Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-01-06

AUTHORS

Mariela Jaskelioff, Florian L. Muller, Ji-Hye Paik, Emily Thomas, Shan Jiang, Andrew C. Adams, Ergun Sahin, Maria Kost-Alimova, Alexei Protopopov, Juan Cadiñanos, James W. Horner, Eleftheria Maratos-Flier, Ronald A. DePinho

ABSTRACT

An ageing world population has fuelled interest in regenerative remedies that may stem declining organ function and maintain fitness. Unanswered is whether elimination of intrinsic instigators driving age-associated degeneration can reverse, as opposed to simply arrest, various afflictions of the aged. Such instigators include progressively damaged genomes. Telomerase-deficient mice have served as a model system to study the adverse cellular and organismal consequences of wide-spread endogenous DNA damage signalling activation in vivo. Telomere loss and uncapping provokes progressive tissue atrophy, stem cell depletion, organ system failure and impaired tissue injury responses. Here, we sought to determine whether entrenched multi-system degeneration in adult mice with severe telomere dysfunction can be halted or possibly reversed by reactivation of endogenous telomerase activity. To this end, we engineered a knock-in allele encoding a 4-hydroxytamoxifen (4-OHT)-inducible telomerase reverse transcriptase-oestrogen receptor (TERT-ER) under transcriptional control of the endogenous TERT promoter. Homozygous TERT-ER mice have short dysfunctional telomeres and sustain increased DNA damage signalling and classical degenerative phenotypes upon successive generational matings and advancing age. Telomerase reactivation in such late generation TERT-ER mice extends telomeres, reduces DNA damage signalling and associated cellular checkpoint responses, allows resumption of proliferation in quiescent cultures, and eliminates degenerative phenotypes across multiple organs including testes, spleens and intestines. Notably, somatic telomerase reactivation reversed neurodegeneration with restoration of proliferating Sox2(+) neural progenitors, Dcx(+) newborn neurons, and Olig2(+) oligodendrocyte populations. Consistent with the integral role of subventricular zone neural progenitors in generation and maintenance of olfactory bulb interneurons, this wave of telomerase-dependent neurogenesis resulted in alleviation of hyposmia and recovery of innate olfactory avoidance responses. Accumulating evidence implicating telomere damage as a driver of age-associated organ decline and disease risk and the marked reversal of systemic degenerative phenotypes in adult mice observed here support the development of regenerative strategies designed to restore telomere integrity. More... »

