Pericytes regulate the blood–brain barrier View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2010-10-13

AUTHORS

Annika Armulik, Guillem Genové, Maarja Mäe, Maya H. Nisancioglu, Elisabet Wallgard, Colin Niaudet, Liqun He, Jenny Norlin, Per Lindblom, Karin Strittmatter, Bengt R. Johansson, Christer Betsholtz

ABSTRACT

Building the blood–brain barrierThe blood–brain barrier is a gatekeeper between the central nervous system and the rest of the body, and is made up of vascular endothelial cells. Previous work upheld the notion that the barrier was formed postnatally as a result of signalling from non-neuronal cells called astrocytes to endothelial cells. Now, two independent studies demonstrate that the barrier is in fact formed during embryogenesis, with the critical factor being the interaction between blood-vessel-surrounding cells called pericytes and epithelial cells. A better understanding of the tight relationship between pericytes, neuroendothelial cells and astrocytes in blood–brain barrier function will contribute to our understanding of the breakdown of the barrier during central nervous system injury and disease. More... »

PAGES

557-561

Journal

TITLE

Nature

ISSUE

7323

VOLUME

468

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature09522

DOI

http://dx.doi.org/10.1038/nature09522

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1045685661

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20944627


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