Comprehensive analysis of the chromatin landscape in Drosophila melanogaster View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-03

AUTHORS

Peter V. Kharchenko, Artyom A. Alekseyenko, Yuri B. Schwartz, Aki Minoda, Nicole C. Riddle, Jason Ernst, Peter J. Sabo, Erica Larschan, Andrey A. Gorchakov, Tingting Gu, Daniela Linder-Basso, Annette Plachetka, Gregory Shanower, Michael Y. Tolstorukov, Lovelace J. Luquette, Ruibin Xi, Youngsook L. Jung, Richard W. Park, Eric P. Bishop, Theresa K. Canfield, Richard Sandstrom, Robert E. Thurman, David M. MacAlpine, John A. Stamatoyannopoulos, Manolis Kellis, Sarah C. R. Elgin, Mitzi I. Kuroda, Vincenzo Pirrotta, Gary H. Karpen, Peter J. Park

ABSTRACT

Chromatin is composed of DNA and a variety of modified histones and non-histone proteins, which have an impact on cell differentiation, gene regulation and other key cellular processes. Here we present a genome-wide chromatin landscape for Drosophila melanogaster based on eighteen histone modifications, summarized by nine prevalent combinatorial patterns. Integrative analysis with other data (non-histone chromatin proteins, DNase I hypersensitivity, GRO-Seq reads produced by engaged polymerase, short/long RNA products) reveals discrete characteristics of chromosomes, genes, regulatory elements and other functional domains. We find that active genes display distinct chromatin signatures that are correlated with disparate gene lengths, exon patterns, regulatory functions and genomic contexts. We also demonstrate a diversity of signatures among Polycomb targets that include a subset with paused polymerase. This systematic profiling and integrative analysis of chromatin signatures provides insights into how genomic elements are regulated, and will serve as a resource for future experimental investigations of genome structure and function. More... »

PAGES

480

References to SciGraph publications

  • 2009-07. Developmental roles of 21 Drosophila transcription factors are determined by quantitative differences in binding to an overlapping set of thousands of genomic regions in GENOME BIOLOGY
  • 2011-01. An assessment of histone-modification antibody quality in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2006-06. Genome-wide analysis of Polycomb targets in Drosophila melanogaster in NATURE GENETICS
  • 2003-01. Controlling the double helix in NATURE
  • 2008-02. Association of cohesin and Nipped-B with transcriptionally active regions of the Drosophila melanogaster genome in CHROMOSOMA
  • 2009-04. Global mapping of protein-DNA interactions in vivo by digital genomic footprinting in NATURE METHODS
  • 1980-08. The 5′ ends of Drosophila heat shock genes in chromatin are hypersensitive to DNase I in NATURE
  • 2011-03. The developmental transcriptome of Drosophila melanogaster in NATURE
  • 2009-02. ChIP-seq accurately predicts tissue-specific activity of enhancers in NATURE
  • 2007-03. Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome in NATURE GENETICS
  • 2009-05. Histone modifications at human enhancers reflect global cell-type-specific gene expression in NATURE
  • 2010-09. Mediator and cohesin connect gene expression and chromatin architecture in NATURE
  • 2009-11. Combinatorial binding predicts spatio-temporal cis-regulatory activity in NATURE
  • 2007-11. Evolution of genes and genomes on the Drosophila phylogeny in NATURE
  • 2009-08. H3.3/H2A.Z double variant–containing nucleosomes mark 'nucleosome-free regions' of active promoters and other regulatory regions in NATURE GENETICS
  • 2010-05. Widespread transcription at neuronal activity-regulated enhancers in NATURE
  • 2010-08. Discovery and characterization of chromatin states for systematic annotation of the human genome in NATURE BIOTECHNOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nature09725

