Neurotransmission selectively regulates synapse formation in parallel circuits in vivo View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2009-08

AUTHORS

Daniel Kerschensteiner, Josh L. Morgan, Edward D. Parker, Renate M. Lewis, Rachel O. L. Wong

ABSTRACT

Activity-dependent synapse formationActivity is presumed to help shape the connectivity within neural circuits, with differences often leading to the elimination of less active connections. Here, to challenge this notion, a subpopulation of bipolar cells was inactivated during development, yet retinal ganglion cells still received input from them, albeit through fewer synapses. This occurred through a reduced rate of synapse formation rather than an increase in synapse elimination. Synaptogenesis and connectivity within a parallel processing stream of bipolar cell input converging onto the same retinal ganglion cell were unaffected. These observations reveal an unexpected and independent role for activity in regulating the rate of synapse formation rather than elimination for specific set of inputs during circuit formation in vivo. More... »

PAGES

1016-1020

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature08236

DOI

http://dx.doi.org/10.1038/nature08236

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1051306650

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19693082


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