Unlocking the molecular secrets of sodium-coupled transporters View Full Text


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Article Info

DATE

2009-05-20

AUTHORS

Harini Krishnamurthy, Chayne L. Piscitelli, Eric Gouaux

ABSTRACT

Transmembrane sodium-ion gradients provide energy that can be harnessed by 'secondary transporters' to drive the translocation of solute molecules into a cell. Decades of study have shown that such sodium-coupled transporters are involved in many physiological processes, making them targets for the treatment of numerous diseases. Within the past year, crystal structures of several sodium-coupled transporters from different families have been reported, showing a remarkable structural conservation between functionally unrelated transporters. These atomic-resolution structures are revealing the mechanism of the sodium-coupled transport of solutes across cellular membranes. More... »

PAGES

347-355

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nature08143

    DOI

    http://dx.doi.org/10.1038/nature08143

    DIMENSIONS

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/19458710


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