Ontology type: schema:ScholarlyArticle Open Access: True
2009-12
AUTHORSPhilip J. Stephens, David J. McBride, Meng-Lay Lin, Ignacio Varela, Erin D. Pleasance, Jared T. Simpson, Lucy A. Stebbings, Catherine Leroy, Sarah Edkins, Laura J. Mudie, Chris D. Greenman, Mingming Jia, Calli Latimer, Jon W. Teague, King Wai Lau, John Burton, Michael A. Quail, Harold Swerdlow, Carol Churcher, Rachael Natrajan, Anieta M. Sieuwerts, John W. M. Martens, Daniel P. Silver, Anita Langerød, Hege E. G. Russnes, John A. Foekens, Jorge S. Reis-Filho, Laura van ’t Veer, Andrea L. Richardson, Anne-Lise Børresen-Dale, Peter J. Campbell, P. Andrew Futreal, Michael R. Stratton
ABSTRACTMultiple somatic rearrangements are often found in cancer genomes; however, the underlying processes of rearrangement and their contribution to cancer development are poorly characterized. Here we use a paired-end sequencing strategy to identify somatic rearrangements in breast cancer genomes. There are more rearrangements in some breast cancers than previously appreciated. Rearrangements are more frequent over gene footprints and most are intrachromosomal. Multiple rearrangement architectures are present, but tandem duplications are particularly common in some cancers, perhaps reflecting a specific defect in DNA maintenance. Short overlapping sequences at most rearrangement junctions indicate that these have been mediated by non-homologous end-joining DNA repair, although varying sequence patterns indicate that multiple processes of this type are operative. Several expressed in-frame fusion genes were identified but none was recurrent. The study provides a new perspective on cancer genomes, highlighting the diversity of somatic rearrangements and their potential contribution to cancer development. More... »
PAGES1005-1010
http://scigraph.springernature.com/pub.10.1038/nature08645
DOIhttp://dx.doi.org/10.1038/nature08645
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1050729897
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/20033038
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Biological Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Genetics",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Oncology and Carcinogenesis",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Breast Neoplasms",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Cell Line, Tumor",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Cells, Cultured",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Chromosome Aberrations",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "DNA Breaks",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Female",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Gene Rearrangement",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Genome, Human",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Genomic Library",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Sequence Analysis, DNA",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK",
"id": "http://www.grid.ac/institutes/grid.10306.34",
"name": [
"Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK"
],
"type": "Organization"
},
"familyName": "Stephens",
"givenName": "Philip J.",
"id": "sg:person.013646440737.20",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013646440737.20"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK",
"id": "http://www.grid.ac/institutes/grid.10306.34",
"name": [
"Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK"
],
"type": "Organization"
},
"familyName": "McBride",
"givenName": "David J.",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK",
"id": "http://www.grid.ac/institutes/grid.10306.34",
"name": [
"Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK"
],
"type": "Organization"
},
"familyName": "Lin",
"givenName": "Meng-Lay",
"id": "sg:person.01134523776.26",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01134523776.26"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK",
"id": "http://www.grid.ac/institutes/grid.10306.34",
"name": [
"Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK"
],
"type": "Organization"
},
"familyName": "Varela",
"givenName": "Ignacio",
"id": "sg:person.01072530632.71",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01072530632.71"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK",
"id": "http://www.grid.ac/institutes/grid.10306.34",
"name": [
"Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK"
],
"type": "Organization"
},
"familyName": "Pleasance",
"givenName": "Erin D.",
"id": "sg:person.0757417552.08",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0757417552.08"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK",
"id": "http://www.grid.ac/institutes/grid.10306.34",
"name": [
"Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK"
],
"type": "Organization"
},
"familyName": "Simpson",
"givenName": "Jared T.",
"id": "sg:person.01353023673.87",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01353023673.87"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK",
"id": "http://www.grid.ac/institutes/grid.10306.34",
"name": [
"Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK"
],
"type": "Organization"
},
"familyName": "Stebbings",
"givenName": "Lucy A.",
