Chronic DLL4 blockade induces vascular neoplasms View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2010-02

AUTHORS

Minhong Yan, Christopher A. Callahan, Joseph C. Beyer, Krishna P. Allamneni, Gu Zhang, John Brady Ridgway, Kyle Niessen, Greg D. Plowman

ABSTRACT

Arising from: J. Ridgway et al.10.1038/nature05313Delta-like 4 (DLL4)-mediated Notch signalling has emerged as an attractive target for cancer therapy1,2. However, the potential side effects of blocking this pathway remain uncertain. Here we show that chronic DLL4 blockade causes pathological activation of endothelial cells, disrupts normal organ homeostasis and induces vascular tumours, raising important safety concerns. More... »

PAGES

e6-e7

Journal

TITLE

Nature

ISSUE

7282

VOLUME

463

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature08751

DOI

http://dx.doi.org/10.1038/nature08751

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1007799896

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20147986


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1117", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Public Health and Health Services", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adaptor Proteins, Signal Transducing", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Calcium-Binding Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chemical and Drug Induced Liver Injury", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Endothelial Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Intracellular Signaling Peptides and Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Macaca fascicularis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Membrane Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Notch", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Signal Transduction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Vascular Neoplasms", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "* Department of Tumor Biology and Angiogenesis, Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA. minhong@gene.com", 
          "id": "http://www.grid.ac/institutes/grid.418158.1", 
          "name": [
            "* Department of Tumor Biology and Angiogenesis, Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA. minhong@gene.com"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yan", 
        "givenName": "Minhong", 
        "id": "sg:person.01357271110.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01357271110.66"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "\u2020 Department of Pathology, Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA", 
          "id": "http://www.grid.ac/institutes/grid.418158.1", 
          "name": [
            "\u2020 Department of Pathology, Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Callahan", 
        "givenName": "Christopher A.", 
        "id": "sg:person.01134666660.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01134666660.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "\u2020 Department of Pathology, Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA", 
          "id": "http://www.grid.ac/institutes/grid.418158.1", 
          "name": [
            "\u2020 Department of Pathology, Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Beyer", 
        "givenName": "Joseph C.", 
        "id": "sg:person.0755275221.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0755275221.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "\u2021 Department of Toxicology, Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA", 
          "id": "http://www.grid.ac/institutes/grid.418158.1", 
          "name": [
            "\u2021 Department of Toxicology, Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Allamneni", 
        "givenName": "Krishna P.", 
        "id": "sg:person.01023410421.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01023410421.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "* Department of Tumor Biology and Angiogenesis, Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA. minhong@gene.com", 
          "id": "http://www.grid.ac/institutes/grid.418158.1", 
          "name": [
            "* Department of Tumor Biology and Angiogenesis, Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA. minhong@gene.com"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhang", 
        "givenName": "Gu", 
        "id": "sg:person.01071523621.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01071523621.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "* Department of Tumor Biology and Angiogenesis, Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA. minhong@gene.com", 
          "id": "http://www.grid.ac/institutes/grid.418158.1", 
          "name": [
            "* Department of Tumor Biology and Angiogenesis, Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA. minhong@gene.com"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ridgway", 
        "givenName": "John Brady", 
        "id": "sg:person.01137637021.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01137637021.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "* Department of Tumor Biology and Angiogenesis, Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA. minhong@gene.com", 
          "id": "http://www.grid.ac/institutes/grid.418158.1", 
          "name": [
            "* Department of Tumor Biology and Angiogenesis, Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA. minhong@gene.com"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Niessen", 
        "givenName": "Kyle", 
        "id": "sg:person.01205752221.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01205752221.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "* Department of Tumor Biology and Angiogenesis, Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA. minhong@gene.com", 
          "id": "http://www.grid.ac/institutes/grid.418158.1", 
          "name": [
            "* Department of Tumor Biology and Angiogenesis, Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA. minhong@gene.com"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Plowman", 
        "givenName": "Greg D.", 
        "id": "sg:person.012243523124.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012243523124.07"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/nrc2719", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047053625", 
          "https://doi.org/10.1038/nrc2719"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt0307-300", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050224385", 
          "https://doi.org/10.1038/nbt0307-300"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature05355", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037678066", 
          "https://doi.org/10.1038/nature05355"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1211029", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020671631", 
          "https://doi.org/10.1038/sj.onc.1211029"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature05313", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034553835", 
          "https://doi.org/10.1038/nature05313"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2010-02", 
    "datePublishedReg": "2010-02-01", 
    "description": "Arising from: J. Ridgway et al.10.1038/nature05313Delta-like 4 (DLL4)-mediated Notch signalling has emerged as an attractive target for cancer therapy1,2. However, the potential side effects of blocking this pathway remain uncertain. Here we show that chronic DLL4 blockade causes pathological activation of endothelial cells, disrupts normal organ homeostasis and induces vascular tumours, raising important safety concerns.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/nature08751", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0028-0836", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "7282", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "463"
      }
    ], 
    "keywords": [
      "Dll4 blockade", 
      "potential side effects", 
      "vascular tumors", 
      "vascular neoplasm", 
      "pathological activation", 
      "side effects", 
      "normal organ homeostasis", 
      "important safety concerns", 
      "endothelial cells", 
      "blockade", 
      "safety concerns", 
      "attractive target", 
      "Notch signaling", 
      "organ homeostasis", 
      "neoplasms", 
      "tumors", 
      "cancer", 
      "homeostasis", 
      "activation", 
      "signaling", 
      "cells", 
      "pathway", 
      "target", 
      "effect", 
      "Ridgway et al", 
      "concern", 
      "et al", 
      "al"
    ], 
    "name": "Chronic DLL4 blockade induces vascular neoplasms", 
    "pagination": "e6-e7", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1007799896"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/nature08751"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "20147986"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/nature08751", 
      "https://app.dimensions.ai/details/publication/pub.1007799896"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-10-01T06:35", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221001/entities/gbq_results/article/article_507.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/nature08751"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nature08751'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nature08751'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nature08751'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nature08751'