PAGES

102

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature09603

DOI

http://dx.doi.org/10.1038/nature09603

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1011608783

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21113150


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aging", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Avoidance Learning", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Brain", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Differentiation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Proliferation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cells, Cultured", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Damage", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Enzyme Activation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Enzyme Reactivators", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred C57BL", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Models, Animal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Myelin Sheath", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neural Stem Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Organ Size", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phenotype", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Estrogen", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Recombinant Fusion Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Regenerative Medicine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Smell", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tamoxifen", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Telomerase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Telomere", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "name": [
            "Belfer Institute for Applied Cancer Science and Departments of Medical Oncology, Medicine and Genetics, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jaskelioff", 
        "givenName": "Mariela", 
        "id": "sg:person.0710677435.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0710677435.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Belfer Institute for Applied Cancer Science and Departments of Medical Oncology, Medicine and Genetics, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Muller", 
        "givenName": "Florian L.", 
        "id": "sg:person.01177077352.93", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01177077352.93"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Belfer Institute for Applied Cancer Science and Departments of Medical Oncology, Medicine and Genetics, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Paik", 
        "givenName": "Ji-Hye", 
        "id": "sg:person.016407503417.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016407503417.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Belfer Institute for Applied Cancer Science and Departments of Medical Oncology, Medicine and Genetics, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Thomas", 
        "givenName": "Emily", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Belfer Institute for Applied Cancer Science and Departments of Medical Oncology, Medicine and Genetics, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jiang", 
        "givenName": "Shan", 
        "id": "sg:person.01317316473.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01317316473.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Division of Endocrinology, Diabetes & Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Adams", 
        "givenName": "Andrew C.", 
        "id": "sg:person.01271071122.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01271071122.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Belfer Institute for Applied Cancer Science and Departments of Medical Oncology, Medicine and Genetics, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sahin", 
        "givenName": "Ergun", 
        "id": "sg:person.011365476077.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011365476077.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Belfer Institute for Applied Cancer Science and Departments of Medical Oncology, Medicine and Genetics, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kost-Alimova", 
        "givenName": "Maria", 
        "id": "sg:person.013752634307.79", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013752634307.79"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Belfer Institute for Applied Cancer Science and Departments of Medical Oncology, Medicine and Genetics, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Protopopov", 
        "givenName": "Alexei", 
        "id": "sg:person.015400534317.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015400534317.99"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Belfer Institute for Applied Cancer Science and Departments of Medical Oncology, Medicine and Genetics, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cadi\u00f1anos", 
        "givenName": "Juan", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Belfer Institute for Applied Cancer Science and Departments of Medical Oncology, Medicine and Genetics, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Horner", 
        "givenName": "James W.", 
        "id": "sg:person.0642025573.57", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0642025573.57"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Division of Endocrinology, Diabetes & Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Maratos-Flier", 
        "givenName": "Eleftheria", 
        "id": "sg:person.01024372422.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01024372422.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Belfer Institute for Applied Cancer Science and Departments of Medical Oncology, Medicine and Genetics, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "DePinho", 
        "givenName": "Ronald A.", 
        "id": "sg:person.012617437444.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012617437444.09"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1056/nejmra0804615", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000521354"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.92.15.6991", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000689979"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.96.16.9230", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001403828"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.otc.2008.09.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002966367"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(01)80006-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004868239"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature01385", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004995747", 
          "https://doi.org/10.1038/nature01385"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature01385", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004995747", 
          "https://doi.org/10.1038/nature01385"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2008.09.034", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010479328"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1749-6632.2009.04373.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010550193"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1749-6632.2009.04373.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010550193"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature06281", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011029519", 
          "https://doi.org/10.1038/nature06281"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.3606-09.2009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012214228"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/embo-reports/kve174", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014329505"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrm2241", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014449689", 
