Role of the polycomb protein EED in the propagation of repressive histone marks View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2009-10-08

AUTHORS

Raphael Margueron, Neil Justin, Katsuhito Ohno, Miriam L. Sharpe, Jinsook Son, William J. Drury, Philipp Voigt, Stephen R. Martin, William R. Taylor, Valeria De Marco, Vincenzo Pirrotta, Danny Reinberg, Steven J. Gamblin

ABSTRACT

Polycomb group proteins have an essential role in the epigenetic maintenance of repressive chromatin states. The gene-silencing activity of the Polycomb repressive complex 2 (PRC2) depends on its ability to trimethylate lysine 27 of histone H3 (H3K27) by the catalytic SET domain of the EZH2 subunit, and at least two other subunits of the complex: SUZ12 and EED. Here we show that the carboxy-terminal domain of EED specifically binds to histone tails carrying trimethyl-lysine residues associated with repressive chromatin marks, and that this leads to the allosteric activation of the methyltransferase activity of PRC2. Mutations in EED that prevent it from recognizing repressive trimethyl-lysine marks abolish the activation of PRC2 in vitro and, in Drosophila, reduce global methylation and disrupt development. These findings suggest a model for the propagation of the H3K27me3 mark that accounts for the maintenance of repressive chromatin domains and for the transmission of a histone modification from mother to daughter cells. More... »

