:pub.10.1038/nature08658
    36 sg:pub.10.1038/nature08768
    37 sg:pub.10.1038/nature08822
    38 sg:pub.10.1038/nature08989
    39 sg:pub.10.1038/nature09004
    40 sg:pub.10.1038/nature09208
    41 sg:pub.10.1038/ng.370
    42 sg:pub.10.1038/ng.371
    43 sg:pub.10.1038/ng.613
    44 sg:pub.10.1038/ng0495-401
    45 sg:pub.10.1038/ng1423
    46 sg:pub.10.1038/nm.2166
    47 schema:datePublished 2011-02-09
    48 schema:datePublishedReg 2011-02-09
    49 schema:description Prostate cancer is the second most common cause of male cancer deaths in the United States. However, the full range of prostate cancer genomic alterations is incompletely characterized. Here we present the complete sequence of seven primary human prostate cancers and their paired normal counterparts. Several tumours contained complex chains of balanced (that is, ‘copy-neutral’) rearrangements that occurred within or adjacent to known cancer genes. Rearrangement breakpoints were enriched near open chromatin, androgen receptor and ERG DNA binding sites in the setting of the ETS gene fusion TMPRSS2–ERG, but inversely correlated with these regions in tumours lacking ETS fusions. This observation suggests a link between chromatin or transcriptional regulation and the genesis of genomic aberrations. Three tumours contained rearrangements that disrupted CADM2, and four harboured events disrupting either PTEN (unbalanced events), a prostate tumour suppressor, or MAGI2 (balanced events), a PTEN interacting protein not previously implicated in prostate tumorigenesis. Thus, genomic rearrangements may arise from transcriptional or chromatin aberrancies and engage prostate tumorigenic mechanisms.
    50 schema:genre article
    51 schema:isAccessibleForFree true
    52 schema:isPartOf N04a8aedbfa1d41eaa1d5202a0d1f4676
    53 Nbda5700d63dc448e8589037ad81574a3
    54 sg:journal.1018957
    55 schema:keywords CADM2
    56 DNA
    57 ETS fusions
    58 MAGI2
    59 PTEN
    60 TMPRSS2-ERG
    61 United States
    62 aberrancies
    63 aberrations
    64 alterations
    65 androgen receptor
    66 balanced rearrangements
    67 breakpoints
    68 cancer
    69 cancer death
    70 cancer genes
    71 cancer genomic alterations
    72 cause
    73 chain
    74 chromatin
    75 common cause
    76 complete sequence
    77 complex chain
    78 complexity
    79 counterparts
    80 death
    81 events
    82 full range
    83 fusion
    84 genes
    85 genesis
    86 genomic aberrations
    87 genomic alterations
    88 genomic complexity
    89 genomic rearrangements
    90 human prostate cancer
    91 link
    92 male cancer deaths
    93 mechanism
    94 normal counterparts
    95 observations
    96 open chromatin
    97 primary human prostate cancers
    98 prostate cancer
    99 prostate tumor suppressor
    100 prostate tumorigenesis
    101 protein
    102 range
    103 rearrangement
    104 rearrangement breakpoints
    105 receptors
    106 region
    107 regulation
    108 sequence
    109 setting
    110 sites
    111 state
    112 suppressor
    113 transcriptional regulation
    114 tumor suppressor
    115 tumorigenesis
    116 tumorigenic mechanisms
    117 tumors
    118 schema:name The genomic complexity of primary human prostate cancer
    119 schema:pagination 214-220
    120 schema:productId N060d193f519a4462ac69d7c0b1367088
    121 N43a87b3e7e2a4f6ab10f47fe87ae9322
    122 Nd019097c02f74e2c8461ac4993e3619b
    123 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026944448
    124 https://doi.org/10.1038/nature09744
    125 schema:sdDatePublished 2022-11-24T20:56
    126 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    127 schema:sdPublisher N3c320d06ac6140f585dfde459d8cb933
    128 schema:url https://doi.org/10.1038/nature09744