    DOI

    http://dx.doi.org/10.1038/nature09725

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1023233286

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/21179089


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Genetics", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Line", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Chromatin", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Chromatin Immunoprecipitation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Chromosomal Proteins, Non-Histone", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Deoxyribonuclease I", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Drosophila Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Drosophila melanogaster", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Exons", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Expression Regulation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genes, Insect", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genome, Insect", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Histones", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Molecular Sequence Annotation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Oligonucleotide Array Sequence Analysis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Polycomb Repressive Complex 1", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "RNA", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Sequence Analysis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Transcription, Genetic", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Boston Children's Hospital", 
              "id": "https://www.grid.ac/institutes/grid.2515.3", 
              "name": [
                "Center for Biomedical Informatics, Harvard Medical School, Boston, Massachusetts 02115, USA", 
                "Children\u2019s Hospital Informatics Program, Boston, Massachusetts 02115, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kharchenko", 
            "givenName": "Peter V.", 
            "id": "sg:person.01050662451.08", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01050662451.08"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Harvard University", 
              "id": "https://www.grid.ac/institutes/grid.38142.3c", 
              "name": [
                "Division of Genetics, Department of Medicine, Brigham & Women\u2019s Hospital, Boston, Massachusetts 02115, USA", 
                "Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Alekseyenko", 
            "givenName": "Artyom A.", 
            "id": "sg:person.0622547614.38", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0622547614.38"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Rutgers University", 
              "id": "https://www.grid.ac/institutes/grid.430387.b", 
              "name": [
                "Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey 08854, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Schwartz", 
            "givenName": "Yuri B.", 
            "id": "sg:person.0755352173.41", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0755352173.41"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of California, Berkeley", 
              "id": "https://www.grid.ac/institutes/grid.47840.3f", 
              "name": [
                "Department of Molecular and Cell Biology, University of California at Berkeley, and Department of Genome Dynamics, Lawrence Berkeley National Lab, Berkeley, California 94720, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Minoda", 
            "givenName": "Aki", 
            "id": "sg:person.01116775651.73", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01116775651.73"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Washington University in St. Louis", 
              "id": "https://www.grid.ac/institutes/grid.4367.6", 
              "name": [
                "Department of Biology, Washington University in St Louis, St Louis, Missouri 63130, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Riddle", 
            "givenName": "Nicole C.", 
            "id": "sg:person.01275476351.87", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01275476351.87"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Broad Institute", 
              "id": "https://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "MIT Computer Science and Artificial Intelligence Laboratory, Cambridge, Massachusetts 02139, USA", 
                "Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ernst", 
            "givenName": "Jason", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Washington", 
              "id": "https://www.grid.ac/institutes/grid.34477.33", 
              "name": [
                "Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sabo", 
            "givenName": "Peter J.", 
            "id": "sg:person.013651751207.65", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013651751207.65"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Brown University", 
              "id": "https://www.grid.ac/institutes/grid.40263.33", 
              "name": [
                "Division of Genetics, Department of Medicine, Brigham & Women\u2019s Hospital, Boston, Massachusetts 02115, USA", 
                "Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA", 
                "Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, Rhode Island 02906, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Larschan", 
            "givenName": "Erica", 
            "id": "sg:person.0632310457.53", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0632310457.53"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Harvard University", 
              "id": "https://www.grid.ac/institutes/grid.38142.3c", 
              "name": [
                "Division of Genetics, Department of Medicine, Brigham & Women\u2019s Hospital, Boston, Massachusetts 02115, USA", 
                "Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gorchakov", 
            "givenName": "Andrey A.", 
            "id": "sg:person.01234537416.78", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01234537416.78"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Washington University in St. Louis", 
              "id": "https://www.grid.ac/institutes/grid.4367.6", 
              "name": [
                "Department of Biology, Washington University in St Louis, St Louis, Missouri 63130, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gu", 
            "givenName": "Tingting", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Rutgers University", 
              "id": "https://www.grid.ac/institutes/grid.430387.b", 
              "name": [
                "Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey 08854, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Linder-Basso", 
            "givenName": "Daniela", 
            "id": "sg:person.01242346452.33", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242346452.33"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Harvard University", 
              "id": "https://www.grid.ac/institutes/grid.38142.3c", 
              "name": [
                "Division of Genetics, Department of Medicine, Brigham & Women\u2019s Hospital, Boston, Massachusetts 02115, USA", 
                "Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Plachetka", 
            "givenName": "Annette", 
            "id": "sg:person.0742675757.47", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0742675757.47"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Rutgers University", 
              "id": "https://www.grid.ac/institutes/grid.430387.b", 
              "name": [
                "Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey 08854, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Shanower", 
            "givenName": "Gregory", 
            "id": "sg:person.01365655201.06", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01365655201.06"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Boston Children's Hospital", 
              "id": "https://www.grid.ac/institutes/grid.2515.3", 
              "name": [
                "Center for Biomedical Informatics, Harvard Medical School, Boston, Massachusetts 02115, USA", 
                "Children\u2019s Hospital Informatics Program, Boston, Massachusetts 02115, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tolstorukov", 
            "givenName": "Michael Y.", 
            "id": "sg:person.011724267107.41", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011724267107.41"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Harvard University", 
              "id": "https://www.grid.ac/institutes/grid.38142.3c", 
              "name": [
                "Center for Biomedical Informatics, Harvard Medical School, Boston, Massachusetts 02115, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Luquette", 
            "givenName": "Lovelace J.", 
            "id": "sg:person.01252725367.32", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01252725367.32"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Harvard University", 
              "id": "https://www.grid.ac/institutes/grid.38142.3c", 
              "name": [
                "Center for Biomedical Informatics, Harvard Medical School, Boston, Massachusetts 02115, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Xi", 
            "givenName": "Ruibin", 
            "id": "sg:person.01025726540.95", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01025726540.95"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Brigham and Women's Hospital", 
              "id": "https://www.grid.ac/institutes/grid.62560.37", 
              "name": [
                "Center for Biomedical Informatics, Harvard Medical School, Boston, Massachusetts 02115, USA", 
                "Division of Genetics, Department of Medicine, Brigham & Women\u2019s Hospital, Boston, Massachusetts 02115, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Jung", 
            "givenName": "Youngsook L.", 
            "id": "sg:person.01173352757.54", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01173352757.54"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Boston University", 
              "id": "https://www.grid.ac/institutes/grid.189504.1", 
              "name": [
                "Center for Biomedical Informatics, Harvard Medical School, Boston, Massachusetts 02115, USA", 
                "Graduate Program in Bioinformatics, Boston University, Boston, Massachusetts 02115, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Park", 
            "givenName": "Richard W.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Boston University", 
              "id": "https://www.grid.ac/institutes/grid.189504.1", 
              "name": [
                "Center for Biomedical Informatics, Harvard Medical School, Boston, Massachusetts 02115, USA", 
                "Graduate Program in Bioinformatics, Boston University, Boston, Massachusetts 02115, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bishop", 
            "givenName": "Eric P.", 
            "id": "sg:person.01336751775.11", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01336751775.11"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Washington", 
              "id": "https://www.grid.ac/institutes/grid.34477.33", 
              "name": [
                "Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Canfield", 
            "givenName": "Theresa K.", 
            "id": "sg:person.01207266134.23", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01207266134.23"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Washington", 
              "id": "https://www.grid.ac/institutes/grid.34477.33", 
              "name": [
                "Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sandstrom", 
            "givenName": "Richard", 
            "id": "sg:person.0630137266.64", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630137266.64"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Washington", 
              "id": "https://www.grid.ac/institutes/grid.34477.33", 
              "name": [
                "Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Thurman", 
            "givenName": "Robert E.", 
            "id": "sg:person.01037622036.25", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01037622036.25"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Duke University Hospital", 
              "id": "https://www.grid.ac/institutes/grid.189509.c", 
              "name": [
                "Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "MacAlpine", 
            "givenName": "David M.", 
            "id": "sg:person.01341552040.69", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01341552040.69"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Washington", 
              "id": "https://www.grid.ac/institutes/grid.34477.33", 
              "name": [
                "Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA", 
                "Department of Medicine, University of Washington, Seattle, Washington 98195, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Stamatoyannopoulos", 
            "givenName": "John A.", 
            "id": "sg:person.01107035267.40", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01107035267.40"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Broad Institute", 
              "id": "https://www.grid.ac/institutes/grid.66859.34", 
              "name": [
                "MIT Computer Science and Artificial Intelligence Laboratory, Cambridge, Massachusetts 02139, USA", 
                "Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kellis", 
            "givenName": "Manolis", 
            "id": "sg:person.0767056320.07", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0767056320.07"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Washington University in St. Louis", 
              "id": "https://www.grid.ac/institutes/grid.4367.6", 
              "name": [
                "Department of Biology, Washington University in St Louis, St Louis, Missouri 63130, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Elgin", 
            "givenName": "Sarah C. R.", 
            "id": "sg:person.01004466250.29", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01004466250.29"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Harvard University", 
