Distant metastasis occurs late during the genetic evolution of pancreatic cancer View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2010-10-28

AUTHORS

Shinichi Yachida, Siân Jones, Ivana Bozic, Tibor Antal, Rebecca Leary, Baojin Fu, Mihoko Kamiyama, Ralph H. Hruban, James R. Eshleman, Martin A. Nowak, Victor E. Velculescu, Kenneth W. Kinzler, Bert Vogelstein, Christine A. Iacobuzio-Donahue

ABSTRACT

Metastasis, the dissemination and growth of neoplastic cells in an organ distinct from that in which they originated, is the most common cause of death in cancer patients. This is particularly true for pancreatic cancers, where most patients are diagnosed with metastatic disease and few show a sustained response to chemotherapy or radiation therapy. Whether the dismal prognosis of patients with pancreatic cancer compared to patients with other types of cancer is a result of late diagnosis or early dissemination of disease to distant organs is not known. Here we rely on data generated by sequencing the genomes of seven pancreatic cancer metastases to evaluate the clonal relationships among primary and metastatic cancers. We find that clonal populations that give rise to distant metastases are represented within the primary carcinoma, but these clones are genetically evolved from the original parental, non-metastatic clone. Thus, genetic heterogeneity of metastases reflects that within the primary carcinoma. A quantitative analysis of the timing of the genetic evolution of pancreatic cancer was performed, indicating at least a decade between the occurrence of the initiating mutation and the birth of the parental, non-metastatic founder cell. At least five more years are required for the acquisition of metastatic ability and patients die an average of two years thereafter. These data provide novel insights into the genetic features underlying pancreatic cancer progression and define a broad time window of opportunity for early detection to prevent deaths from metastatic disease. More... »

