RNA polymerase II–TFIIB structure and mechanism of transcription initiation View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2009-10-09

AUTHORS

Dirk Kostrewa, Mirijam E. Zeller, Karim-Jean Armache, Martin Seizl, Kristin Leike, Michael Thomm, Patrick Cramer

ABSTRACT

To initiate gene transcription, RNA polymerase II (Pol II) requires the transcription factor IIB (B). Here we present the crystal structure of the complete Pol II–B complex at 4.3 Å resolution, and complementary functional data. The results indicate the mechanism of transcription initiation, including the transition to RNA elongation. Promoter DNA is positioned over the Pol II active centre cleft with the ‘B-core’ domain that binds the wall at the end of the cleft. DNA is then opened with the help of the ‘B-linker’ that binds the Pol II rudder and clamp coiled-coil at the edge of the cleft. The DNA template strand slips into the cleft and is scanned for the transcription start site with the help of the ‘B-reader’ that approaches the active site. Synthesis of the RNA chain and rewinding of upstream DNA displace the B-reader and B-linker, respectively, to trigger B release and elongation complex formation. More... »

PAGES

323-330

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature08548

DOI

http://dx.doi.org/10.1038/nature08548

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1009664227

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19820686


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