              "id": "https://www.grid.ac/institutes/grid.38142.3c", 
              "name": [
                "Division of Genetics, Department of Medicine, Brigham & Women\u2019s Hospital, Boston, Massachusetts 02115, USA", 
                "Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kuroda", 
            "givenName": "Mitzi I.", 
            "id": "sg:person.01347452651.31", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01347452651.31"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Rutgers University", 
              "id": "https://www.grid.ac/institutes/grid.430387.b", 
              "name": [
                "Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey 08854, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Pirrotta", 
            "givenName": "Vincenzo", 
            "id": "sg:person.0624046551.15", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0624046551.15"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of California, Berkeley", 
              "id": "https://www.grid.ac/institutes/grid.47840.3f", 
              "name": [
                "Department of Molecular and Cell Biology, University of California at Berkeley, and Department of Genome Dynamics, Lawrence Berkeley National Lab, Berkeley, California 94720, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Karpen", 
            "givenName": "Gary H.", 
            "id": "sg:person.0672161751.93", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0672161751.93"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Brigham and Women's Hospital", 
              "id": "https://www.grid.ac/institutes/grid.62560.37", 
              "name": [
                "Center for Biomedical Informatics, Harvard Medical School, Boston, Massachusetts 02115, USA", 
                "Children\u2019s Hospital Informatics Program, Boston, Massachusetts 02115, USA", 
                "Division of Genetics, Department of Medicine, Brigham & Women\u2019s Hospital, Boston, Massachusetts 02115, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Park", 
            "givenName": "Peter J.", 
            "id": "sg:person.01024612701.33", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01024612701.33"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1016/j.cell.2007.05.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002139821"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gr.112961.110", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002625924"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1937-6448(08)01801-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003114920"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09380", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004695178", 
              "https://doi.org/10.1038/nature09380"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09380", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004695178", 
              "https://doi.org/10.1038/nature09380"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2010.09.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006611187"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2010.03.019", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006770285"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nsmb.1972", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008987895", 
              "https://doi.org/10.1038/nsmb.1972"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pgen.1000805", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009531383"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1966", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010017851", 
              "https://doi.org/10.1038/ng1966"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2007.01.015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012044562"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.gde.2008.01.010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012407502"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.110149597", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013374054"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1162228", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013963804"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1162228", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013963804"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1198374", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014130276"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkn788", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014344525"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09033", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016906145", 
              "https://doi.org/10.1038/nature09033"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09033", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016906145", 
              "https://doi.org/10.1038/nature09033"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.409", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018502205", 
              "https://doi.org/10.1038/ng.409"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/286854a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019703219", 
              "https://doi.org/10.1038/286854a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.287.5461.2185", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019737566"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature07730", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021031479", 
              "https://doi.org/10.1038/nature07730"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1186777", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021233025"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1186777", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021233025"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature07829", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023938796", 
              "https://doi.org/10.1038/nature07829"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature07829", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023938796", 
              "https://doi.org/10.1038/nature07829"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2007.08.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024374939"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08531", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026284611", 
              "https://doi.org/10.1038/nature08531"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08531", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026284611", 
              "https://doi.org/10.1038/nature08531"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1817", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026324467", 
              "https://doi.org/10.1038/ng1817"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1817", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026324467", 
              "https://doi.org/10.1038/ng1817"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/btp152", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027639615"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2009.08.021", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028040594"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.1246404", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030113964"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2006.02.041", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030427346"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09715", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031240109", 
              "https://doi.org/10.1038/nature09715"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gr.110098.110", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031330457"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/gb-2009-10-7-r80", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031389085", 
              "https://doi.org/10.1186/gb-2009-10-7-r80"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.1313", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034214816", 
              "https://doi.org/10.1038/nmeth.1313"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.1313", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034214816", 
              "https://doi.org/10.1038/nmeth.1313"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature01411", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034943207", 
              "https://doi.org/10.1038/nature01411"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature01411", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034943207", 
              "https://doi.org/10.1038/nature01411"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gr.097873.109", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036947984"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(79)90095-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038564384"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature06341", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040143850", 
              "https://doi.org/10.1038/nature06341"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ceb.2008.03.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041347486"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gr.087619.108", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041897544"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1181421", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044122107"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1196914", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044555726"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pbio.1000013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045483703"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pbio.0030328", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049469158"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pbio.0030328", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049469158"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.1662", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050061238", 
              "https://doi.org/10.1038/nbt.1662"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00412-007-0129-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050759605", 
              "https://doi.org/10.1007/s00412-007-0129-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00412-007-0129-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050759605", 
              "https://doi.org/10.1007/s00412-007-0129-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/sqb.1974.038.01.024", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060404319"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1139816", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062455315"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1079607957", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2011-03", 
        "datePublishedReg": "2011-03-01", 
        "description": "Chromatin is composed of DNA and a variety of modified histones and non-histone proteins, which have an impact on cell differentiation, gene regulation and other key cellular processes. Here we present a genome-wide chromatin landscape for Drosophila melanogaster based on eighteen histone modifications, summarized by nine prevalent combinatorial patterns. Integrative analysis with other data (non-histone chromatin proteins, DNase I hypersensitivity, GRO-Seq reads produced by engaged polymerase, short/long RNA products) reveals discrete characteristics of chromosomes, genes, regulatory elements and other functional domains. We find that active genes display distinct chromatin signatures that are correlated with disparate gene lengths, exon patterns, regulatory functions and genomic contexts. We also demonstrate a diversity of signatures among Polycomb targets that include a subset with paused polymerase. This systematic profiling and integrative analysis of chromatin signatures provides insights into how genomic elements are regulated, and will serve as a resource for future experimental investigations of genome structure and function.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/nature09725", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2699344", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2691234", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.3100105", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2529276", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2519756", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2518518", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2635302", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2669374", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2668772", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2691243", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1018957", 
            "issn": [
              "0090-0028", 
              "1476-4687"
            ], 
            "name": "Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "7339", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "471"
          }
        ], 
        "name": "Comprehensive analysis of the chromatin landscape in Drosophila melanogaster", 
        "pagination": "480", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "6eb04b7b7dd809317a033b5fa655b8b27e775c5311dbc05b4862f36852253c2f"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "21179089"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "0410462"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/nature09725"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1023233286"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/nature09725", 
          "https://app.dimensions.ai/details/publication/pub.1023233286"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T23:31", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8693_00000550.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/nature09725"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nature09725'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nature09725'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nature09725'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nature09725'