PAGES

1114

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature09515

DOI

http://dx.doi.org/10.1038/nature09515

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1029325111

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20981102


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adenocarcinoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Autopsy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Lineage", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Clone Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Mutational Analysis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Progression", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Early Detection of Cancer", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Evolution, Molecular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Liver Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lung Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Models, Biological", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Metastasis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pancreas", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pancreatic Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Peritoneal Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Time Factors", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yachida", 
        "givenName": "Shinichi", 
        "id": "sg:person.01311713313.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01311713313.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "The Ludwig Center for Cancer Genetics and Therapeutics and The Howard Hughes Medical Institute at The Johns Hopkins Kimmel Cancer Center, Baltimore, Maryland 21231, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jones", 
        "givenName": "Si\u00e2n", 
        "id": "sg:person.01024421573.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01024421573.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Harvard University", 
          "id": "https://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "Program for Evolutionary Dynamics, Department of Mathematics, Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bozic", 
        "givenName": "Ivana", 
        "id": "sg:person.01066027314.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01066027314.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Edinburgh", 
          "id": "https://www.grid.ac/institutes/grid.4305.2", 
          "name": [
            "Program for Evolutionary Dynamics, Department of Mathematics, Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA", 
            "School of Mathematics, University of Edinburgh, Edinburgh EH9 3JZ, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Antal", 
        "givenName": "Tibor", 
        "id": "sg:person.01072165702.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01072165702.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "The Ludwig Center for Cancer Genetics and Therapeutics and The Howard Hughes Medical Institute at The Johns Hopkins Kimmel Cancer Center, Baltimore, Maryland 21231, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Leary", 
        "givenName": "Rebecca", 
        "id": "sg:person.01251235473.73", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01251235473.73"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fu", 
        "givenName": "Baojin", 
        "id": "sg:person.01366574634.71", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01366574634.71"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kamiyama", 
        "givenName": "Mihoko", 
        "id": "sg:person.0664621034.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0664621034.86"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA", 
            "Department of Oncology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hruban", 
        "givenName": "Ralph H.", 
        "id": "sg:person.07624111077.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07624111077.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Eshleman", 
        "givenName": "James R.", 
        "id": "sg:person.01063415267.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01063415267.74"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Harvard University", 
          "id": "https://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "Program for Evolutionary Dynamics, Department of Mathematics, Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nowak", 
        "givenName": "Martin A.", 
        "id": "sg:person.01161070716.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01161070716.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "The Ludwig Center for Cancer Genetics and Therapeutics and The Howard Hughes Medical Institute at The Johns Hopkins Kimmel Cancer Center, Baltimore, Maryland 21231, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Velculescu", 
        "givenName": "Victor E.", 
        "id": "sg:person.010354303077.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010354303077.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "The Ludwig Center for Cancer Genetics and Therapeutics and The Howard Hughes Medical Institute at The Johns Hopkins Kimmel Cancer Center, Baltimore, Maryland 21231, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kinzler", 
        "givenName": "Kenneth W.", 
        "id": "sg:person.0620642630.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0620642630.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "The Ludwig Center for Cancer Genetics and Therapeutics and The Howard Hughes Medical Institute at The Johns Hopkins Kimmel Cancer Center, Baltimore, Maryland 21231, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vogelstein", 
        "givenName": "Bert", 
        "id": "sg:person.011173760757.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011173760757.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA", 
            "Department of Oncology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA", 
            "Department of Surgery, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Iacobuzio-Donahue", 
        "givenName": "Christine A.", 
        "id": "sg:person.016324315037.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016324315037.55"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1002/1097-0142(19880901)62:5<989::aid-cncr2820620525>3.0.co;2-u", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002540794"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08768", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002735811", 
          "https://doi.org/10.1038/nature08768"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08768", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002735811", 
