Progesterone induces adult mammary stem cell expansion View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2010-06

AUTHORS

Purna A. Joshi, Hartland W. Jackson, Alexander G. Beristain, Marco A. Di Grappa, Patricia A. Mote, Christine L. Clarke, John Stingl, Paul D. Waterhouse, Rama Khokha

ABSTRACT

Reproductive history is the strongest risk factor for breast cancer after age, genetics and breast density. Increased breast cancer risk is entwined with a greater number of ovarian hormone-dependent reproductive cycles, yet the basis for this predisposition is unknown. Mammary stem cells (MaSCs) are located within a specialized niche in the basal epithelial compartment that is under local and systemic regulation. The emerging role of MaSCs in cancer initiation warrants the study of ovarian hormones in MaSC homeostasis. Here we show that the MaSC pool increases 14-fold during maximal progesterone levels at the luteal dioestrus phase of the mouse. Stem-cell-enriched CD49fhi cells amplify at dioestrus, or with exogenous progesterone, demonstrating a key role for progesterone in propelling this expansion. In aged mice, CD49fhi cells display stasis upon cessation of the reproductive cycle. Progesterone drives a series of events where luminal cells probably provide Wnt4 and RANKL signals to basal cells which in turn respond by upregulating their cognate receptors, transcriptional targets and cell cycle markers. Our findings uncover a dynamic role for progesterone in activating adult MaSCs within the mammary stem cell niche during the reproductive cycle, where MaSCs are putative targets for cell transformation events leading to breast cancer. More... »

