Direct conversion of human fibroblasts to multilineage blood progenitors View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2010-11-25

AUTHORS

Eva Szabo, Shravanti Rampalli, Ruth M. Risueño, Angelique Schnerch, Ryan Mitchell, Aline Fiebig-Comyn, Marilyne Levadoux-Martin, Mickie Bhatia

ABSTRACT

As is the case for embryo-derived stem cells, application of reprogrammed human induced pluripotent stem cells is limited by our understanding of lineage specification. Here we demonstrate the ability to generate progenitors and mature cells of the haematopoietic fate directly from human dermal fibroblasts without establishing pluripotency. Ectopic expression of OCT4 (also called POU5F1)-activated haematopoietic transcription factors, together with specific cytokine treatment, allowed generation of cells expressing the pan-leukocyte marker CD45. These unique fibroblast-derived cells gave rise to granulocytic, monocytic, megakaryocytic and erythroid lineages, and demonstrated in vivo engraftment capacity. We note that adult haematopoietic programs are activated, consistent with bypassing the pluripotent state to generate blood fate: this is distinct from haematopoiesis involving pluripotent stem cells, where embryonic programs are activated. These findings demonstrate restoration of multipotency from human fibroblasts, and suggest an alternative approach to cellular reprogramming for autologous cell-replacement therapies that avoids complications associated with the use of human pluripotent stem cells. More... »

PAGES

521

References to SciGraph publications

  • 2007-10. Transcriptional control of granulocyte and monocyte development in ONCOGENE
  • 2009-10-18. A chemical platform for improved induction of human iPSCs in NATURE METHODS
  • 2005-12. Graft clonogenicity and intensity of pre-treatment: factors affecting outcome of autologous peripheral hematopoietic cell transplantation in patients with acute myeloid leukemia in first remission in BONE MARROW TRANSPLANTATION
  • 2006-11. Functional engraftment of human ES cell–derived dopaminergic neurons enriched by coculture with telomerase-immortalized midbrain astrocytes in NATURE MEDICINE
  • 2002-04. Hematopoiesis and stem cells: plasticity versus developmental heterogeneity in NATURE IMMUNOLOGY
  • 2004-07. Acute myeloid leukemia originates from a hierarchy of leukemic stem cell classes that differ in self-renewal capacity in NATURE IMMUNOLOGY
  • 2009-10. Direct reprogramming of human neural stem cells by OCT4 in NATURE
  • 2008-07-03. Dissecting direct reprogramming through integrative genomic analysis in NATURE
  • 2005-06. Role of Transcription Factors C/EBPα and PU.1 in Normal Hematopoiesis and Leukemia in INTERNATIONAL JOURNAL OF HEMATOLOGY
  • 1994-09. An early haematopoietic defect in mice lacking the transcription factor GATA-2 in NATURE
  • 1995-02. Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL in NATURE
  • 2007-12. p38 MAPK signaling regulates recruitment of Ash2L-containing methyltransferase complexes to specific genes during differentiation in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2010-02. Direct conversion of fibroblasts to functional neurons by defined factors in NATURE
  • 2009-11. Live cell imaging distinguishes bona fide human iPS cells from partially reprogrammed cells in NATURE BIOTECHNOLOGY
  • Journal