          "https://doi.org/10.1038/nature08768"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1164368", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006710792"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1171362", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008567341"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1171362", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008567341"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gr.5402306", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018459854"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0712345105", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018833150"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc2622", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020158834", 
          "https://doi.org/10.1038/nrc2622"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc2622", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020158834", 
          "https://doi.org/10.1038/nrc2622"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/djj068", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025553372"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/scitranslmed.3000702", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030440398"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/scitranslmed.3000702", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030440398"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.pathmechdis.3.121806.154305", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031737156"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/ejso.1999.0907", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032339876"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/25292", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033871070", 
          "https://doi.org/10.1038/25292"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/25292", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033871070", 
          "https://doi.org/10.1038/25292"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrclinonc.2009.236", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044620521", 
          "https://doi.org/10.1038/nrclinonc.2009.236"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrclinonc.2009.236", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044620521", 
          "https://doi.org/10.1038/nrclinonc.2009.236"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/scbi.2001.0416", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048653187"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc755", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049934401", 
          "https://doi.org/10.1038/nrc755"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc755", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049934401", 
          "https://doi.org/10.1038/nrc755"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3748/wjg.14.1958", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071360219"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/cbt.4.5.1663", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072293745"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/cbt.6.10.4708", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072294347"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1043/1543-2165-133.3.413", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077858809"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02788531", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082439026", 
          "https://doi.org/10.1007/bf02788531"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083204935", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2010-10-28", 
    "datePublishedReg": "2010-10-28", 
    "description": "Metastasis, the dissemination and growth of neoplastic cells in an organ distinct from that in which they originated, is the most common cause of death in cancer patients. This is particularly true for pancreatic cancers, where most patients are diagnosed with metastatic disease and few show a sustained response to chemotherapy or radiation therapy. Whether the dismal prognosis of patients with pancreatic cancer compared to patients with other types of cancer is a result of late diagnosis or early dissemination of disease to distant organs is not known. Here we rely on data generated by sequencing the genomes of seven pancreatic cancer metastases to evaluate the clonal relationships among primary and metastatic cancers. We find that clonal populations that give rise to distant metastases are represented within the primary carcinoma, but these clones are genetically evolved from the original parental, non-metastatic clone. Thus, genetic heterogeneity of metastases reflects that within the primary carcinoma. A quantitative analysis of the timing of the genetic evolution of pancreatic cancer was performed, indicating at least a decade between the occurrence of the initiating mutation and the birth of the parental, non-metastatic founder cell. At least five more years are required for the acquisition of metastatic ability and patients die an average of two years thereafter. These data provide novel insights into the genetic features underlying pancreatic cancer progression and define a broad time window of opportunity for early detection to prevent deaths from metastatic disease.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/nature09515", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2519328", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6582210", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2469185", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2634365", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2480549", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2411125", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2478763", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2634325", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2440141", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2471197", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0090-0028", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "7319", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "467"
      }
    ], 
    "name": "Distant metastasis occurs late during the genetic evolution of pancreatic cancer", 
    "pagination": "1114", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "8bb302f1ac80878e9e1555a2dbabe5cc5befa9fe1f5cef14eaff1247b239d610"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "20981102"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0410462"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/nature09515"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1029325111"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/nature09515", 
      "https://app.dimensions.ai/details/publication/pub.1029325111"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T10:52", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000351_0000000351/records_43229_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/nature09515"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nature09515'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nature09515'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nature09515'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nature09515'