    129 sgo:license sg:explorer/license/
    130 sgo:sdDataset articles
    131 rdf:type schema:ScholarlyArticle
    132 N04a8aedbfa1d41eaa1d5202a0d1f4676 schema:issueNumber 7333
    133 rdf:type schema:PublicationIssue
    134 N060d193f519a4462ac69d7c0b1367088 schema:name dimensions_id
    135 schema:value pub.1026944448
    136 rdf:type schema:PropertyValue
    137 N07a04b23cd174d978220e5fec14444b8 rdf:first N3e63c8cf9bba423f9636b7a3aea73c73
    138 rdf:rest N6a331cadaf17478cbf9679e5bc56453a
    139 N09218919d5c84d5688d869b4a7197ce3 rdf:first sg:person.01131126727.99
    140 rdf:rest Nf26e87d4b65646cb93b13d8aa379f29a
    141 N0fd23c4553b341bf9ce37090b7cf3768 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    142 schema:name Chromatin
    143 rdf:type schema:DefinedTerm
    144 N17693054c22a48c19f12050488e4b824 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    145 schema:name Chromosome Aberrations
    146 rdf:type schema:DefinedTerm
    147 N1c7a14a54f494f04b7613c25beaf78bf rdf:first sg:person.01243371302.09
    148 rdf:rest N1f24f3304b0f41318e0eb68f7d1daba0
    149 N1df777aecbc144ffb09c4293acbcab8a rdf:first sg:person.0653777340.46
    150 rdf:rest N91058b534ff6444f99498f22ede93b70
    151 N1f0058d25eb24fb6b57cdcf0cf9f806d rdf:first N615c9e67f90b45e2bf694acb77f83d40
    152 rdf:rest N77eba3e3c6ad4172b32bcc6b4810758c
    153 N1f24f3304b0f41318e0eb68f7d1daba0 rdf:first sg:person.01274645753.56
    154 rdf:rest Nb9d324b21d9a4c0faf17204ab9c83dd3
    155 N22f8f41184e34ac68678670a492296e1 schema:affiliation grid-institutes:grid.66859.34
    156 schema:familyName Carter
    157 schema:givenName Scott L.
    158 rdf:type schema:Person
    159 N24d45da86b0c4e5485d61cfe63acf568 schema:affiliation grid-institutes:grid.66859.34
    160 schema:familyName Lawrence
    161 schema:givenName Michael S.
    162 rdf:type schema:Person
    163 N24dc4c16ced84ffc86108f23bf0bad6a rdf:first sg:person.0715340031.86
    164 rdf:rest N1c7a14a54f494f04b7613c25beaf78bf
    165 N2575a5653b804108968de647e4d635a7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    166 schema:name Cell Adhesion Molecules
    167 rdf:type schema:DefinedTerm
    168 N2c11696e2c714434a2f4fb43b2998577 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    169 schema:name Humans
    170 rdf:type schema:DefinedTerm
    171 N31e38f1b108642dfb4845a095d70007f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    172 schema:name Case-Control Studies
    173 rdf:type schema:DefinedTerm
    174 N3407f2b1d5644e6a93953ce68da65b93 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    175 schema:name Recombination, Genetic
    176 rdf:type schema:DefinedTerm
    177 N347db462c57c4980bf66c504c1f9f6c6 rdf:first sg:person.016002575237.78
    178 rdf:rest N44c87a12e66c4734bb9d0973a752da2c
    179 N3558a67cbf254a7399906b88ac0cef6b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    180 schema:name Transcription, Genetic
    181 rdf:type schema:DefinedTerm
    182 N3c320d06ac6140f585dfde459d8cb933 schema:name Springer Nature - SN SciGraph project
    183 rdf:type schema:Organization
    184 N3e63c8cf9bba423f9636b7a3aea73c73 schema:affiliation grid-institutes:grid.66859.34
    185 schema:familyName Wilkinson
    186 schema:givenName Jane
    187 rdf:type schema:Person
    188 N419f77746e8743e5a54fecc3cacf08fb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    189 schema:name Carrier Proteins
    190 rdf:type schema:DefinedTerm
    191 N43a87b3e7e2a4f6ab10f47fe87ae9322 schema:name doi
    192 schema:value 10.1038/nature09744
    193 rdf:type schema:PropertyValue
    194 N44c87a12e66c4734bb9d0973a752da2c rdf:first sg:person.0665470253.21
    195 rdf:rest N84d306bf4a2b4babb9d8ced260dd8741