 

This table displays all metadata directly associated to this object as RDF triples.

222 TRIPLES      21 PREDICATES      74 URIs      61 LITERALS      22 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/nature08751 schema:about N3036c9b5cbc34e68a7b1b6c7d03b00f4
2 N3093c2cc90e14c5c860c6a611196ff42
3 N54a96ff02ae346cbb4690e9b73f98277
4 N64d9b664192448268e3ef3a1935fa38d
5 N66e12b31586444e3b330d2c503fff684
6 N8700f2049181491b94320d11a8093acb
7 N94f420c8ba1a4dadb1d8cf6640acc7b4
8 N9dd4ee86629d4d6099d18bc589d307fe
9 Nb4cba4e2d58c4ff79f6a3bf6c4d553c7
10 Nc00b37d66fa74456bd8a4ac0424b6693
11 Nd411d8389ad54bc681c6b10512edf17f
12 Nd922913412e647538e60ad9c25e516bb
13 Ndc5cebc8cc6947c3affcccb76f4ca07a
14 Ne700534c4fd94fad882047dfb7b15ad6
15 Nf71039fb7a594efabb889a675d956178
16 anzsrc-for:11
17 anzsrc-for:1117
18 schema:author Nb9f5e9da6f044821ab9ecab9cd56f541
19 schema:citation sg:pub.10.1038/nature05313
20 sg:pub.10.1038/nature05355
21 sg:pub.10.1038/nbt0307-300
22 sg:pub.10.1038/nrc2719
23 sg:pub.10.1038/sj.onc.1211029
24 schema:datePublished 2010-02
25 schema:datePublishedReg 2010-02-01
26 schema:description Arising from: J. Ridgway et al.10.1038/nature05313Delta-like 4 (DLL4)-mediated Notch signalling has emerged as an attractive target for cancer therapy1,2. However, the potential side effects of blocking this pathway remain uncertain. Here we show that chronic DLL4 blockade causes pathological activation of endothelial cells, disrupts normal organ homeostasis and induces vascular tumours, raising important safety concerns.
27 schema:genre article
28 schema:isAccessibleForFree false
29 schema:isPartOf N17ace917a9654cc4b500d81f764d65fd
30 N9fbb7dfd0782428fa2fb3259f834df95
31 sg:journal.1018957
32 schema:keywords Dll4 blockade
33 Notch signaling
34 Ridgway et al
35 activation
36 al
37 attractive target
38 blockade
39 cancer
40 cells
41 concern
42 effect
43 endothelial cells
44 et al
45 homeostasis
46 important safety concerns
47 neoplasms
48 normal organ homeostasis
49 organ homeostasis
50 pathological activation
51 pathway
52 potential side effects
53 safety concerns
54 side effects
55 signaling
56 target
57 tumors
58 vascular neoplasm
59 vascular tumors
60 schema:name Chronic DLL4 blockade induces vascular neoplasms
61 schema:pagination e6-e7
62 schema:productId N4372a08ab2e04274ac11fac0e55feec1
63 N475090e87530480b8edb27aeb4662f07
64 N926ccd1679d54a47ba0415cc47752e51
65 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007799896
66 https://doi.org/10.1038/nature08751
67 schema:sdDatePublished 2022-10-01T06:35
68 schema:sdLicense https://scigraph.springernature.com/explorer/license/
69 schema:sdPublisher N4d8bd03885c84584bd22b0a968b45408
70 schema:url https://doi.org/10.1038/nature08751
71 sgo:license sg:explorer/license/
72 sgo:sdDataset articles
73 rdf:type schema:ScholarlyArticle
74 N0d41c38d846f480cbebffa9ae8dea2e2 rdf:first sg:person.0755275221.22
75 rdf:rest Nddc71895a9cd4b99a5a68027cc3d354a
76 N17ace917a9654cc4b500d81f764d65fd schema:volumeNumber 463
77 rdf:type schema:PublicationVolume
78 N1999cfb7054b45128b509afd0aea3414 rdf:first sg:person.012243523124.07
79 rdf:rest rdf:nil
80 N3036c9b5cbc34e68a7b1b6c7d03b00f4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
81 schema:name Animals
82 rdf:type schema:DefinedTerm
83 N3093c2cc90e14c5c860c6a611196ff42 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
84 schema:name Calcium-Binding Proteins
85 rdf:type schema:DefinedTerm
86 N4372a08ab2e04274ac11fac0e55feec1 schema:name dimensions_id