PAGES

762

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature08398

DOI

http://dx.doi.org/10.1038/nature08398

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1014254479

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19767730


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Allosteric Regulation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromatin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Crystallography, X-Ray", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drosophila Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drosophila melanogaster", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Enzyme Activation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Silencing", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Histone-Lysine N-Methyltransferase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Histones", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lysine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Methylation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Models, Biological", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Models, Molecular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nuclear Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nucleosomes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polycomb Repressive Complex 2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Binding", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Structure, Tertiary", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Repressor Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Substrate Specificity", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "New York University", 
          "id": "https://www.grid.ac/institutes/grid.137628.9", 
          "name": [
            "Howard Hughes Medical Institute and Department of Biochemistry, New York University Medical School, 522 First Avenue, New York, New York 10016, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Margueron", 
        "givenName": "Raphael", 
        "id": "sg:person.01273277707.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01273277707.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Francis Crick Institute", 
          "id": "https://www.grid.ac/institutes/grid.451388.3", 
          "name": [
            "MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Justin", 
        "givenName": "Neil", 
        "id": "sg:person.01231601756.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01231601756.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Rutgers University", 
          "id": "https://www.grid.ac/institutes/grid.430387.b", 
          "name": [
            "Department of Molecular Biology and Biochemistry, Rutgers University, Nelson Laboratories, 604 Allison Road, Piscataway, New Jersey 08854, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ohno", 
        "givenName": "Katsuhito", 
        "id": "sg:person.01227401371.73", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01227401371.73"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Francis Crick Institute", 
          "id": "https://www.grid.ac/institutes/grid.451388.3", 
          "name": [
            "MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sharpe", 
        "givenName": "Miriam L.", 
        "id": "sg:person.0625507742.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0625507742.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "New York University", 
          "id": "https://www.grid.ac/institutes/grid.137628.9", 
          "name": [
            "Howard Hughes Medical Institute and Department of Biochemistry, New York University Medical School, 522 First Avenue, New York, New York 10016, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Son", 
        "givenName": "Jinsook", 
        "id": "sg:person.0770466725.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0770466725.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "New York University", 
          "id": "https://www.grid.ac/institutes/grid.137628.9", 
          "name": [
            "Howard Hughes Medical Institute and Department of Biochemistry, New York University Medical School, 522 First Avenue, New York, New York 10016, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Drury", 
        "givenName": "William J.", 
        "id": "sg:person.0666651335.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0666651335.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "New York University", 
          "id": "https://www.grid.ac/institutes/grid.137628.9", 
          "name": [
            "Howard Hughes Medical Institute and Department of Biochemistry, New York University Medical School, 522 First Avenue, New York, New York 10016, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Voigt", 
        "givenName": "Philipp", 
        "id": "sg:person.01045442400.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01045442400.98"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Francis Crick Institute", 
          "id": "https://www.grid.ac/institutes/grid.451388.3", 
          "name": [
            "MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Martin", 
        "givenName": "Stephen R.", 
        "id": "sg:person.010355726752.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010355726752.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Francis Crick Institute", 
          "id": "https://www.grid.ac/institutes/grid.451388.3", 
          "name": [
            "MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Taylor", 
        "givenName": "William R.", 
        "id": "sg:person.014227333147.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014227333147.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Francis Crick Institute", 
          "id": "https://www.grid.ac/institutes/grid.451388.3", 
          "name": [
            "MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "De Marco", 
        "givenName": "Valeria", 
        "id": "sg:person.01121214456.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01121214456.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Rutgers University", 
          "id": "https://www.grid.ac/institutes/grid.430387.b", 
          "name": [
            "Department of Molecular Biology and Biochemistry, Rutgers University, Nelson Laboratories, 604 Allison Road, Piscataway, New Jersey 08854, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pirrotta", 
        "givenName": "Vincenzo", 
        "id": "sg:person.0624046551.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0624046551.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "New York University", 
          "id": "https://www.grid.ac/institutes/grid.137628.9", 
          "name": [
            "Howard Hughes Medical Institute and Department of Biochemistry, New York University Medical School, 522 First Avenue, New York, New York 10016, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Reinberg", 
        "givenName": "Danny", 
        "id": "sg:person.0672601630.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0672601630.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Francis Crick Institute", 
          "id": "https://www.grid.ac/institutes/grid.451388.3", 
          "name": [
            "MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gamblin", 
        "givenName": "Steven J.", 
        "id": "sg:person.014166377647.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014166377647.07"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.mod.2008.01.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002020112"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0108767393007597", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002475686"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0076-6879(97)76066-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004907170"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb1787", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005538911", 
          "https://doi.org/10.1038/ncb1787"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ydbio.2007.10.025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006071078"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0907444999000839", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008525008"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(02)00976-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009600594"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/dev.02723", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010597130"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2008.12.029", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013732214"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.str.2007.08.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013976059"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(02)00975-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013988165"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0108767390010224", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014210169"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.str.2008.05.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014555623"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0907444998003254", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019779527"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0907444904019158", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020281098"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0907444997005696", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022493994"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m309771200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022597179"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2007.02.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022937373"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04814", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023378568", 
          "https://doi.org/10.1038/nature04814"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04814", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023378568", 
          "https://doi.org/10.1038/nature04814"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04814", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023378568", 
          "https://doi.org/10.1038/nature04814"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0907444994003112", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025573949"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04802", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025701396", 
          "https://doi.org/10.1038/nature04802"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04802", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025701396", 
          "https://doi.org/10.1038/nature04802"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04802", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025701396", 
          "https://doi.org/10.1038/nature04802"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1817", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026324467", 
          "https://doi.org/10.1038/ng1817"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1817", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026324467", 
          "https://doi.org/10.1038/ng1817"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.388706", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026603580"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.01822-06", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030775929"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2006.12.041", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032622691"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2006.12.041", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032622691"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2007.02.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032874898"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.embor.7400376", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032976911"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.1035902", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033394366"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/jmbi.1997.1235", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035443314"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.02017-07", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036575885"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0907444900005072", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038886912"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1534/genetics.106.056945", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039938897"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1534/genetics.106.056945", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039938897"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ceb.2008.03.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041347486"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.emboj.7601837", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044794985"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(82)90428-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046298202"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1076997", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050318758"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0611511104", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050367125"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)81326-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051752247"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2008.11.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053484531"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1125162", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062453584"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079343524", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2009-10-08", 
    "datePublishedReg": "2009-10-08", 
    "description": "Polycomb group proteins have an essential role in the epigenetic maintenance of repressive chromatin states. The gene-silencing activity of the Polycomb repressive complex 2 (PRC2) depends on its ability to trimethylate lysine 27 of histone H3 (H3K27) by the catalytic SET domain of the EZH2 subunit, and at least two other subunits of the complex: SUZ12 and EED. Here we show that the carboxy-terminal domain of EED specifically binds to histone tails carrying trimethyl-lysine residues associated with repressive chromatin marks, and that this leads to the allosteric activation of the methyltransferase activity of PRC2. Mutations in EED that prevent it from recognizing repressive trimethyl-lysine marks abolish the activation of PRC2 in vitro and, in Drosophila, reduce global methylation and disrupt development. These findings suggest a model for the propagation of the H3K27me3 mark that accounts for the maintenance of repressive chromatin domains and for the transmission of a histone modification from mother to daughter cells.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/nature08398", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2517338", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2511807", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2635240", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2766383", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0090-0028", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "7265", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "461"
      }
    ], 
    "name": "Role of the polycomb protein EED in the propagation of repressive histone marks", 
    "pagination": "762", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "43e8712b0fa4a982ce7c96b9e7e21de2818b89473de3a4b55abf65508ae9a3dc"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "19767730"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0410462"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/nature08398"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1014254479"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/nature08398", 
      "https://app.dimensions.ai/details/publication/pub.1014254479"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T09:38", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000346_0000000346/records_99833_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/nature08398"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nature08398'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nature08398'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nature08398'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nature08398'