          "https://doi.org/10.1038/nrm2241"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.pneurobio.2009.07.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014534420"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/carcin/bgp268", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015845298"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/carcin/bgp268", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015845298"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.2751-04.2004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016596945"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.01354-06", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017030776"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08982", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017093183", 
          "https://doi.org/10.1038/nature08982"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08982", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017093183", 
          "https://doi.org/10.1038/nature08982"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11064-009-0044-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021002217", 
          "https://doi.org/10.1007/s11064-009-0044-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11064-009-0044-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021002217", 
          "https://doi.org/10.1007/s11064-009-0044-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1937", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022872782", 
          "https://doi.org/10.1038/ng1937"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1937", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022872782", 
          "https://doi.org/10.1038/ng1937"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biochi.2007.09.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022979667"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1117/12.763858", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031963719"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.stem.2009.09.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036343109"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.3836-09.2009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037287880"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1474-9726.2008.00369.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037291431"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/dev.01215", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037669734"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(03)12384-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039145859"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(03)12384-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039145859"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuroscience.2006.11.052", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039554818"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/71630", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042917021", 
          "https://doi.org/10.1038/71630"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/71630", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042917021", 
          "https://doi.org/10.1038/71630"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0091-679x(01)64024-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044329591"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.00339-07", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048832946"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.279.5349.349", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051728512"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1044-7431(03)00103-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051930576"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1044-7431(03)00103-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051930576"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0031-9384(01)00530-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052076778"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/rej.2009.0847", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059308200"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2011-01-06", 
    "datePublishedReg": "2011-01-06", 
    "description": "An ageing world population has fuelled interest in regenerative remedies that may stem declining organ function and maintain fitness. Unanswered is whether elimination of intrinsic instigators driving age-associated degeneration can reverse, as opposed to simply arrest, various afflictions of the aged. Such instigators include progressively damaged genomes. Telomerase-deficient mice have served as a model system to study the adverse cellular and organismal consequences of wide-spread endogenous DNA damage signalling activation in vivo. Telomere loss and uncapping provokes progressive tissue atrophy, stem cell depletion, organ system failure and impaired tissue injury responses. Here, we sought to determine whether entrenched multi-system degeneration in adult mice with severe telomere dysfunction can be halted or possibly reversed by reactivation of endogenous telomerase activity. To this end, we engineered a knock-in allele encoding a 4-hydroxytamoxifen (4-OHT)-inducible telomerase reverse transcriptase-oestrogen receptor (TERT-ER) under transcriptional control of the endogenous TERT promoter. Homozygous TERT-ER mice have short dysfunctional telomeres and sustain increased DNA damage signalling and classical degenerative phenotypes upon successive generational matings and advancing age. Telomerase reactivation in such late generation TERT-ER mice extends telomeres, reduces DNA damage signalling and associated cellular checkpoint responses, allows resumption of proliferation in quiescent cultures, and eliminates degenerative phenotypes across multiple organs including testes, spleens and intestines. Notably, somatic telomerase reactivation reversed neurodegeneration with restoration of proliferating Sox2(+) neural progenitors, Dcx(+) newborn neurons, and Olig2(+) oligodendrocyte populations. Consistent with the integral role of subventricular zone neural progenitors in generation and maintenance of olfactory bulb interneurons, this wave of telomerase-dependent neurogenesis resulted in alleviation of hyposmia and recovery of innate olfactory avoidance responses. Accumulating evidence implicating telomere damage as a driver of age-associated organ decline and disease risk and the marked reversal of systemic degenerative phenotypes in adult mice observed here support the development of regenerative strategies designed to restore telomere integrity.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/nature09603", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2689137", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2474710", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0090-0028", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "7328", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "469"
      }
    ], 
    "name": "Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice", 
    "pagination": "102", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "374f4dc23b7edbc4d41be191c1c62f0be63ae79f2632129894ea42f043599e43"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "21113150"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0410462"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/nature09603"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1011608783"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/nature09603", 
      "https://app.dimensions.ai/details/publication/pub.1011608783"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T18:09", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8675_00000434.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/nature09603"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nature09603'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nature09603'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nature09603'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nature09603'


