Chronic DLL4 blockade induces vascular neoplasms View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2010-02

AUTHORS

Minhong Yan, Christopher A. Callahan, Joseph C. Beyer, Krishna P. Allamneni, Gu Zhang, John Brady Ridgway, Kyle Niessen, Greg D. Plowman

ABSTRACT

Arising from: J. Ridgway et al.10.1038/nature05313Delta-like 4 (DLL4)-mediated Notch signalling has emerged as an attractive target for cancer therapy1,2. However, the potential side effects of blocking this pathway remain uncertain. Here we show that chronic DLL4 blockade causes pathological activation of endothelial cells, disrupts normal organ homeostasis and induces vascular tumours, raising important safety concerns. More... »

PAGES

e6-e7

Journal

TITLE

Nature

ISSUE

7282

VOLUME

463

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature08751

DOI

http://dx.doi.org/10.1038/nature08751

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1007799896

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20147986


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