87 schema:value pub.1007799896
88 rdf:type schema:PropertyValue
89 N475090e87530480b8edb27aeb4662f07 schema:name doi
90 schema:value 10.1038/nature08751
91 rdf:type schema:PropertyValue
92 N4d8bd03885c84584bd22b0a968b45408 schema:name Springer Nature - SN SciGraph project
93 rdf:type schema:Organization
94 N54a96ff02ae346cbb4690e9b73f98277 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Intracellular Signaling Peptides and Proteins
96 rdf:type schema:DefinedTerm
97 N591ef94856ae4c3e82e0ec88bd469a6c rdf:first sg:person.01071523621.50
98 rdf:rest Naa4406fe16f3444090931d647462908a
99 N64d9b664192448268e3ef3a1935fa38d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Rats
101 rdf:type schema:DefinedTerm
102 N66e12b31586444e3b330d2c503fff684 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Adaptor Proteins, Signal Transducing
104 rdf:type schema:DefinedTerm
105 N8700f2049181491b94320d11a8093acb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Mice
107 rdf:type schema:DefinedTerm
108 N926ccd1679d54a47ba0415cc47752e51 schema:name pubmed_id
109 schema:value 20147986
110 rdf:type schema:PropertyValue
111 N94f420c8ba1a4dadb1d8cf6640acc7b4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Endothelial Cells
113 rdf:type schema:DefinedTerm
114 N9dd4ee86629d4d6099d18bc589d307fe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Antineoplastic Agents
116 rdf:type schema:DefinedTerm
117 N9fbb7dfd0782428fa2fb3259f834df95 schema:issueNumber 7282
118 rdf:type schema:PublicationIssue
119 Naa4406fe16f3444090931d647462908a rdf:first sg:person.01137637021.27
120 rdf:rest Ne9162c72c0ca4d3daa0d8e869787061e
121 Nae41b43f20e34f7bae8269722f44c733 rdf:first sg:person.01134666660.40
122 rdf:rest N0d41c38d846f480cbebffa9ae8dea2e2
123 Nb4cba4e2d58c4ff79f6a3bf6c4d553c7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Signal Transduction
125 rdf:type schema:DefinedTerm
126 Nb9f5e9da6f044821ab9ecab9cd56f541 rdf:first sg:person.01357271110.66
127 rdf:rest Nae41b43f20e34f7bae8269722f44c733
128 Nc00b37d66fa74456bd8a4ac0424b6693 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Receptors, Notch
130 rdf:type schema:DefinedTerm
131 Nd411d8389ad54bc681c6b10512edf17f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Vascular Neoplasms
133 rdf:type schema:DefinedTerm
134 Nd922913412e647538e60ad9c25e516bb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Membrane Proteins
136 rdf:type schema:DefinedTerm
137 Ndc5cebc8cc6947c3affcccb76f4ca07a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Chemical and Drug Induced Liver Injury
139 rdf:type schema:DefinedTerm
140 Nddc71895a9cd4b99a5a68027cc3d354a rdf:first sg:person.01023410421.14
141 rdf:rest N591ef94856ae4c3e82e0ec88bd469a6c
142 Ne700534c4fd94fad882047dfb7b15ad6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Macaca fascicularis
144 rdf:type schema:DefinedTerm
145 Ne9162c72c0ca4d3daa0d8e869787061e rdf:first sg:person.01205752221.27
146 rdf:rest N1999cfb7054b45128b509afd0aea3414
147 Nf71039fb7a594efabb889a675d956178 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Humans
149 rdf:type schema:DefinedTerm
150 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
151 schema:name Medical and Health Sciences
152 rdf:type schema:DefinedTerm
153 anzsrc-for:1117 schema:inDefinedTermSet anzsrc-for:
154 schema:name Public Health and Health Services
155 rdf:type schema:DefinedTerm
156 sg:journal.1018957 schema:issn 0028-0836
157 1476-4687
158 schema:name Nature
