Ontology type: schema:ScholarlyArticle Open Access: True
2010-04-15
AUTHORSRajnish A. Gupta, Nilay Shah, Kevin C. Wang, Jeewon Kim, Hugo M. Horlings, David J. Wong, Miao-Chih Tsai, Tiffany Hung, Pedram Argani, John L. Rinn, Yulei Wang, Pius Brzoska, Benjamin Kong, Rui Li, Robert B. West, Marc J. van de Vijver, Saraswati Sukumar, Howard Y. Chang
ABSTRACTLarge intervening non-coding RNAs (lincRNAs) are pervasively transcribed in the genome yet their potential involvement in human disease is not well understood. Recent studies of dosage compensation, imprinting, and homeotic gene expression suggest that individual lincRNAs can function as the interface between DNA and specific chromatin remodelling activities. Here we show that lincRNAs in the HOX loci become systematically dysregulated during breast cancer progression. The lincRNA termed HOTAIR is increased in expression in primary breast tumours and metastases, and HOTAIR expression level in primary tumours is a powerful predictor of eventual metastasis and death. Enforced expression of HOTAIR in epithelial cancer cells induced genome-wide re-targeting of Polycomb repressive complex 2 (PRC2) to an occupancy pattern more resembling embryonic fibroblasts, leading to altered histone H3 lysine 27 methylation, gene expression, and increased cancer invasiveness and metastasis in a manner dependent on PRC2. Conversely, loss of HOTAIR can inhibit cancer invasiveness, particularly in cells that possess excessive PRC2 activity. These findings indicate that lincRNAs have active roles in modulating the cancer epigenome and may be important targets for cancer diagnosis and therapy. More... »
PAGES1071
http://scigraph.springernature.com/pub.10.1038/nature08975
DOIhttp://dx.doi.org/10.1038/nature08975
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1017276958
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/20393566
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Genetics",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Biological Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Animals",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Breast Neoplasms",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Cell Line, Tumor",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Cell Proliferation",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Chromatin",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Chromatin Assembly and Disassembly",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Disease Progression",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Epigenesis, Genetic",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Female",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Gene Expression Regulation, Neoplastic",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Genes, Homeobox",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Genome, Human",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Histones",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Methylation",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Mice",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Mice, Nude",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Mice, SCID",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Middle Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Neoplasm Invasiveness",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Neoplasm Metastasis",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Neoplasm Transplantation",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Polycomb-Group Proteins",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Prognosis",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "RNA Interference",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "RNA, Untranslated",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Repressor Proteins",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Survival Rate",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"name": [
"Howard Hughes Medical Institute and Program in Epithelial Biology,"
],
"type": "Organization"
},
"familyName": "Gupta",
"givenName": "Rajnish A.",
"id": "sg:person.01060245005.44",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01060245005.44"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Sidney Kimmel Comprehensive Cancer Center,"
],
"type": "Organization"
},
"familyName": "Shah",
"givenName": "Nilay",
"id": "sg:person.01357260444.23",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01357260444.23"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Howard Hughes Medical Institute and Program in Epithelial Biology,"
],
"type": "Organization"
},
"familyName": "Wang",
"givenName": "Kevin C.",
"id": "sg:person.0602221107.91",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0602221107.91"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Stanford Cancer Center and Transgenic Mouse Research Center,"
],
"type": "Organization"
},
"familyName": "Kim",
"givenName": "Jeewon",
"id": "sg:person.01242606605.51",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242606605.51"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Academic Medical Center",
"id": "https://www.grid.ac/institutes/grid.5650.6",
"name": [
"Department of Pathology, Academic Medical Center, Meibergdreef 9, 1105AZ, Amsterdam, The Netherlands"
],
"type": "Organization"
},
"familyName": "Horlings",
"givenName": "Hugo M.",
"id": "sg:person.01154231750.22",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01154231750.22"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Howard Hughes Medical Institute and Program in Epithelial Biology,"
],
"type": "Organization"
},
"familyName": "Wong",
"givenName": "David J.",
"id": "sg:person.0640402300.84",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0640402300.84"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Howard Hughes Medical Institute and Program in Epithelial Biology,"
],
"type": "Organization"
},
"familyName": "Tsai",
"givenName": "Miao-Chih",