 

This table displays all metadata directly associated to this object as RDF triples.

330 TRIPLES      21 PREDICATES      67 URIs      38 LITERALS      27 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/nature09515 schema:about N17ebe86aac044f4c95768477c5278e12
2 N2977f79fd32544749a97a47429875e3b
3 N33ef78a44d01474c9995ee21021704f4
4 N38bb92b914b74df1bcf6d67c17db59b9
5 N3b20e09b0a8d4cb994e5d78ff20b5eb4
6 N43e5271e513943a19274ab8799fa6454
7 N452f9ef4b144433ab3759455df7a02a3
8 N4a6f905e6361469d9601c79ea61834f9
9 N9ab50ae28193462bba9ab9428d6787ab
10 Nacb99cbff8d04d9494fcffbe88e2c7ed
11 Nacbe378d0fb74f3287a69d7b9ed8193a
12 Nb687e29a6d9f4bf09219fc6a16396775
13 Nc755f6b2dfa847e4981c088ba62238a3
14 Nd32e8b9279334d0abdc3382b504701e9
15 Nd708dbf9e1674aba9829ebf3452cf10d
16 Nda13e5ebd9ff484b8e7f9687ca267d2c
17 Neae6fb85166d403e9d070e97a7b80077
18 Nfec81422d7bc4a098f65eb2fede13633
19 anzsrc-for:11
20 anzsrc-for:1112
21 schema:author N9ae4977a64a94c8bbac5daa79836a034
22 schema:citation sg:pub.10.1007/bf02788531
23 sg:pub.10.1038/25292
24 sg:pub.10.1038/nature08768
25 sg:pub.10.1038/nrc2622
26 sg:pub.10.1038/nrc755
27 sg:pub.10.1038/nrclinonc.2009.236
28 https://app.dimensions.ai/details/publication/pub.1083204935
29 https://doi.org/10.1002/1097-0142(19880901)62:5<989::aid-cncr2820620525>3.0.co;2-u
30 https://doi.org/10.1006/scbi.2001.0416
31 https://doi.org/10.1043/1543-2165-133.3.413
32 https://doi.org/10.1053/ejso.1999.0907
33 https://doi.org/10.1073/pnas.0712345105
34 https://doi.org/10.1093/jnci/djj068
35 https://doi.org/10.1101/gr.5402306
36 https://doi.org/10.1126/science.1164368
37 https://doi.org/10.1126/science.1171362
38 https://doi.org/10.1126/scitranslmed.3000702
39 https://doi.org/10.1146/annurev.pathmechdis.3.121806.154305
40 https://doi.org/10.3748/wjg.14.1958
41 https://doi.org/10.4161/cbt.4.5.1663
42 https://doi.org/10.4161/cbt.6.10.4708
43 schema:datePublished 2010-10-28
44 schema:datePublishedReg 2010-10-28
45 schema:description Metastasis, the dissemination and growth of neoplastic cells in an organ distinct from that in which they originated, is the most common cause of death in cancer patients. This is particularly true for pancreatic cancers, where most patients are diagnosed with metastatic disease and few show a sustained response to chemotherapy or radiation therapy. Whether the dismal prognosis of patients with pancreatic cancer compared to patients with other types of cancer is a result of late diagnosis or early dissemination of disease to distant organs is not known. Here we rely on data generated by sequencing the genomes of seven pancreatic cancer metastases to evaluate the clonal relationships among primary and metastatic cancers. We find that clonal populations that give rise to distant metastases are represented within the primary carcinoma, but these clones are genetically evolved from the original parental, non-metastatic clone. Thus, genetic heterogeneity of metastases reflects that within the primary carcinoma. A quantitative analysis of the timing of the genetic evolution of pancreatic cancer was performed, indicating at least a decade between the occurrence of the initiating mutation and the birth of the parental, non-metastatic founder cell. At least five more years are required for the acquisition of metastatic ability and patients die an average of two years thereafter. These data provide novel insights into the genetic features underlying pancreatic cancer progression and define a broad time window of opportunity for early detection to prevent deaths from metastatic disease.
46 schema:genre research_article
47 schema:inLanguage en
48 schema:isAccessibleForFree true
49 schema:isPartOf Nb3dc304c278547e88442959bfa18d443
50 Nfe5d50f218364a6d8a3bb15197fb6bf6
51 sg:journal.1018957
52 schema:name Distant metastasis occurs late during the genetic evolution of pancreatic cancer
53 schema:pagination 1114
54 schema:productId N1eb6d679b6c34be2b605a730be22c1c1
55 N9656324a34564b58951ea7cb8e6f81a5
56 N975f9597c00042899be7643a996e6062
57 N980c13e5561444798079af2c3095bfff
58 Nd1dbcf36f6eb45b7a9a498deb14fd8f3
59 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029325111
60 https://doi.org/10.1038/nature09515
61 schema:sdDatePublished 2019-04-11T10:52
62 schema:sdLicense https://scigraph.springernature.com/explorer/license/
63 schema:sdPublisher N8752accd4456477893d67de935f8493c
64 schema:url https://www.nature.com/articles/nature09515
65 sgo:license sg:explorer/license/
66 sgo:sdDataset articles
67 rdf:type schema:ScholarlyArticle
68 N17ebe86aac044f4c95768477c5278e12 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
69 schema:name Peritoneal Neoplasms
70 rdf:type schema:DefinedTerm
