Innate production of TH2 cytokines by adipose tissue-associated c-Kit+Sca-1+ lymphoid cells View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2010-01

AUTHORS

Kazuyo Moro, Taketo Yamada, Masanobu Tanabe, Tsutomu Takeuchi, Tomokatsu Ikawa, Hiroshi Kawamoto, Jun-ichi Furusawa, Masashi Ohtani, Hideki Fujii, Shigeo Koyasu

ABSTRACT

Innate immune responses are important in combating various microbes during the early phases of infection. Natural killer (NK) cells are innate lymphocytes that, unlike T and B lymphocytes, do not express antigen receptors but rapidly exhibit cytotoxic activities against virus-infected cells and produce various cytokines. Here we report a new type of innate lymphocyte present in a novel lymphoid structure associated with adipose tissues in the peritoneal cavity. These cells do not express lineage (Lin) markers but do express c-Kit, Sca-1 (also known as Ly6a), IL7R and IL33R. Similar lymphoid clusters were found in both human and mouse mesentery and we term this tissue 'FALC' (fat-associated lymphoid cluster). FALC Lin(-)c-Kit(+)Sca-1(+) cells are distinct from lymphoid progenitors and lymphoid tissue inducer cells. These cells proliferate in response to IL2 and produce large amounts of T(H)2 cytokines such as IL5, IL6 and IL13. IL5 and IL6 regulate B-cell antibody production and self-renewal of B1 cells. Indeed, FALC Lin(-)c-Kit(+)Sca-1(+) cells support the self-renewal of B1 cells and enhance IgA production. IL5 and IL13 mediate allergic inflammation and protection against helminth infection. After helminth infection and in response to IL33, FALC Lin(-)c-Kit(+)Sca-1(+) cells produce large amounts of IL13, which leads to goblet cell hyperplasia-a critical step for helminth expulsion. In mice devoid of FALC Lin(-)c-Kit(+)Sca-1(+) cells, such goblet cell hyperplasia was not induced. Thus, FALC Lin(-)c-Kit(+)Sca-1(+) cells are T(H)2-type innate lymphocytes, and we propose that these cells be called 'natural helper cells'. More... »