PAGES

803

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature09091

DOI

http://dx.doi.org/10.1038/nature09091

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1010449747

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20445538


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aging", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Count", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Division", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Transformation, Neoplastic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Estrogens", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Estrous Cycle", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Homeostasis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Integrin alpha6", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mammary Glands, Animal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ovariectomy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Paracrine Communication", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Progesterone", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RANK Ligand", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Estrogen", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Progesterone", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Stem Cell Niche", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Stem Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Wnt Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Wnt4 Protein", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Toronto", 
          "id": "https://www.grid.ac/institutes/grid.17063.33", 
          "name": [
            "Ontario Cancer Institute, Department of Medical Biophysics and Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto M5G 2M9, Ontario, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Joshi", 
        "givenName": "Purna A.", 
        "id": "sg:person.01153075271.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01153075271.88"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Toronto", 
          "id": "https://www.grid.ac/institutes/grid.17063.33", 
          "name": [
            "Ontario Cancer Institute, Department of Medical Biophysics and Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto M5G 2M9, Ontario, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jackson", 
        "givenName": "Hartland W.", 
        "id": "sg:person.0767743773.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0767743773.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Toronto", 
          "id": "https://www.grid.ac/institutes/grid.17063.33", 
          "name": [
            "Ontario Cancer Institute, Department of Medical Biophysics and Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto M5G 2M9, Ontario, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Beristain", 
        "givenName": "Alexander G.", 
        "id": "sg:person.01212743355.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01212743355.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Toronto", 
          "id": "https://www.grid.ac/institutes/grid.17063.33", 
          "name": [
            "Ontario Cancer Institute, Department of Medical Biophysics and Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto M5G 2M9, Ontario, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Di Grappa", 
        "givenName": "Marco A.", 
        "id": "sg:person.01327171755.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01327171755.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Westmead Institute for Medical Research", 
          "id": "https://www.grid.ac/institutes/grid.452919.2", 
          "name": [
            "Westmead Institute for Cancer Research, University of Sydney at Westmead Millennium Institute, Westmead, New South Wales 2145, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mote", 
        "givenName": "Patricia A.", 
        "id": "sg:person.01032777214.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01032777214.58"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Westmead Institute for Medical Research", 
          "id": "https://www.grid.ac/institutes/grid.452919.2", 
          "name": [
            "Westmead Institute for Cancer Research, University of Sydney at Westmead Millennium Institute, Westmead, New South Wales 2145, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Clarke", 
        "givenName": "Christine L.", 
        "id": "sg:person.01370425453.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01370425453.91"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cancer Research UK Cambridge Institute", 
          "id": "https://www.grid.ac/institutes/grid.470869.4", 
          "name": [
            "Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge CB2 0RE, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Stingl", 
        "givenName": "John", 
        "id": "sg:person.01234170001.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01234170001.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Toronto", 
          "id": "https://www.grid.ac/institutes/grid.17063.33", 
          "name": [
            "Ontario Cancer Institute, Department of Medical Biophysics and Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto M5G 2M9, Ontario, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Waterhouse", 
        "givenName": "Paul D.", 
        "id": "sg:person.0614032635.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0614032635.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Toronto", 
          "id": "https://www.grid.ac/institutes/grid.17063.33", 
          "name": [
            "Ontario Cancer Institute, Department of Medical Biophysics and Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto M5G 2M9, Ontario, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Khokha", 
        "givenName": "Rama", 
        "id": "sg:person.0743632150.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0743632150.50"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1001/jama.288.3.321", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000900542"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.89.19.9064", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003919328"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1015714305420", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009081275", 
          "https://doi.org/10.1023/a:1015714305420"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10911-009-9111-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009626514", 
          "https://doi.org/10.1007/s10911-009-9111-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj1820127", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012265823"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj1820127", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012265823"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1732707100", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014909974"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12015-007-0019-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016054472", 
          "https://doi.org/10.1007/s12015-007-0019-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1018752519356", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022166579", 
          "https://doi.org/10.1023/a:1018752519356"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/djj267", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022622258"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb1530", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023411079", 
          "https://doi.org/10.1038/ncb1530"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb1530", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023411079", 
          "https://doi.org/10.1038/ncb1530"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0006594", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023770932"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/dev.01609", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025725319"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0915148107", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031095192"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(05)66546-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032685840"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(05)66546-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032685840"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.95.9.5076", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036663759"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04372", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037658738", 
          "https://doi.org/10.1038/nature04372"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04372", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037658738", 
          "https://doi.org/10.1038/nature04372"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04372", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037658738", 
          "https://doi.org/10.1038/nature04372"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04496", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040185730", 
          "https://doi.org/10.1038/nature04496"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04496", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040185730", 
          "https://doi.org/10.1038/nature04496"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04496", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040185730", 
          "https://doi.org/10.1038/nature04496"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)00103-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047141592"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1095/biolreprod65.3.680", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047979851"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1095/biolreprod65.3.680", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047979851"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.2910440506", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048128746"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1130471", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062454565"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/en.2006-0040", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064247911"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/en.2006-1493", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064248413"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/en.2008-1630", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064249824"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/er.18.4.502", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064285707"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074521014", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074610572", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079884584", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080781500", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/oxfordjournals.epirev.a036115", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082792720"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2010-06", 
    "datePublishedReg": "2010-06-01", 
    "description": "Reproductive history is the strongest risk factor for breast cancer after age, genetics and breast density. Increased breast cancer risk is entwined with a greater number of ovarian hormone-dependent reproductive cycles, yet the basis for this predisposition is unknown. Mammary stem cells (MaSCs) are located within a specialized niche in the basal epithelial compartment that is under local and systemic regulation. The emerging role of MaSCs in cancer initiation warrants the study of ovarian hormones in MaSC homeostasis. Here we show that the MaSC pool increases 14-fold during maximal progesterone levels at the luteal dioestrus phase of the mouse. Stem-cell-enriched CD49fhi cells amplify at dioestrus, or with exogenous progesterone, demonstrating a key role for progesterone in propelling this expansion. In aged mice, CD49fhi cells display stasis upon cessation of the reproductive cycle. Progesterone drives a series of events where luminal cells probably provide Wnt4 and RANKL signals to basal cells which in turn respond by upregulating their cognate receptors, transcriptional targets and cell cycle markers. Our findings uncover a dynamic role for progesterone in activating adult MaSCs within the mammary stem cell niche during the reproductive cycle, where MaSCs are putative targets for cell transformation events leading to breast cancer.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/nature09091", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2752941", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0090-0028", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "7299", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "465"
      }
    ], 
    "name": "Progesterone induces adult mammary stem cell expansion", 
    "pagination": "803", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "31c84adfcb1c10963f04f6d378cd46295221aa716f0de62b27a0d6241a8a8fae"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "20445538"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0410462"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/nature09091"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1010449747"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/nature09091", 
      "https://app.dimensions.ai/details/publication/pub.1010449747"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T10:36", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000349_0000000349/records_113673_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/nature09091"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nature09091'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nature09091'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nature09091'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nature09091'


 

This table displays all metadata directly associated to this object as RDF triples.