71 N1eb6d679b6c34be2b605a730be22c1c1 schema:name readcube_id
72 schema:value 8bb302f1ac80878e9e1555a2dbabe5cc5befa9fe1f5cef14eaff1247b239d610
73 rdf:type schema:PropertyValue
74 N271e9704feed4db296e69df5a27cfffd rdf:first sg:person.016324315037.55
75 rdf:rest rdf:nil
76 N2977f79fd32544749a97a47429875e3b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
77 schema:name Autopsy
78 rdf:type schema:DefinedTerm
79 N2b422ff6a458497ea7d8ae4acb0996e3 rdf:first sg:person.01161070716.44
80 rdf:rest N5a2ec08ea2ab46d78fc17e2b0758b6f3
81 N33ef78a44d01474c9995ee21021704f4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
82 schema:name Evolution, Molecular
83 rdf:type schema:DefinedTerm
84 N360e9f5af7e94ecfa591efbbeeb46215 rdf:first sg:person.01251235473.73
85 rdf:rest N7bc3fee933cd429cb2b9db34c5ef921d
86 N38bb92b914b74df1bcf6d67c17db59b9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name Time Factors
88 rdf:type schema:DefinedTerm
89 N3b20e09b0a8d4cb994e5d78ff20b5eb4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Pancreas
91 rdf:type schema:DefinedTerm
92 N3cf0e8021765465ab905959132066d3c rdf:first sg:person.01063415267.74
93 rdf:rest N2b422ff6a458497ea7d8ae4acb0996e3
94 N43e5271e513943a19274ab8799fa6454 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Early Detection of Cancer
96 rdf:type schema:DefinedTerm
97 N452f9ef4b144433ab3759455df7a02a3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Mutation
99 rdf:type schema:DefinedTerm
100 N4a6f905e6361469d9601c79ea61834f9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Pancreatic Neoplasms
102 rdf:type schema:DefinedTerm
103 N5a2ec08ea2ab46d78fc17e2b0758b6f3 rdf:first sg:person.010354303077.37
104 rdf:rest N8314f242b3194f9c82d048f589be674b
105 N7bc3fee933cd429cb2b9db34c5ef921d rdf:first sg:person.01366574634.71
106 rdf:rest Nb7a9d68bb46b419fae6828d9452a7ec4
107 N8314f242b3194f9c82d048f589be674b rdf:first sg:person.0620642630.54
108 rdf:rest Nea06fddd0cbb43569c2b29c728449288
109 N85ddf04fb8a143c9913e14b0d7cddfc5 rdf:first sg:person.07624111077.08
110 rdf:rest N3cf0e8021765465ab905959132066d3c
111 N8752accd4456477893d67de935f8493c schema:name Springer Nature - SN SciGraph project
112 rdf:type schema:Organization
113 N95cfa5eb041b41f1bb3a8cbb0b738106 rdf:first sg:person.01024421573.29
114 rdf:rest Nd9aed4a5ade64d08870b24190f14b603
115 N9656324a34564b58951ea7cb8e6f81a5 schema:name pubmed_id
116 schema:value 20981102
117 rdf:type schema:PropertyValue
118 N975f9597c00042899be7643a996e6062 schema:name nlm_unique_id
119 schema:value 0410462
120 rdf:type schema:PropertyValue
121 N980c13e5561444798079af2c3095bfff schema:name dimensions_id
122 schema:value pub.1029325111
123 rdf:type schema:PropertyValue
124 N9ab50ae28193462bba9ab9428d6787ab schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Humans
126 rdf:type schema:DefinedTerm
127 N9ae4977a64a94c8bbac5daa79836a034 rdf:first sg:person.01311713313.29
128 rdf:rest N95cfa5eb041b41f1bb3a8cbb0b738106
129 Nacb99cbff8d04d9494fcffbe88e2c7ed schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Neoplasm Metastasis
131 rdf:type schema:DefinedTerm
132 Nacbe378d0fb74f3287a69d7b9ed8193a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Liver Neoplasms
134 rdf:type schema:DefinedTerm
135 Nb3dc304c278547e88442959bfa18d443 schema:issueNumber 7319
136 rdf:type schema:PublicationIssue
137 Nb64e57cff8c042b3877d4d4301d3da02 rdf:first sg:person.01072165702.40
138 rdf:rest N360e9f5af7e94ecfa591efbbeeb46215
139 Nb687e29a6d9f4bf09219fc6a16396775 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Adenocarcinoma
141 rdf:type schema:DefinedTerm
142 Nb7a9d68bb46b419fae6828d9452a7ec4 rdf:first sg:person.0664621034.86
143 rdf:rest N85ddf04fb8a143c9913e14b0d7cddfc5
144 Nc755f6b2dfa847e4981c088ba62238a3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Disease Progression
146 rdf:type schema:DefinedTerm
147 Nd1dbcf36f6eb45b7a9a498deb14fd8f3 schema:name doi
148 schema:value 10.1038/nature09515
149 rdf:type schema:PropertyValue
150 Nd32e8b9279334d0abdc3382b504701e9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name DNA Mutational Analysis
152 rdf:type schema:DefinedTerm
153 Nd708dbf9e1674aba9829ebf3452cf10d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Clone Cells
155 rdf:type schema:DefinedTerm
156 Nd9aed4a5ade64d08870b24190f14b603 rdf:first sg:person.01066027314.25
157 rdf:rest Nb64e57cff8c042b3877d4d4301d3da02
158 Nda13e5ebd9ff484b8e7f9687ca267d2c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Cell Lineage
160 rdf:type schema:DefinedTerm
161 Nea06fddd0cbb43569c2b29c728449288 rdf:first sg:person.011173760757.54
162 rdf:rest N271e9704feed4db296e69df5a27cfffd
163 Neae6fb85166d403e9d070e97a7b80077 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Lung Neoplasms
