The ploidy conveyor of mature hepatocytes as a source of genetic variation View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2010-09-22

AUTHORS

Andrew W. Duncan, Matthew H. Taylor, Raymond D. Hickey, Amy E. Hanlon Newell, Michelle L. Lenzi, Susan B. Olson, Milton J. Finegold, Markus Grompe

ABSTRACT

Polyploidy in liver cellsMany liver cells are polyploid, containing 4, 8, 16 or more times the haploid chromosome complement, although the significance of the phenomenon is not known. A study in mice now shows that hepatocytes can both increase and decrease their ploidy in vivo. Ploidy reversal was previously thought to be exclusive to meiosis, but this work shows that it can also occur in normal somatic cells. Increases in ploidy occur through failed cytokinesis, and decreases as a result of multipolar mitosis. The resulting genetic heterogeneity might be advantageous following hepatic injury when 'genetically robust' cells could be selected from a pre-existing pool of diverse genotypes. More... »

PAGES

707-710

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature09414

DOI

http://dx.doi.org/10.1038/nature09414

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1044509580

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20861837


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