Role of the polycomb protein EED in the propagation of repressive histone marks View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2009-10-08

AUTHORS

Raphael Margueron, Neil Justin, Katsuhito Ohno, Miriam L. Sharpe, Jinsook Son, William J. Drury, Philipp Voigt, Stephen R. Martin, William R. Taylor, Valeria De Marco, Vincenzo Pirrotta, Danny Reinberg, Steven J. Gamblin

ABSTRACT

Polycomb group proteins have an essential role in the epigenetic maintenance of repressive chromatin states. The gene-silencing activity of the Polycomb repressive complex 2 (PRC2) depends on its ability to trimethylate lysine 27 of histone H3 (H3K27) by the catalytic SET domain of the EZH2 subunit, and at least two other subunits of the complex: SUZ12 and EED. Here we show that the carboxy-terminal domain of EED specifically binds to histone tails carrying trimethyl-lysine residues associated with repressive chromatin marks, and that this leads to the allosteric activation of the methyltransferase activity of PRC2. Mutations in EED that prevent it from recognizing repressive trimethyl-lysine marks abolish the activation of PRC2 in vitro and, in Drosophila, reduce global methylation and disrupt development. These findings suggest a model for the propagation of the H3K27me3 mark that accounts for the maintenance of repressive chromatin domains and for the transmission of a histone modification from mother to daughter cells. More... »

PAGES

762

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature08398

DOI

http://dx.doi.org/10.1038/nature08398

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1014254479

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19767730


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