 

This table displays all metadata directly associated to this object as RDF triples.

383 TRIPLES      21 PREDICATES      86 URIs      44 LITERALS      33 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/nature09603 schema:about N0173a677bb8644eea50415753dccdb86
2 N0a30b6a72858475ca0e77e94a4865d58
3 N17c09bb88ee645dd8473846585e87aef
4 N262169984a82455d8f635fcddb24bbb4
5 N33a021b403074155b87221f8956d0601
6 N3bb22a3535414dd4adb812295211ded7
7 N5aa1fa76c39648db90843f9a4b225d45
8 N60a88e536acf4539a302850cae8a8f76
9 N6c50f2dd17564a869f0668b7c5a91d35
10 N6fb76a18ec6d47419b8891cdc52440a5
11 N6ff75dae244e4f0083d9d513a0d8f6a8
12 N78326c862a9e4ee583f1f8092c3853e6
13 N8594a4cffc57450a908eecfba0aeb132
14 N873941e7dd9b4617b9ecf22cb9104e2b
15 N9ac2724e7fb541c69776d1182771a3c6
16 Nb63e98937ce2495aa160a8603cc8627b
17 Nb653893fc5fd4fb9b86af849b0a90149
18 Nb8abc9a6814d4118a9ef6c969e07b328
19 Nbb9d680c5f6845769eb6b80e21935f9c
20 Nc5d49b4efdd14fb583a36382af3b5e49
21 Ncbdf1c7e6ac64b9aa4216b787e678529
22 Nd2b956cc686747bcad04dcc22d58b546
23 Ne80c3abf5671409da151273934c9c0c3
24 Nea62a058d6364661ae01c6d5c97f2fd7
25 anzsrc-for:06
26 anzsrc-for:0604
27 schema:author N0755617a42554c3b8ff8871f4839eeef
28 schema:citation sg:pub.10.1007/s11064-009-0044-3
29 sg:pub.10.1038/71630
30 sg:pub.10.1038/nature01385
31 sg:pub.10.1038/nature06281
32 sg:pub.10.1038/nature08982
33 sg:pub.10.1038/ng1937
34 sg:pub.10.1038/nrm2241
35 https://doi.org/10.1016/j.biochi.2007.09.006
36 https://doi.org/10.1016/j.cell.2008.09.034
37 https://doi.org/10.1016/j.neuroscience.2006.11.052
38 https://doi.org/10.1016/j.otc.2008.09.001
39 https://doi.org/10.1016/j.pneurobio.2009.07.003
40 https://doi.org/10.1016/j.stem.2009.09.013
41 https://doi.org/10.1016/s0031-9384(01)00530-3
42 https://doi.org/10.1016/s0091-679x(01)64024-x
43 https://doi.org/10.1016/s0092-8674(01)80006-4
44 https://doi.org/10.1016/s0140-6736(03)12384-7
45 https://doi.org/10.1016/s1044-7431(03)00103-9
46 https://doi.org/10.1056/nejmra0804615
47 https://doi.org/10.1073/pnas.92.15.6991
48 https://doi.org/10.1073/pnas.96.16.9230
49 https://doi.org/10.1089/rej.2009.0847
50 https://doi.org/10.1093/carcin/bgp268
51 https://doi.org/10.1093/embo-reports/kve174
52 https://doi.org/10.1111/j.1474-9726.2008.00369.x
53 https://doi.org/10.1111/j.1749-6632.2009.04373.x
54 https://doi.org/10.1117/12.763858
55 https://doi.org/10.1126/science.279.5349.349
56 https://doi.org/10.1128/mcb.00339-07
57 https://doi.org/10.1128/mcb.01354-06
58 https://doi.org/10.1242/dev.01215
59 https://doi.org/10.1523/jneurosci.2751-04.2004
60 https://doi.org/10.1523/jneurosci.3606-09.2009
61 https://doi.org/10.1523/jneurosci.3836-09.2009
62 schema:datePublished 2011-01-06
63 schema:datePublishedReg 2011-01-06
64 schema:description An ageing world population has fuelled interest in regenerative remedies that may stem declining organ function and maintain fitness. Unanswered is whether elimination of intrinsic instigators driving age-associated degeneration can reverse, as opposed to simply arrest, various afflictions of the aged. Such instigators include progressively damaged genomes. Telomerase-deficient mice have served as a model system to study the adverse cellular and organismal consequences of wide-spread endogenous DNA damage signalling activation in vivo. Telomere loss and uncapping provokes progressive tissue atrophy, stem cell depletion, organ system failure and impaired tissue injury responses. Here, we sought to determine whether entrenched multi-system degeneration in adult mice with severe telomere dysfunction can be halted or possibly reversed by reactivation of endogenous telomerase activity. To this end, we engineered a knock-in allele encoding a 4-hydroxytamoxifen (4-OHT)-inducible telomerase reverse transcriptase-oestrogen receptor (TERT-ER) under transcriptional control of the endogenous TERT promoter. Homozygous TERT-ER mice have short dysfunctional telomeres and sustain increased DNA damage signalling and classical degenerative phenotypes upon successive generational matings and advancing age. Telomerase reactivation in such late generation TERT-ER mice extends telomeres, reduces DNA damage signalling and associated cellular checkpoint responses, allows resumption of proliferation in quiescent cultures, and eliminates degenerative phenotypes across multiple organs including testes, spleens and intestines. Notably, somatic telomerase reactivation reversed neurodegeneration with restoration of proliferating Sox2(+) neural progenitors, Dcx(+) newborn neurons, and Olig2(+) oligodendrocyte populations. Consistent with the integral role of subventricular zone neural progenitors in generation and maintenance of olfactory bulb interneurons, this wave of telomerase-dependent neurogenesis resulted in alleviation of hyposmia and recovery of innate olfactory avoidance responses. Accumulating evidence implicating telomere damage as a driver of age-associated organ decline and disease risk and the marked reversal of systemic degenerative phenotypes in adult mice observed here support the development of regenerative strategies designed to restore telomere integrity.