 

This table displays all metadata directly associated to this object as RDF triples.

381 TRIPLES      21 PREDICATES      91 URIs      42 LITERALS      31 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/nature08398 schema:about N1073c92007624a528f9a20bd01f53d2e
2 N1a2873bcb957423781e5b3cc7f804bec
3 N2842b6e3403d40f2bf04818d635f3634
4 N337676b11cad490eb6832829aa0c59e8
5 N362182efa9a94945adee1c3a99f98254
6 N36ace21f37c249de95c45766c72fc48c
7 N3ae0e7dfb93d448b8630e88443f5c17a
8 N3e6b7096fe634bae9fb09586a44ea56c
9 N483639efc163429b87caccbc7fd1bc69
10 N5eff443cbcd24153b1c084cb9caf1b0d
11 N68e1c66aaaa94777b8ae61aa2b3cd5a8
12 N738fbd75cc4040cd8cf985061badbb98
13 N8407afcabf4249588a2807189bfd91c9
14 N950b5246ac1b41069c0259d49e76c8e9
15 Nac7d5966cf904454a5817b94b276dec9
16 Nb444da4d80144c5e9e58c2c3d975fda5
17 Nb95b0c1a8347466fa6742053f9c8c7db
18 Nc36a0fe0c4914d1ab4374bbc2d6d0843
19 Ncdbbe2e340f0453682058ff74e5f3e2f
20 Nd7cde48ed5244bf6b50fbde3e954ce34
21 Ne1664143a1754f909757dbdb6e097eb7
22 Ne515f84eea0c434282cfaefd2f8ab9a4
23 anzsrc-for:06
24 anzsrc-for:0601
25 schema:author N28f52228c32d4656b8d79278bcdd493c
26 schema:citation sg:pub.10.1038/nature04802
27 sg:pub.10.1038/nature04814
28 sg:pub.10.1038/ncb1787
29 sg:pub.10.1038/ng1817
30 https://app.dimensions.ai/details/publication/pub.1079343524
31 https://doi.org/10.1006/jmbi.1997.1235
32 https://doi.org/10.1016/0092-8674(82)90428-7
33 https://doi.org/10.1016/j.ceb.2008.03.002
34 https://doi.org/10.1016/j.cell.2006.12.041
35 https://doi.org/10.1016/j.cell.2007.02.005
36 https://doi.org/10.1016/j.cell.2007.02.009
37 https://doi.org/10.1016/j.mod.2008.01.002
38 https://doi.org/10.1016/j.molcel.2008.11.004
39 https://doi.org/10.1016/j.molcel.2008.12.029
40 https://doi.org/10.1016/j.str.2007.08.007
41 https://doi.org/10.1016/j.str.2008.05.006
42 https://doi.org/10.1016/j.ydbio.2007.10.025
43 https://doi.org/10.1016/s0076-6879(97)76066-x
44 https://doi.org/10.1016/s0092-8674(00)81326-4
45 https://doi.org/10.1016/s0092-8674(02)00975-3
46 https://doi.org/10.1016/s0092-8674(02)00976-5
47 https://doi.org/10.1038/sj.emboj.7601837
48 https://doi.org/10.1038/sj.embor.7400376
49 https://doi.org/10.1073/pnas.0611511104
50 https://doi.org/10.1074/jbc.m309771200
51 https://doi.org/10.1101/gad.1035902
52 https://doi.org/10.1101/gad.388706
53 https://doi.org/10.1107/s0108767390010224
54 https://doi.org/10.1107/s0108767393007597
55 https://doi.org/10.1107/s0907444900005072
56 https://doi.org/10.1107/s0907444904019158
57 https://doi.org/10.1107/s0907444994003112
58 https://doi.org/10.1107/s0907444997005696
59 https://doi.org/10.1107/s0907444998003254
60 https://doi.org/10.1107/s0907444999000839
61 https://doi.org/10.1126/science.1076997
62 https://doi.org/10.1126/science.1125162
63 https://doi.org/10.1128/mcb.01822-06
64 https://doi.org/10.1128/mcb.02017-07
65 https://doi.org/10.1242/dev.02723
66 https://doi.org/10.1534/genetics.106.056945
67 schema:datePublished 2009-10-08
68 schema:datePublishedReg 2009-10-08
69 schema:description Polycomb group proteins have an essential role in the epigenetic maintenance of repressive chromatin states. The gene-silencing activity of the Polycomb repressive complex 2 (PRC2) depends on its ability to trimethylate lysine 27 of histone H3 (H3K27) by the catalytic SET domain of the EZH2 subunit, and at least two other subunits of the complex: SUZ12 and EED. Here we show that the carboxy-terminal domain of EED specifically binds to histone tails carrying trimethyl-lysine residues associated with repressive chromatin marks, and that this leads to the allosteric activation of the methyltransferase activity of PRC2. Mutations in EED that prevent it from recognizing repressive trimethyl-lysine marks abolish the activation of PRC2 in vitro and, in Drosophila, reduce global methylation and disrupt development. These findings suggest a model for the propagation of the H3K27me3 mark that accounts for the maintenance of repressive chromatin domains and for the transmission of a histone modification from mother to daughter cells.
70 schema:genre research_article
71 schema:inLanguage en
72 schema:isAccessibleForFree true
73 schema:isPartOf N0cd8d9f600ca4ffd86c91f647e0c6e86
74 Nc2301d0d3b0847c6b1ac95b8c850cb4d
75 sg:journal.1018957