    TITLE

    Nature

    ISSUE

    7323

    VOLUME

    468

    Author Affiliations

    Related Patents

  • Methods For Production Of Platelets From Pluripotent Stem Cells And Compositions Thereof
  • Modified Polynucleotides For The Production Of Secreted Proteins
  • Engineered Nucleic Acids Encoding A Modified Erythropoietin And Their Expression
  • Modified Polynucleotides For The Production Of Biologics And Proteins Associated With Human Disease
  • Modified Polynucleotides Encoding Granulysin
  • Modified Polynucleotides For Treating Galactosylceramidase Protein Deficiency
  • Hematopoietic Precursor Cell Production By Programming
  • Megakaryocyte And Platelet Production From Stem Cells
  • Conversion Of Somatic Cells Into Functional Spinal Motor Neurons, And Methods And Uses Thereof
  • Modified Nucleosides, Nucleotides, And Nucleic Acids, And Uses Thereof
  • Rna Preparations Comprising Purified Modified Rna For Reprogramming Cells
  • Methods For The Identification And Isolation Of Hematopoietic Stem And Progenitor Cells
  • Modified Polynucleotides Encoding Cited4
  • Modified Polynucleotides For The Production Of Nuclear Proteins
  • Modified Polynucleotides Encoding Septin-4
  • Compositions And Methods For Reprogramming Eukaryotic Cells
  • Methods For Programming Differentiated Cells Into Hematopoietic Stem Cells
  • Modified Polynucleotides For Treating Protein Deficiency
  • Engineered Nucleic Acids And Methods Of Use Thereof
  • Modified Polynucleotides Encoding Apoptosis Inducing Factor 1
  • Delivery And Formulation Of Engineered Nucleic Acids
  • Direct Reprogramming Of Somatic Cells Into Neural Stem Cells
  • Modified Polynucleotides For The Production Of Proteins Associated With Human Disease
  • Delivery And Formulation Of Engineered Nucleic Acids
  • Engineered Nucleic Acids And Methods Of Use Thereof
  • Modified Polynucleotides Encoding Copper Metabolism (Murr1) Domain Containing 1
  • Engineered Nucleic Acids And Methods Of Use Thereof
  • Cell Populations, Methods Of Transdifferentiation And Methods Of Use Thereof
  • Formulation And Delivery Of Plga Microspheres
  • Bioengineered Liver Constructs And Methods Relating Thereto
  • Compositions And Methods For Reprogramming Eukaryotic Cells
  • Modified Polynucleotides Encoding Basic Helix-Loop-Helix Family Member E41
  • Modified Polynucleotides For The Production Of Proteins
  • Engineered Nucleic Acids And Methods Of Use Thereof
  • Engineered Nucleic Acids And Methods Of Use Thereof
  • Modified Polynucleotides For The Production Of Oncology-Related Proteins And Peptides
  • Engineered Nucleic Acids And Methods Of Use Thereof
  • Modified Polynucleotides For The Production Of G-Csf
  • Modified Nucleosides, Nucleotides, And Nucleic Acids, And Uses Thereof
  • Engineered Nucleic Acids And Methods Of Use Thereof
  • Terminally Modified Rna
  • Modified Polynucleotides For The Production Of Cosmetic Proteins And Peptides
  • Compositions And Methods For Reprogramming Hematopoietic Stem Cell Lineages
  • In Vivo Production Of Proteins
  • Modified Polynucleotides Encoding Siah E3 Ubiquitin Protein Ligase 1
  • Modified Polynucleotides Encoding Hepatitis A Virus Cellular Receptor 2
  • Dlin-Kc2-Dma Lipid Nanoparticle Delivery Of Modified Polynucleotides
  • Modified Polynucleotides For The Production Of Secreted Proteins
  • Rna Preparations Comprising Purified Modified Rna For Reprogramming Cells
  • Modified Polynucleotides For The Production Of Proteins
  • Method For Producing A Protein Of Interest In A Primate
  • Rna Preparations Comprising Purified Modified Rna For Reprogramming Cells
  • Modified Nucleosides, Nucleotides, And Nucleic Acids, And Uses Thereof
  • Cell Culture Platform For Single Cell Sorting And Enhanced Reprogramming Of Ipscs
  • Modified Polynucleotides For The Production Of Cytoplasmic And Cytoskeletal Proteins
  • Modified Polynucleotides For The Production Of Cytoplasmic And Cytoskeletal Proteins
  • Modified Polynucleotides Encoding Aquaporin-5
  • Modified Polynucleotides For The Production Of Proteins Associated With Blood And Lymphatic Disorders
  • Modified Polynucleotides Encoding Aryl Hydrocarbon Receptor Nuclear Translocator
  • Modified Polynucleotides For The Production Of Proteins Associated With Blood And Lymphatic Disorders
  • Modified Nucleosides, Nucleotides, And Nucleic Acids, And Uses Thereof
  • Rna Preparations Comprising Purified Modified Rna For Reprogramming Cells
  • Split Dose Administration
  • Modified Polynucleotides For The Production Of Biologics And Proteins Associated With Human Disease
  • Formulation And Delivery Of Plga Microspheres
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nature09591