165 rdf:type schema:DefinedTerm
166 Nfe5d50f218364a6d8a3bb15197fb6bf6 schema:volumeNumber 467
167 rdf:type schema:PublicationVolume
168 Nfec81422d7bc4a098f65eb2fede13633 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Models, Biological
170 rdf:type schema:DefinedTerm
171 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
172 schema:name Medical and Health Sciences
173 rdf:type schema:DefinedTerm
174 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
175 schema:name Oncology and Carcinogenesis
176 rdf:type schema:DefinedTerm
177 sg:grant.2411125 http://pending.schema.org/fundedItem sg:pub.10.1038/nature09515
178 rdf:type schema:MonetaryGrant
179 sg:grant.2440141 http://pending.schema.org/fundedItem sg:pub.10.1038/nature09515
180 rdf:type schema:MonetaryGrant
181 sg:grant.2469185 http://pending.schema.org/fundedItem sg:pub.10.1038/nature09515
182 rdf:type schema:MonetaryGrant
183 sg:grant.2471197 http://pending.schema.org/fundedItem sg:pub.10.1038/nature09515
184 rdf:type schema:MonetaryGrant
185 sg:grant.2478763 http://pending.schema.org/fundedItem sg:pub.10.1038/nature09515
186 rdf:type schema:MonetaryGrant
187 sg:grant.2480549 http://pending.schema.org/fundedItem sg:pub.10.1038/nature09515
188 rdf:type schema:MonetaryGrant
189 sg:grant.2519328 http://pending.schema.org/fundedItem sg:pub.10.1038/nature09515
190 rdf:type schema:MonetaryGrant
191 sg:grant.2634325 http://pending.schema.org/fundedItem sg:pub.10.1038/nature09515
192 rdf:type schema:MonetaryGrant
193 sg:grant.2634365 http://pending.schema.org/fundedItem sg:pub.10.1038/nature09515
194 rdf:type schema:MonetaryGrant
195 sg:grant.6582210 http://pending.schema.org/fundedItem sg:pub.10.1038/nature09515
196 rdf:type schema:MonetaryGrant
197 sg:journal.1018957 schema:issn 0090-0028
198 1476-4687
199 schema:name Nature
200 rdf:type schema:Periodical
201 sg:person.01024421573.29 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
202 schema:familyName Jones
203 schema:givenName Siân
204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01024421573.29
205 rdf:type schema:Person
206 sg:person.010354303077.37 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
207 schema:familyName Velculescu
208 schema:givenName Victor E.
209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010354303077.37
210 rdf:type schema:Person
211 sg:person.01063415267.74 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
212 schema:familyName Eshleman
213 schema:givenName James R.
214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01063415267.74
215 rdf:type schema:Person
216 sg:person.01066027314.25 schema:affiliation https://www.grid.ac/institutes/grid.38142.3c
217 schema:familyName Bozic
218 schema:givenName Ivana
219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01066027314.25
220 rdf:type schema:Person
221 sg:person.01072165702.40 schema:affiliation https://www.grid.ac/institutes/grid.4305.2
222 schema:familyName Antal
223 schema:givenName Tibor
224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01072165702.40
225 rdf:type schema:Person
226 sg:person.011173760757.54 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
227 schema:familyName Vogelstein
228 schema:givenName Bert
229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011173760757.54
230 rdf:type schema:Person
231 sg:person.01161070716.44 schema:affiliation https://www.grid.ac/institutes/grid.38142.3c
232 schema:familyName Nowak
233 schema:givenName Martin A.
234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01161070716.44
235 rdf:type schema:Person
236 sg:person.01251235473.73 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
237 schema:familyName Leary
238 schema:givenName Rebecca
239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01251235473.73
240 rdf:type schema:Person
241 sg:person.01311713313.29 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
242 schema:familyName Yachida
243 schema:givenName Shinichi
244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01311713313.29
245 rdf:type schema:Person
246 sg:person.01366574634.71 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
247 schema:familyName Fu
248 schema:givenName Baojin
249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01366574634.71
250 rdf:type schema:Person
251 sg:person.016324315037.55 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
252 schema:familyName Iacobuzio-Donahue
253 schema:givenName Christine A.
254 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016324315037.55
255 rdf:type schema:Person
256 sg:person.0620642630.54 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
257 schema:familyName Kinzler
258 schema:givenName Kenneth W.
259 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0620642630.54