76 schema:name Role of the polycomb protein EED in the propagation of repressive histone marks
77 schema:pagination 762
78 schema:productId N4f77ce2298af41adb9d00a4f8edb411a
79 N73eed1fdcae84a55a0cdccbf189587c8
80 Na74f3f1ee8eb47dca54dd14708e38590
81 Ne84f3e1d513f48d5b567ad0124f5f287
82 Nff65fc6f6d1f4c5a856ad2c302ca391c
83 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014254479
84 https://doi.org/10.1038/nature08398
85 schema:sdDatePublished 2019-04-11T09:38
86 schema:sdLicense https://scigraph.springernature.com/explorer/license/
87 schema:sdPublisher N25fd4202600d418bbb193b57e093d977
88 schema:url https://www.nature.com/articles/nature08398
89 sgo:license sg:explorer/license/
90 sgo:sdDataset articles
91 rdf:type schema:ScholarlyArticle
92 N049fbbc52bdd41de91ee8e7c8d1d62e1 rdf:first sg:person.010355726752.41
93 rdf:rest N2721d7f2831545f5971954b5fac4bd5f
94 N0cd8d9f600ca4ffd86c91f647e0c6e86 schema:issueNumber 7265
95 rdf:type schema:PublicationIssue
96 N1073c92007624a528f9a20bd01f53d2e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Chromatin
98 rdf:type schema:DefinedTerm
99 N1a2873bcb957423781e5b3cc7f804bec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Repressor Proteins
101 rdf:type schema:DefinedTerm
102 N215d2cada49a4fe5844dd82b0468fe29 rdf:first sg:person.0625507742.05
103 rdf:rest Nb148221409d945059744cff2a4239c5d
104 N25fd4202600d418bbb193b57e093d977 schema:name Springer Nature - SN SciGraph project
105 rdf:type schema:Organization
106 N2721d7f2831545f5971954b5fac4bd5f rdf:first sg:person.014227333147.06
107 rdf:rest N37751b5ac1a5447888485967ea958bc9
108 N2842b6e3403d40f2bf04818d635f3634 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Allosteric Regulation
110 rdf:type schema:DefinedTerm
111 N28f52228c32d4656b8d79278bcdd493c rdf:first sg:person.01273277707.39
112 rdf:rest N723d24585acb44898a872f6e46049014
113 N2ccca5f5f280413cbd9ff5417dc944f8 rdf:first sg:person.0624046551.15
114 rdf:rest Nb5ad3b34d3ec4cd3bbb56bf95b4de63f
115 N337676b11cad490eb6832829aa0c59e8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Enzyme Activation
117 rdf:type schema:DefinedTerm
118 N362182efa9a94945adee1c3a99f98254 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Cell Line
120 rdf:type schema:DefinedTerm
121 N36ace21f37c249de95c45766c72fc48c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Histones
123 rdf:type schema:DefinedTerm
124 N37751b5ac1a5447888485967ea958bc9 rdf:first sg:person.01121214456.04
125 rdf:rest N2ccca5f5f280413cbd9ff5417dc944f8
126 N3ae0e7dfb93d448b8630e88443f5c17a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Histone-Lysine N-Methyltransferase
128 rdf:type schema:DefinedTerm
129 N3e6b7096fe634bae9fb09586a44ea56c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Lysine
131 rdf:type schema:DefinedTerm
132 N483639efc163429b87caccbc7fd1bc69 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Nuclear Proteins
134 rdf:type schema:DefinedTerm
135 N4f77ce2298af41adb9d00a4f8edb411a schema:name nlm_unique_id
136 schema:value 0410462
137 rdf:type schema:PropertyValue
138 N5eff443cbcd24153b1c084cb9caf1b0d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Models, Molecular
140 rdf:type schema:DefinedTerm
141 N65bc06ea33ba4b6d983d354a66492896 rdf:first sg:person.01045442400.98
142 rdf:rest N049fbbc52bdd41de91ee8e7c8d1d62e1
143 N663f3af0b79f4adaaa348c95bb6c5f42 rdf:first sg:person.014166377647.07
144 rdf:rest rdf:nil
145 N68e1c66aaaa94777b8ae61aa2b3cd5a8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Drosophila melanogaster
147 rdf:type schema:DefinedTerm
148 N723d24585acb44898a872f6e46049014 rdf:first sg:person.01231601756.06
149 rdf:rest Nb85b9715ebfb4995826390dedc327ed0
150 N738fbd75cc4040cd8cf985061badbb98 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Substrate Specificity
152 rdf:type schema:DefinedTerm
153 N73eed1fdcae84a55a0cdccbf189587c8 schema:name pubmed_id
154 schema:value 19767730
155 rdf:type schema:PropertyValue
156 N742976c8dba7450a996d22771a3df6e4 rdf:first sg:person.0666651335.26
157 rdf:rest N65bc06ea33ba4b6d983d354a66492896
158 N8407afcabf4249588a2807189bfd91c9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Protein Structure, Tertiary
160 rdf:type schema:DefinedTerm
161 N950b5246ac1b41069c0259d49e76c8e9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Nucleosomes