    196 N465c7e22fbde440aa84d41582da748b4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    197 schema:name Guanylate Kinases
    198 rdf:type schema:DefinedTerm
    199 N511a7318183e48d1aa89bfca33d25aa7 rdf:first sg:person.011314310445.23
    200 rdf:rest N07a04b23cd174d978220e5fec14444b8
    201 N51a84ce2795d41d99ecfa5036bc61553 rdf:first N8dd9ff8fca654626a51e25d797204156
    202 rdf:rest N6da2108199da4a6caa3ab6e1876df628
    203 N5b7478e408264f0887a572b535a172bf rdf:first sg:person.0577023315.83
    204 rdf:rest N726c07f72c574d2e821e60a2b69cf93e
    205 N615c9e67f90b45e2bf694acb77f83d40 schema:affiliation grid-institutes:grid.65499.37
    206 schema:familyName Chin
    207 schema:givenName Lynda
    208 rdf:type schema:Person
    209 N6359afc93dc042ad8c24fa0d6c4d3e5b rdf:first Nfdc14eb980a940dd947ccf89b59a1a40
    210 rdf:rest N7b198fc30aba4f12a7377133782ce780
    211 N694da6802bd844aba4f41ce58486cd89 rdf:first sg:person.016012720777.47
    212 rdf:rest N51a84ce2795d41d99ecfa5036bc61553
    213 N6a331cadaf17478cbf9679e5bc56453a rdf:first Na78574fbc4f14659a6ecc4512ae96754
    214 rdf:rest N81bf0c2c94314fd2ae5a43aa5539bcca
    215 N6afe18e95111479ea53a7760b0684975 rdf:first sg:person.01155160665.19
    216 rdf:rest N9774d2f4e2c94831ae1384b4b5eb1f27
    217 N6c07e2362e194e4189bbecacb781e9e0 rdf:first sg:person.01260666165.62
    218 rdf:rest Nf3eb2470a29444bd9f8cdfdd17731421
    219 N6da2108199da4a6caa3ab6e1876df628 rdf:first sg:person.01027152075.90
    220 rdf:rest N6359afc93dc042ad8c24fa0d6c4d3e5b
    221 N6dfe1175c7a74d8eb1a9aaf497c2743a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    222 schema:name Gene Expression Regulation, Neoplastic
    223 rdf:type schema:DefinedTerm
    224 N726c07f72c574d2e821e60a2b69cf93e rdf:first sg:person.01011536500.23
    225 rdf:rest N694da6802bd844aba4f41ce58486cd89
    226 N72935a2d95c1407bae74b8ac1434f598 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    227 schema:name Epigenesis, Genetic
    228 rdf:type schema:DefinedTerm
    229 N77eba3e3c6ad4172b32bcc6b4810758c rdf:first sg:person.012151177437.05
    230 rdf:rest Nf11d142434bb4aafb37d12675476eed3
    231 N7a6c31953349452e948b61decbe990c3 schema:affiliation grid-institutes:grid.413734.6
    232 schema:familyName Tewari
    233 schema:givenName Ashutosh
    234 rdf:type schema:Person
    235 N7b198fc30aba4f12a7377133782ce780 rdf:first sg:person.01260766452.93
    236 rdf:rest N511a7318183e48d1aa89bfca33d25aa7
    237 N81bf0c2c94314fd2ae5a43aa5539bcca rdf:first sg:person.01346637410.20
    238 rdf:rest Nff23bb8cb7fc489f8c0dee57bb56ea88
    239 N82393db979564cd9af0aa703c23552b8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    240 schema:name Genome, Human
    241 rdf:type schema:DefinedTerm
    242 N84d306bf4a2b4babb9d8ced260dd8741 rdf:first sg:person.01143726715.14
    243 rdf:rest Nde6226ff12894fce9d21cf303292b763
    244 N8654cec226dd4ccab41268046b21a30f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    245 schema:name Adaptor Proteins, Signal Transducing
    246 rdf:type schema:DefinedTerm
    247 N8dd9ff8fca654626a51e25d797204156 schema:affiliation grid-institutes:grid.66859.34
    248 schema:familyName Parkin
    249 schema:givenName Melissa
    250 rdf:type schema:Person
    251 N91058b534ff6444f99498f22ede93b70 rdf:first N24d45da86b0c4e5485d61cfe63acf568
    252 rdf:rest N6afe18e95111479ea53a7760b0684975
    253 N9220b060050540d8b04cd0e9c2fe3d06 rdf:first sg:person.01354065210.34
    254 rdf:rest rdf:nil
    255 N927d35138e3749e8959904d4db0fa878 rdf:first N22f8f41184e34ac68678670a492296e1
    256 rdf:rest Nd0b96ace6c7440af98831ad057838a33
    257 N9774d2f4e2c94831ae1384b4b5eb1f27 rdf:first sg:person.01113243415.98
    258 rdf:rest Nd29e62dfd9694ea7a716d977e6446158