65 schema:genre research_article
66 schema:inLanguage en
67 schema:isAccessibleForFree true
68 schema:isPartOf N4eb06cef504b4dac9fa2a2af080a03d3
69 N6b79808a966c4cd0926159440b114fda
70 sg:journal.1018957
71 schema:name Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice
72 schema:pagination 102
73 schema:productId N0a70013b36454c78b91cd1578f1aa7fd
74 N2f39e688302445f4bec28ff39ecf51aa
75 N39b9467bf1fb4add94c1f63c9a41c0d7
76 N6b290248f06b47eab766895a0b65dded
77 Nac0a30c0efb1412697f56b22ae56f1a7
78 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011608783
79 https://doi.org/10.1038/nature09603
80 schema:sdDatePublished 2019-04-10T18:09
81 schema:sdLicense https://scigraph.springernature.com/explorer/license/
82 schema:sdPublisher N6036ae1622ff4b7a86887598e3167cd6
83 schema:url https://www.nature.com/articles/nature09603
84 sgo:license sg:explorer/license/
85 sgo:sdDataset articles
86 rdf:type schema:ScholarlyArticle
87 N0173a677bb8644eea50415753dccdb86 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
88 schema:name Aging
89 rdf:type schema:DefinedTerm
90 N0755617a42554c3b8ff8871f4839eeef rdf:first sg:person.0710677435.16
91 rdf:rest Na19954d4a40f49fa9f85785b34dcd006
92 N0a1d9b67ec5640f585df505817153c23 rdf:first sg:person.015400534317.99
93 rdf:rest N2ec4ab5923564ac5a176b19e6ec6b55f
94 N0a30b6a72858475ca0e77e94a4865d58 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Myelin Sheath
96 rdf:type schema:DefinedTerm
97 N0a70013b36454c78b91cd1578f1aa7fd schema:name doi
98 schema:value 10.1038/nature09603
99 rdf:type schema:PropertyValue
100 N0c21383d648a4e7197812e62f40a00f0 rdf:first sg:person.0642025573.57
101 rdf:rest N7d40d869af7a4751b8eb27f4a1c6eefd
102 N117c3cedddaf45e6b37f7a8413388af0 schema:affiliation Na2f47e5a27444a3eb7a2c58dba5ffdee
103 schema:familyName Cadiñanos
104 schema:givenName Juan
105 rdf:type schema:Person
106 N12d6c2a40147412f829b3ec3cb7251f2 rdf:first sg:person.013752634307.79
107 rdf:rest N0a1d9b67ec5640f585df505817153c23
108 N12e0a2cceeb447c2b57679dda5051365 schema:name Belfer Institute for Applied Cancer Science and Departments of Medical Oncology, Medicine and Genetics, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
109 rdf:type schema:Organization
110 N17c09bb88ee645dd8473846585e87aef schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Telomerase
112 rdf:type schema:DefinedTerm
113 N262169984a82455d8f635fcddb24bbb4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Tamoxifen
115 rdf:type schema:DefinedTerm
116 N26dd969fcb104065896890b1b29f32b4 schema:name Belfer Institute for Applied Cancer Science and Departments of Medical Oncology, Medicine and Genetics, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
117 rdf:type schema:Organization
118 N2ec4ab5923564ac5a176b19e6ec6b55f rdf:first N117c3cedddaf45e6b37f7a8413388af0
119 rdf:rest N0c21383d648a4e7197812e62f40a00f0
120 N2f39e688302445f4bec28ff39ecf51aa schema:name readcube_id
121 schema:value 374f4dc23b7edbc4d41be191c1c62f0be63ae79f2632129894ea42f043599e43
122 rdf:type schema:PropertyValue
123 N33a021b403074155b87221f8956d0601 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Regenerative Medicine
125 rdf:type schema:DefinedTerm
126 N36cbfe57730c43f391940c6d31a9f99c rdf:first sg:person.01317316473.06
127 rdf:rest N3e3547e3a31e45f49058cb71afa217f8
128 N39b9467bf1fb4add94c1f63c9a41c0d7 schema:name nlm_unique_id
129 schema:value 0410462
130 rdf:type schema:PropertyValue
131 N3bb22a3535414dd4adb812295211ded7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name DNA Damage
133 rdf:type schema:DefinedTerm
134 N3e3547e3a31e45f49058cb71afa217f8 rdf:first sg:person.01271071122.40
135 rdf:rest Nfeab57dd07f54dbcb1559a588bbce9fb
136 N469490d403ae4ad692ff75f9ed4a67d1 rdf:first sg:person.016407503417.17
137 rdf:rest Nf50fabb3f2e14ad280c2cea2338b030d
138 N4eb06cef504b4dac9fa2a2af080a03d3 schema:volumeNumber 469
139 rdf:type schema:PublicationVolume
140 N589063233dbe4a13b5645c4cf86a30b6 schema:name Division of Endocrinology, Diabetes & Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
141 rdf:type schema:Organization
142 N5aa1fa76c39648db90843f9a4b225d45 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Neural Stem Cells
144 rdf:type schema:DefinedTerm
145 N6036ae1622ff4b7a86887598e3167cd6 schema:name Springer Nature - SN SciGraph project
146 rdf:type schema:Organization
