Functional roles for noise in genetic circuits View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2010-09-09

AUTHORS

Avigdor Eldar, Michael B. Elowitz

ABSTRACT

The genetic circuits that regulate cellular functions are subject to stochastic fluctuations, or 'noise', in the levels of their components. Noise, far from just a nuisance, has begun to be appreciated for its essential role in key cellular activities. Noise functions in both microbial and eukaryotic cells, in multicellular development, and in evolution. It enables coordination of gene expression across large regulons, as well as probabilistic differentiation strategies that function across cell populations. At the longest timescales, noise may facilitate evolutionary transitions. Here we review examples and emerging principles that connect noise, the architecture of the gene circuits in which it is present, and the biological functions it enables. We further indicate some of the important challenges and opportunities going forward. More... »

PAGES

167

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nature09326

    DOI

    http://dx.doi.org/10.1038/nature09326

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1006717915

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/20829787


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