Recent progress in the biology and physiology of sirtuins View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2009-07

AUTHORS

Toren Finkel, Chu-Xia Deng, Raul Mostoslavsky

ABSTRACT

The sirtuins are a highly conserved family of NAD(+)-dependent enzymes that regulate lifespan in lower organisms. Recently, the mammalian sirtuins have been connected to an ever widening circle of activities that encompass cellular stress resistance, genomic stability, tumorigenesis and energy metabolism. Here we review the recent progress in sirtuin biology, the role these proteins have in various age-related diseases and the tantalizing notion that the activity of this family of enzymes somehow regulates how long we live. More... »

PAGES

587

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature08197

DOI

http://dx.doi.org/10.1038/nature08197

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1016140945

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19641587


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