260 rdf:type schema:Person
261 sg:person.0664621034.86 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
262 schema:familyName Kamiyama
263 schema:givenName Mihoko
264 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0664621034.86
265 rdf:type schema:Person
266 sg:person.07624111077.08 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
267 schema:familyName Hruban
268 schema:givenName Ralph H.
269 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07624111077.08
270 rdf:type schema:Person
271 sg:pub.10.1007/bf02788531 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082439026
272 https://doi.org/10.1007/bf02788531
273 rdf:type schema:CreativeWork
274 sg:pub.10.1038/25292 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033871070
275 https://doi.org/10.1038/25292
276 rdf:type schema:CreativeWork
277 sg:pub.10.1038/nature08768 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002735811
278 https://doi.org/10.1038/nature08768
279 rdf:type schema:CreativeWork
280 sg:pub.10.1038/nrc2622 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020158834
281 https://doi.org/10.1038/nrc2622
282 rdf:type schema:CreativeWork
283 sg:pub.10.1038/nrc755 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049934401
284 https://doi.org/10.1038/nrc755
285 rdf:type schema:CreativeWork
286 sg:pub.10.1038/nrclinonc.2009.236 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044620521
287 https://doi.org/10.1038/nrclinonc.2009.236
288 rdf:type schema:CreativeWork
289 https://app.dimensions.ai/details/publication/pub.1083204935 schema:CreativeWork
290 https://doi.org/10.1002/1097-0142(19880901)62:5<989::aid-cncr2820620525>3.0.co;2-u schema:sameAs https://app.dimensions.ai/details/publication/pub.1002540794
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1006/scbi.2001.0416 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048653187
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1043/1543-2165-133.3.413 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077858809
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1053/ejso.1999.0907 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032339876
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1073/pnas.0712345105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018833150
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1093/jnci/djj068 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025553372
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1101/gr.5402306 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018459854
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1126/science.1164368 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006710792
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1126/science.1171362 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008567341
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1126/scitranslmed.3000702 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030440398
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1146/annurev.pathmechdis.3.121806.154305 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031737156
311 rdf:type schema:CreativeWork
312 https://doi.org/10.3748/wjg.14.1958 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071360219
313 rdf:type schema:CreativeWork
314 https://doi.org/10.4161/cbt.4.5.1663 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072293745
315 rdf:type schema:CreativeWork
316 https://doi.org/10.4161/cbt.6.10.4708 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072294347
317 rdf:type schema:CreativeWork
318 https://www.grid.ac/institutes/grid.21107.35 schema:alternateName Johns Hopkins University
319 schema:name Department of Oncology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
320 Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
321 Department of Surgery, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
322 The Ludwig Center for Cancer Genetics and Therapeutics and The Howard Hughes Medical Institute at The Johns Hopkins Kimmel Cancer Center, Baltimore, Maryland 21231, USA
323 rdf:type schema:Organization
324 https://www.grid.ac/institutes/grid.38142.3c schema:alternateName Harvard University
325 schema:name Program for Evolutionary Dynamics, Department of Mathematics, Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA
326 rdf:type schema:Organization
327 https://www.grid.ac/institutes/grid.4305.2 schema:alternateName University of Edinburgh
328 schema:name Program for Evolutionary Dynamics, Department of Mathematics, Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA
329 School of Mathematics, University of Edinburgh, Edinburgh EH9 3JZ, UK
330 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...