    259 Na3ed6b1ba5754c38942267d917b0a2fb schema:affiliation grid-institutes:grid.66859.34
    260 schema:familyName Mahan
    261 schema:givenName Scott
    262 rdf:type schema:Person
    263 Na78574fbc4f14659a6ecc4512ae96754 schema:affiliation grid-institutes:grid.66859.34
    264 schema:familyName Fisher
    265 schema:givenName Sheila
    266 rdf:type schema:Person
    267 Naac726f5ffa64fb985ef920c9e6eaa38 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    268 schema:name PTEN Phosphohydrolase
    269 rdf:type schema:DefinedTerm
    270 Nac8d673b87df401cab574ffaf631c2de rdf:first N7a6c31953349452e948b61decbe990c3
    271 rdf:rest N6c07e2362e194e4189bbecacb781e9e0
    272 Nb52be36de4fc4f03ae737b58e0c50d1a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    273 schema:name Signal Transduction
    274 rdf:type schema:DefinedTerm
    275 Nb9d324b21d9a4c0faf17204ab9c83dd3 rdf:first sg:person.0650274766.39
    276 rdf:rest Nd87e55bf863a4fe1af1ce53bd5dd57c5
    277 Nbda5700d63dc448e8589037ad81574a3 schema:volumeNumber 470
    278 rdf:type schema:PublicationVolume
    279 Nc6bc73976bd343d2a493abbf71697a51 rdf:first sg:person.0707456775.47
    280 rdf:rest Nac8d673b87df401cab574ffaf631c2de
    281 Nc9729423ab0c471687633eb1382fd5d4 schema:affiliation grid-institutes:grid.66859.34
    282 schema:familyName Baldwin
    283 schema:givenName Jennifer
    284 rdf:type schema:Person
    285 Nd019097c02f74e2c8461ac4993e3619b schema:name pubmed_id
    286 schema:value 21307934
    287 rdf:type schema:PropertyValue
    288 Nd0b96ace6c7440af98831ad057838a33 rdf:first Ne40f2fc05a8347bba9b948615620a92e
    289 rdf:rest N5b7478e408264f0887a572b535a172bf
    290 Nd29e62dfd9694ea7a716d977e6446158 rdf:first sg:person.01340751121.56
    291 rdf:rest N24dc4c16ced84ffc86108f23bf0bad6a
    292 Nd437c10767094307a8765bbe86b8ccc2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    293 schema:name Male
    294 rdf:type schema:DefinedTerm
    295 Nd55b5fa466a14a64974596e13c282657 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    296 schema:name Chromosome Breakpoints
    297 rdf:type schema:DefinedTerm
    298 Nd87e55bf863a4fe1af1ce53bd5dd57c5 rdf:first sg:person.0727475244.45
    299 rdf:rest Nddbfb38e1fcc4f618691b35368302fbb
    300 Nd96dc597d80c4bef8e3bdc6667c4a67a rdf:first sg:person.01152644406.14
    301 rdf:rest Nc6bc73976bd343d2a493abbf71697a51
    302 Ndbed37a515fd43d99a3989c9e711cc8d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    303 schema:name Prostatic Neoplasms
    304 rdf:type schema:DefinedTerm
    305 Nddbfb38e1fcc4f618691b35368302fbb rdf:first sg:person.01234470615.07
    306 rdf:rest N927d35138e3749e8959904d4db0fa878
    307 Nde6226ff12894fce9d21cf303292b763 rdf:first sg:person.010572036137.03
    308 rdf:rest N1f0058d25eb24fb6b57cdcf0cf9f806d
    309 Ne40f2fc05a8347bba9b948615620a92e schema:affiliation grid-institutes:grid.5386.8
    310 schema:familyName Park
    311 schema:givenName Kyung
    312 rdf:type schema:Person
    313 Nf11d142434bb4aafb37d12675476eed3 rdf:first sg:person.011677655217.83
    314 rdf:rest Nd96dc597d80c4bef8e3bdc6667c4a67a
    315 Nf26e87d4b65646cb93b13d8aa379f29a rdf:first Nc9729423ab0c471687633eb1382fd5d4
    316 rdf:rest N347db462c57c4980bf66c504c1f9f6c6
    317 Nf3eb2470a29444bd9f8cdfdd17731421 rdf:first sg:person.01316313531.32
    318 rdf:rest Nf83c843268a54b109982a3bb5ab28a2c
    319 Nf83c843268a54b109982a3bb5ab28a2c rdf:first sg:person.01012625411.99
    320 rdf:rest N9220b060050540d8b04cd0e9c2fe3d06
    321 Nfdc14eb980a940dd947ccf89b59a1a40 schema:affiliation grid-institutes:grid.66859.34
    322 schema:familyName Voet
    323 schema:givenName Douglas
    324 rdf:type schema:Person
    325 Nff23bb8cb7fc489f8c0dee57bb56ea88 rdf:first Na3ed6b1ba5754c38942267d917b0a2fb