PAGES

540

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature08636

DOI

http://dx.doi.org/10.1038/nature08636

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1027865662

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20023630


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adipose Tissue", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antigens, Ly", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "B-Lymphocytes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Proliferation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cytokines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymphocytes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Membrane Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mesentery", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred C57BL", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nematoda", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nematode Infections", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proto-Oncogene Proteins c-kit", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Th2 Cells", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Japan Science and Technology Agency", 
          "id": "https://www.grid.ac/institutes/grid.419082.6", 
          "name": [
            "Department of Microbiology and Immunology,", 
            "Japan Science and Technology Agency (JST), CREST, Chiyoda-ku, Tokyo 102-0075, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Moro", 
        "givenName": "Kazuyo", 
        "id": "sg:person.01036654645.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01036654645.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Pathology,"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yamada", 
        "givenName": "Taketo", 
        "id": "sg:person.010412371544.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010412371544.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Keio University", 
          "id": "https://www.grid.ac/institutes/grid.26091.3c", 
          "name": [
            "Department of Tropical Medicine and Parasitology, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tanabe", 
        "givenName": "Masanobu", 
        "id": "sg:person.011145642131.63", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011145642131.63"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Keio University", 
          "id": "https://www.grid.ac/institutes/grid.26091.3c", 
          "name": [
            "Department of Tropical Medicine and Parasitology, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Takeuchi", 
        "givenName": "Tsutomu", 
        "id": "sg:person.01041661127.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01041661127.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "RIKEN", 
          "id": "https://www.grid.ac/institutes/grid.7597.c", 
          "name": [
            "Laboratory for Lymphocyte Development, Riken Research Center for Allergy and Immunology, Yokohama, Kanagawa 230-0045, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ikawa", 
        "givenName": "Tomokatsu", 
        "id": "sg:person.01361176430.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01361176430.43"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "RIKEN", 
          "id": "https://www.grid.ac/institutes/grid.7597.c", 
          "name": [
            "Laboratory for Lymphocyte Development, Riken Research Center for Allergy and Immunology, Yokohama, Kanagawa 230-0045, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kawamoto", 
        "givenName": "Hiroshi", 
        "id": "sg:person.01250611130.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01250611130.75"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Microbiology and Immunology,"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Furusawa", 
        "givenName": "Jun-ichi", 
        "id": "sg:person.01357243603.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01357243603.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kansai Medical University", 
          "id": "https://www.grid.ac/institutes/grid.410783.9", 
          "name": [
            "Department of Microbiology and Immunology,", 
            "Department of Cell Signalling, Institute of Biomedical Science, Kansai Medical University, Moriguchi, Osaka 570-8506, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ohtani", 
        "givenName": "Masashi", 
        "id": "sg:person.0643012021.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0643012021.70"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Microbiology and Immunology,"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fujii", 
        "givenName": "Hideki", 
        "id": "sg:person.014173406752.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014173406752.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Japan Society for the Promotion of Science", 
          "id": "https://www.grid.ac/institutes/grid.54432.34", 
          "name": [
            "Department of Microbiology and Immunology,", 
            "Research Center for Science Systems, Japan Society for the Promotion of Science (JSPS), Chiyoda-ku, Tokyo 102-8472, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Koyasu", 
        "givenName": "Shigeo", 
        "id": "sg:person.015472375125.94", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015472375125.94"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.immuni.2005.09.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001616606"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.immuni.2005.09.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001616606"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.191.5.771", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003163525"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/1074-7613(95)90047-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004958298"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(92)90029-c", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009230025"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-065x.2008.00624.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010125824"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.immuni.2008.05.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012343856"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni.1684", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013769615", 