159 schema:publisher Springer Nature
160 rdf:type schema:Periodical
161 sg:person.01023410421.14 schema:affiliation grid-institutes:grid.418158.1
162 schema:familyName Allamneni
163 schema:givenName Krishna P.
164 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01023410421.14
165 rdf:type schema:Person
166 sg:person.01071523621.50 schema:affiliation grid-institutes:grid.418158.1
167 schema:familyName Zhang
168 schema:givenName Gu
169 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01071523621.50
170 rdf:type schema:Person
171 sg:person.01134666660.40 schema:affiliation grid-institutes:grid.418158.1
172 schema:familyName Callahan
173 schema:givenName Christopher A.
174 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01134666660.40
175 rdf:type schema:Person
176 sg:person.01137637021.27 schema:affiliation grid-institutes:grid.418158.1
177 schema:familyName Ridgway
178 schema:givenName John Brady
179 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01137637021.27
180 rdf:type schema:Person
181 sg:person.01205752221.27 schema:affiliation grid-institutes:grid.418158.1
182 schema:familyName Niessen
183 schema:givenName Kyle
184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01205752221.27
185 rdf:type schema:Person
186 sg:person.012243523124.07 schema:affiliation grid-institutes:grid.418158.1
187 schema:familyName Plowman
188 schema:givenName Greg D.
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012243523124.07
190 rdf:type schema:Person
191 sg:person.01357271110.66 schema:affiliation grid-institutes:grid.418158.1
192 schema:familyName Yan
193 schema:givenName Minhong
194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01357271110.66
195 rdf:type schema:Person
196 sg:person.0755275221.22 schema:affiliation grid-institutes:grid.418158.1
197 schema:familyName Beyer
198 schema:givenName Joseph C.
199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0755275221.22
200 rdf:type schema:Person
201 sg:pub.10.1038/nature05313 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034553835
202 https://doi.org/10.1038/nature05313
203 rdf:type schema:CreativeWork
204 sg:pub.10.1038/nature05355 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037678066
205 https://doi.org/10.1038/nature05355
206 rdf:type schema:CreativeWork
207 sg:pub.10.1038/nbt0307-300 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050224385
208 https://doi.org/10.1038/nbt0307-300
209 rdf:type schema:CreativeWork
210 sg:pub.10.1038/nrc2719 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047053625
211 https://doi.org/10.1038/nrc2719
212 rdf:type schema:CreativeWork
213 sg:pub.10.1038/sj.onc.1211029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020671631
214 https://doi.org/10.1038/sj.onc.1211029
215 rdf:type schema:CreativeWork
216 grid-institutes:grid.418158.1 schema:alternateName * Department of Tumor Biology and Angiogenesis, Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA. minhong@gene.com
217 † Department of Pathology, Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA
218 ‡ Department of Toxicology, Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA
219 schema:name * Department of Tumor Biology and Angiogenesis, Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA. minhong@gene.com
220 † Department of Pathology, Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA
221 ‡ Department of Toxicology, Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA
222 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...