     

    This table displays all metadata directly associated to this object as RDF triples.

    569 TRIPLES      21 PREDICATES      97 URIs      41 LITERALS      29 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/nature09725 schema:about N1b0a7a30f98542099170d02ebf5f47ef
    2 N284b298826de4c28947233509748e8c6
    3 N29415b3b69e746a0836e676c8330f46c
    4 N2d82e7a62b2b47a4b78ce9868ac922c0
    5 N2f47458e7ce845e295785c6c6a28c02e
    6 N3bab40b585014d5fbbaf914bc16a045a
    7 N4444ebbdb2d74d98ba4293a468d8d831
    8 N7491158da87c424c90c3296c8a1413ef
    9 N754675e1e4574b158b7b3e455dedf04d
    10 N8aa1cf2b7f444964b91ed98e1e9ee72a
    11 N9546aaf2ee9d4dd3a95a73cce06c73f0
    12 N95e1bef8503b429a88bfe9032d305c4c
    13 N9ff7f3a111b745f3a3a5262e3f57fe68
    14 Naaecd8a00361439888e77b54f9f82da4
    15 Nb6adf3b46abe4c3d93fc583becac608b
    16 Nbe0a8d43e41f45c8b0827735d0e7ac88
    17 Nc1b0867373ae49028102deb8c415e19a
    18 Nc308163f314b49c293372a014a12996a
    19 Nc781e5f3b2bc4201b492313630c481f8
    20 Nd57cf7144ec84f4cb1a34c9ad7e878b4
    21 anzsrc-for:06
    22 anzsrc-for:0604
    23 schema:author N19a4c086697e46ea9b15e496f090de1e
    24 schema:citation sg:pub.10.1007/s00412-007-0129-1
    25 sg:pub.10.1038/286854a0
    26 sg:pub.10.1038/nature01411
    27 sg:pub.10.1038/nature06341
    28 sg:pub.10.1038/nature07730
    29 sg:pub.10.1038/nature07829
    30 sg:pub.10.1038/nature08531
    31 sg:pub.10.1038/nature09033
    32 sg:pub.10.1038/nature09380
    33 sg:pub.10.1038/nature09715
    34 sg:pub.10.1038/nbt.1662
    35 sg:pub.10.1038/ng.409
    36 sg:pub.10.1038/ng1817
    37 sg:pub.10.1038/ng1966
    38 sg:pub.10.1038/nmeth.1313
    39 sg:pub.10.1038/nsmb.1972
    40 sg:pub.10.1186/gb-2009-10-7-r80
    41 https://app.dimensions.ai/details/publication/pub.1079607957
    42 https://doi.org/10.1016/0092-8674(79)90095-3
    43 https://doi.org/10.1016/j.ceb.2008.03.002
    44 https://doi.org/10.1016/j.cell.2006.02.041
    45 https://doi.org/10.1016/j.cell.2007.01.015
    46 https://doi.org/10.1016/j.cell.2007.05.009
    47 https://doi.org/10.1016/j.cell.2010.09.009
    48 https://doi.org/10.1016/j.gde.2008.01.010
    49 https://doi.org/10.1016/j.immuni.2009.08.021
    50 https://doi.org/10.1016/j.molcel.2007.08.011
    51 https://doi.org/10.1016/j.molcel.2010.03.019
    52 https://doi.org/10.1016/s1937-6448(08)01801-7
    53 https://doi.org/10.1073/pnas.110149597
    54 https://doi.org/10.1093/bioinformatics/btp152
    55 https://doi.org/10.1093/nar/gkn788
    56 https://doi.org/10.1101/gad.1246404
    57 https://doi.org/10.1101/gr.087619.108
    58 https://doi.org/10.1101/gr.097873.109
    59 https://doi.org/10.1101/gr.110098.110
    60 https://doi.org/10.1101/gr.112961.110
    61 https://doi.org/10.1101/sqb.1974.038.01.024
    62 https://doi.org/10.1126/science.1139816
    63 https://doi.org/10.1126/science.1162228
    64 https://doi.org/10.1126/science.1181421
    65 https://doi.org/10.1126/science.1186777
    66 https://doi.org/10.1126/science.1196914
    67 https://doi.org/10.1126/science.1198374
    68 https://doi.org/10.1126/science.287.5461.2185
    69 https://doi.org/10.1371/journal.pbio.0030328
    70 https://doi.org/10.1371/journal.pbio.1000013
    71 https://doi.org/10.1371/journal.pgen.1000805
    72 schema:datePublished 2011-03
    73 schema:datePublishedReg 2011-03-01
    74 schema:description Chromatin is composed of DNA and a variety of modified histones and non-histone proteins, which have an impact on cell differentiation, gene regulation and other key cellular processes. Here we present a genome-wide chromatin landscape for Drosophila melanogaster based on eighteen histone modifications, summarized by nine prevalent combinatorial patterns. Integrative analysis with other data (non-histone chromatin proteins, DNase I hypersensitivity, GRO-Seq reads produced by engaged polymerase, short/long RNA products) reveals discrete characteristics of chromosomes, genes, regulatory elements and other functional domains. We find that active genes display distinct chromatin signatures that are correlated with disparate gene lengths, exon patterns, regulatory functions and genomic contexts. We also demonstrate a diversity of signatures among Polycomb targets that include a subset with paused polymerase. This systematic profiling and integrative analysis of chromatin signatures provides insights into how genomic elements are regulated, and will serve as a resource for future experimental investigations of genome structure and function.
    75 schema:genre research_article
    76 schema:inLanguage en
    77 schema:isAccessibleForFree true
    78 schema:isPartOf N396fba99778640cfb28dbbbd1f0751dc
    79 Ncb2fab74d9c34d68a541ad3337bab8f6
    80 sg:journal.1018957
    81 schema:name Comprehensive analysis of the chromatin landscape in Drosophila melanogaster
    82 schema:pagination 480
    83 schema:productId N0c0f480dd6d54d29badf58639bf47a71
    84 N27d0d52ebc5640898b0daafe183b7048
    85 N296d4aa280f843beb8225ce63d0c0ee4
    86 N5966e0845ffb48cc97f30d22e8a74684
    87 Ncf23fe6064734a049176951c240661d6
    88 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023233286
    89 https://doi.org/10.1038/nature09725
    90 schema:sdDatePublished 2019-04-10T23:31
    91 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    92 schema:sdPublisher Nbc6dc3eee6db467bb01e6e3232eb444f
    93 schema:url https://www.nature.com/articles/nature09725
    94 sgo:license sg:explorer/license/
    95 sgo:sdDataset articles
    96 rdf:type schema:ScholarlyArticle
    97 N06c478e6256645f89d91853482df7fed rdf:first sg:person.013651751207.65
    98 rdf:rest N905c2bcce02c408ab904a7f1338bf75a
    99 N0c0f480dd6d54d29badf58639bf47a71 schema:name dimensions_id
    100 schema:value pub.1023233286
    101 rdf:type schema:PropertyValue
    102 N19a4c086697e46ea9b15e496f090de1e rdf:first sg:person.01050662451.08
    103 rdf:rest Ncceb63b1f4be451ababfd5fc8819f73d
    104 N1b0a7a30f98542099170d02ebf5f47ef schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    105 schema:name Drosophila Proteins
    106 rdf:type schema:DefinedTerm
    107 N21966f10da864265ad51dbb256d8c852 schema:affiliation https://www.grid.ac/institutes/grid.189504.1
    108 schema:familyName Park
    109 schema:givenName Richard W.
    110 rdf:type schema:Person
    111 N27d0d52ebc5640898b0daafe183b7048 schema:name pubmed_id
    112 schema:value 21179089
    113 rdf:type schema:PropertyValue
    114 N284b298826de4c28947233509748e8c6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    115 schema:name Histones
    116 rdf:type schema:DefinedTerm
    117 N29415b3b69e746a0836e676c8330f46c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    118 schema:name Deoxyribonuclease I
    119 rdf:type schema:DefinedTerm
    120 N296d4aa280f843beb8225ce63d0c0ee4 schema:name doi
    121 schema:value 10.1038/nature09725
    122 rdf:type schema:PropertyValue
