Chimpanzee and human Y chromosomes are remarkably divergent in structure and gene content View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2010-01-13

AUTHORS

Jennifer F. Hughes, Helen Skaletsky, Tatyana Pyntikova, Tina A. Graves, Saskia K. M. van Daalen, Patrick J. Minx, Robert S. Fulton, Sean D. McGrath, Devin P. Locke, Cynthia Friedman, Barbara J. Trask, Elaine R. Mardis, Wesley C. Warren, Sjoerd Repping, Steve Rozen, Richard K. Wilson, David C. Page

ABSTRACT

The Y factorWith the sequencing of the male-specific region of the chimpanzee Y chromosome, it is now possible to make comparisons with the human Y sequence and to learn more about the recent evolution of the human Y chromosome. The two sequences differ markedly in structure and gene content, indicating rapid evolution during the past 6 million years. This finding is at odds with the common view that Y chromosomes are essentially static structures that evolve only very slowly by genetic loss. Rather, renovation and remodelling dominate the evolution of human and chimpanzee Y chromosomes. Possible reasons for this extraordinary divergence include genetic hitchhiking effects, species-specific mating behaviours and the Y chromosome's role in sperm production. More... »

PAGES

536-539

References to SciGraph publications

  • 2006-08. Has the chimpanzee Y chromosome been sequenced? in NATURE GENETICS
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  • 2006-02-26. High mutation rates have driven extensive structural polymorphism among human Y chromosomes in NATURE GENETICS
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  • 2002-03. Reduced adaptation of a non-recombining neo-Y chromosome in NATURE
  • 2004-01. A primitive Y chromosome in papaya marks incipient sex chromosome evolution in NATURE
  • 2006-01-01. Comparative analysis of chimpanzee and human Y chromosomes unveils complex evolutionary pathway in NATURE GENETICS
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  • 2003-06. Abundant gene conversion between arms of palindromes in human and ape Y chromosomes in NATURE
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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nature08700

    DOI

    http://dx.doi.org/10.1038/nature08700

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1022287415

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/20072128


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