A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2010-09

AUTHORS

Matthias Heinig, Enrico Petretto, Chris Wallace, Leonardo Bottolo, Maxime Rotival, Han Lu, Yoyo Li, Rizwan Sarwar, Sarah R. Langley, Anja Bauerfeind, Oliver Hummel, Young-Ae Lee, Svetlana Paskas, Carola Rintisch, Kathrin Saar, Jason Cooper, Rachel Buchan, Elizabeth E. Gray, Jason G. Cyster, Cardiogenics Consortium, Peter Braund, Jay Gracey, Unni Krishnan, Jasbir S. Moore, Chris P. Nelson, Helen Pollard, Tony Attwood, Abi Crisp-Hihn, Nicola Foad, Jennifer Jolley, Heather Lloyd-Jones, David Muir, Elizabeth Murray, Karen O’Leary, Angela Rankin, Jennifer Sambrook, Tiphaine Godfroy, Jessy Brocheton, Carole Proust, Gerd Schmitz, Susanne Heimerl, Ingrid Lugauer, Stephanie Belz, Stefanie Gulde, Patrick Linsel-Nitschke, Hendrik Sager, Laura Schroeder, Per Lundmark, Ann-Christine Syvannen, Jessica Neudert, Michael Scholz, Panos Deloukas, Emma Gray, Rhian Gwilliams, David Niblett., Jeanette Erdmann, Christian Hengstenberg, Seraya Maouche, Willem H. Ouwehand, Catherine M. Rice, Nilesh J. Samani, Heribert Schunkert, Alison H. Goodall, Herbert Schulz, Helge G. Roider, Martin Vingron, Stefan Blankenberg, Thomas Münzel, Tanja Zeller, Silke Szymczak, Andreas Ziegler, Laurence Tiret, Deborah J. Smyth, Michal Pravenec, Timothy J. Aitman, Francois Cambien, David Clayton, John A. Todd, Norbert Hubner, Stuart A. Cook

ABSTRACT

Combined analyses of gene networks and DNA sequence variation can provide new insights into the aetiology of common diseases that may not be apparent from genome-wide association studies alone. Recent advances in rat genomics are facilitating systems-genetics approaches. Here we report the use of integrated genome-wide approaches across seven rat tissues to identify gene networks and the loci underlying their regulation. We defined an interferon regulatory factor 7 (IRF7)-driven inflammatory network (IDIN) enriched for viral response genes, which represents a molecular biomarker for macrophages and which was regulated in multiple tissues by a locus on rat chromosome 15q25. We show that Epstein-Barr virus induced gene 2 (Ebi2, also known as Gpr183), which lies at this locus and controls B lymphocyte migration, is expressed in macrophages and regulates the IDIN. The human orthologous locus on chromosome 13q32 controlled the human equivalent of the IDIN, which was conserved in monocytes. IDIN genes were more likely to associate with susceptibility to type 1 diabetes (T1D)-a macrophage-associated autoimmune disease-than randomly selected immune response genes (P = 8.85 × 10(-6)). The human locus controlling the IDIN was associated with the risk of T1D at single nucleotide polymorphism rs9585056 (P = 7.0 × 10(-10); odds ratio, 1.15), which was one of five single nucleotide polymorphisms in this region associated with EBI2 (GPR183) expression. These data implicate IRF7 network genes and their regulatory locus in the pathogenesis of T1D. More... »

PAGES

460

References to SciGraph publications

  • 2004-10. Interferon-α induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6 in NATURE IMMUNOLOGY
  • 2007-06-07. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls in NATURE
  • 2005-04. IRF-7 is the master regulator of type-I interferon-dependent immune responses in NATURE
  • 2008-03. Variations in DNA elucidate molecular networks that cause disease in NATURE
  • 2009-04. The role of inflammation in insulitis and β-cell loss in type 1 diabetes in NATURE REVIEWS ENDOCRINOLOGY
  • 2009-05. Diabetes: A virus–gene collaboration in NATURE
  • 2009-12. Follow-up of 1715 SNPs from the Wellcome Trust Case Control Consortium genome-wide association study in type I diabetes families in GENES & IMMUNITY
  • 2006-06. A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region in NATURE GENETICS
  • 2003-09. Trans-acting regulatory variation in Saccharomyces cerevisiae and the role of transcription factors in NATURE GENETICS
  • 2009-06. Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes in NATURE GENETICS
  • 2005-03. Integrated transcriptional profiling and linkage analysis for identification of genes underlying disease in NATURE GENETICS
  • 2008-05. SNP and haplotype mapping for genetic analysis in the rat in NATURE GENETICS
  • 2009-08. EBI2 mediates B cell segregation between the outer and centre follicle in NATURE
  • 2009-09-10. Molecular networks as sensors and drivers of common human diseases in NATURE
  • 2008-05. Integrated genomic approaches implicate osteoglycin (Ogn) in the regulation of left ventricular mass in NATURE GENETICS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nature09386

    DOI

    http://dx.doi.org/10.1038/nature09386

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1052043691

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/20827270


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