Direct reprogramming of human neural stem cells by OCT4 View Full Text


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Article Info

DATE

2009-10

AUTHORS

Jeong Beom Kim, Boris Greber, Marcos J. Araúzo-Bravo, Johann Meyer, Kook In Park, Holm Zaehres, Hans R. Schöler

ABSTRACT

Induced pluripotent stem (iPS) cells have been generated from mouse and human somatic cells by ectopic expression of four transcription factors (OCT4 (also called POU5F1), SOX2, c-Myc and KLF4). We previously reported that Oct4 alone is sufficient to reprogram directly adult mouse neural stem cells to iPS cells. Here we report the generation of one-factor human iPS cells from human fetal neural stem cells (one-factor (1F) human NiPS cells) by ectopic expression of OCT4 alone. One-factor human NiPS cells resemble human embryonic stem cells in global gene expression profiles, epigenetic status, as well as pluripotency in vitro and in vivo. These findings demonstrate that the transcription factor OCT4 is sufficient to reprogram human neural stem cells to pluripotency. One-factor iPS cell generation will advance the field further towards understanding reprogramming and generating patient-specific pluripotent stem cells. More... »

PAGES

649

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature08436

DOI

http://dx.doi.org/10.1038/nature08436

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1002503252

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19718018


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