Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2009-10

AUTHORS

Sohrab P. Shah, Ryan D. Morin, Jaswinder Khattra, Leah Prentice, Trevor Pugh, Angela Burleigh, Allen Delaney, Karen Gelmon, Ryan Guliany, Janine Senz, Christian Steidl, Robert A. Holt, Steven Jones, Mark Sun, Gillian Leung, Richard Moore, Tesa Severson, Greg A. Taylor, Andrew E. Teschendorff, Kane Tse, Gulisa Turashvili, Richard Varhol, René L. Warren, Peter Watson, Yongjun Zhao, Carlos Caldas, David Huntsman, Martin Hirst, Marco A. Marra, Samuel Aparicio

ABSTRACT

A cancer evolves: heterogeneity and mutational evolution in a breast tumourNext-generation sequencing approaches have been used to investigate the genomes and transcriptomes of an oestrogen-receptor-α-positive metastatic lobular breast cancer from a patient — rather than from a cell line or xenograft — over a 9-year period between the diagnosis of the primary tumour and the appearance of metastasis. Comparison of the somatic non-synonymous coding mutations in the metastasis and the primary tumour of the same patient and the combined analysis of genome and transcriptome data provided insights into the mutational evolution that can occur with disease progression. The cover shows sequence elements of the HAUS3 locus, one of the genes found to be mutated in the tissue (shown in the background) from the primary lobular cancer used for this work. More... »

PAGES

809-813

Journal

TITLE

Nature

ISSUE

7265

VOLUME

461

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nature08489

    DOI

    http://dx.doi.org/10.1038/nature08489

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1006711248

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/19812674


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