Formate-driven growth coupled with H2 production View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2010-09

AUTHORS

Yun Jae Kim, Hyun Sook Lee, Eun Sook Kim, Seung Seob Bae, Jae Kyu Lim, Rie Matsumi, Alexander V. Lebedinsky, Tatyana G. Sokolova, Darya A. Kozhevnikova, Sun-Shin Cha, Sang-Jin Kim, Kae Kyoung Kwon, Tadayuki Imanaka, Haruyuki Atomi, Elizaveta A. Bonch-Osmolovskaya, Jung-Hyun Lee, Sung Gyun Kang

ABSTRACT

Although a common reaction in anaerobic environments, the conversion of formate and water to bicarbonate and H(2) (with a change in Gibbs free energy of ΔG° = +1.3 kJ mol(-1)) has not been considered energetic enough to support growth of microorganisms. Recently, experimental evidence for growth on formate was reported for syntrophic communities of Moorella sp. strain AMP and a hydrogen-consuming Methanothermobacter species and of Desulfovibrio sp. strain G11 and Methanobrevibacter arboriphilus strain AZ. The basis of the sustainable growth of the formate-users is explained by H(2) consumption by the methanogens, which lowers the H(2) partial pressure, thus making the pathway exergonic. However, it has not been shown that a single strain can grow on formate by catalysing its conversion to bicarbonate and H(2). Here we report that several hyperthermophilic archaea belonging to the Thermococcus genus are capable of formate-oxidizing, H(2)-producing growth. The actual ΔG values for the formate metabolism are calculated to range between -8 and -20 kJ mol(-1) under the physiological conditions where Thermococcus onnurineus strain NA1 are grown. Furthermore, we detected ATP synthesis in the presence of formate as a sole energy source. Gene expression profiling and disruption identified the gene cluster encoding formate hydrogen lyase, cation/proton antiporter and formate transporter, which were responsible for the growth of T. onnurineus NA1 on formate. This work shows formate-driven growth by a single microorganism with protons as the electron acceptor, and reports the biochemical basis of this ability. More... »

PAGES

352

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature09375

DOI

http://dx.doi.org/10.1038/nature09375

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1015326716

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20844539


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