314 TRIPLES      21 PREDICATES      81 URIs      43 LITERALS      31 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/nature09091 schema:about N04fde4b3cf3045febd4f0b81c5560f28
2 N0c4ccfc3bf5f417681e10aa8aa3f3d89
3 N2d82be596e2444e99d31849369bef288
4 N37a3c2022e5e4487bdc927b98db82927
5 N39062248cf3548eba8da3c71f39921b0
6 N3f745f99a1da49e799892051dd89a47d
7 N472b41a560214f5b82e3e60f4ecdf3a3
8 N498a401a89bf49e6b7cccf5e13178056
9 N766d88bcdc3642a78c902a79ba7d9382
10 N7a94200b72cc44d78dc7e948636074ab
11 N99bd98d81c2442f38898c9d53bb6c63d
12 Na5cd466fb54c4fd2b58488d60cbefe62
13 Nab9e106f94b04688a76c4430ce46d09c
14 Nc0c0bb10f2d74823af144620a8d0eaed
15 Nc912d0cf2d6645c59f754f51ab9c8350
16 Ncaa4e2f4035a4d01846ae9600b7270cd
17 Ncf6c2ccaceb24e60800833402f4df84a
18 Ncfab0e0f94c843409d8d130d8e4caa75
19 Ne15b1d62be3041c8a57b27a26614a905
20 Ne43f77edf5af4c22b83ad6c72ab067e6
21 Nec16a953809a419793554b94d00c483e
22 Nfd06940cd66e4ea7be009b41295a00e5
23 anzsrc-for:11
24 anzsrc-for:1112
25 schema:author Ne43bc9fa21be4b589aaf82df5b9b3ffb
26 schema:citation sg:pub.10.1007/s10911-009-9111-2
27 sg:pub.10.1007/s12015-007-0019-1
28 sg:pub.10.1023/a:1015714305420
29 sg:pub.10.1023/a:1018752519356
30 sg:pub.10.1038/nature04372
31 sg:pub.10.1038/nature04496
32 sg:pub.10.1038/ncb1530
33 https://app.dimensions.ai/details/publication/pub.1074521014
34 https://app.dimensions.ai/details/publication/pub.1074610572
35 https://app.dimensions.ai/details/publication/pub.1079884584
36 https://app.dimensions.ai/details/publication/pub.1080781500
37 https://doi.org/10.1001/jama.288.3.321
38 https://doi.org/10.1002/ijc.2910440506
39 https://doi.org/10.1016/s0092-8674(00)00103-3
40 https://doi.org/10.1016/s0140-6736(05)66546-4
41 https://doi.org/10.1042/bj1820127
42 https://doi.org/10.1073/pnas.0915148107
43 https://doi.org/10.1073/pnas.1732707100
44 https://doi.org/10.1073/pnas.89.19.9064
45 https://doi.org/10.1073/pnas.95.9.5076
46 https://doi.org/10.1093/jnci/djj267
47 https://doi.org/10.1093/oxfordjournals.epirev.a036115
48 https://doi.org/10.1095/biolreprod65.3.680
49 https://doi.org/10.1126/science.1130471
50 https://doi.org/10.1210/en.2006-0040
51 https://doi.org/10.1210/en.2006-1493
52 https://doi.org/10.1210/en.2008-1630
53 https://doi.org/10.1210/er.18.4.502
54 https://doi.org/10.1242/dev.01609
55 https://doi.org/10.1371/journal.pone.0006594
56 schema:datePublished 2010-06
57 schema:datePublishedReg 2010-06-01
58 schema:description Reproductive history is the strongest risk factor for breast cancer after age, genetics and breast density. Increased breast cancer risk is entwined with a greater number of ovarian hormone-dependent reproductive cycles, yet the basis for this predisposition is unknown. Mammary stem cells (MaSCs) are located within a specialized niche in the basal epithelial compartment that is under local and systemic regulation. The emerging role of MaSCs in cancer initiation warrants the study of ovarian hormones in MaSC homeostasis. Here we show that the MaSC pool increases 14-fold during maximal progesterone levels at the luteal dioestrus phase of the mouse. Stem-cell-enriched CD49fhi cells amplify at dioestrus, or with exogenous progesterone, demonstrating a key role for progesterone in propelling this expansion. In aged mice, CD49fhi cells display stasis upon cessation of the reproductive cycle. Progesterone drives a series of events where luminal cells probably provide Wnt4 and RANKL signals to basal cells which in turn respond by upregulating their cognate receptors, transcriptional targets and cell cycle markers. Our findings uncover a dynamic role for progesterone in activating adult MaSCs within the mammary stem cell niche during the reproductive cycle, where MaSCs are putative targets for cell transformation events leading to breast cancer.
59 schema:genre research_article
60 schema:inLanguage en
61 schema:isAccessibleForFree false
62 schema:isPartOf N2c18d149b7d94df3b5dc3cc477f57eb1
63 Ne3c4dfe40ce94d799625f64b84287924
64 sg:journal.1018957
65 schema:name Progesterone induces adult mammary stem cell expansion
66 schema:pagination 803
67 schema:productId N8a2d3dfb23474124bc3e9ac26c97c4cf
68 Na2af9e17675d4e92a3a6ed2f9358ea6b
69 Na45b724141ca450399914896da932c76
70 Na67c2cdf95ca46baa1c3c6efefaa6342
71 Nc329a65f8d0f4af89d577606df0deb12
72 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010449747
