A mechanism linking extra centrosomes to chromosomal instability View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2009-06-07

AUTHORS

Neil J. Ganem, Susana A. Godinho, David Pellman

ABSTRACT

Chromosome instability: extra centrosomes do battle in tug of warThe mechanism underlying chromosomal instability (CIN), an increased rate of gain or loss of whole chromosomes that is common in cancer cells, has been the subject of much debate. Long-term live-cell imaging now reveals that extra-centrosomal cancer cells pass through a transitory multipolar spindle stage, when abnormal kinetochore-microtubule attachments accumulate. Many attachment errors persist even after the extra centrosomes cluster to form proper bipolar spindles, increasing the likelihood of chromosome missegregation. The cover shows a transient multipolar spindle intermediate in a human cell with extra centrosomes. Microtubules are shown red, centrosomes green and chromosomes white. More... »

PAGES

278-282

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature08136

DOI

http://dx.doi.org/10.1038/nature08136

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1014745794

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19506557


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