147 N60a88e536acf4539a302850cae8a8f76 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Enzyme Reactivators
149 rdf:type schema:DefinedTerm
150 N6b290248f06b47eab766895a0b65dded schema:name pubmed_id
151 schema:value 21113150
152 rdf:type schema:PropertyValue
153 N6b79808a966c4cd0926159440b114fda schema:issueNumber 7328
154 rdf:type schema:PublicationIssue
155 N6c50f2dd17564a869f0668b7c5a91d35 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Mice
157 rdf:type schema:DefinedTerm
158 N6fb76a18ec6d47419b8891cdc52440a5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Models, Animal
160 rdf:type schema:DefinedTerm
161 N6ff75dae244e4f0083d9d513a0d8f6a8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Mice, Inbred C57BL
163 rdf:type schema:DefinedTerm
164 N78326c862a9e4ee583f1f8092c3853e6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Animals
166 rdf:type schema:DefinedTerm
167 N7d40d869af7a4751b8eb27f4a1c6eefd rdf:first sg:person.01024372422.49
168 rdf:rest N9174765b565c43d0800270ddcd93ae00
169 N7e9e96fae752461a99043c3821be3c98 schema:name Belfer Institute for Applied Cancer Science and Departments of Medical Oncology, Medicine and Genetics, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
170 rdf:type schema:Organization
171 N8594a4cffc57450a908eecfba0aeb132 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Cell Differentiation
173 rdf:type schema:DefinedTerm
174 N873941e7dd9b4617b9ecf22cb9104e2b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name Cells, Cultured
176 rdf:type schema:DefinedTerm
177 N89176d259c294f449bd5e4de640e558e schema:name Belfer Institute for Applied Cancer Science and Departments of Medical Oncology, Medicine and Genetics, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
178 rdf:type schema:Organization
179 N8be0d3efb78849e79961641cd5583c05 schema:name Belfer Institute for Applied Cancer Science and Departments of Medical Oncology, Medicine and Genetics, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
180 rdf:type schema:Organization
181 N9174765b565c43d0800270ddcd93ae00 rdf:first sg:person.012617437444.09
182 rdf:rest rdf:nil
183 N9ac2724e7fb541c69776d1182771a3c6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
184 schema:name Brain
185 rdf:type schema:DefinedTerm
186 Na19954d4a40f49fa9f85785b34dcd006 rdf:first sg:person.01177077352.93
187 rdf:rest N469490d403ae4ad692ff75f9ed4a67d1
188 Na2f47e5a27444a3eb7a2c58dba5ffdee schema:name Belfer Institute for Applied Cancer Science and Departments of Medical Oncology, Medicine and Genetics, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
189 rdf:type schema:Organization
190 Nac0a30c0efb1412697f56b22ae56f1a7 schema:name dimensions_id
191 schema:value pub.1011608783
192 rdf:type schema:PropertyValue
193 Nb568d168eb1f4ccea4407030e81d3590 schema:name Division of Endocrinology, Diabetes & Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
194 rdf:type schema:Organization
195 Nb63e98937ce2495aa160a8603cc8627b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
196 schema:name Phenotype
197 rdf:type schema:DefinedTerm
198 Nb653893fc5fd4fb9b86af849b0a90149 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
199 schema:name Enzyme Activation
200 rdf:type schema:DefinedTerm
201 Nb76691ed6c2c4ce0873fed41646f959e schema:affiliation Nd0a51b53e9aa4a03ba32392d002b099b
202 schema:familyName Thomas
203 schema:givenName Emily
204 rdf:type schema:Person
205 Nb8abc9a6814d4118a9ef6c969e07b328 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
206 schema:name Cell Proliferation
207 rdf:type schema:DefinedTerm
208 Nbb9d680c5f6845769eb6b80e21935f9c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
209 schema:name Telomere
210 rdf:type schema:DefinedTerm
211 Nc0a4af86645c495e9ea57ecec1184df6 schema:name Belfer Institute for Applied Cancer Science and Departments of Medical Oncology, Medicine and Genetics, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
212 rdf:type schema:Organization
213 Nc5d49b4efdd14fb583a36382af3b5e49 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
214 schema:name Receptors, Estrogen
215 rdf:type schema:DefinedTerm
216 Nc61374c6759248aba9e347d438d697e9 schema:name Belfer Institute for Applied Cancer Science and Departments of Medical Oncology, Medicine and Genetics, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
217 rdf:type schema:Organization
218 Ncbdf1c7e6ac64b9aa4216b787e678529 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
219 schema:name Avoidance Learning
220 rdf:type schema:DefinedTerm
221 Nd0a51b53e9aa4a03ba32392d002b099b schema:name Belfer Institute for Applied Cancer Science and Departments of Medical Oncology, Medicine and Genetics, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
222 rdf:type schema:Organization