    123 N2d82e7a62b2b47a4b78ce9868ac922c0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    124 schema:name Polycomb Repressive Complex 1
    125 rdf:type schema:DefinedTerm
    126 N2eafd3525a054f799f92ecf5bad4db9c rdf:first sg:person.01173352757.54
    127 rdf:rest Nf2f4304f328b4958af3db1ff71174e41
    128 N2f47458e7ce845e295785c6c6a28c02e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    129 schema:name Molecular Sequence Annotation
    130 rdf:type schema:DefinedTerm
    131 N325706ca1ee74647bba1cef4b32cc786 rdf:first sg:person.01275476351.87
    132 rdf:rest N480b033eb3c0430ca9cc2c466882cb72
    133 N396fba99778640cfb28dbbbd1f0751dc schema:issueNumber 7339
    134 rdf:type schema:PublicationIssue
    135 N3bab40b585014d5fbbaf914bc16a045a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    136 schema:name RNA
    137 rdf:type schema:DefinedTerm
    138 N3f239a08ffb640ba9ff741338af2c5d5 rdf:first sg:person.01242346452.33
    139 rdf:rest Na62d8027bbc9413d8e102f340756988f
    140 N402cbacc706743db911ae80fddb9bef4 rdf:first sg:person.0630137266.64
    141 rdf:rest N9a4e62a8b6b44d09a0aa0a7e3a65d304
    142 N4444ebbdb2d74d98ba4293a468d8d831 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    143 schema:name Chromatin Immunoprecipitation
    144 rdf:type schema:DefinedTerm
    145 N480b033eb3c0430ca9cc2c466882cb72 rdf:first Nd236ba59dd74446d9137179c359477f2
    146 rdf:rest N06c478e6256645f89d91853482df7fed
    147 N4b21792000de4c7994f2e3d58f630b84 rdf:first sg:person.01116775651.73
    148 rdf:rest N325706ca1ee74647bba1cef4b32cc786
    149 N4d93a2fe2891465294a9d5a46e397c32 rdf:first sg:person.01207266134.23
    150 rdf:rest N402cbacc706743db911ae80fddb9bef4
    151 N5966e0845ffb48cc97f30d22e8a74684 schema:name readcube_id
    152 schema:value 6eb04b7b7dd809317a033b5fa655b8b27e775c5311dbc05b4862f36852253c2f
    153 rdf:type schema:PropertyValue
    154 N5bd939ed5ca049ac9ed58157dfd0e273 rdf:first Na76d8977b8cc4eceb1dc0d012a308dbd
    155 rdf:rest N3f239a08ffb640ba9ff741338af2c5d5
    156 N5bf0d4231e4d424cadd7fb64826be191 rdf:first sg:person.0672161751.93
    157 rdf:rest Nac1cd6f95b994365b14dc5b8703d6c7f
    158 N6b6b3b9afbac4b74b967a65664a955fb rdf:first sg:person.01365655201.06
    159 rdf:rest N94b60a44e0e143fab5494a0e80916891
    160 N6e255b3353fc41f39bd10e3a510f6d49 rdf:first sg:person.01341552040.69
    161 rdf:rest N94efc0ff5371495598ab4f2002a39cd1
    162 N7491158da87c424c90c3296c8a1413ef schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    163 schema:name Transcription, Genetic
    164 rdf:type schema:DefinedTerm
    165 N754675e1e4574b158b7b3e455dedf04d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    166 schema:name Drosophila melanogaster
    167 rdf:type schema:DefinedTerm
    168 N75c0c93502ad4412a35182300facf754 rdf:first sg:person.0755352173.41
    169 rdf:rest N4b21792000de4c7994f2e3d58f630b84
    170 N7b942895692d493781c1f06876abc407 rdf:first sg:person.01234537416.78
    171 rdf:rest N5bd939ed5ca049ac9ed58157dfd0e273
    172 N85fc53e9d84c4f34b26bd06e3eecfa8a rdf:first sg:person.01025726540.95
    173 rdf:rest N2eafd3525a054f799f92ecf5bad4db9c
    174 N8aa1cf2b7f444964b91ed98e1e9ee72a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    175 schema:name Sequence Analysis
    176 rdf:type schema:DefinedTerm
    177 N905c2bcce02c408ab904a7f1338bf75a rdf:first sg:person.0632310457.53
    178 rdf:rest N7b942895692d493781c1f06876abc407
    179 N94b60a44e0e143fab5494a0e80916891 rdf:first sg:person.011724267107.41
    180 rdf:rest Ncf3437e8637745789889304f6436f0d6
    181 N94efc0ff5371495598ab4f2002a39cd1 rdf:first sg:person.01107035267.40
    182 rdf:rest Nf28308c3300f472b87ba9d797a733767
    183 N9546aaf2ee9d4dd3a95a73cce06c73f0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    184 schema:name Cell Line
    185 rdf:type schema:DefinedTerm
    186 N95e1bef8503b429a88bfe9032d305c4c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    187 schema:name Oligonucleotide Array Sequence Analysis
    188 rdf:type schema:DefinedTerm
    189 N9751cab32bb44b3dabc49171e721b1c9 rdf:first sg:person.0624046551.15
    190 rdf:rest N5bf0d4231e4d424cadd7fb64826be191
    191 N9a4e62a8b6b44d09a0aa0a7e3a65d304 rdf:first sg:person.01037622036.25
    192 rdf:rest N6e255b3353fc41f39bd10e3a510f6d49
    193 N9ff7f3a111b745f3a3a5262e3f57fe68 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    194 schema:name Chromatin
    195 rdf:type schema:DefinedTerm
    196 Na62d8027bbc9413d8e102f340756988f rdf:first sg:person.0742675757.47
    197 rdf:rest N6b6b3b9afbac4b74b967a65664a955fb
    198 Na76d8977b8cc4eceb1dc0d012a308dbd schema:affiliation https://www.grid.ac/institutes/grid.4367.6
    199 schema:familyName Gu
    200 schema:givenName Tingting
    201 rdf:type schema:Person
    202 Naaecd8a00361439888e77b54f9f82da4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    203 schema:name Genome, Insect
    204 rdf:type schema:DefinedTerm
    205 Nac1cd6f95b994365b14dc5b8703d6c7f rdf:first sg:person.01024612701.33
    206 rdf:rest rdf:nil
    207 Nb6adf3b46abe4c3d93fc583becac608b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    208 schema:name Genes, Insect
    209 rdf:type schema:DefinedTerm
    210 Nb94c678cca0749d3ab789d4868034976 rdf:first sg:person.01336751775.11
    211 rdf:rest N4d93a2fe2891465294a9d5a46e397c32
    212 Nbc6dc3eee6db467bb01e6e3232eb444f schema:name Springer Nature - SN SciGraph project
    213 rdf:type schema:Organization
    214 Nbe0a8d43e41f45c8b0827735d0e7ac88 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    215 schema:name Animals
    216 rdf:type schema:DefinedTerm
    217 Nbffdc4fb4bcb456eb7ed97437d99af47 rdf:first sg:person.01347452651.31
    218 rdf:rest N9751cab32bb44b3dabc49171e721b1c9
    219 Nc1b0867373ae49028102deb8c415e19a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    220 schema:name Chromosomal Proteins, Non-Histone
    221 rdf:type schema:DefinedTerm
    222 Nc308163f314b49c293372a014a12996a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    223 schema:name Male
    224 rdf:type schema:DefinedTerm
    225 Nc781e5f3b2bc4201b492313630c481f8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    226 schema:name Exons
    227 rdf:type schema:DefinedTerm
    228 Ncb2fab74d9c34d68a541ad3337bab8f6 schema:volumeNumber 471
    229 rdf:type schema:PublicationVolume
    230 Ncceb63b1f4be451ababfd5fc8819f73d rdf:first sg:person.0622547614.38
    231 rdf:rest N75c0c93502ad4412a35182300facf754
    232 Ncf23fe6064734a049176951c240661d6 schema:name nlm_unique_id
    233 schema:value 0410462
    234 rdf:type schema:PropertyValue
    235 Ncf3437e8637745789889304f6436f0d6 rdf:first sg:person.01252725367.32
    236 rdf:rest N85fc53e9d84c4f34b26bd06e3eecfa8a
    237 Nd236ba59dd74446d9137179c359477f2 schema:affiliation https://www.grid.ac/institutes/grid.66859.34
    238 schema:familyName Ernst
    239 schema:givenName Jason
