Genome evolution and adaptation in a long-term experiment with Escherichia coli View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2009-10

AUTHORS

Jeffrey E. Barrick, Dong Su Yu, Sung Ho Yoon, Haeyoung Jeong, Tae Kwang Oh, Dominique Schneider, Richard E. Lenski, Jihyun F. Kim

ABSTRACT

The relationship between rates of genomic evolution and organismal adaptation remains uncertain, despite considerable interest. The feasibility of obtaining genome sequences from experimentally evolving populations offers the opportunity to investigate this relationship with new precision. Here we sequence genomes sampled through 40,000 generations from a laboratory population of Escherichia coli. Although adaptation decelerated sharply, genomic evolution was nearly constant for 20,000 generations. Such clock-like regularity is usually viewed as the signature of neutral evolution, but several lines of evidence indicate that almost all of these mutations were beneficial. This same population later evolved an elevated mutation rate and accumulated hundreds of additional mutations dominated by a neutral signature. Thus, the coupling between genomic and adaptive evolution is complex and can be counterintuitive even in a constant environment. In particular, beneficial substitutions were surprisingly uniform over time, whereas neutral substitutions were highly variable. More... »

PAGES

1243

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature08480

DOI

http://dx.doi.org/10.1038/nature08480

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1008340720

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19838166


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