163 rdf:type schema:DefinedTerm
164 Na74f3f1ee8eb47dca54dd14708e38590 schema:name doi
165 schema:value 10.1038/nature08398
166 rdf:type schema:PropertyValue
167 Nac7d5966cf904454a5817b94b276dec9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Gene Silencing
169 rdf:type schema:DefinedTerm
170 Nb148221409d945059744cff2a4239c5d rdf:first sg:person.0770466725.25
171 rdf:rest N742976c8dba7450a996d22771a3df6e4
172 Nb444da4d80144c5e9e58c2c3d975fda5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Crystallography, X-Ray
174 rdf:type schema:DefinedTerm
175 Nb5ad3b34d3ec4cd3bbb56bf95b4de63f rdf:first sg:person.0672601630.11
176 rdf:rest N663f3af0b79f4adaaa348c95bb6c5f42
177 Nb85b9715ebfb4995826390dedc327ed0 rdf:first sg:person.01227401371.73
178 rdf:rest N215d2cada49a4fe5844dd82b0468fe29
179 Nb95b0c1a8347466fa6742053f9c8c7db schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
180 schema:name Models, Biological
181 rdf:type schema:DefinedTerm
182 Nc2301d0d3b0847c6b1ac95b8c850cb4d schema:volumeNumber 461
183 rdf:type schema:PublicationVolume
184 Nc36a0fe0c4914d1ab4374bbc2d6d0843 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
185 schema:name Polycomb Repressive Complex 2
186 rdf:type schema:DefinedTerm
187 Ncdbbe2e340f0453682058ff74e5f3e2f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
188 schema:name Drosophila Proteins
189 rdf:type schema:DefinedTerm
190 Nd7cde48ed5244bf6b50fbde3e954ce34 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
191 schema:name Animals
192 rdf:type schema:DefinedTerm
193 Ne1664143a1754f909757dbdb6e097eb7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
194 schema:name Methylation
195 rdf:type schema:DefinedTerm
196 Ne515f84eea0c434282cfaefd2f8ab9a4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
197 schema:name Protein Binding
198 rdf:type schema:DefinedTerm
199 Ne84f3e1d513f48d5b567ad0124f5f287 schema:name dimensions_id
200 schema:value pub.1014254479
201 rdf:type schema:PropertyValue
202 Nff65fc6f6d1f4c5a856ad2c302ca391c schema:name readcube_id
203 schema:value 43e8712b0fa4a982ce7c96b9e7e21de2818b89473de3a4b55abf65508ae9a3dc
204 rdf:type schema:PropertyValue
205 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
206 schema:name Biological Sciences
207 rdf:type schema:DefinedTerm
208 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
209 schema:name Biochemistry and Cell Biology
210 rdf:type schema:DefinedTerm
211 sg:grant.2511807 http://pending.schema.org/fundedItem sg:pub.10.1038/nature08398
212 rdf:type schema:MonetaryGrant
213 sg:grant.2517338 http://pending.schema.org/fundedItem sg:pub.10.1038/nature08398
214 rdf:type schema:MonetaryGrant
215 sg:grant.2635240 http://pending.schema.org/fundedItem sg:pub.10.1038/nature08398
216 rdf:type schema:MonetaryGrant
217 sg:grant.2766383 http://pending.schema.org/fundedItem sg:pub.10.1038/nature08398
218 rdf:type schema:MonetaryGrant
219 sg:journal.1018957 schema:issn 0090-0028
220 1476-4687
221 schema:name Nature
222 rdf:type schema:Periodical
223 sg:person.010355726752.41 schema:affiliation https://www.grid.ac/institutes/grid.451388.3
224 schema:familyName Martin
225 schema:givenName Stephen R.
226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010355726752.41
227 rdf:type schema:Person
228 sg:person.01045442400.98 schema:affiliation https://www.grid.ac/institutes/grid.137628.9
229 schema:familyName Voigt
230 schema:givenName Philipp
231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01045442400.98
232 rdf:type schema:Person
233 sg:person.01121214456.04 schema:affiliation https://www.grid.ac/institutes/grid.451388.3
234 schema:familyName De Marco
235 schema:givenName Valeria
236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01121214456.04
237 rdf:type schema:Person
238 sg:person.01227401371.73 schema:affiliation https://www.grid.ac/institutes/grid.430387.b
239 schema:familyName Ohno
240 schema:givenName Katsuhito
241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01227401371.73
242 rdf:type schema:Person
243 sg:person.01231601756.06 schema:affiliation https://www.grid.ac/institutes/grid.451388.3
244 schema:familyName Justin
245 schema:givenName Neil
246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01231601756.06