    DOI

    http://dx.doi.org/10.1038/nature09591

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1018338276

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/21057492


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Genetics", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Culture Techniques", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Differentiation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Dermis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Fibroblasts", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Hematopoietic Stem Cells", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Pluripotent Stem Cells", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Stem Cells", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "McMaster University", 
              "id": "https://www.grid.ac/institutes/grid.25073.33", 
              "name": [
                "Stem Cell and Cancer Research Institute, McMaster University, Hamilton, Ontario, Canada L8N 3Z5"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Szabo", 
            "givenName": "Eva", 
            "id": "sg:person.01227770221.16", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01227770221.16"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "McMaster University", 
              "id": "https://www.grid.ac/institutes/grid.25073.33", 
              "name": [
                "Stem Cell and Cancer Research Institute, McMaster University, Hamilton, Ontario, Canada L8N 3Z5"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rampalli", 
            "givenName": "Shravanti", 
            "id": "sg:person.01032401276.20", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01032401276.20"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "McMaster University", 
              "id": "https://www.grid.ac/institutes/grid.25073.33", 
              "name": [
                "Stem Cell and Cancer Research Institute, McMaster University, Hamilton, Ontario, Canada L8N 3Z5"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Risue\u00f1o", 
            "givenName": "Ruth M.", 
            "id": "sg:person.0753172207.95", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0753172207.95"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "McMaster University", 
              "id": "https://www.grid.ac/institutes/grid.25073.33", 
              "name": [
                "Stem Cell and Cancer Research Institute, McMaster University, Hamilton, Ontario, Canada L8N 3Z5", 
                "Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada L8N 3Z5"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Schnerch", 
            "givenName": "Angelique", 
            "id": "sg:person.01366125721.19", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01366125721.19"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "McMaster University", 
              "id": "https://www.grid.ac/institutes/grid.25073.33", 
              "name": [
                "Stem Cell and Cancer Research Institute, McMaster University, Hamilton, Ontario, Canada L8N 3Z5", 
                "Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada L8N 3Z5"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mitchell", 
            "givenName": "Ryan", 
            "id": "sg:person.0666725721.71", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0666725721.71"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "McMaster University", 
              "id": "https://www.grid.ac/institutes/grid.25073.33", 
              "name": [
                "Stem Cell and Cancer Research Institute, McMaster University, Hamilton, Ontario, Canada L8N 3Z5"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fiebig-Comyn", 
            "givenName": "Aline", 
            "id": "sg:person.01122100631.95", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01122100631.95"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "McMaster University", 
              "id": "https://www.grid.ac/institutes/grid.25073.33", 
              "name": [
                "Stem Cell and Cancer Research Institute, McMaster University, Hamilton, Ontario, Canada L8N 3Z5"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Levadoux-Martin", 
            "givenName": "Marilyne", 
            "id": "sg:person.0630476271.03", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630476271.03"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "McMaster University", 
              "id": "https://www.grid.ac/institutes/grid.25073.33", 
              "name": [
                "Stem Cell and Cancer Research Institute, McMaster University, Hamilton, Ontario, Canada L8N 3Z5", 
                "Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada L8N 3Z5"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bhatia", 
            "givenName": "Mickie", 
            "id": "sg:person.01160110173.62", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01160110173.62"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/371221a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000056814", 
              "https://doi.org/10.1038/371221a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2009.01.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001400503"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2007.07.013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001428318"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(93)90325-k", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001747744"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1210764", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002450332", 
              "https://doi.org/10.1038/sj.onc.1210764"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08436", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002503252", 
              "https://doi.org/10.1038/nature08436"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.98.1.31", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005356386"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.stem.2008.12.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006865797"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni0402-323", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006997368", 
              "https://doi.org/10.1038/ni0402-323"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni0402-323", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006997368", 
              "https://doi.org/10.1038/ni0402-323"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.exphem.2009.05.010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007337141"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.93.5.1935", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007567328"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2007.11.019", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010904856"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1532/ijh97.05051", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011130935", 
              "https://doi.org/10.1532/ijh97.05051"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1532/ijh97.05051", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011130935", 
              "https://doi.org/10.1532/ijh97.05051"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1242/dev.01657", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011265112"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0711961105", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011932205"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2008.01.015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012430287"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbrc.2006.03.119", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014279487"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2006.07.024", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014573758"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000203893", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016544645"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/373432a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019482424", 