          "https://doi.org/10.1038/ni.1684"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.20070406", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014560026"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1189/jlb.0708452", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016035099"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0008-8749(92)90299-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017301019"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1017/s0031182008004319", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017560051"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.it.2009.03.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020562142"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/eji.1830240224", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023549183"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.it.2009.03.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024438148"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.20051615", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027619975"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0012-1606(85)90363-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028667470"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.exppara.2007.03.019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029086072"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.93.14.7172", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029279631"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.185.3.499", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030425501"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.coi.2006.05.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034931695"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.20052448", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038334229"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-065x.2006.00465.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041211872"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.180.4.2443", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043310845"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.immuni.2009.03.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044912229"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/17812", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045754219", 
          "https://doi.org/10.1038/17812"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/17812", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045754219", 
          "https://doi.org/10.1038/17812"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.169.6.2133", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046118839"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbrc.2009.04.081", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049699565"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni1022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049866186", 
          "https://doi.org/10.1038/ni1022"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni1022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049866186", 
          "https://doi.org/10.1038/ni1022"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.170.4.1415", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050014414"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1034/j.1600-065x.2003.00063.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051468858"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.166.3.1531", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074751358"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.167.5.2511", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074866556"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/j.1460-2075.1990.tb08305.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077289163"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2010-01", 
    "datePublishedReg": "2010-01-01", 
    "description": "Innate immune responses are important in combating various microbes during the early phases of infection. Natural killer (NK) cells are innate lymphocytes that, unlike T and B lymphocytes, do not express antigen receptors but rapidly exhibit cytotoxic activities against virus-infected cells and produce various cytokines. Here we report a new type of innate lymphocyte present in a novel lymphoid structure associated with adipose tissues in the peritoneal cavity. These cells do not express lineage (Lin) markers but do express c-Kit, Sca-1 (also known as Ly6a), IL7R and IL33R. Similar lymphoid clusters were found in both human and mouse mesentery and we term this tissue 'FALC' (fat-associated lymphoid cluster). FALC Lin(-)c-Kit(+)Sca-1(+) cells are distinct from lymphoid progenitors and lymphoid tissue inducer cells. These cells proliferate in response to IL2 and produce large amounts of T(H)2 cytokines such as IL5, IL6 and IL13. IL5 and IL6 regulate B-cell antibody production and self-renewal of B1 cells. Indeed, FALC Lin(-)c-Kit(+)Sca-1(+) cells support the self-renewal of B1 cells and enhance IgA production. IL5 and IL13 mediate allergic inflammation and protection against helminth infection. After helminth infection and in response to IL33, FALC Lin(-)c-Kit(+)Sca-1(+) cells produce large amounts of IL13, which leads to goblet cell hyperplasia-a critical step for helminth expulsion. In mice devoid of FALC Lin(-)c-Kit(+)Sca-1(+) cells, such goblet cell hyperplasia was not induced. Thus, FALC Lin(-)c-Kit(+)Sca-1(+) cells are T(H)2-type innate lymphocytes, and we propose that these cells be called 'natural helper cells'.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/nature08636", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.5825023", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.5952312", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6015472", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6043098", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.5891583", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0090-0028", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "7280", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "463"
      }
    ], 
    "name": "Innate production of TH2 cytokines by adipose tissue-associated c-Kit+Sca-1+ lymphoid cells", 
    "pagination": "540", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "84be3434fa4d60b1744d0a2c96ba7444e8f1e58891d4d6d13855ebc858fe10e4"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "20023630"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0410462"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/nature08636"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1027865662"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/nature08636", 
      "https://app.dimensions.ai/details/publication/pub.1027865662"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T10:03", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000347_0000000347/records_89824_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/nature08636"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nature08636'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nature08636'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nature08636'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nature08636'