247 rdf:type schema:Person
248 sg:person.01273277707.39 schema:affiliation https://www.grid.ac/institutes/grid.137628.9
249 schema:familyName Margueron
250 schema:givenName Raphael
251 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01273277707.39
252 rdf:type schema:Person
253 sg:person.014166377647.07 schema:affiliation https://www.grid.ac/institutes/grid.451388.3
254 schema:familyName Gamblin
255 schema:givenName Steven J.
256 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014166377647.07
257 rdf:type schema:Person
258 sg:person.014227333147.06 schema:affiliation https://www.grid.ac/institutes/grid.451388.3
259 schema:familyName Taylor
260 schema:givenName William R.
261 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014227333147.06
262 rdf:type schema:Person
263 sg:person.0624046551.15 schema:affiliation https://www.grid.ac/institutes/grid.430387.b
264 schema:familyName Pirrotta
265 schema:givenName Vincenzo
266 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0624046551.15
267 rdf:type schema:Person
268 sg:person.0625507742.05 schema:affiliation https://www.grid.ac/institutes/grid.451388.3
269 schema:familyName Sharpe
270 schema:givenName Miriam L.
271 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0625507742.05
272 rdf:type schema:Person
273 sg:person.0666651335.26 schema:affiliation https://www.grid.ac/institutes/grid.137628.9
274 schema:familyName Drury
275 schema:givenName William J.
276 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0666651335.26
277 rdf:type schema:Person
278 sg:person.0672601630.11 schema:affiliation https://www.grid.ac/institutes/grid.137628.9
279 schema:familyName Reinberg
280 schema:givenName Danny
281 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0672601630.11
282 rdf:type schema:Person
283 sg:person.0770466725.25 schema:affiliation https://www.grid.ac/institutes/grid.137628.9
284 schema:familyName Son
285 schema:givenName Jinsook
286 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0770466725.25
287 rdf:type schema:Person
288 sg:pub.10.1038/nature04802 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025701396
289 https://doi.org/10.1038/nature04802
290 rdf:type schema:CreativeWork
291 sg:pub.10.1038/nature04814 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023378568
292 https://doi.org/10.1038/nature04814
293 rdf:type schema:CreativeWork
294 sg:pub.10.1038/ncb1787 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005538911
295 https://doi.org/10.1038/ncb1787
296 rdf:type schema:CreativeWork
297 sg:pub.10.1038/ng1817 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026324467
298 https://doi.org/10.1038/ng1817
299 rdf:type schema:CreativeWork
300 https://app.dimensions.ai/details/publication/pub.1079343524 schema:CreativeWork
301 https://doi.org/10.1006/jmbi.1997.1235 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035443314
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1016/0092-8674(82)90428-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046298202
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1016/j.ceb.2008.03.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041347486
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1016/j.cell.2006.12.041 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032622691
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1016/j.cell.2007.02.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022937373
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1016/j.cell.2007.02.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032874898
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1016/j.mod.2008.01.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002020112
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1016/j.molcel.2008.11.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053484531
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1016/j.molcel.2008.12.029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013732214
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1016/j.str.2007.08.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013976059
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1016/j.str.2008.05.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014555623
