An RNA polymerase II- and AGO4-associated protein acts in RNA-directed DNA methylation View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2010-04-21

AUTHORS

Zhihuan Gao, Hai-Liang Liu, Lucia Daxinger, Olga Pontes, Xinjian He, Weiqiang Qian, Huixin Lin, Mingtang Xie, Zdravko J. Lorkovic, Shoudong Zhang, Daisuke Miki, Xiangqiang Zhan, Dominique Pontier, Thierry Lagrange, Hailing Jin, Antonius J. M. Matzke, Marjori Matzke, Craig S. Pikaard, Jian-Kang Zhu

ABSTRACT

RNA-directed DNA methylation in ArabidopsisSmall interfering RNAs (siRNAs) are important regulators of gene expression in the plant model Arabidopsis, and intriguingly the vast majority of the small RNAs involved are generated from methylated regions of the genome. A previously unknown protein termed RdDM (for regulator of RNA-directed DNA methylation) has now been identified in Arabidopsis, throwing more light on the interactions of epigenetics, DNA methylation and small RNAs in plants. RDM1 is a novel methyl DNA-binding protein that binds to single-stranded methylated DNA: the many methyl DNA-binding proteins known previously in plants and animals bind only to double-stranded methylated DNA. RDM1 interacts with complexes of the effector protein Argonaute 4 (AGO4) with siRNAs to direct de novo DNA methylation and gene silencing. More... »

PAGES

106-109

Journal

TITLE

Nature

ISSUE

7294

VOLUME

465

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature09025

DOI

http://dx.doi.org/10.1038/nature09025

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1026235218

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20410883


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23 schema:description RNA-directed DNA methylation in ArabidopsisSmall interfering RNAs (siRNAs) are important regulators of gene expression in the plant model Arabidopsis, and intriguingly the vast majority of the small RNAs involved are generated from methylated regions of the genome. A previously unknown protein termed RdDM (for regulator of RNA-directed DNA methylation) has now been identified in Arabidopsis, throwing more light on the interactions of epigenetics, DNA methylation and small RNAs in plants. RDM1 is a novel methyl DNA-binding protein that binds to single-stranded methylated DNA: the many methyl DNA-binding proteins known previously in plants and animals bind only to double-stranded methylated DNA. RDM1 interacts with complexes of the effector protein Argonaute 4 (AGO4) with siRNAs to direct de novo DNA methylation and gene silencing.
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