The avian Z-linked gene DMRT1 is required for male sex determination in the chicken View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2009-08-26

AUTHORS

Craig A. Smith, Kelly N. Roeszler, Thomas Ohnesorg, David M. Cummins, Peter G. Farlie, Timothy J. Doran, Andrew H. Sinclair

ABSTRACT

Avian sex determination: the Z factorThe mammalian sex-determining gene SRY is well known, but the mechanisms underpinning sex determination in birds have been the subject of much debate. One hypothesis posits that the dosage of a Z-linked gene may mediate sex determination, two doses being required for male development (ZZ). Here Smith et al. show that reducing DMRT1 expression in early chicken embryos feminizes the embryonic gonads in genetically male (ZZ) embryos. This study shows that DMRT1 is required for testis formation and lends support to the theory that a double dose of a Z-linked gene is needed to make bird embryos male. More... »

PAGES

267-271

Journal

TITLE

Nature

ISSUE

7261

VOLUME

461

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature08298

DOI

http://dx.doi.org/10.1038/nature08298

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1026768312

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19710650


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