    240 rdf:type schema:Person
    241 Nd57cf7144ec84f4cb1a34c9ad7e878b4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    242 schema:name Gene Expression Regulation
    243 rdf:type schema:DefinedTerm
    244 Ne5b04b60cc41491ba24e9bd4215e5481 rdf:first sg:person.01004466250.29
    245 rdf:rest Nbffdc4fb4bcb456eb7ed97437d99af47
    246 Nf28308c3300f472b87ba9d797a733767 rdf:first sg:person.0767056320.07
    247 rdf:rest Ne5b04b60cc41491ba24e9bd4215e5481
    248 Nf2f4304f328b4958af3db1ff71174e41 rdf:first N21966f10da864265ad51dbb256d8c852
    249 rdf:rest Nb94c678cca0749d3ab789d4868034976
    250 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    251 schema:name Biological Sciences
    252 rdf:type schema:DefinedTerm
    253 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
    254 schema:name Genetics
    255 rdf:type schema:DefinedTerm
    256 sg:grant.2518518 http://pending.schema.org/fundedItem sg:pub.10.1038/nature09725
    257 rdf:type schema:MonetaryGrant
    258 sg:grant.2519756 http://pending.schema.org/fundedItem sg:pub.10.1038/nature09725
    259 rdf:type schema:MonetaryGrant
    260 sg:grant.2529276 http://pending.schema.org/fundedItem sg:pub.10.1038/nature09725
    261 rdf:type schema:MonetaryGrant
    262 sg:grant.2635302 http://pending.schema.org/fundedItem sg:pub.10.1038/nature09725
    263 rdf:type schema:MonetaryGrant
    264 sg:grant.2668772 http://pending.schema.org/fundedItem sg:pub.10.1038/nature09725
    265 rdf:type schema:MonetaryGrant
    266 sg:grant.2669374 http://pending.schema.org/fundedItem sg:pub.10.1038/nature09725
    267 rdf:type schema:MonetaryGrant
    268 sg:grant.2691234 http://pending.schema.org/fundedItem sg:pub.10.1038/nature09725
    269 rdf:type schema:MonetaryGrant
    270 sg:grant.2691243 http://pending.schema.org/fundedItem sg:pub.10.1038/nature09725
    271 rdf:type schema:MonetaryGrant
    272 sg:grant.2699344 http://pending.schema.org/fundedItem sg:pub.10.1038/nature09725
    273 rdf:type schema:MonetaryGrant
    274 sg:grant.3100105 http://pending.schema.org/fundedItem sg:pub.10.1038/nature09725
    275 rdf:type schema:MonetaryGrant
    276 sg:journal.1018957 schema:issn 0090-0028
    277 1476-4687
    278 schema:name Nature
    279 rdf:type schema:Periodical
    280 sg:person.01004466250.29 schema:affiliation https://www.grid.ac/institutes/grid.4367.6
    281 schema:familyName Elgin
    282 schema:givenName Sarah C. R.
    283 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01004466250.29
    284 rdf:type schema:Person
    285 sg:person.01024612701.33 schema:affiliation https://www.grid.ac/institutes/grid.62560.37
    286 schema:familyName Park
    287 schema:givenName Peter J.
    288 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01024612701.33
    289 rdf:type schema:Person
    290 sg:person.01025726540.95 schema:affiliation https://www.grid.ac/institutes/grid.38142.3c
    291 schema:familyName Xi
    292 schema:givenName Ruibin
    293 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01025726540.95
    294 rdf:type schema:Person
    295 sg:person.01037622036.25 schema:affiliation https://www.grid.ac/institutes/grid.34477.33
    296 schema:familyName Thurman
    297 schema:givenName Robert E.
    298 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01037622036.25
    299 rdf:type schema:Person
    300 sg:person.01050662451.08 schema:affiliation https://www.grid.ac/institutes/grid.2515.3
    301 schema:familyName Kharchenko
    302 schema:givenName Peter V.
    303 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01050662451.08
    304 rdf:type schema:Person
    305 sg:person.01107035267.40 schema:affiliation https://www.grid.ac/institutes/grid.34477.33
    306 schema:familyName Stamatoyannopoulos
    307 schema:givenName John A.
    308 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01107035267.40
    309 rdf:type schema:Person
    310 sg:person.01116775651.73 schema:affiliation https://www.grid.ac/institutes/grid.47840.3f
    311 schema:familyName Minoda
    312 schema:givenName Aki
    313 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01116775651.73
    314 rdf:type schema:Person
    315 sg:person.011724267107.41 schema:affiliation https://www.grid.ac/institutes/grid.2515.3
    316 schema:familyName Tolstorukov
    317 schema:givenName Michael Y.
    318 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011724267107.41
    319 rdf:type schema:Person
    320 sg:person.01173352757.54 schema:affiliation https://www.grid.ac/institutes/grid.62560.37
    321 schema:familyName Jung
    322 schema:givenName Youngsook L.
    323 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01173352757.54
    324 rdf:type schema:Person
    325 sg:person.01207266134.23 schema:affiliation https://www.grid.ac/institutes/grid.34477.33
    326 schema:familyName Canfield
    327 schema:givenName Theresa K.
    328 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01207266134.23
    329 rdf:type schema:Person
    330 sg:person.01234537416.78 schema:affiliation https://www.grid.ac/institutes/grid.38142.3c
    331 schema:familyName Gorchakov
    332 schema:givenName Andrey A.
    333 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01234537416.78
    334 rdf:type schema:Person
    335 sg:person.01242346452.33 schema:affiliation https://www.grid.ac/institutes/grid.430387.b
    336 schema:familyName Linder-Basso
    337 schema:givenName Daniela
    338 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242346452.33
    339 rdf:type schema:Person
    340 sg:person.01252725367.32 schema:affiliation https://www.grid.ac/institutes/grid.38142.3c
    341 schema:familyName Luquette
    342 schema:givenName Lovelace J.
    343 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01252725367.32
    344 rdf:type schema:Person
    345 sg:person.01275476351.87 schema:affiliation https://www.grid.ac/institutes/grid.4367.6
    346 schema:familyName Riddle
    347 schema:givenName Nicole C.
    348 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01275476351.87
    349 rdf:type schema:Person
    350 sg:person.01336751775.11 schema:affiliation https://www.grid.ac/institutes/grid.189504.1
    351 schema:familyName Bishop
    352 schema:givenName Eric P.
    353 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01336751775.11
    354 rdf:type schema:Person
    355 sg:person.01341552040.69 schema:affiliation https://www.grid.ac/institutes/grid.189509.c
    356 schema:familyName MacAlpine
    357 schema:givenName David M.
    358 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01341552040.69
    359 rdf:type schema:Person
    360 sg:person.01347452651.31 schema:affiliation https://www.grid.ac/institutes/grid.38142.3c
    361 schema:familyName Kuroda
    362 schema:givenName Mitzi I.
    363 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01347452651.31
    364 rdf:type schema:Person