 

This table displays all metadata directly associated to this object as RDF triples.

333 TRIPLES      21 PREDICATES      79 URIs      38 LITERALS      26 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/nature08636 schema:about N19856bafa08743d6b1936d74745b0f8c
2 N238b475f04824f1492e02227831faf16
3 N4bea67f4e9444efab920cee8df90dcce
4 N4e2a276b422f49b1b36e208c313c524c
5 N508cc10a9d784fa5bbc2c84724a6eb27
6 N57bca39fd3cb462d928a3a55a524c566
7 N58016c7def5747f48cd388554e1547ba
8 N715474a11ae64ab8acfe7b821e517e6b
9 N8055c99c227d4d26bd1d18c58589d7ff
10 N8b1ae2ccb13345ee9ba541a5188def8b
11 N910fc7e7a7ba49548949bf45de3a1530
12 Nb9243db4c0984948bd09de913b4d3db1
13 Ncedd534dccc345b3805c3bf89d401442
14 Nd0423b5a2bb5456ab9ca23070c6da499
15 Ndd08874b221e4f9b8ce9ea32de15f8a6
16 Nec720d9a820c4565a9d0bbc986dc22ef
17 Neffeb14eef7e476197664c2a45103774
18 anzsrc-for:11
19 anzsrc-for:1107
20 schema:author N130310173c5f4d418fdbdc0e7f12c390
21 schema:citation sg:pub.10.1038/17812
22 sg:pub.10.1038/ni.1684
23 sg:pub.10.1038/ni1022
24 https://doi.org/10.1002/eji.1830240224
25 https://doi.org/10.1002/j.1460-2075.1990.tb08305.x
26 https://doi.org/10.1016/0008-8749(92)90299-5
27 https://doi.org/10.1016/0012-1606(85)90363-x
28 https://doi.org/10.1016/0092-8674(92)90029-c
29 https://doi.org/10.1016/1074-7613(95)90047-0
30 https://doi.org/10.1016/j.bbrc.2009.04.081
31 https://doi.org/10.1016/j.coi.2006.05.002
32 https://doi.org/10.1016/j.exppara.2007.03.019
33 https://doi.org/10.1016/j.immuni.2005.09.015
34 https://doi.org/10.1016/j.immuni.2008.05.014
35 https://doi.org/10.1016/j.immuni.2009.03.014
36 https://doi.org/10.1016/j.it.2009.03.001
37 https://doi.org/10.1016/j.it.2009.03.003
38 https://doi.org/10.1017/s0031182008004319
39 https://doi.org/10.1034/j.1600-065x.2003.00063.x
40 https://doi.org/10.1073/pnas.93.14.7172
41 https://doi.org/10.1084/jem.169.6.2133
42 https://doi.org/10.1084/jem.170.4.1415
43 https://doi.org/10.1084/jem.185.3.499
44 https://doi.org/10.1084/jem.191.5.771
45 https://doi.org/10.1084/jem.20051615
46 https://doi.org/10.1084/jem.20052448
47 https://doi.org/10.1084/jem.20070406
48 https://doi.org/10.1111/j.1600-065x.2006.00465.x
49 https://doi.org/10.1111/j.1600-065x.2008.00624.x
50 https://doi.org/10.1189/jlb.0708452
51 https://doi.org/10.4049/jimmunol.166.3.1531
52 https://doi.org/10.4049/jimmunol.167.5.2511
53 https://doi.org/10.4049/jimmunol.180.4.2443
54 schema:datePublished 2010-01
55 schema:datePublishedReg 2010-01-01
56 schema:description Innate immune responses are important in combating various microbes during the early phases of infection. Natural killer (NK) cells are innate lymphocytes that, unlike T and B lymphocytes, do not express antigen receptors but rapidly exhibit cytotoxic activities against virus-infected cells and produce various cytokines. Here we report a new type of innate lymphocyte present in a novel lymphoid structure associated with adipose tissues in the peritoneal cavity. These cells do not express lineage (Lin) markers but do express c-Kit, Sca-1 (also known as Ly6a), IL7R and IL33R. Similar lymphoid clusters were found in both human and mouse mesentery and we term this tissue 'FALC' (fat-associated lymphoid cluster). FALC Lin(-)c-Kit(+)Sca-1(+) cells are distinct from lymphoid progenitors and lymphoid tissue inducer cells. These cells proliferate in response to IL2 and produce large amounts of T(H)2 cytokines such as IL5, IL6 and IL13. IL5 and IL6 regulate B-cell antibody production and self-renewal of B1 cells. Indeed, FALC Lin(-)c-Kit(+)Sca-1(+) cells support the self-renewal of B1 cells and enhance IgA production. IL5 and IL13 mediate allergic inflammation and protection against helminth infection. After helminth infection and in response to IL33, FALC Lin(-)c-Kit(+)Sca-1(+) cells produce large amounts of IL13, which leads to goblet cell hyperplasia-a critical step for helminth expulsion. In mice devoid of FALC Lin(-)c-Kit(+)Sca-1(+) cells, such goblet cell hyperplasia was not induced. Thus, FALC Lin(-)c-Kit(+)Sca-1(+) cells are T(H)2-type innate lymphocytes, and we propose that these cells be called 'natural helper cells'.
57 schema:genre research_article
58 schema:inLanguage en
59 schema:isAccessibleForFree false
60 schema:isPartOf N10145004a3b449c49ab9cab89cac0584
61 N982d56f79f484697be77baee399f2845
62 sg:journal.1018957
63 schema:name Innate production of TH2 cytokines by adipose tissue-associated c-Kit+Sca-1+ lymphoid cells
64 schema:pagination 540
65 schema:productId N0de64abd5033483d9d039176f12059dd
66 N3536dd9fa7a04217bbd977ad7a2aff51
67 N45f837b14f4a4fa6b7fd19aa3b457544
68 N465783b3d6ae498a94024dadb103fc47
69 Nbba47e0619d54f1a92df8d5af66a6d6a
70 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027865662
71 https://doi.org/10.1038/nature08636
72 schema:sdDatePublished 2019-04-11T10:03
73 schema:sdLicense https://scigraph.springernature.com/explorer/license/