73 https://doi.org/10.1038/nature09091
74 schema:sdDatePublished 2019-04-11T10:36
75 schema:sdLicense https://scigraph.springernature.com/explorer/license/
76 schema:sdPublisher N084cda3e49124c3da51e5a31d382ce57
77 schema:url https://www.nature.com/articles/nature09091
78 sgo:license sg:explorer/license/
79 sgo:sdDataset articles
80 rdf:type schema:ScholarlyArticle
81 N04fde4b3cf3045febd4f0b81c5560f28 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
82 schema:name Mice
83 rdf:type schema:DefinedTerm
84 N084cda3e49124c3da51e5a31d382ce57 schema:name Springer Nature - SN SciGraph project
85 rdf:type schema:Organization
86 N0c4ccfc3bf5f417681e10aa8aa3f3d89 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name Wnt4 Protein
88 rdf:type schema:DefinedTerm
89 N27d7abf7da154b4aa809b368ea4b901c rdf:first sg:person.01327171755.40
90 rdf:rest Nf0027a27b1174bfb9ea0e32c7bc59639
91 N2a6435b01da645ef88a591c6408066de rdf:first sg:person.0743632150.50
92 rdf:rest rdf:nil
93 N2c18d149b7d94df3b5dc3cc477f57eb1 schema:volumeNumber 465
94 rdf:type schema:PublicationVolume
95 N2d82be596e2444e99d31849369bef288 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Paracrine Communication
97 rdf:type schema:DefinedTerm
98 N37a3c2022e5e4487bdc927b98db82927 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Mammary Glands, Animal
100 rdf:type schema:DefinedTerm
101 N39062248cf3548eba8da3c71f39921b0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Integrin alpha6
103 rdf:type schema:DefinedTerm
104 N3f745f99a1da49e799892051dd89a47d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Cell Transformation, Neoplastic
106 rdf:type schema:DefinedTerm
107 N472b41a560214f5b82e3e60f4ecdf3a3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Ovariectomy
109 rdf:type schema:DefinedTerm
110 N498a401a89bf49e6b7cccf5e13178056 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name RANK Ligand
112 rdf:type schema:DefinedTerm
113 N766d88bcdc3642a78c902a79ba7d9382 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Stem Cells
115 rdf:type schema:DefinedTerm
116 N7a94200b72cc44d78dc7e948636074ab schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Homeostasis
118 rdf:type schema:DefinedTerm
119 N82c113197d364a4f85d8dc6f52987d7a rdf:first sg:person.01234170001.03
120 rdf:rest Ncff3eeb2fdee42a780be1b9602444f95
121 N8a2d3dfb23474124bc3e9ac26c97c4cf schema:name dimensions_id
122 schema:value pub.1010449747
123 rdf:type schema:PropertyValue
124 N99bd98d81c2442f38898c9d53bb6c63d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Receptors, Progesterone
126 rdf:type schema:DefinedTerm
127 N9b25b15b658c41ee845ae37f2d0d351b rdf:first sg:person.01212743355.12
128 rdf:rest N27d7abf7da154b4aa809b368ea4b901c
129 Na2af9e17675d4e92a3a6ed2f9358ea6b schema:name pubmed_id
130 schema:value 20445538
131 rdf:type schema:PropertyValue
132 Na45b724141ca450399914896da932c76 schema:name nlm_unique_id
133 schema:value 0410462
134 rdf:type schema:PropertyValue
135 Na5cd466fb54c4fd2b58488d60cbefe62 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Aging
137 rdf:type schema:DefinedTerm
138 Na67c2cdf95ca46baa1c3c6efefaa6342 schema:name readcube_id
139 schema:value 31c84adfcb1c10963f04f6d378cd46295221aa716f0de62b27a0d6241a8a8fae
140 rdf:type schema:PropertyValue
141 Nab9e106f94b04688a76c4430ce46d09c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Stem Cell Niche
143 rdf:type schema:DefinedTerm
144 Nc0c0bb10f2d74823af144620a8d0eaed schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Female
146 rdf:type schema:DefinedTerm
147 Nc2f745aaada9491e8ac75f0ac56d46bc rdf:first sg:person.01370425453.91
148 rdf:rest N82c113197d364a4f85d8dc6f52987d7a
149 Nc329a65f8d0f4af89d577606df0deb12 schema:name doi
150 schema:value 10.1038/nature09091
151 rdf:type schema:PropertyValue
152 Nc912d0cf2d6645c59f754f51ab9c8350 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Progesterone
154 rdf:type schema:DefinedTerm
155 Ncaa4e2f4035a4d01846ae9600b7270cd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Wnt Proteins
157 rdf:type schema:DefinedTerm
158 Ncf6c2ccaceb24e60800833402f4df84a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Animals
160 rdf:type schema:DefinedTerm
161 Ncfab0e0f94c843409d8d130d8e4caa75 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Cell Count
163 rdf:type schema:DefinedTerm
164 Ncff3eeb2fdee42a780be1b9602444f95 rdf:first sg:person.0614032635.49