    326 rdf:rest N09218919d5c84d5688d869b4a7197ce3
    327 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    328 schema:name Biological Sciences
    329 rdf:type schema:DefinedTerm
    330 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
    331 schema:name Biochemistry and Cell Biology
    332 rdf:type schema:DefinedTerm
    333 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
    334 schema:name Genetics
    335 rdf:type schema:DefinedTerm
    336 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    337 schema:name Medical and Health Sciences
    338 rdf:type schema:DefinedTerm
    339 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    340 schema:name Oncology and Carcinogenesis
    341 rdf:type schema:DefinedTerm
    342 sg:grant.2355258 http://pending.schema.org/fundedItem sg:pub.10.1038/nature09744
    343 rdf:type schema:MonetaryGrant
    344 sg:grant.2440165 http://pending.schema.org/fundedItem sg:pub.10.1038/nature09744
    345 rdf:type schema:MonetaryGrant
    346 sg:grant.2631831 http://pending.schema.org/fundedItem sg:pub.10.1038/nature09744
    347 rdf:type schema:MonetaryGrant
    348 sg:grant.2699326 http://pending.schema.org/fundedItem sg:pub.10.1038/nature09744
    349 rdf:type schema:MonetaryGrant
    350 sg:grant.7144153 http://pending.schema.org/fundedItem sg:pub.10.1038/nature09744
    351 rdf:type schema:MonetaryGrant
    352 sg:journal.1018957 schema:issn 0028-0836
    353 1476-4687
    354 schema:name Nature
    355 schema:publisher Springer Nature
    356 rdf:type schema:Periodical
    357 sg:person.01011536500.23 schema:affiliation grid-institutes:grid.66859.34
    358 schema:familyName Ambrogio
    359 schema:givenName Lauren
    360 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01011536500.23
    361 rdf:type schema:Person
    362 sg:person.01012625411.99 schema:affiliation grid-institutes:grid.5386.8
    363 schema:familyName Rubin
    364 schema:givenName Mark A.
    365 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01012625411.99
    366 rdf:type schema:Person
    367 sg:person.01027152075.90 schema:affiliation grid-institutes:grid.66859.34
    368 schema:familyName Saksena
    369 schema:givenName Gordon
    370 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01027152075.90
    371 rdf:type schema:Person
    372 sg:person.010572036137.03 schema:affiliation grid-institutes:grid.65499.37
    373 schema:familyName Kantoff
    374 schema:givenName Philip W.
    375 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010572036137.03
    376 rdf:type schema:Person
    377 sg:person.01113243415.98 schema:affiliation grid-institutes:grid.13992.30
    378 schema:familyName Drier
    379 schema:givenName Yotam
    380 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01113243415.98
    381 rdf:type schema:Person
    382 sg:person.01131126727.99 schema:affiliation grid-institutes:grid.66859.34
    383 schema:familyName Ardlie
    384 schema:givenName Kristin
    385 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01131126727.99
    386 rdf:type schema:Person
    387 sg:person.011314310445.23 schema:affiliation grid-institutes:grid.65499.37
    388 schema:familyName Pugh
    389 schema:givenName Trevor J.
    390 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011314310445.23
    391 rdf:type schema:Person
    392 sg:person.01143726715.14 schema:affiliation grid-institutes:grid.5386.8
    393 schema:familyName MacDonald
    394 schema:givenName Theresa Y.
    395 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01143726715.14
    396 rdf:type schema:Person
    397 sg:person.01152644406.14 schema:affiliation grid-institutes:grid.65499.37
    398 schema:familyName Golub
    399 schema:givenName Todd R.