              "https://doi.org/10.1038/373432a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nsmb1316", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020559439", 
              "https://doi.org/10.1038/nsmb1316"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08797", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022463782", 
              "https://doi.org/10.1038/nature08797"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08797", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022463782", 
              "https://doi.org/10.1038/nature08797"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2010.07.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022964788"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2005-11-011874", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023657343"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.20072049", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024466964"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bmt.1705176", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025099075", 
              "https://doi.org/10.1038/sj.bmt.1705176"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tibs.2009.06.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025369828"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m502573200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026550690"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1537-2995.2003.00446.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027962880"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.1393", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029588621", 
              "https://doi.org/10.1038/nmeth.1393"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.20022014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033832800"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/bies.200800204", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034302604"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm1495", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034580186", 
              "https://doi.org/10.1038/nm1495"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm1495", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034580186", 
              "https://doi.org/10.1038/nm1495"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.bi.46.070177.003321", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037218480"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature07056", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037743725", 
              "https://doi.org/10.1038/nature07056"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.84.3.685", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039925798"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2008-09-178863", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043966221"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1080", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047014502", 
              "https://doi.org/10.1038/ni1080"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1080", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047014502", 
              "https://doi.org/10.1038/ni1080"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1151526", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048905674"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2005.08.020", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049638413"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2005.08.020", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049638413"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pmed.1000029", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049772051"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.1580", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052579867", 
              "https://doi.org/10.1038/nbt.1580"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.1580", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052579867", 
              "https://doi.org/10.1038/nbt.1580"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.16.11.6160", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053126858"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4161/cc.3.6.951", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072297977"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074955570", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082416191", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082913030", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2010-11-25", 
        "datePublishedReg": "2010-11-25", 
        "description": "As is the case for embryo-derived stem cells, application of reprogrammed human induced pluripotent stem cells is limited by our understanding of lineage specification. Here we demonstrate the ability to generate progenitors and mature cells of the haematopoietic fate directly from human dermal fibroblasts without establishing pluripotency. Ectopic expression of OCT4 (also called POU5F1)-activated haematopoietic transcription factors, together with specific cytokine treatment, allowed generation of cells expressing the pan-leukocyte marker CD45. These unique fibroblast-derived cells gave rise to granulocytic, monocytic, megakaryocytic and erythroid lineages, and demonstrated in vivo engraftment capacity. We note that adult haematopoietic programs are activated, consistent with bypassing the pluripotent state to generate blood fate: this is distinct from haematopoiesis involving pluripotent stem cells, where embryonic programs are activated. These findings demonstrate restoration of multipotency from human fibroblasts, and suggest an alternative approach to cellular reprogramming for autologous cell-replacement therapies that avoids complications associated with the use of human pluripotent stem cells.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/nature09591", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1018957", 
            "issn": [
              "0090-0028", 
              "1476-4687"
            ], 
            "name": "Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "7323", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "468"
          }
        ], 
        "name": "Direct conversion of human fibroblasts to multilineage blood progenitors", 
        "pagination": "521", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "575fd4744556bcd8ada783f4d63f01f487867363ff747267abe826974c0a9e3f"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "21057492"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "0410462"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/nature09591"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1018338276"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/nature09591", 
          "https://app.dimensions.ai/details/publication/pub.1018338276"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T10:55", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000351_0000000351/records_43262_00000000.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/nature09591"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nature09591'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nature09591'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nature09591'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nature09591'