"id": "sg:person.0757631507.51",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0757631507.51"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Howard Hughes Medical Institute and Program in Epithelial Biology,"
],
"type": "Organization"
},
"familyName": "Hung",
"givenName": "Tiffany",
"id": "sg:person.0602260630.23",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0602260630.23"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Johns Hopkins University",
"id": "https://www.grid.ac/institutes/grid.21107.35",
"name": [
"Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA"
],
"type": "Organization"
},
"familyName": "Argani",
"givenName": "Pedram",
"id": "sg:person.010340527017.07",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010340527017.07"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Broad Institute",
"id": "https://www.grid.ac/institutes/grid.66859.34",
"name": [
"The Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA"
],
"type": "Organization"
},
"familyName": "Rinn",
"givenName": "John L.",
"id": "sg:person.015653074047.50",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015653074047.50"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Thermo Fisher Scientific (United States)",
"id": "https://www.grid.ac/institutes/grid.418190.5",
"name": [
"Applied Biosystems, Foster City, California 94404, USA"
],
"type": "Organization"
},
"familyName": "Wang",
"givenName": "Yulei",
"id": "sg:person.01060122124.22",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01060122124.22"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Thermo Fisher Scientific (United States)",
"id": "https://www.grid.ac/institutes/grid.418190.5",
"name": [
"Applied Biosystems, Foster City, California 94404, USA"
],
"type": "Organization"
},
"familyName": "Brzoska",
"givenName": "Pius",
"id": "sg:person.01067242657.99",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01067242657.99"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Thermo Fisher Scientific (United States)",
"id": "https://www.grid.ac/institutes/grid.418190.5",
"name": [
"Applied Biosystems, Foster City, California 94404, USA"
],
"type": "Organization"
},
"familyName": "Kong",
"givenName": "Benjamin",
"id": "sg:person.01200334505.08",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01200334505.08"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Stanford University",
"id": "https://www.grid.ac/institutes/grid.168010.e",
"name": [
"Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA"
],
"type": "Organization"
},
"familyName": "Li",
"givenName": "Rui",
"id": "sg:person.0664716320.45",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0664716320.45"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Stanford University",
"id": "https://www.grid.ac/institutes/grid.168010.e",
"name": [
"Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA"
],
"type": "Organization"
},
"familyName": "West",
"givenName": "Robert B.",
"id": "sg:person.014757641277.31",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014757641277.31"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Academic Medical Center",
"id": "https://www.grid.ac/institutes/grid.5650.6",
"name": [
"Department of Pathology, Academic Medical Center, Meibergdreef 9, 1105AZ, Amsterdam, The Netherlands"
],
"type": "Organization"
},
"familyName": "van de Vijver",
"givenName": "Marc J.",
"id": "sg:person.01367247364.80",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01367247364.80"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Sidney Kimmel Comprehensive Cancer Center,"
],
"type": "Organization"
},
"familyName": "Sukumar",
"givenName": "Saraswati",
"id": "sg:person.012346532237.62",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012346532237.62"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Howard Hughes Medical Institute and Program in Epithelial Biology,"
],
"type": "Organization"
},
"familyName": "Chang",
"givenName": "Howard Y.",
"id": "sg:person.013510743257.71",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013510743257.71"
],
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1158/0008-5472.can-06-0734",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004182087"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.1933744100",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1006013665"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/0008-5472.can-08-1419",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007848436"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.cell.2009.02.006",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008070972"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature06468",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010330089",
"https://doi.org/10.1038/nature06468"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrc2089",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010911630",
"https://doi.org/10.1038/nrc2089"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/0008-5472.can-05-4470",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013281694"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature06174",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014546686",
"https://doi.org/10.1038/nature06174"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1101/gad.1524107",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019255192"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.95.25.14863",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020882317"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.pgen.0020119",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020998590"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/0008-5472.can-07-3057",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022511543"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.0904715106",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022579887"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ng1434",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024993077",
"https://doi.org/10.1038/ng1434"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ng1434",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024993077",