    365 sg:person.013651751207.65 schema:affiliation https://www.grid.ac/institutes/grid.34477.33
    366 schema:familyName Sabo
    367 schema:givenName Peter J.
    368 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013651751207.65
    369 rdf:type schema:Person
    370 sg:person.01365655201.06 schema:affiliation https://www.grid.ac/institutes/grid.430387.b
    371 schema:familyName Shanower
    372 schema:givenName Gregory
    373 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01365655201.06
    374 rdf:type schema:Person
    375 sg:person.0622547614.38 schema:affiliation https://www.grid.ac/institutes/grid.38142.3c
    376 schema:familyName Alekseyenko
    377 schema:givenName Artyom A.
    378 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0622547614.38
    379 rdf:type schema:Person
    380 sg:person.0624046551.15 schema:affiliation https://www.grid.ac/institutes/grid.430387.b
    381 schema:familyName Pirrotta
    382 schema:givenName Vincenzo
    383 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0624046551.15
    384 rdf:type schema:Person
    385 sg:person.0630137266.64 schema:affiliation https://www.grid.ac/institutes/grid.34477.33
    386 schema:familyName Sandstrom
    387 schema:givenName Richard
    388 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630137266.64
    389 rdf:type schema:Person
    390 sg:person.0632310457.53 schema:affiliation https://www.grid.ac/institutes/grid.40263.33
    391 schema:familyName Larschan
    392 schema:givenName Erica
    393 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0632310457.53
    394 rdf:type schema:Person
    395 sg:person.0672161751.93 schema:affiliation https://www.grid.ac/institutes/grid.47840.3f
    396 schema:familyName Karpen
    397 schema:givenName Gary H.
    398 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0672161751.93
    399 rdf:type schema:Person
    400 sg:person.0742675757.47 schema:affiliation https://www.grid.ac/institutes/grid.38142.3c
    401 schema:familyName Plachetka
    402 schema:givenName Annette
    403 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0742675757.47
    404 rdf:type schema:Person
    405 sg:person.0755352173.41 schema:affiliation https://www.grid.ac/institutes/grid.430387.b
    406 schema:familyName Schwartz
    407 schema:givenName Yuri B.
    408 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0755352173.41
    409 rdf:type schema:Person
    410 sg:person.0767056320.07 schema:affiliation https://www.grid.ac/institutes/grid.66859.34
    411 schema:familyName Kellis
    412 schema:givenName Manolis
    413 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0767056320.07
    414 rdf:type schema:Person
    415 sg:pub.10.1007/s00412-007-0129-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050759605
    416 https://doi.org/10.1007/s00412-007-0129-1
    417 rdf:type schema:CreativeWork
    418 sg:pub.10.1038/286854a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019703219
    419 https://doi.org/10.1038/286854a0
    420 rdf:type schema:CreativeWork
    421 sg:pub.10.1038/nature01411 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034943207
    422 https://doi.org/10.1038/nature01411
    423 rdf:type schema:CreativeWork
    424 sg:pub.10.1038/nature06341 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040143850
    425 https://doi.org/10.1038/nature06341
    426 rdf:type schema:CreativeWork
    427 sg:pub.10.1038/nature07730 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021031479
    428 https://doi.org/10.1038/nature07730
    429 rdf:type schema:CreativeWork
    430 sg:pub.10.1038/nature07829 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023938796
    431 https://doi.org/10.1038/nature07829
    432 rdf:type schema:CreativeWork
    433 sg:pub.10.1038/nature08531 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026284611
    434 https://doi.org/10.1038/nature08531
    435 rdf:type schema:CreativeWork
    436 sg:pub.10.1038/nature09033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016906145
    437 https://doi.org/10.1038/nature09033
    438 rdf:type schema:CreativeWork
    439 sg:pub.10.1038/nature09380 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004695178
    440 https://doi.org/10.1038/nature09380
    441 rdf:type schema:CreativeWork
    442 sg:pub.10.1038/nature09715 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031240109
    443 https://doi.org/10.1038/nature09715
    444 rdf:type schema:CreativeWork
    445 sg:pub.10.1038/nbt.1662 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050061238
    446 https://doi.org/10.1038/nbt.1662
    447 rdf:type schema:CreativeWork
    448 sg:pub.10.1038/ng.409 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018502205
    449 https://doi.org/10.1038/ng.409
    450 rdf:type schema:CreativeWork
    451 sg:pub.10.1038/ng1817 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026324467
    452 https://doi.org/10.1038/ng1817
    453 rdf:type schema:CreativeWork
    454 sg:pub.10.1038/ng1966 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010017851
    455 https://doi.org/10.1038/ng1966
    456 rdf:type schema:CreativeWork
    457 sg:pub.10.1038/nmeth.1313 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034214816
    458 https://doi.org/10.1038/nmeth.1313
    459 rdf:type schema:CreativeWork
    460 sg:pub.10.1038/nsmb.1972 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008987895
    461 https://doi.org/10.1038/nsmb.1972
    462 rdf:type schema:CreativeWork
    463 sg:pub.10.1186/gb-2009-10-7-r80 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031389085
    464 https://doi.org/10.1186/gb-2009-10-7-r80
    465 rdf:type schema:CreativeWork
    466 https://app.dimensions.ai/details/publication/pub.1079607957 schema:CreativeWork
    467 https://doi.org/10.1016/0092-8674(79)90095-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038564384
    468 rdf:type schema:CreativeWork
    469 https://doi.org/10.1016/j.ceb.2008.03.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041347486
    470 rdf:type schema:CreativeWork
    471 https://doi.org/10.1016/j.cell.2006.02.041 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030427346
    472 rdf:type schema:CreativeWork
    473 https://doi.org/10.1016/j.cell.2007.01.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012044562
    474 rdf:type schema:CreativeWork
    475 https://doi.org/10.1016/j.cell.2007.05.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002139821
    476 rdf:type schema:CreativeWork
    477 https://doi.org/10.1016/j.cell.2010.09.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006611187
    478 rdf:type schema:CreativeWork
    479 https://doi.org/10.1016/j.gde.2008.01.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012407502
    480 rdf:type schema:CreativeWork
    481 https://doi.org/10.1016/j.immuni.2009.08.021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028040594