"id": "sg:person.0610440537.14",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0610440537.14"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK",
"id": "http://www.grid.ac/institutes/grid.10306.34",
"name": [
"Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK"
],
"type": "Organization"
},
"familyName": "Leroy",
"givenName": "Catherine",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK",
"id": "http://www.grid.ac/institutes/grid.10306.34",
"name": [
"Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK"
],
"type": "Organization"
},
"familyName": "Edkins",
"givenName": "Sarah",
"id": "sg:person.0744515657.65",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0744515657.65"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK",
"id": "http://www.grid.ac/institutes/grid.10306.34",
"name": [
"Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK"
],
"type": "Organization"
},
"familyName": "Mudie",
"givenName": "Laura J.",
"id": "sg:person.01265731437.34",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01265731437.34"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK",
"id": "http://www.grid.ac/institutes/grid.10306.34",
"name": [
"Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK"
],
"type": "Organization"
},
"familyName": "Greenman",
"givenName": "Chris D.",
"id": "sg:person.0632335004.87",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0632335004.87"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK",
"id": "http://www.grid.ac/institutes/grid.10306.34",
"name": [
"Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK"
],
"type": "Organization"
},
"familyName": "Jia",
"givenName": "Mingming",
"id": "sg:person.0776213413.27",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0776213413.27"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK",
"id": "http://www.grid.ac/institutes/grid.10306.34",
"name": [
"Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK"
],
"type": "Organization"
},
"familyName": "Latimer",
"givenName": "Calli",
"id": "sg:person.01166432644.99",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01166432644.99"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK",
"id": "http://www.grid.ac/institutes/grid.10306.34",
"name": [
"Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK"
],
"type": "Organization"
},
"familyName": "Teague",
"givenName": "Jon W.",
"id": "sg:person.01177240404.72",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01177240404.72"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK",
"id": "http://www.grid.ac/institutes/grid.10306.34",
"name": [
"Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK"
],
"type": "Organization"
},
"familyName": "Lau",
"givenName": "King Wai",
"id": "sg:person.01345003425.70",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01345003425.70"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK",
"id": "http://www.grid.ac/institutes/grid.10306.34",
"name": [
"Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK"
],
"type": "Organization"
},
"familyName": "Burton",
"givenName": "John",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK",
"id": "http://www.grid.ac/institutes/grid.10306.34",
"name": [
"Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK"
],
"type": "Organization"
},
"familyName": "Quail",
"givenName": "Michael A.",
"id": "sg:person.01346001520.94",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01346001520.94"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK",
"id": "http://www.grid.ac/institutes/grid.10306.34",
"name": [
"Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK"
],
"type": "Organization"
},
"familyName": "Swerdlow",
"givenName": "Harold",
"id": "sg:person.01353651207.83",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01353651207.83"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK",
"id": "http://www.grid.ac/institutes/grid.10306.34",
"name": [
"Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK"
],
"type": "Organization"
},
"familyName": "Churcher",
"givenName": "Carol",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Molecular Pathology Laboratory, The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK",
"id": "http://www.grid.ac/institutes/None",
"name": [
"Molecular Pathology Laboratory, The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK"
],
"type": "Organization"
},
"familyName": "Natrajan",
"givenName": "Rachael",
"id": "sg:person.0713552055.91",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0713552055.91"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Medical Oncology, Josephine Nefkens Institute, Erasmus University Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands",
"id": "http://www.grid.ac/institutes/grid.5645.2",
"name": [
"Department of Medical Oncology, Josephine Nefkens Institute, Erasmus University Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands"
],
"type": "Organization"
},
"familyName": "Sieuwerts",
"givenName": "Anieta M.",
"id": "sg:person.01344323132.58",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01344323132.58"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Medical Oncology, Josephine Nefkens Institute, Erasmus University Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands",
"id": "http://www.grid.ac/institutes/grid.5645.2",