165 rdf:rest N2a6435b01da645ef88a591c6408066de
166 Ne15b1d62be3041c8a57b27a26614a905 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Estrous Cycle
168 rdf:type schema:DefinedTerm
169 Ne3c4dfe40ce94d799625f64b84287924 schema:issueNumber 7299
170 rdf:type schema:PublicationIssue
171 Ne43bc9fa21be4b589aaf82df5b9b3ffb rdf:first sg:person.01153075271.88
172 rdf:rest Ne7140601a5da4978af3a3075d458acf5
173 Ne43f77edf5af4c22b83ad6c72ab067e6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Receptors, Estrogen
175 rdf:type schema:DefinedTerm
176 Ne7140601a5da4978af3a3075d458acf5 rdf:first sg:person.0767743773.09
177 rdf:rest N9b25b15b658c41ee845ae37f2d0d351b
178 Nec16a953809a419793554b94d00c483e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name Estrogens
180 rdf:type schema:DefinedTerm
181 Nf0027a27b1174bfb9ea0e32c7bc59639 rdf:first sg:person.01032777214.58
182 rdf:rest Nc2f745aaada9491e8ac75f0ac56d46bc
183 Nfd06940cd66e4ea7be009b41295a00e5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
184 schema:name Cell Division
185 rdf:type schema:DefinedTerm
186 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
187 schema:name Medical and Health Sciences
188 rdf:type schema:DefinedTerm
189 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
190 schema:name Oncology and Carcinogenesis
191 rdf:type schema:DefinedTerm
192 sg:grant.2752941 http://pending.schema.org/fundedItem sg:pub.10.1038/nature09091
193 rdf:type schema:MonetaryGrant
194 sg:journal.1018957 schema:issn 0090-0028
195 1476-4687
196 schema:name Nature
197 rdf:type schema:Periodical
198 sg:person.01032777214.58 schema:affiliation https://www.grid.ac/institutes/grid.452919.2
199 schema:familyName Mote
200 schema:givenName Patricia A.
201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01032777214.58
202 rdf:type schema:Person
203 sg:person.01153075271.88 schema:affiliation https://www.grid.ac/institutes/grid.17063.33
204 schema:familyName Joshi
205 schema:givenName Purna A.
206 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01153075271.88
207 rdf:type schema:Person
208 sg:person.01212743355.12 schema:affiliation https://www.grid.ac/institutes/grid.17063.33
209 schema:familyName Beristain
210 schema:givenName Alexander G.
211 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01212743355.12
212 rdf:type schema:Person
213 sg:person.01234170001.03 schema:affiliation https://www.grid.ac/institutes/grid.470869.4
214 schema:familyName Stingl
215 schema:givenName John
216 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01234170001.03
217 rdf:type schema:Person
218 sg:person.01327171755.40 schema:affiliation https://www.grid.ac/institutes/grid.17063.33
219 schema:familyName Di Grappa
220 schema:givenName Marco A.
221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01327171755.40
222 rdf:type schema:Person
223 sg:person.01370425453.91 schema:affiliation https://www.grid.ac/institutes/grid.452919.2
224 schema:familyName Clarke
225 schema:givenName Christine L.
226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01370425453.91
227 rdf:type schema:Person
228 sg:person.0614032635.49 schema:affiliation https://www.grid.ac/institutes/grid.17063.33
229 schema:familyName Waterhouse
230 schema:givenName Paul D.
231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0614032635.49
232 rdf:type schema:Person
233 sg:person.0743632150.50 schema:affiliation https://www.grid.ac/institutes/grid.17063.33
234 schema:familyName Khokha
235 schema:givenName Rama
236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0743632150.50
237 rdf:type schema:Person
238 sg:person.0767743773.09 schema:affiliation https://www.grid.ac/institutes/grid.17063.33
239 schema:familyName Jackson
240 schema:givenName Hartland W.
241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0767743773.09
242 rdf:type schema:Person
243 sg:pub.10.1007/s10911-009-9111-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009626514
244 https://doi.org/10.1007/s10911-009-9111-2
245 rdf:type schema:CreativeWork
246 sg:pub.10.1007/s12015-007-0019-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016054472
247 https://doi.org/10.1007/s12015-007-0019-1
248 rdf:type schema:CreativeWork
249 sg:pub.10.1023/a:1015714305420 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009081275
250 https://doi.org/10.1023/a:1015714305420
251 rdf:type schema:CreativeWork
252 sg:pub.10.1023/a:1018752519356 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022166579