"https://doi.org/10.1038/ng1434"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/science.1155472",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025637266"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrc1991",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1029188015",
"https://doi.org/10.1038/nrc1991"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrc1991",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1029188015",
"https://doi.org/10.1038/nrc1991"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/1078-0432.ccr-07-4082",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1029200496"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1101/gad.1673508",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032353888"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/0008-5472.can-07-2318",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036528178"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejmoa021967",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038600096"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ccr.2007.07.027",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038624607"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ng1752",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040129101",
"https://doi.org/10.1038/ng1752"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ng1752",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040129101",
"https://doi.org/10.1038/ng1752"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/75556",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1044135237",
"https://doi.org/10.1038/75556"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/75556",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1044135237",
"https://doi.org/10.1038/75556"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/35016125",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045061122",
"https://doi.org/10.1038/35016125"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/35016125",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045061122",
"https://doi.org/10.1038/35016125"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.bjc.6604970",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047262275",
"https://doi.org/10.1038/sj.bjc.6604970"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.bbrc.2004.04.102",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050688278"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature07672",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051133532",
"https://doi.org/10.1038/nature07672"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.cell.2007.05.022",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051644950"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/science.1112014",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052847323"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1082830923",
"type": "CreativeWork"
}
],
"datePublished": "2010-04-15",
"datePublishedReg": "2010-04-15",
"description": "Large intervening non-coding RNAs (lincRNAs) are pervasively transcribed in the genome yet their potential involvement in human disease is not well understood. Recent studies of dosage compensation, imprinting, and homeotic gene expression suggest that individual lincRNAs can function as the interface between DNA and specific chromatin remodelling activities. Here we show that lincRNAs in the HOX loci become systematically dysregulated during breast cancer progression. The lincRNA termed HOTAIR is increased in expression in primary breast tumours and metastases, and HOTAIR expression level in primary tumours is a powerful predictor of eventual metastasis and death. Enforced expression of HOTAIR in epithelial cancer cells induced genome-wide re-targeting of Polycomb repressive complex 2 (PRC2) to an occupancy pattern more resembling embryonic fibroblasts, leading to altered histone H3 lysine 27 methylation, gene expression, and increased cancer invasiveness and metastasis in a manner dependent on PRC2. Conversely, loss of HOTAIR can inhibit cancer invasiveness, particularly in cells that possess excessive PRC2 activity. These findings indicate that lincRNAs have active roles in modulating the cancer epigenome and may be important targets for cancer diagnosis and therapy.",
"genre": "research_article",
"id": "sg:pub.10.1038/nature08975",
"inLanguage": [
"en"
],
"isAccessibleForFree": true,
"isFundedItemOf": [
{
"id": "sg:grant.2529302",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.2478520",
"type": "MonetaryGrant"
}
],
"isPartOf": [
{
"id": "sg:journal.1018957",
"issn": [
"0090-0028",
"1476-4687"
],
"name": "Nature",
"type": "Periodical"
},
{
"issueNumber": "7291",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "464"
}
],
"name": "Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis",
"pagination": "1071",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"52507e759cf422be5b6cd773b3bd0ea07e31807f7aee7ab34fa66f9866e25db4"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"20393566"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"0410462"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/nature08975"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1017276958"
]
}
],
"sameAs": [
"https://doi.org/10.1038/nature08975",
"https://app.dimensions.ai/details/publication/pub.1017276958"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-11T13:20",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000368_0000000368/records_78965_00000000.jsonl",
"type": "ScholarlyArticle",
"url": "https://www.nature.com/articles/nature08975"
}
]
Download the RDF metadata as:Â json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nature08975'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nature08975'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nature08975'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nature08975'
This table displays all metadata directly associated to this object as RDF triples.
433 TRIPLES
21 PREDICATES
86 URIs
48 LITERALS
37 BLANK NODES