"name": [
"Department of Medical Oncology, Josephine Nefkens Institute, Erasmus University Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands"
],
"type": "Organization"
},
"familyName": "Martens",
"givenName": "John W. M.",
"id": "sg:person.010223261137.51",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010223261137.51"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA",
"id": "http://www.grid.ac/institutes/grid.65499.37",
"name": [
"Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA"
],
"type": "Organization"
},
"familyName": "Silver",
"givenName": "Daniel P.",
"id": "sg:person.01032227660.87",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01032227660.87"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Genetics, Norwegian Radium Hospital, Oslo University Hospital, Montebello, N-0310 Oslo, Norway",
"id": "http://www.grid.ac/institutes/grid.55325.34",
"name": [
"Department of Genetics, Norwegian Radium Hospital, Oslo University Hospital, Montebello, N-0310 Oslo, Norway"
],
"type": "Organization"
},
"familyName": "Langer\u00f8d",
"givenName": "Anita",
"id": "sg:person.0775176315.38",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0775176315.38"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Genetics, Norwegian Radium Hospital, Oslo University Hospital, Montebello, N-0310 Oslo, Norway",
"id": "http://www.grid.ac/institutes/grid.55325.34",
"name": [
"Department of Genetics, Norwegian Radium Hospital, Oslo University Hospital, Montebello, N-0310 Oslo, Norway"
],
"type": "Organization"
},
"familyName": "Russnes",
"givenName": "Hege E. G.",
"id": "sg:person.01226717423.30",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01226717423.30"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Medical Oncology, Josephine Nefkens Institute, Erasmus University Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands",
"id": "http://www.grid.ac/institutes/grid.5645.2",
"name": [
"Department of Medical Oncology, Josephine Nefkens Institute, Erasmus University Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands"
],
"type": "Organization"
},
"familyName": "Foekens",
"givenName": "John A.",
"id": "sg:person.0733151301.48",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0733151301.48"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Molecular Pathology Laboratory, The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK",
"id": "http://www.grid.ac/institutes/None",
"name": [
"Molecular Pathology Laboratory, The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK"
],
"type": "Organization"
},
"familyName": "Reis-Filho",
"givenName": "Jorge S.",
"id": "sg:person.01045625165.06",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01045625165.06"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "The Netherlands Cancer Institute, 121 Plesmanlaan, 1066 CX Amsterdam, The Netherlands",
"id": "http://www.grid.ac/institutes/grid.430814.a",
"name": [
"The Netherlands Cancer Institute, 121 Plesmanlaan, 1066 CX Amsterdam, The Netherlands"
],
"type": "Organization"
},
"familyName": "van \u2019t Veer",
"givenName": "Laura",
"id": "sg:person.0715025702.14",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0715025702.14"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Pathology, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA",
"id": "http://www.grid.ac/institutes/grid.62560.37",
"name": [
"Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA",
"Department of Pathology, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA"
],
"type": "Organization"
},
"familyName": "Richardson",
"givenName": "Andrea L.",
"id": "sg:person.01325463611.20",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01325463611.20"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Montebello, 0310 Oslo, Norway",
"id": "http://www.grid.ac/institutes/grid.55325.34",
"name": [
"Department of Genetics, Norwegian Radium Hospital, Oslo University Hospital, Montebello, N-0310 Oslo, Norway",
"Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Montebello, 0310 Oslo, Norway"
],
"type": "Organization"
},
"familyName": "B\u00f8rresen-Dale",
"givenName": "Anne-Lise",
"id": "sg:person.01361622203.97",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01361622203.97"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK",
"id": "http://www.grid.ac/institutes/grid.10306.34",
"name": [
"Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK"
],
"type": "Organization"
},
"familyName": "Campbell",
"givenName": "Peter J.",
"id": "sg:person.0716350025.21",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0716350025.21"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK",
"id": "http://www.grid.ac/institutes/grid.10306.34",
"name": [
"Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK"
],
"type": "Organization"
},
"familyName": "Futreal",
"givenName": "P. Andrew",
"id": "sg:person.0653224107.08",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0653224107.08"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Institute of Cancer Research, Sutton, Surrey SM2 5NG, UK.",
"id": "http://www.grid.ac/institutes/grid.18886.3f",
"name": [
"Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK",
"Institute of Cancer Research, Sutton, Surrey SM2 5NG, UK."