    400 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01152644406.14
    401 rdf:type schema:Person
    402 sg:person.01155160665.19 schema:affiliation grid-institutes:grid.5386.8
    403 schema:familyName Demichelis
    404 schema:givenName Francesca
    405 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01155160665.19
    406 rdf:type schema:Person
    407 sg:person.011677655217.83 schema:affiliation grid-institutes:grid.47100.32
    408 schema:familyName Gerstein
    409 schema:givenName Mark B.
    410 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011677655217.83
    411 rdf:type schema:Person
    412 sg:person.012151177437.05 schema:affiliation grid-institutes:grid.66859.34
    413 schema:familyName Gabriel
    414 schema:givenName Stacey B.
    415 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012151177437.05
    416 rdf:type schema:Person
    417 sg:person.01234470615.07 schema:affiliation grid-institutes:grid.66859.34
    418 schema:familyName Onofrio
    419 schema:givenName Robert
    420 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01234470615.07
    421 rdf:type schema:Person
    422 sg:person.01243371302.09 schema:affiliation grid-institutes:grid.47100.32
    423 schema:familyName Sboner
    424 schema:givenName Andrea
    425 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01243371302.09
    426 rdf:type schema:Person
    427 sg:person.01260666165.62 schema:affiliation grid-institutes:grid.270301.7
    428 schema:familyName Lander
    429 schema:givenName Eric S.
    430 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01260666165.62
    431 rdf:type schema:Person
    432 sg:person.01260766452.93 schema:affiliation grid-institutes:grid.38142.3c
    433 schema:familyName Ramos
    434 schema:givenName Alex H.
    435 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01260766452.93
    436 rdf:type schema:Person
    437 sg:person.01274645753.56 schema:affiliation grid-institutes:grid.5386.8
    438 schema:familyName Esgueva
    439 schema:givenName Raquel
    440 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274645753.56
    441 rdf:type schema:Person
    442 sg:person.01316313531.32 schema:affiliation grid-institutes:grid.66859.34
    443 schema:familyName Getz
    444 schema:givenName Gad
    445 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01316313531.32
    446 rdf:type schema:Person
    447 sg:person.01340751121.56 schema:affiliation grid-institutes:grid.66859.34
    448 schema:familyName Cibulskis
    449 schema:givenName Kristian
    450 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01340751121.56
    451 rdf:type schema:Person
    452 sg:person.01346637410.20 schema:affiliation grid-institutes:grid.66859.34
    453 schema:familyName Winckler
    454 schema:givenName Wendy
    455 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01346637410.20
    456 rdf:type schema:Person
    457 sg:person.01354065210.34 schema:affiliation grid-institutes:grid.65499.37
    458 schema:familyName Garraway
    459 schema:givenName Levi A.
    460 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354065210.34
    461 rdf:type schema:Person
    462 sg:person.016002575237.78 schema:affiliation grid-institutes:grid.453146.1
    463 schema:familyName Simons
    464 schema:givenName Jonathan W.
    465 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016002575237.78
    466 rdf:type schema:Person
    467 sg:person.016012720777.47 schema:affiliation grid-institutes:grid.66859.34
    468 schema:familyName Fennell
    469 schema:givenName Timothy
    470 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016012720777.47
    471 rdf:type schema:Person
    472 sg:person.0577023315.83 schema:affiliation grid-institutes:grid.47100.32
    473 schema:familyName Habegger
    474 schema:givenName Lukas
    475 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577023315.83
    476 rdf:type schema:Person
    477 sg:person.0650274766.39 schema:affiliation grid-institutes:grid.5386.8
    478 schema:familyName Pflueger
    479 schema:givenName Dorothee
    480 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0650274766.39
    481 rdf:type schema:Person
    482 sg:person.0653777340.46 schema:affiliation grid-institutes:grid.51462.34
    483 schema:familyName Berger
    484 schema:givenName Michael F.
    485 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0653777340.46
    486 rdf:type schema:Person
    487 sg:person.0665470253.21 schema:affiliation grid-institutes:grid.5386.8
    488 schema:familyName Kitabayashi
    489 schema:givenName Naoki
    490 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0665470253.21
    491 rdf:type schema:Person
    492 sg:person.0707456775.47 schema:affiliation grid-institutes:grid.65499.37
    493 schema:familyName Meyerson
    494 schema:givenName Matthew
    495 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0707456775.47
    496 rdf:type schema:Person
    497 sg:person.0715340031.86 schema:affiliation grid-institutes:grid.66859.34
    498 schema:familyName Sivachenko
    499 schema:givenName Andrey Y.
