Ontology type: schema:ScholarlyArticle Open Access: True
2009-10
AUTHORSSohrab P. Shah, Ryan D. Morin, Jaswinder Khattra, Leah Prentice, Trevor Pugh, Angela Burleigh, Allen Delaney, Karen Gelmon, Ryan Guliany, Janine Senz, Christian Steidl, Robert A. Holt, Steven Jones, Mark Sun, Gillian Leung, Richard Moore, Tesa Severson, Greg A. Taylor, Andrew E. Teschendorff, Kane Tse, Gulisa Turashvili, Richard Varhol, René L. Warren, Peter Watson, Yongjun Zhao, Carlos Caldas, David Huntsman, Martin Hirst, Marco A. Marra, Samuel Aparicio
ABSTRACTA cancer evolves: heterogeneity and mutational evolution in a breast tumourNext-generation sequencing approaches have been used to investigate the genomes and transcriptomes of an oestrogen-receptor-α-positive metastatic lobular breast cancer from a patient — rather than from a cell line or xenograft — over a 9-year period between the diagnosis of the primary tumour and the appearance of metastasis. Comparison of the somatic non-synonymous coding mutations in the metastasis and the primary tumour of the same patient and the combined analysis of genome and transcriptome data provided insights into the mutational evolution that can occur with disease progression. The cover shows sequence elements of the HAUS3 locus, one of the genes found to be mutated in the tissue (shown in the background) from the primary lobular cancer used for this work. More... »
PAGES809-813
http://scigraph.springernature.com/pub.10.1038/nature08489
DOIhttp://dx.doi.org/10.1038/nature08489
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1006711248
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/19812674
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]Download the RDF metadata as: json-ld nt turtle xml License info
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curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nature08489'
This table displays all metadata directly associated to this object as RDF triples.
432 TRIPLES
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103 URIs
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26 BLANK NODES