     

    This table displays all metadata directly associated to this object as RDF triples.

    303 TRIPLES      21 PREDICATES      83 URIs      28 LITERALS      17 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/nature09591 schema:about N26cab0e1f4ee4a37baf19880307fa3e5
    2 N35b42c9f1c8847cc853f9706152a93f5
    3 N4f2c0695636a433f94ad88184caa8ba2
    4 N82c758efef974c708b49ecd80088c2fb
    5 Nb330b9d4de6a4894a861ca9b4d83e2dd
    6 Nd058b705f2914771908618b55da1e26f
    7 Ne82a55723d0b4fa4891a9f3add1420a4
    8 Nf5dab08322bb4c2492e8f297641b64d5
    9 anzsrc-for:06
    10 anzsrc-for:0604
    11 schema:author N36c654bfb60a4395bc7620d1bee5b36d
    12 schema:citation sg:pub.10.1038/371221a0
    13 sg:pub.10.1038/373432a0
    14 sg:pub.10.1038/nature07056
    15 sg:pub.10.1038/nature08436
    16 sg:pub.10.1038/nature08797
    17 sg:pub.10.1038/nbt.1580
    18 sg:pub.10.1038/ni0402-323
    19 sg:pub.10.1038/ni1080
    20 sg:pub.10.1038/nm1495
    21 sg:pub.10.1038/nmeth.1393
    22 sg:pub.10.1038/nsmb1316
    23 sg:pub.10.1038/sj.bmt.1705176
    24 sg:pub.10.1038/sj.onc.1210764
    25 sg:pub.10.1532/ijh97.05051
    26 https://app.dimensions.ai/details/publication/pub.1074955570
    27 https://app.dimensions.ai/details/publication/pub.1082416191
    28 https://app.dimensions.ai/details/publication/pub.1082913030
    29 https://doi.org/10.1002/bies.200800204
    30 https://doi.org/10.1016/0092-8674(93)90325-k
    31 https://doi.org/10.1016/j.bbrc.2006.03.119
    32 https://doi.org/10.1016/j.ccr.2007.07.013
    33 https://doi.org/10.1016/j.cell.2005.08.020
    34 https://doi.org/10.1016/j.cell.2006.07.024
    35 https://doi.org/10.1016/j.cell.2007.11.019
    36 https://doi.org/10.1016/j.cell.2008.01.015
    37 https://doi.org/10.1016/j.cell.2009.01.001
    38 https://doi.org/10.1016/j.cell.2010.07.002
    39 https://doi.org/10.1016/j.exphem.2009.05.010
    40 https://doi.org/10.1016/j.stem.2008.12.011
    41 https://doi.org/10.1016/j.tibs.2009.06.003
    42 https://doi.org/10.1046/j.1537-2995.2003.00446.x
    43 https://doi.org/10.1073/pnas.0711961105
    44 https://doi.org/10.1073/pnas.84.3.685
    45 https://doi.org/10.1073/pnas.93.5.1935
    46 https://doi.org/10.1073/pnas.98.1.31
    47 https://doi.org/10.1074/jbc.m502573200
    48 https://doi.org/10.1084/jem.20022014
    49 https://doi.org/10.1084/jem.20072049
    50 https://doi.org/10.1126/science.1151526
    51 https://doi.org/10.1128/mcb.16.11.6160
    52 https://doi.org/10.1146/annurev.bi.46.070177.003321
    53 https://doi.org/10.1159/000203893
    54 https://doi.org/10.1182/blood-2005-11-011874
    55 https://doi.org/10.1182/blood-2008-09-178863
    56 https://doi.org/10.1242/dev.01657
    57 https://doi.org/10.1371/journal.pmed.1000029
    58 https://doi.org/10.4161/cc.3.6.951
    59 schema:datePublished 2010-11-25
    60 schema:datePublishedReg 2010-11-25
    61 schema:description As is the case for embryo-derived stem cells, application of reprogrammed human induced pluripotent stem cells is limited by our understanding of lineage specification. Here we demonstrate the ability to generate progenitors and mature cells of the haematopoietic fate directly from human dermal fibroblasts without establishing pluripotency. Ectopic expression of OCT4 (also called POU5F1)-activated haematopoietic transcription factors, together with specific cytokine treatment, allowed generation of cells expressing the pan-leukocyte marker CD45. These unique fibroblast-derived cells gave rise to granulocytic, monocytic, megakaryocytic and erythroid lineages, and demonstrated in vivo engraftment capacity. We note that adult haematopoietic programs are activated, consistent with bypassing the pluripotent state to generate blood fate: this is distinct from haematopoiesis involving pluripotent stem cells, where embryonic programs are activated. These findings demonstrate restoration of multipotency from human fibroblasts, and suggest an alternative approach to cellular reprogramming for autologous cell-replacement therapies that avoids complications associated with the use of human pluripotent stem cells.
    62 schema:genre research_article
    63 schema:inLanguage en
    64 schema:isAccessibleForFree false
    65 schema:isPartOf N017fb81e36f843c19e33463b901bfe77
    66 N5d3907980b764b7fa5121778d44f7f08
    67 sg:journal.1018957
    68 schema:name Direct conversion of human fibroblasts to multilineage blood progenitors
    69 schema:pagination 521
    70 schema:productId N11384d5bddf646c9948e7dea6ff73018
    71 N1b49ca829e424a608b7b912e30f4f2fb
    72 N414dae874ca3495881ee0327ccea14f5
    73 Nb55be365518040bbb8ae406b58323039