    482 rdf:type schema:CreativeWork
    483 https://doi.org/10.1016/j.molcel.2007.08.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024374939
    484 rdf:type schema:CreativeWork
    485 https://doi.org/10.1016/j.molcel.2010.03.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006770285
    486 rdf:type schema:CreativeWork
    487 https://doi.org/10.1016/s1937-6448(08)01801-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003114920
    488 rdf:type schema:CreativeWork
    489 https://doi.org/10.1073/pnas.110149597 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013374054
    490 rdf:type schema:CreativeWork
    491 https://doi.org/10.1093/bioinformatics/btp152 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027639615
    492 rdf:type schema:CreativeWork
    493 https://doi.org/10.1093/nar/gkn788 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014344525
    494 rdf:type schema:CreativeWork
    495 https://doi.org/10.1101/gad.1246404 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030113964
    496 rdf:type schema:CreativeWork
    497 https://doi.org/10.1101/gr.087619.108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041897544
    498 rdf:type schema:CreativeWork
    499 https://doi.org/10.1101/gr.097873.109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036947984
    500 rdf:type schema:CreativeWork
    501 https://doi.org/10.1101/gr.110098.110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031330457
    502 rdf:type schema:CreativeWork
    503 https://doi.org/10.1101/gr.112961.110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002625924
    504 rdf:type schema:CreativeWork
    505 https://doi.org/10.1101/sqb.1974.038.01.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060404319
    506 rdf:type schema:CreativeWork
    507 https://doi.org/10.1126/science.1139816 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062455315
    508 rdf:type schema:CreativeWork
    509 https://doi.org/10.1126/science.1162228 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013963804
    510 rdf:type schema:CreativeWork
    511 https://doi.org/10.1126/science.1181421 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044122107
    512 rdf:type schema:CreativeWork
    513 https://doi.org/10.1126/science.1186777 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021233025
    514 rdf:type schema:CreativeWork
    515 https://doi.org/10.1126/science.1196914 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044555726
    516 rdf:type schema:CreativeWork
    517 https://doi.org/10.1126/science.1198374 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014130276
    518 rdf:type schema:CreativeWork
    519 https://doi.org/10.1126/science.287.5461.2185 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019737566
    520 rdf:type schema:CreativeWork
    521 https://doi.org/10.1371/journal.pbio.0030328 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049469158
    522 rdf:type schema:CreativeWork
    523 https://doi.org/10.1371/journal.pbio.1000013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045483703
    524 rdf:type schema:CreativeWork
    525 https://doi.org/10.1371/journal.pgen.1000805 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009531383
    526 rdf:type schema:CreativeWork
    527 https://www.grid.ac/institutes/grid.189504.1 schema:alternateName Boston University
    528 schema:name Center for Biomedical Informatics, Harvard Medical School, Boston, Massachusetts 02115, USA
    529 Graduate Program in Bioinformatics, Boston University, Boston, Massachusetts 02115, USA
    530 rdf:type schema:Organization
    531 https://www.grid.ac/institutes/grid.189509.c schema:alternateName Duke University Hospital
    532 schema:name Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    533 rdf:type schema:Organization
    534 https://www.grid.ac/institutes/grid.2515.3 schema:alternateName Boston Children's Hospital
    535 schema:name Center for Biomedical Informatics, Harvard Medical School, Boston, Massachusetts 02115, USA
    536 Children’s Hospital Informatics Program, Boston, Massachusetts 02115, USA
    537 rdf:type schema:Organization
    538 https://www.grid.ac/institutes/grid.34477.33 schema:alternateName University of Washington
    539 schema:name Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA
    540 Department of Medicine, University of Washington, Seattle, Washington 98195, USA
    541 rdf:type schema:Organization
    542 https://www.grid.ac/institutes/grid.38142.3c schema:alternateName Harvard University
    543 schema:name Center for Biomedical Informatics, Harvard Medical School, Boston, Massachusetts 02115, USA
    544 Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    545 Division of Genetics, Department of Medicine, Brigham & Women’s Hospital, Boston, Massachusetts 02115, USA
    546 rdf:type schema:Organization
    547 https://www.grid.ac/institutes/grid.40263.33 schema:alternateName Brown University
    548 schema:name Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    549 Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, Rhode Island 02906, USA
    550 Division of Genetics, Department of Medicine, Brigham & Women’s Hospital, Boston, Massachusetts 02115, USA
    551 rdf:type schema:Organization
    552 https://www.grid.ac/institutes/grid.430387.b schema:alternateName Rutgers University
    553 schema:name Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey 08854, USA
    554 rdf:type schema:Organization
    555 https://www.grid.ac/institutes/grid.4367.6 schema:alternateName Washington University in St. Louis
    556 schema:name Department of Biology, Washington University in St Louis, St Louis, Missouri 63130, USA
    557 rdf:type schema:Organization
    558 https://www.grid.ac/institutes/grid.47840.3f schema:alternateName University of California, Berkeley
    559 schema:name Department of Molecular and Cell Biology, University of California at Berkeley, and Department of Genome Dynamics, Lawrence Berkeley National Lab, Berkeley, California 94720, USA
    560 rdf:type schema:Organization
    561 https://www.grid.ac/institutes/grid.62560.37 schema:alternateName Brigham and Women's Hospital
    562 schema:name Center for Biomedical Informatics, Harvard Medical School, Boston, Massachusetts 02115, USA
    563 Children’s Hospital Informatics Program, Boston, Massachusetts 02115, USA
    564 Division of Genetics, Department of Medicine, Brigham & Women’s Hospital, Boston, Massachusetts 02115, USA
    565 rdf:type schema:Organization
    566 https://www.grid.ac/institutes/grid.66859.34 schema:alternateName Broad Institute
    567 schema:name Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA
    568 MIT Computer Science and Artificial Intelligence Laboratory, Cambridge, Massachusetts 02139, USA
    569 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...