74 schema:sdPublisher N1ce1117bc29f464b859a6b4263cb8d37
75 schema:url https://www.nature.com/articles/nature08636
76 sgo:license sg:explorer/license/
77 sgo:sdDataset articles
78 rdf:type schema:ScholarlyArticle
79 N0de64abd5033483d9d039176f12059dd schema:name pubmed_id
80 schema:value 20023630
81 rdf:type schema:PropertyValue
82 N10145004a3b449c49ab9cab89cac0584 schema:issueNumber 7280
83 rdf:type schema:PublicationIssue
84 N130310173c5f4d418fdbdc0e7f12c390 rdf:first sg:person.01036654645.46
85 rdf:rest Nb6f5d22f19d84827bf9917d1e864df7a
86 N169b647f64c54ea0827f918f86dcba96 schema:name Department of Microbiology and Immunology,
87 rdf:type schema:Organization
88 N19856bafa08743d6b1936d74745b0f8c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
89 schema:name Cytokines
90 rdf:type schema:DefinedTerm
91 N1ce1117bc29f464b859a6b4263cb8d37 schema:name Springer Nature - SN SciGraph project
92 rdf:type schema:Organization
93 N238b475f04824f1492e02227831faf16 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name Lymphocytes
95 rdf:type schema:DefinedTerm
96 N2d2e431fc5654b51a05299e95be7dc63 schema:name Department of Pathology,
97 rdf:type schema:Organization
98 N3536dd9fa7a04217bbd977ad7a2aff51 schema:name nlm_unique_id
99 schema:value 0410462
100 rdf:type schema:PropertyValue
101 N3a68f8f7ae9e4e6d8ccc29fa03e84e3c rdf:first sg:person.011145642131.63
102 rdf:rest N9a144dbaf14346389955172e0b74c3c7
103 N45f837b14f4a4fa6b7fd19aa3b457544 schema:name readcube_id
104 schema:value 84be3434fa4d60b1744d0a2c96ba7444e8f1e58891d4d6d13855ebc858fe10e4
105 rdf:type schema:PropertyValue
106 N465783b3d6ae498a94024dadb103fc47 schema:name dimensions_id
107 schema:value pub.1027865662
108 rdf:type schema:PropertyValue
109 N4bea67f4e9444efab920cee8df90dcce schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Proto-Oncogene Proteins c-kit
111 rdf:type schema:DefinedTerm
112 N4dc8de2a8b48450b8efbd887481c1dc5 rdf:first sg:person.01361176430.43
113 rdf:rest Nef753cff546848e8aeae7a5350f32f69
114 N4e2a276b422f49b1b36e208c313c524c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Membrane Proteins
116 rdf:type schema:DefinedTerm
117 N508cc10a9d784fa5bbc2c84724a6eb27 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Animals
119 rdf:type schema:DefinedTerm
120 N57bca39fd3cb462d928a3a55a524c566 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name B-Lymphocytes
122 rdf:type schema:DefinedTerm
123 N58016c7def5747f48cd388554e1547ba schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Humans
125 rdf:type schema:DefinedTerm
126 N5a06f3c5153a406b94ec8cb208818010 rdf:first sg:person.014173406752.52
127 rdf:rest Nbf189659a25e41dcb1d9911f182f8c63
128 N715474a11ae64ab8acfe7b821e517e6b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Nematode Infections
130 rdf:type schema:DefinedTerm
131 N8055c99c227d4d26bd1d18c58589d7ff schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Cell Proliferation
133 rdf:type schema:DefinedTerm
134 N8b1ae2ccb13345ee9ba541a5188def8b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Adipose Tissue
136 rdf:type schema:DefinedTerm
137 N910fc7e7a7ba49548949bf45de3a1530 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Nematoda
139 rdf:type schema:DefinedTerm
140 N982d56f79f484697be77baee399f2845 schema:volumeNumber 463
141 rdf:type schema:PublicationVolume
142 N9a144dbaf14346389955172e0b74c3c7 rdf:first sg:person.01041661127.18
143 rdf:rest N4dc8de2a8b48450b8efbd887481c1dc5
144 Na13562931f7948ffa3e16e7f82a7406f rdf:first sg:person.0643012021.70
145 rdf:rest N5a06f3c5153a406b94ec8cb208818010
146 Nb6f5d22f19d84827bf9917d1e864df7a rdf:first sg:person.010412371544.47
147 rdf:rest N3a68f8f7ae9e4e6d8ccc29fa03e84e3c
148 Nb9243db4c0984948bd09de913b4d3db1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Antigens, Ly
150 rdf:type schema:DefinedTerm
151 Nbba47e0619d54f1a92df8d5af66a6d6a schema:name doi
152 schema:value 10.1038/nature08636
153 rdf:type schema:PropertyValue
154 Nbf189659a25e41dcb1d9911f182f8c63 rdf:first sg:person.015472375125.94
155 rdf:rest rdf:nil
156 Ncedd534dccc345b3805c3bf89d401442 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Th2 Cells
158 rdf:type schema:DefinedTerm
159 Nd0423b5a2bb5456ab9ca23070c6da499 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Mesentery
161 rdf:type schema:DefinedTerm
162 Ndd08874b221e4f9b8ce9ea32de15f8a6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Mice, Inbred C57BL
164 rdf:type schema:DefinedTerm
165 Nec720d9a820c4565a9d0bbc986dc22ef schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Gene Expression Regulation
167 rdf:type schema:DefinedTerm
168 Nef753cff546848e8aeae7a5350f32f69 rdf:first sg:person.01250611130.75
169 rdf:rest Nf409b2e5c49249f09322af6fbe3f18a9
170 Neffeb14eef7e476197664c2a45103774 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Mice
172 rdf:type schema:DefinedTerm