223 Nd2b956cc686747bcad04dcc22d58b546 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
224 schema:name Recombinant Fusion Proteins
225 rdf:type schema:DefinedTerm
226 Ne37fdda10dc045999afd28b3ef1e2d4c schema:name Belfer Institute for Applied Cancer Science and Departments of Medical Oncology, Medicine and Genetics, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
227 rdf:type schema:Organization
228 Ne80c3abf5671409da151273934c9c0c3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
229 schema:name Smell
230 rdf:type schema:DefinedTerm
231 Nea62a058d6364661ae01c6d5c97f2fd7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
232 schema:name Organ Size
233 rdf:type schema:DefinedTerm
234 Nedd1091ef50d40cda82cfc6a9e188d17 schema:name Belfer Institute for Applied Cancer Science and Departments of Medical Oncology, Medicine and Genetics, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
235 rdf:type schema:Organization
236 Nf50fabb3f2e14ad280c2cea2338b030d rdf:first Nb76691ed6c2c4ce0873fed41646f959e
237 rdf:rest N36cbfe57730c43f391940c6d31a9f99c
238 Nfeab57dd07f54dbcb1559a588bbce9fb rdf:first sg:person.011365476077.52
239 rdf:rest N12d6c2a40147412f829b3ec3cb7251f2
240 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
241 schema:name Biological Sciences
242 rdf:type schema:DefinedTerm
243 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
244 schema:name Genetics
245 rdf:type schema:DefinedTerm
246 sg:grant.2474710 http://pending.schema.org/fundedItem sg:pub.10.1038/nature09603
247 rdf:type schema:MonetaryGrant
248 sg:grant.2689137 http://pending.schema.org/fundedItem sg:pub.10.1038/nature09603
249 rdf:type schema:MonetaryGrant
250 sg:journal.1018957 schema:issn 0090-0028
251 1476-4687
252 schema:name Nature
253 rdf:type schema:Periodical
254 sg:person.01024372422.49 schema:affiliation Nb568d168eb1f4ccea4407030e81d3590
255 schema:familyName Maratos-Flier
256 schema:givenName Eleftheria
257 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01024372422.49
258 rdf:type schema:Person
259 sg:person.011365476077.52 schema:affiliation N7e9e96fae752461a99043c3821be3c98
260 schema:familyName Sahin
261 schema:givenName Ergun
262 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011365476077.52
263 rdf:type schema:Person
264 sg:person.01177077352.93 schema:affiliation N89176d259c294f449bd5e4de640e558e
265 schema:familyName Muller
266 schema:givenName Florian L.
267 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01177077352.93
268 rdf:type schema:Person
269 sg:person.012617437444.09 schema:affiliation Nedd1091ef50d40cda82cfc6a9e188d17
270 schema:familyName DePinho
271 schema:givenName Ronald A.
272 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012617437444.09
273 rdf:type schema:Person
274 sg:person.01271071122.40 schema:affiliation N589063233dbe4a13b5645c4cf86a30b6
275 schema:familyName Adams
276 schema:givenName Andrew C.
277 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01271071122.40
278 rdf:type schema:Person
279 sg:person.01317316473.06 schema:affiliation N26dd969fcb104065896890b1b29f32b4
280 schema:familyName Jiang
281 schema:givenName Shan
282 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01317316473.06
283 rdf:type schema:Person
284 sg:person.013752634307.79 schema:affiliation Ne37fdda10dc045999afd28b3ef1e2d4c
285 schema:familyName Kost-Alimova
286 schema:givenName Maria
287 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013752634307.79
288 rdf:type schema:Person
289 sg:person.015400534317.99 schema:affiliation Nc0a4af86645c495e9ea57ecec1184df6
290 schema:familyName Protopopov
291 schema:givenName Alexei
292 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015400534317.99
293 rdf:type schema:Person
294 sg:person.016407503417.17 schema:affiliation N8be0d3efb78849e79961641cd5583c05
295 schema:familyName Paik
296 schema:givenName Ji-Hye
297 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016407503417.17
298 rdf:type schema:Person
299 sg:person.0642025573.57 schema:affiliation Nc61374c6759248aba9e347d438d697e9
300 schema:familyName Horner
301 schema:givenName James W.
302 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0642025573.57
303 rdf:type schema:Person
304 sg:person.0710677435.16 schema:affiliation N12e0a2cceeb447c2b57679dda5051365
305 schema:familyName Jaskelioff
306 schema:givenName Mariela
307 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0710677435.16
308 rdf:type schema:Person
309 sg:pub.10.1007/s11064-009-0044-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021002217
310 https://doi.org/10.1007/s11064-009-0044-3
311 rdf:type schema:CreativeWork
312 sg:pub.10.1038/71630 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042917021
313 https://doi.org/10.1038/71630