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1016/j.ydbio.2007.10.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006071078
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1016/s0076-6879(97)76066-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1004907170
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1016/s0092-8674(00)81326-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051752247
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1016/s0092-8674(02)00975-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013988165
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1016/s0092-8674(02)00976-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009600594
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1038/sj.emboj.7601837 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044794985
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1038/sj.embor.7400376 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032976911
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1073/pnas.0611511104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050367125
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1074/jbc.m309771200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022597179
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1101/gad.1035902 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033394366
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1101/gad.388706 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026603580
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1107/s0108767390010224 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014210169
346 rdf:type schema:CreativeWork
347 https://doi.org/10.1107/s0108767393007597 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002475686
348 rdf:type schema:CreativeWork
349 https://doi.org/10.1107/s0907444900005072 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038886912
350 rdf:type schema:CreativeWork
351 https://doi.org/10.1107/s0907444904019158 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020281098
352 rdf:type schema:CreativeWork
353 https://doi.org/10.1107/s0907444994003112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025573949
354 rdf:type schema:CreativeWork
355 https://doi.org/10.1107/s0907444997005696 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022493994
356 rdf:type schema:CreativeWork
357 https://doi.org/10.1107/s0907444998003254 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019779527
358 rdf:type schema:CreativeWork
359 https://doi.org/10.1107/s0907444999000839 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008525008
360 rdf:type schema:CreativeWork
361 https://doi.org/10.1126/science.1076997 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050318758
362 rdf:type schema:CreativeWork
363 https://doi.org/10.1126/science.1125162 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062453584
364 rdf:type schema:CreativeWork
365 https://doi.org/10.1128/mcb.01822-06 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030775929
366 rdf:type schema:CreativeWork
367 https://doi.org/10.1128/mcb.02017-07 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036575885
368 rdf:type schema:CreativeWork
369 https://doi.org/10.1242/dev.02723 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010597130
370 rdf:type schema:CreativeWork
371 https://doi.org/10.1534/genetics.106.056945 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039938897
372 rdf:type schema:CreativeWork
373 https://www.grid.ac/institutes/grid.137628.9 schema:alternateName New York University
374 schema:name Howard Hughes Medical Institute and Department of Biochemistry, New York University Medical School, 522 First Avenue, New York, New York 10016, USA
375 rdf:type schema:Organization
376 https://www.grid.ac/institutes/grid.430387.b schema:alternateName Rutgers University
377 schema:name Department of Molecular Biology and Biochemistry, Rutgers University, Nelson Laboratories, 604 Allison Road, Piscataway, New Jersey 08854, USA
378 rdf:type schema:Organization
379 https://www.grid.ac/institutes/grid.451388.3 schema:alternateName The Francis Crick Institute
380 schema:name MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
381 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...