173 Nf409b2e5c49249f09322af6fbe3f18a9 rdf:first sg:person.01357243603.21
174 rdf:rest Na13562931f7948ffa3e16e7f82a7406f
175 Nfa887eb20f2046c6a341a26366125670 schema:name Department of Microbiology and Immunology,
176 rdf:type schema:Organization
177 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
178 schema:name Medical and Health Sciences
179 rdf:type schema:DefinedTerm
180 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
181 schema:name Immunology
182 rdf:type schema:DefinedTerm
183 sg:grant.5825023 http://pending.schema.org/fundedItem sg:pub.10.1038/nature08636
184 rdf:type schema:MonetaryGrant
185 sg:grant.5891583 http://pending.schema.org/fundedItem sg:pub.10.1038/nature08636
186 rdf:type schema:MonetaryGrant
187 sg:grant.5952312 http://pending.schema.org/fundedItem sg:pub.10.1038/nature08636
188 rdf:type schema:MonetaryGrant
189 sg:grant.6015472 http://pending.schema.org/fundedItem sg:pub.10.1038/nature08636
190 rdf:type schema:MonetaryGrant
191 sg:grant.6043098 http://pending.schema.org/fundedItem sg:pub.10.1038/nature08636
192 rdf:type schema:MonetaryGrant
193 sg:journal.1018957 schema:issn 0090-0028
194 1476-4687
195 schema:name Nature
196 rdf:type schema:Periodical
197 sg:person.01036654645.46 schema:affiliation https://www.grid.ac/institutes/grid.419082.6
198 schema:familyName Moro
199 schema:givenName Kazuyo
200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01036654645.46
201 rdf:type schema:Person
202 sg:person.010412371544.47 schema:affiliation N2d2e431fc5654b51a05299e95be7dc63
203 schema:familyName Yamada
204 schema:givenName Taketo
205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010412371544.47
206 rdf:type schema:Person
207 sg:person.01041661127.18 schema:affiliation https://www.grid.ac/institutes/grid.26091.3c
208 schema:familyName Takeuchi
209 schema:givenName Tsutomu
210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01041661127.18
211 rdf:type schema:Person
212 sg:person.011145642131.63 schema:affiliation https://www.grid.ac/institutes/grid.26091.3c
213 schema:familyName Tanabe
214 schema:givenName Masanobu
215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011145642131.63
216 rdf:type schema:Person
217 sg:person.01250611130.75 schema:affiliation https://www.grid.ac/institutes/grid.7597.c
218 schema:familyName Kawamoto
219 schema:givenName Hiroshi
220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01250611130.75
221 rdf:type schema:Person
222 sg:person.01357243603.21 schema:affiliation N169b647f64c54ea0827f918f86dcba96
223 schema:familyName Furusawa
224 schema:givenName Jun-ichi
225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01357243603.21
226 rdf:type schema:Person
227 sg:person.01361176430.43 schema:affiliation https://www.grid.ac/institutes/grid.7597.c
228 schema:familyName Ikawa
229 schema:givenName Tomokatsu
230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01361176430.43
231 rdf:type schema:Person
232 sg:person.014173406752.52 schema:affiliation Nfa887eb20f2046c6a341a26366125670
233 schema:familyName Fujii
234 schema:givenName Hideki
235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014173406752.52
236 rdf:type schema:Person
237 sg:person.015472375125.94 schema:affiliation https://www.grid.ac/institutes/grid.54432.34
238 schema:familyName Koyasu
239 schema:givenName Shigeo
240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015472375125.94
241 rdf:type schema:Person
242 sg:person.0643012021.70 schema:affiliation https://www.grid.ac/institutes/grid.410783.9
243 schema:familyName Ohtani
244 schema:givenName Masashi
245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0643012021.70
246 rdf:type schema:Person
247 sg:pub.10.1038/17812 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045754219
248 https://doi.org/10.1038/17812
249 rdf:type schema:CreativeWork
250 sg:pub.10.1038/ni.1684 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013769615
251 https://doi.org/10.1038/ni.1684
252 rdf:type schema:CreativeWork
253 sg:pub.10.1038/ni1022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049866186
254 https://doi.org/10.1038/ni1022
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1002/eji.1830240224 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023549183
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1002/j.1460-2075.1990.tb08305.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1077289163
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1016/0008-8749(92)90299-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017301019
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1016/0012-1606(85)90363-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1028667470
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1016/0092-8674(92)90029-c schema:sameAs https://app.dimensions.ai/details/publication/pub.1009230025