253 https://doi.org/10.1023/a:1018752519356
254 rdf:type schema:CreativeWork
255 sg:pub.10.1038/nature04372 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037658738
256 https://doi.org/10.1038/nature04372
257 rdf:type schema:CreativeWork
258 sg:pub.10.1038/nature04496 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040185730
259 https://doi.org/10.1038/nature04496
260 rdf:type schema:CreativeWork
261 sg:pub.10.1038/ncb1530 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023411079
262 https://doi.org/10.1038/ncb1530
263 rdf:type schema:CreativeWork
264 https://app.dimensions.ai/details/publication/pub.1074521014 schema:CreativeWork
265 https://app.dimensions.ai/details/publication/pub.1074610572 schema:CreativeWork
266 https://app.dimensions.ai/details/publication/pub.1079884584 schema:CreativeWork
267 https://app.dimensions.ai/details/publication/pub.1080781500 schema:CreativeWork
268 https://doi.org/10.1001/jama.288.3.321 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000900542
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1002/ijc.2910440506 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048128746
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1016/s0092-8674(00)00103-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047141592
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1016/s0140-6736(05)66546-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032685840
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1042/bj1820127 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012265823
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1073/pnas.0915148107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031095192
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1073/pnas.1732707100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014909974
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1073/pnas.89.19.9064 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003919328
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1073/pnas.95.9.5076 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036663759
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1093/jnci/djj267 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022622258
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1093/oxfordjournals.epirev.a036115 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082792720
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1095/biolreprod65.3.680 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047979851
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1126/science.1130471 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062454565
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1210/en.2006-0040 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064247911
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1210/en.2006-1493 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064248413
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1210/en.2008-1630 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064249824
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1210/er.18.4.502 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064285707
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1242/dev.01609 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025725319
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1371/journal.pone.0006594 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023770932
305 rdf:type schema:CreativeWork
306 https://www.grid.ac/institutes/grid.17063.33 schema:alternateName University of Toronto
307 schema:name Ontario Cancer Institute, Department of Medical Biophysics and Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto M5G 2M9, Ontario, Canada
308 rdf:type schema:Organization
309 https://www.grid.ac/institutes/grid.452919.2 schema:alternateName Westmead Institute for Medical Research
310 schema:name Westmead Institute for Cancer Research, University of Sydney at Westmead Millennium Institute, Westmead, New South Wales 2145, Australia
311 rdf:type schema:Organization
312 https://www.grid.ac/institutes/grid.470869.4 schema:alternateName Cancer Research UK Cambridge Institute
313 schema:name Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge CB2 0RE, UK
314 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...