    500 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0715340031.86
    501 rdf:type schema:Person
    502 sg:person.0727475244.45 schema:affiliation grid-institutes:grid.66859.34
    503 schema:familyName Sougnez
    504 schema:givenName Carrie
    505 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0727475244.45
    506 rdf:type schema:Person
    507 sg:pub.10.1038/modpathol.2009.69 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032303147
    508 https://doi.org/10.1038/modpathol.2009.69
    509 rdf:type schema:CreativeWork
    510 sg:pub.10.1038/nature05874 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005913886
    511 https://doi.org/10.1038/nature05874
    512 rdf:type schema:CreativeWork
    513 sg:pub.10.1038/nature06024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027447235
    514 https://doi.org/10.1038/nature06024
    515 rdf:type schema:CreativeWork
    516 sg:pub.10.1038/nature07385 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039570773
    517 https://doi.org/10.1038/nature07385
    518 rdf:type schema:CreativeWork
    519 sg:pub.10.1038/nature07485 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034796960
    520 https://doi.org/10.1038/nature07485
    521 rdf:type schema:CreativeWork
    522 sg:pub.10.1038/nature08212 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021803949
    523 https://doi.org/10.1038/nature08212
    524 rdf:type schema:CreativeWork
    525 sg:pub.10.1038/nature08460 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002209653
    526 https://doi.org/10.1038/nature08460
    527 rdf:type schema:CreativeWork
    528 sg:pub.10.1038/nature08489 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006711248
    529 https://doi.org/10.1038/nature08489
    530 rdf:type schema:CreativeWork
    531 sg:pub.10.1038/nature08629 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041012667
    532 https://doi.org/10.1038/nature08629
    533 rdf:type schema:CreativeWork
    534 sg:pub.10.1038/nature08645 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050729897
    535 https://doi.org/10.1038/nature08645
    536 rdf:type schema:CreativeWork
    537 sg:pub.10.1038/nature08658 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014288207
    538 https://doi.org/10.1038/nature08658
    539 rdf:type schema:CreativeWork
    540 sg:pub.10.1038/nature08768 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002735811
    541 https://doi.org/10.1038/nature08768
    542 rdf:type schema:CreativeWork
    543 sg:pub.10.1038/nature08822 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010635813
    544 https://doi.org/10.1038/nature08822
    545 rdf:type schema:CreativeWork
    546 sg:pub.10.1038/nature08989 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051657357
    547 https://doi.org/10.1038/nature08989
    548 rdf:type schema:CreativeWork
    549 sg:pub.10.1038/nature09004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042375369
    550 https://doi.org/10.1038/nature09004
    551 rdf:type schema:CreativeWork
    552 sg:pub.10.1038/nature09208 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048324405
    553 https://doi.org/10.1038/nature09208
    554 rdf:type schema:CreativeWork
    555 sg:pub.10.1038/ng.370 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049961568
    556 https://doi.org/10.1038/ng.370
    557 rdf:type schema:CreativeWork
    558 sg:pub.10.1038/ng.371 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010653128
    559 https://doi.org/10.1038/ng.371
    560 rdf:type schema:CreativeWork
    561 sg:pub.10.1038/ng.613 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017624697
    562 https://doi.org/10.1038/ng.613
    563 rdf:type schema:CreativeWork
    564 sg:pub.10.1038/ng0495-401 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021884717
    565 https://doi.org/10.1038/ng0495-401
    566 rdf:type schema:CreativeWork
    567 sg:pub.10.1038/ng1423 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013569568
    568 https://doi.org/10.1038/ng1423
    569 rdf:type schema:CreativeWork
    570 sg:pub.10.1038/nm.2166 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038009239
    571 https://doi.org/10.1038/nm.2166
    572 rdf:type schema:CreativeWork
    573 grid-institutes:grid.13992.30 schema:alternateName Department of Physics of Complex Systems, Weizmann Institute of Science, 76100, Rehovot, Israel
    574 schema:name Department of Physics of Complex Systems, Weizmann Institute of Science, 76100, Rehovot, Israel