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1016/1074-7613(95)90047-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004958298
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1016/j.bbrc.2009.04.081 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049699565
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1016/j.coi.2006.05.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034931695
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1016/j.exppara.2007.03.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029086072
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1016/j.immuni.2005.09.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001616606
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1016/j.immuni.2008.05.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012343856
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1016/j.immuni.2009.03.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044912229
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1016/j.it.2009.03.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024438148
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1016/j.it.2009.03.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020562142
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1017/s0031182008004319 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017560051
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1034/j.1600-065x.2003.00063.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1051468858
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1073/pnas.93.14.7172 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029279631
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1084/jem.169.6.2133 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046118839
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1084/jem.170.4.1415 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050014414
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1084/jem.185.3.499 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030425501
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1084/jem.191.5.771 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003163525
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1084/jem.20051615 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027619975
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1084/jem.20052448 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038334229
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1084/jem.20070406 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014560026
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1111/j.1600-065x.2006.00465.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1041211872
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1111/j.1600-065x.2008.00624.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1010125824
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1189/jlb.0708452 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016035099
309 rdf:type schema:CreativeWork
310 https://doi.org/10.4049/jimmunol.166.3.1531 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074751358
311 rdf:type schema:CreativeWork
312 https://doi.org/10.4049/jimmunol.167.5.2511 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074866556
313 rdf:type schema:CreativeWork
314 https://doi.org/10.4049/jimmunol.180.4.2443 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043310845
315 rdf:type schema:CreativeWork
316 https://www.grid.ac/institutes/grid.26091.3c schema:alternateName Keio University
317 schema:name Department of Tropical Medicine and Parasitology, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan
318 rdf:type schema:Organization
319 https://www.grid.ac/institutes/grid.410783.9 schema:alternateName Kansai Medical University
320 schema:name Department of Cell Signalling, Institute of Biomedical Science, Kansai Medical University, Moriguchi, Osaka 570-8506, Japan
321 Department of Microbiology and Immunology,
322 rdf:type schema:Organization
323 https://www.grid.ac/institutes/grid.419082.6 schema:alternateName Japan Science and Technology Agency
324 schema:name Department of Microbiology and Immunology,
325 Japan Science and Technology Agency (JST), CREST, Chiyoda-ku, Tokyo 102-0075, Japan
326 rdf:type schema:Organization
327 https://www.grid.ac/institutes/grid.54432.34 schema:alternateName Japan Society for the Promotion of Science
328 schema:name Department of Microbiology and Immunology,
329 Research Center for Science Systems, Japan Society for the Promotion of Science (JSPS), Chiyoda-ku, Tokyo 102-8472, Japan
330 rdf:type schema:Organization
331 https://www.grid.ac/institutes/grid.7597.c schema:alternateName RIKEN
332 schema:name Laboratory for Lymphocyte Development, Riken Research Center for Allergy and Immunology, Yokohama, Kanagawa 230-0045, Japan
333 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...