314 rdf:type schema:CreativeWork
315 sg:pub.10.1038/nature01385 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004995747
316 https://doi.org/10.1038/nature01385
317 rdf:type schema:CreativeWork
318 sg:pub.10.1038/nature06281 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011029519
319 https://doi.org/10.1038/nature06281
320 rdf:type schema:CreativeWork
321 sg:pub.10.1038/nature08982 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017093183
322 https://doi.org/10.1038/nature08982
323 rdf:type schema:CreativeWork
324 sg:pub.10.1038/ng1937 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022872782
325 https://doi.org/10.1038/ng1937
326 rdf:type schema:CreativeWork
327 sg:pub.10.1038/nrm2241 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014449689
328 https://doi.org/10.1038/nrm2241
329 rdf:type schema:CreativeWork
330 https://doi.org/10.1016/j.biochi.2007.09.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022979667
331 rdf:type schema:CreativeWork
332 https://doi.org/10.1016/j.cell.2008.09.034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010479328
333 rdf:type schema:CreativeWork
334 https://doi.org/10.1016/j.neuroscience.2006.11.052 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039554818
335 rdf:type schema:CreativeWork
336 https://doi.org/10.1016/j.otc.2008.09.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002966367
337 rdf:type schema:CreativeWork
338 https://doi.org/10.1016/j.pneurobio.2009.07.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014534420
339 rdf:type schema:CreativeWork
340 https://doi.org/10.1016/j.stem.2009.09.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036343109
341 rdf:type schema:CreativeWork
342 https://doi.org/10.1016/s0031-9384(01)00530-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052076778
343 rdf:type schema:CreativeWork
344 https://doi.org/10.1016/s0091-679x(01)64024-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1044329591
345 rdf:type schema:CreativeWork
346 https://doi.org/10.1016/s0092-8674(01)80006-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004868239
347 rdf:type schema:CreativeWork
348 https://doi.org/10.1016/s0140-6736(03)12384-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039145859
349 rdf:type schema:CreativeWork
350 https://doi.org/10.1016/s1044-7431(03)00103-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051930576
351 rdf:type schema:CreativeWork
352 https://doi.org/10.1056/nejmra0804615 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000521354
353 rdf:type schema:CreativeWork
354 https://doi.org/10.1073/pnas.92.15.6991 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000689979
355 rdf:type schema:CreativeWork
356 https://doi.org/10.1073/pnas.96.16.9230 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001403828
357 rdf:type schema:CreativeWork
358 https://doi.org/10.1089/rej.2009.0847 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059308200
359 rdf:type schema:CreativeWork
360 https://doi.org/10.1093/carcin/bgp268 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015845298
361 rdf:type schema:CreativeWork
362 https://doi.org/10.1093/embo-reports/kve174 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014329505
363 rdf:type schema:CreativeWork
364 https://doi.org/10.1111/j.1474-9726.2008.00369.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1037291431
365 rdf:type schema:CreativeWork
366 https://doi.org/10.1111/j.1749-6632.2009.04373.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1010550193
367 rdf:type schema:CreativeWork
368 https://doi.org/10.1117/12.763858 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031963719
369 rdf:type schema:CreativeWork
370 https://doi.org/10.1126/science.279.5349.349 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051728512
371 rdf:type schema:CreativeWork
372 https://doi.org/10.1128/mcb.00339-07 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048832946
373 rdf:type schema:CreativeWork
374 https://doi.org/10.1128/mcb.01354-06 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017030776
375 rdf:type schema:CreativeWork
376 https://doi.org/10.1242/dev.01215 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037669734
377 rdf:type schema:CreativeWork
378 https://doi.org/10.1523/jneurosci.2751-04.2004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016596945
379 rdf:type schema:CreativeWork
380 https://doi.org/10.1523/jneurosci.3606-09.2009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012214228
381 rdf:type schema:CreativeWork
382 https://doi.org/10.1523/jneurosci.3836-09.2009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037287880
383 rdf:type schema:CreativeWork
 




Preview window. Press ESC to close (or click here)


...