    575 rdf:type schema:Organization
    576 grid-institutes:grid.270301.7 schema:alternateName Whitehead Institute for Biomedical Research, 9 Cambridge Center, 02142, Cambridge, Massachusetts, USA
    577 schema:name Harvard Medical School, 02115, Boston, Massachusetts, USA
    578 The Broad Institute of Harvard and MIT, 02142, Cambridge, Massachusetts, USA
    579 Whitehead Institute for Biomedical Research, 9 Cambridge Center, 02142, Cambridge, Massachusetts, USA
    580 rdf:type schema:Organization
    581 grid-institutes:grid.38142.3c schema:alternateName Harvard Medical School, 02115, Boston, Massachusetts, USA
    582 schema:name Harvard Medical School, 02115, Boston, Massachusetts, USA
    583 The Broad Institute of Harvard and MIT, 02142, Cambridge, Massachusetts, USA
    584 rdf:type schema:Organization
    585 grid-institutes:grid.413734.6 schema:alternateName Department of Urology, Institute of Prostate Cancer and Lefrak Center of Robotic Surgery, Weill Cornell Medical College and New York Presbyterian Hospitals, 10065, New York, New York, USA
    586 schema:name Department of Urology, Institute of Prostate Cancer and Lefrak Center of Robotic Surgery, Weill Cornell Medical College and New York Presbyterian Hospitals, 10065, New York, New York, USA
    587 rdf:type schema:Organization
    588 grid-institutes:grid.453146.1 schema:alternateName The Prostate Cancer Foundation, 90401, Santa Monica, California, USA
    589 schema:name The Prostate Cancer Foundation, 90401, Santa Monica, California, USA
    590 rdf:type schema:Organization
    591 grid-institutes:grid.47100.32 schema:alternateName Department of Computer Science, Yale University, 06520, New Haven, Connecticut, USA
    592 Program in Computational Biology and Bioinformatics, Yale University, 06520, New Haven, Connecticut, USA
    593 schema:name Department of Computer Science, Yale University, 06520, New Haven, Connecticut, USA
    594 Department of Molecular Biophysics and Biochemistry, Yale University, 06520, New Haven, Connecticut, USA
    595 Program in Computational Biology and Bioinformatics, Yale University, 06520, New Haven, Connecticut, USA
    596 rdf:type schema:Organization
    597 grid-institutes:grid.51462.34 schema:alternateName Present address: Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA.
    598 schema:name Present address: Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA.
    599 The Broad Institute of Harvard and MIT, 02142, Cambridge, Massachusetts, USA
    600 rdf:type schema:Organization
    601 grid-institutes:grid.5386.8 schema:alternateName Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, 10065, New York, New York, USA
    602 Institute for Computational Biomedicine, Weill Cornell Medical College, 10021, New York, New York, USA
    603 schema:name Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, 10065, New York, New York, USA
    604 Institute for Computational Biomedicine, Weill Cornell Medical College, 10021, New York, New York, USA
    605 rdf:type schema:Organization
    606 grid-institutes:grid.65499.37 schema:alternateName Belfer Institute for Applied Cancer Science, Dana-Farber Cancer Institute, 02115, Boston, Massachusetts, USA
    607 Center for Cancer Genome Discovery, Dana-Farber Cancer Institute, 02115, Boston, Massachusetts, USA
    608 Department of Medical Oncology, Dana-Farber Cancer Institute, 02115, Boston, Massachusetts, USA
    609 schema:name Belfer Institute for Applied Cancer Science, Dana-Farber Cancer Institute, 02115, Boston, Massachusetts, USA
    610 Center for Cancer Genome Discovery, Dana-Farber Cancer Institute, 02115, Boston, Massachusetts, USA
    611 Department of Medical Oncology, Dana-Farber Cancer Institute, 02115, Boston, Massachusetts, USA
    612 Department of Pediatric Oncology, Dana-Farber Cancer Institute, 02115, Boston, Massachusetts, USA
    613 Harvard Medical School, 02115, Boston, Massachusetts, USA
    614 Howard Hughes Medical Institute, 20815, Chevy Chase, Maryland, USA
    615 The Broad Institute of Harvard and MIT, 02142, Cambridge, Massachusetts, USA
    616 rdf:type schema:Organization
    617 grid-institutes:grid.66859.34 schema:alternateName The Broad Institute of Harvard and MIT, 02142, Cambridge, Massachusetts, USA
    618 schema:name The Broad Institute of Harvard and MIT, 02142, Cambridge, Massachusetts, USA
    619 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...