Ontology type: schema:ScholarlyArticle Open Access: True
2009-08
AUTHORSDaniel Kerschensteiner, Josh L. Morgan, Edward D. Parker, Renate M. Lewis, Rachel O. L. Wong
ABSTRACTActivity-dependent synapse formationActivity is presumed to help shape the connectivity within neural circuits, with differences often leading to the elimination of less active connections. Here, to challenge this notion, a subpopulation of bipolar cells was inactivated during development, yet retinal ganglion cells still received input from them, albeit through fewer synapses. This occurred through a reduced rate of synapse formation rather than an increase in synapse elimination. Synaptogenesis and connectivity within a parallel processing stream of bipolar cell input converging onto the same retinal ganglion cell were unaffected. These observations reveal an unexpected and independent role for activity in regulating the rate of synapse formation rather than elimination for specific set of inputs during circuit formation in vivo. More... »
PAGES1016-1020
http://scigraph.springernature.com/pub.10.1038/nature08236
DOIhttp://dx.doi.org/10.1038/nature08236
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