    74 Nb8fef240e08a4e9eb77efa3ef670bab9
    75 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018338276
    76 https://doi.org/10.1038/nature09591
    77 schema:sdDatePublished 2019-04-11T10:55
    78 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    79 schema:sdPublisher N61b918eb26a64411983f6e25185462f3
    80 schema:url https://www.nature.com/articles/nature09591
    81 sgo:license sg:explorer/license/
    82 sgo:sdDataset articles
    83 rdf:type schema:ScholarlyArticle
    84 N017fb81e36f843c19e33463b901bfe77 schema:volumeNumber 468
    85 rdf:type schema:PublicationVolume
    86 N11384d5bddf646c9948e7dea6ff73018 schema:name nlm_unique_id
    87 schema:value 0410462
    88 rdf:type schema:PropertyValue
    89 N1b49ca829e424a608b7b912e30f4f2fb schema:name readcube_id
    90 schema:value 575fd4744556bcd8ada783f4d63f01f487867363ff747267abe826974c0a9e3f
    91 rdf:type schema:PropertyValue
    92 N26cab0e1f4ee4a37baf19880307fa3e5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    93 schema:name Hematopoietic Stem Cells
    94 rdf:type schema:DefinedTerm
    95 N35b42c9f1c8847cc853f9706152a93f5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    96 schema:name Fibroblasts
    97 rdf:type schema:DefinedTerm
    98 N36c654bfb60a4395bc7620d1bee5b36d rdf:first sg:person.01227770221.16
    99 rdf:rest N9f83765a03cb44c3947e4a0afa7ceddf
    100 N3b0afc1171f9460487721620fb75226a rdf:first sg:person.01122100631.95
    101 rdf:rest Ne8791620430847929401f9aa67497506
    102 N414dae874ca3495881ee0327ccea14f5 schema:name pubmed_id
    103 schema:value 21057492
    104 rdf:type schema:PropertyValue
    105 N4f2c0695636a433f94ad88184caa8ba2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    106 schema:name Pluripotent Stem Cells
    107 rdf:type schema:DefinedTerm
    108 N5d3907980b764b7fa5121778d44f7f08 schema:issueNumber 7323
    109 rdf:type schema:PublicationIssue
    110 N61b918eb26a64411983f6e25185462f3 schema:name Springer Nature - SN SciGraph project
    111 rdf:type schema:Organization
    112 N6e7890cc63b54574a64c12f87fce894f rdf:first sg:person.01160110173.62
    113 rdf:rest rdf:nil
    114 N82c758efef974c708b49ecd80088c2fb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    115 schema:name Dermis
    116 rdf:type schema:DefinedTerm
    117 N8417bac074bf4aaba71dc8a25afd5ae9 rdf:first sg:person.01366125721.19
    118 rdf:rest Nb8fb9fa5fe1049c4896a2cc28e384883
    119 N9f83765a03cb44c3947e4a0afa7ceddf rdf:first sg:person.01032401276.20
    120 rdf:rest Nbbe200e880bc495a84ee68b3fbfb4599
    121 Nb330b9d4de6a4894a861ca9b4d83e2dd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    122 schema:name Stem Cells
    123 rdf:type schema:DefinedTerm
    124 Nb55be365518040bbb8ae406b58323039 schema:name doi
    125 schema:value 10.1038/nature09591
    126 rdf:type schema:PropertyValue
    127 Nb8fb9fa5fe1049c4896a2cc28e384883 rdf:first sg:person.0666725721.71
    128 rdf:rest N3b0afc1171f9460487721620fb75226a
    129 Nb8fef240e08a4e9eb77efa3ef670bab9 schema:name dimensions_id
    130 schema:value pub.1018338276
    131 rdf:type schema:PropertyValue
    132 Nbbe200e880bc495a84ee68b3fbfb4599 rdf:first sg:person.0753172207.95
    133 rdf:rest N8417bac074bf4aaba71dc8a25afd5ae9
    134 Nd058b705f2914771908618b55da1e26f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    135 schema:name Cell Differentiation
    136 rdf:type schema:DefinedTerm
    137 Ne82a55723d0b4fa4891a9f3add1420a4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    138 schema:name Cell Culture Techniques
    139 rdf:type schema:DefinedTerm
    140 Ne8791620430847929401f9aa67497506 rdf:first sg:person.0630476271.03
    141 rdf:rest N6e7890cc63b54574a64c12f87fce894f
    142 Nf5dab08322bb4c2492e8f297641b64d5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    143 schema:name Humans
    144 rdf:type schema:DefinedTerm
    145 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    146 schema:name Biological Sciences
    147 rdf:type schema:DefinedTerm
    148 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
    149 schema:name Genetics
    150 rdf:type schema:DefinedTerm
    151 sg:journal.1018957 schema:issn 0090-0028
    152 1476-4687
    153 schema:name Nature
    154 rdf:type schema:Periodical
    155 sg:person.01032401276.20 schema:affiliation https://www.grid.ac/institutes/grid.25073.33
    156 schema:familyName Rampalli
    157 schema:givenName Shravanti
    158 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01032401276.20
    159 rdf:type schema:Person
    160 sg:person.01122100631.95 schema:affiliation https://www.grid.ac/institutes/grid.25073.33
