Systems-level dynamic analyses of fate change in murine embryonic stem cells View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2009-11-19

AUTHORS

Rong Lu, Florian Markowetz, Richard D. Unwin, Jeffrey T. Leek, Edoardo M. Airoldi, Ben D. MacArthur, Alexander Lachmann, Roye Rozov, Avi Ma’ayan, Laurie A. Boyer, Olga G. Troyanskaya, Anthony D. Whetton, Ihor R. Lemischka

ABSTRACT

Cell fate at the systems levelRong Lu et al. present a dynamic systems-level study of cell fate changes in mouse embryonic stem cells following a single well-defined perturbation by downregulating the pluripotency factor Nanog. They measure global changes in histone acetylation, chromatin-bound RNA polymerase II, mRNA and nuclear protein levels for five days, and find progressive widespread changes in multiple molecular regulatory layers and provide a dynamic view of information flow in the epigenome, transcriptome and proteome. More... »

PAGES

358-362

Journal

TITLE

Nature

ISSUE

7271

VOLUME

462

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature08575

DOI

http://dx.doi.org/10.1038/nature08575

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1036433014

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19924215


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