],
"type": "Organization"
},
"familyName": "Stratton",
"givenName": "Michael R.",
"id": "sg:person.010101505177.49",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010101505177.49"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1038/nrc1299",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022731034",
"https://doi.org/10.1038/nrc1299"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature05945",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017221313",
"https://doi.org/10.1038/nature05945"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ng0298-184",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047807659",
"https://doi.org/10.1038/ng0298-184"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature06020",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021023869",
"https://doi.org/10.1038/nature06020"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.onc.1210871",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014304085",
"https://doi.org/10.1038/sj.onc.1210871"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature07385",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039570773",
"https://doi.org/10.1038/nature07385"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrc2091",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043783272",
"https://doi.org/10.1038/nrc2091"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/cr.2008.3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015186979",
"https://doi.org/10.1038/cr.2008.3"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/labinvest.3700390",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048816971",
"https://doi.org/10.1038/labinvest.3700390"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrc2500",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048291905",
"https://doi.org/10.1038/nrc2500"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature06358",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019681472",
"https://doi.org/10.1038/nature06358"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature07943",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004829095",
"https://doi.org/10.1038/nature07943"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrg2593",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011096945",
"https://doi.org/10.1038/nrg2593"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ng1335",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051360590",
"https://doi.org/10.1038/ng1335"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature05610",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033482125",
"https://doi.org/10.1038/nature05610"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/35021093",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033846543",
"https://doi.org/10.1038/35021093"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ng.128",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047246435",
"https://doi.org/10.1038/ng.128"
],
"type": "CreativeWork"
}
],
"datePublished": "2009-12",
"datePublishedReg": "2009-12-01",
"description": "Multiple somatic rearrangements are often found in cancer genomes; however, the underlying processes of rearrangement and their contribution to cancer development are poorly characterized. Here we use a paired-end sequencing strategy to identify somatic rearrangements in breast cancer genomes. There are more rearrangements in some breast cancers than previously appreciated. Rearrangements are more frequent over gene footprints and most are intrachromosomal. Multiple rearrangement architectures are present, but tandem duplications are particularly common in some cancers, perhaps reflecting a specific defect in DNA maintenance. Short overlapping sequences at most rearrangement junctions indicate that these have been mediated by non-homologous end-joining DNA repair, although varying sequence patterns indicate that multiple processes of this type are operative. Several expressed in-frame fusion genes were identified but none was recurrent. The study provides a new perspective on cancer genomes, highlighting the diversity of somatic rearrangements and their potential contribution to cancer development.",
"genre": "article",
"id": "sg:pub.10.1038/nature08645",
"isAccessibleForFree": true,
"isFundedItemOf": [
{
"id": "sg:grant.8483119",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.4661283",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.2440162",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.4660787",
"type": "MonetaryGrant"
}
],
"isPartOf": [
{
"id": "sg:journal.1018957",
"issn": [
"0028-0836",
"1476-4687"
],
"name": "Nature",
"publisher": "Springer Nature",
"type": "Periodical"
},
{
"issueNumber": "7276",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "462"
}
],
"keywords": [
"cancer genomes",
"somatic rearrangements",
"breast cancer genomes",
"paired-end sequencing strategy",
"non-homologous end-joining DNA repair",
"frame fusion genes",
"cancer development",
"DNA maintenance",
"DNA repair",
"genome",
"rearrangement junctions",
"tandem duplication",
"sequencing strategy",
"more rearrangements",
"fusion gene",
"process of rearrangement",
"sequence patterns",
"specific defects",
"complex landscape",
"breast cancer",
"multiple processes",
"rearrangement",
"cancer",
"genes",
"duplication",
"diversity",
"sequence",
"potential contribution",
"new perspective",
"landscape",
"maintenance",
"repair",
"development",
"patterns",
"defects",
"junction",
"process",
"study",
"contribution",
"types",
"strategies",
"architecture",
"footprint",
"perspective"
],
"name": "Complex landscapes of somatic rearrangement in human breast cancer genomes",
"pagination": "1005-1010",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1050729897"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/nature08645"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"20033038"
]
}
],
"sameAs": [
"https://doi.org/10.1038/nature08645",
"https://app.dimensions.ai/details/publication/pub.1050729897"
],
"sdDataset": "articles",
"sdDatePublished": "2022-08-04T16:58",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220804/entities/gbq_results/article/article_491.jsonl",
"type": "ScholarlyArticle",
"url": "https://doi.org/10.1038/nature08645"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nature08645'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nature08645'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nature08645'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nature08645'
This table displays all metadata directly associated to this object as RDF triples.
478 TRIPLES
21 PREDICATES
100 URIs
73 LITERALS
18 BLANK NODES