    161 schema:familyName Fiebig-Comyn
    162 schema:givenName Aline
    163 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01122100631.95
    164 rdf:type schema:Person
    165 sg:person.01160110173.62 schema:affiliation https://www.grid.ac/institutes/grid.25073.33
    166 schema:familyName Bhatia
    167 schema:givenName Mickie
    168 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01160110173.62
    169 rdf:type schema:Person
    170 sg:person.01227770221.16 schema:affiliation https://www.grid.ac/institutes/grid.25073.33
    171 schema:familyName Szabo
    172 schema:givenName Eva
    173 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01227770221.16
    174 rdf:type schema:Person
    175 sg:person.01366125721.19 schema:affiliation https://www.grid.ac/institutes/grid.25073.33
    176 schema:familyName Schnerch
    177 schema:givenName Angelique
    178 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01366125721.19
    179 rdf:type schema:Person
    180 sg:person.0630476271.03 schema:affiliation https://www.grid.ac/institutes/grid.25073.33
    181 schema:familyName Levadoux-Martin
    182 schema:givenName Marilyne
    183 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630476271.03
    184 rdf:type schema:Person
    185 sg:person.0666725721.71 schema:affiliation https://www.grid.ac/institutes/grid.25073.33
    186 schema:familyName Mitchell
    187 schema:givenName Ryan
    188 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0666725721.71
    189 rdf:type schema:Person
    190 sg:person.0753172207.95 schema:affiliation https://www.grid.ac/institutes/grid.25073.33
    191 schema:familyName Risueño
    192 schema:givenName Ruth M.
    193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0753172207.95
    194 rdf:type schema:Person
    195 sg:pub.10.1038/371221a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000056814
    196 https://doi.org/10.1038/371221a0
    197 rdf:type schema:CreativeWork
    198 sg:pub.10.1038/373432a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019482424
    199 https://doi.org/10.1038/373432a0
    200 rdf:type schema:CreativeWork
    201 sg:pub.10.1038/nature07056 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037743725
    202 https://doi.org/10.1038/nature07056
    203 rdf:type schema:CreativeWork
    204 sg:pub.10.1038/nature08436 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002503252
    205 https://doi.org/10.1038/nature08436
    206 rdf:type schema:CreativeWork
    207 sg:pub.10.1038/nature08797 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022463782
    208 https://doi.org/10.1038/nature08797
    209 rdf:type schema:CreativeWork
    210 sg:pub.10.1038/nbt.1580 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052579867
    211 https://doi.org/10.1038/nbt.1580
    212 rdf:type schema:CreativeWork
    213 sg:pub.10.1038/ni0402-323 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006997368
    214 https://doi.org/10.1038/ni0402-323
    215 rdf:type schema:CreativeWork
    216 sg:pub.10.1038/ni1080 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047014502
    217 https://doi.org/10.1038/ni1080
    218 rdf:type schema:CreativeWork
    219 sg:pub.10.1038/nm1495 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034580186
    220 https://doi.org/10.1038/nm1495
    221 rdf:type schema:CreativeWork
    222 sg:pub.10.1038/nmeth.1393 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029588621
    223 https://doi.org/10.1038/nmeth.1393
    224 rdf:type schema:CreativeWork
    225 sg:pub.10.1038/nsmb1316 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020559439
    226 https://doi.org/10.1038/nsmb1316
    227 rdf:type schema:CreativeWork
    228 sg:pub.10.1038/sj.bmt.1705176 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025099075
    229 https://doi.org/10.1038/sj.bmt.1705176
    230 rdf:type schema:CreativeWork
    231 sg:pub.10.1038/sj.onc.1210764 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002450332
    232 https://doi.org/10.1038/sj.onc.1210764
    233 rdf:type schema:CreativeWork
    234 sg:pub.10.1532/ijh97.05051 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011130935
    235 https://doi.org/10.1532/ijh97.05051
    236 rdf:type schema:CreativeWork
    237 https://app.dimensions.ai/details/publication/pub.1074955570 schema:CreativeWork
    238 https://app.dimensions.ai/details/publication/pub.1082416191 schema:CreativeWork
    239 https://app.dimensions.ai/details/publication/pub.1082913030 schema:CreativeWork
    240 https://doi.org/10.1002/bies.200800204 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034302604
    241 rdf:type schema:CreativeWork
    242 https://doi.org/10.1016/0092-8674(93)90325-k schema:sameAs https://app.dimensions.ai/details/publication/pub.1001747744
    243 rdf:type schema:CreativeWork
    244 https://doi.org/10.1016/j.bbrc.2006.03.119 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014279487
    245 rdf:type schema:CreativeWork
    246 https://doi.org/10.1016/j.ccr.2007.07.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001428318
    247 rdf:type schema:CreativeWork
    248 https://doi.org/10.1016/j.cell.2005.08.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049638413
    249 rdf:type schema:CreativeWork
    250 https://doi.org/10.1016/j.cell.2006.07.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014573758
    251 rdf:type schema:CreativeWork
    252 https://doi.org/10.1016/j.cell.2007.11.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010904856
    253 rdf:type schema:CreativeWork
    254 https://doi.org/10.1016/j.cell.2008.01.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012430287
    255 rdf:type schema:CreativeWork
    256 https://doi.org/10.1016/j.cell.2009.01.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001400503
    257 rdf:type schema:CreativeWork
    258 https://doi.org/10.1016/j.cell.2010.07.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022964788
    259 rdf:type schema:CreativeWork
    260 https://doi.org/10.1016/j.exphem.2009.05.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007337141
    261 rdf:type schema:CreativeWork
    262 https://doi.org/10.1016/j.stem.2008.12.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006865797
    263 rdf:type schema:CreativeWork
    264 https://doi.org/10.1016/j.tibs.2009.06.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025369828
    265 rdf:type schema:CreativeWork
    266 https://doi.org/10.1046/j.1537-2995.2003.00446.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1027962880
    267 rdf:type schema:CreativeWork
    268 https://doi.org/10.1073/pnas.0711961105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011932205
    269 rdf:type schema:CreativeWork
    270 https://doi.org/10.1073/pnas.84.3.685 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039925798
    271 rdf:type schema:CreativeWork
    272 https://doi.org/10.1073/pnas.93.5.1935 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007567328
    273 rdf:type schema:CreativeWork
    274 https://doi.org/10.1073/pnas.98.1.31 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005356386
    275 rdf:type schema:CreativeWork
    276 https://doi.org/10.1074/jbc.m502573200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026550690
    277 rdf:type schema:CreativeWork
    278 https://doi.org/10.1084/jem.20022014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033832800
    279 rdf:type schema:CreativeWork
    280 https://doi.org/10.1084/jem.20072049 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024466964
    281 rdf:type schema:CreativeWork
    282 https://doi.org/10.1126/science.1151526 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048905674
    283 rdf:type schema:CreativeWork
    284 https://doi.org/10.1128/mcb.16.11.6160 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053126858
    285 rdf:type schema:CreativeWork
    286 https://doi.org/10.1146/annurev.bi.46.070177.003321 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037218480
    287 rdf:type schema:CreativeWork
    288 https://doi.org/10.1159/000203893 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016544645
    289 rdf:type schema:CreativeWork
    290 https://doi.org/10.1182/blood-2005-11-011874 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023657343
    291 rdf:type schema:CreativeWork
    292 https://doi.org/10.1182/blood-2008-09-178863 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043966221
    293 rdf:type schema:CreativeWork
    294 https://doi.org/10.1242/dev.01657 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011265112
    295 rdf:type schema:CreativeWork
    296 https://doi.org/10.1371/journal.pmed.1000029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049772051
    297 rdf:type schema:CreativeWork
    298 https://doi.org/10.4161/cc.3.6.951 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072297977
    299 rdf:type schema:CreativeWork
    300 https://www.grid.ac/institutes/grid.25073.33 schema:alternateName McMaster University
    301 schema:name Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada L8N 3Z5
    302 Stem Cell and Cancer Research Institute, McMaster University, Hamilton, Ontario, Canada L8N 3Z5
    303 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...