The RNA-binding protein KSRP promotes the biogenesis of a subset of microRNAs View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2009-06

AUTHORS

Michele Trabucchi, Paola Briata, MariaFlor Garcia-Mayoral, Astrid D. Haase, Witold Filipowicz, Andres Ramos, Roberto Gherzi, Michael G. Rosenfeld

ABSTRACT

Consistent with the role of microRNAs (miRNAs) in down-regulating gene expression by reducing the translation and/or stability of target messenger RNAs, the levels of specific miRNAs are important for correct embryonic development and have been linked to several forms of cancer. However, the regulatory mechanisms by which primary miRNAs (pri-miRNAs) are processed first to precursor miRNAs (pre-miRNAs) and then to mature miRNAs by the multiprotein Drosha and Dicer complexes, respectively, remain largely unknown. The KH-type splicing regulatory protein (KSRP, also known as KHSRP) interacts with single-strand AU-rich-element-containing mRNAs and is a key mediator of mRNA decay. Here we show in mammalian cells that KSRP also serves as a component of both Drosha and Dicer complexes and regulates the biogenesis of a subset of miRNAs. KSRP binds with high affinity to the terminal loop of the target miRNA precursors and promotes their maturation. This mechanism is required for specific changes in target mRNA expression that affect specific biological programs, including proliferation, apoptosis and differentiation. These findings reveal an unexpected mechanism that links KSRP to the machinery regulating maturation of a cohort of miRNAs that, in addition to its role in promoting mRNA decay, independently serves to integrate specific regulatory programs of protein expression. More... »

PAGES

1010

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature08025

DOI

http://dx.doi.org/10.1038/nature08025

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1000219429

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19458619


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Proliferation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "MicroRNAs", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA Processing, Post-Transcriptional", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA-Binding Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ribonuclease III", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Trans-Activators", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of California, San Diego", 
          "id": "https://www.grid.ac/institutes/grid.266100.3", 
          "name": [
            "Howard Hughes Medical Institute, Department and School of Medicine, University of California, San Diego, 9500 Gilman Drive, Room 345, La Jolla, California 92093-0648, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Trabucchi", 
        "givenName": "Michele", 
        "id": "sg:person.0617503470.71", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617503470.71"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ospedale San Martino", 
          "id": "https://www.grid.ac/institutes/grid.410345.7", 
          "name": [
            "Istituto Nazionale per la Ricerca sul Cancro (IST), Largo R. Benzi, 10; 16132 Genova, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Briata", 
        "givenName": "Paola", 
        "id": "sg:person.0740354470.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0740354470.90"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Francis Crick Institute", 
          "id": "https://www.grid.ac/institutes/grid.451388.3", 
          "name": [
            "Division of Molecular Structure, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Garcia-Mayoral", 
        "givenName": "MariaFlor", 
        "id": "sg:person.014362222567.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014362222567.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Friedrich Miescher Institute", 
          "id": "https://www.grid.ac/institutes/grid.482245.d", 
          "name": [
            "Friedrich Miescher Institute for Biomedical Research, PO Box 2543, 4002 Basel, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Haase", 
        "givenName": "Astrid D.", 
        "id": "sg:person.01172432123.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01172432123.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Friedrich Miescher Institute", 
          "id": "https://www.grid.ac/institutes/grid.482245.d", 
          "name": [
            "Friedrich Miescher Institute for Biomedical Research, PO Box 2543, 4002 Basel, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Filipowicz", 
        "givenName": "Witold", 
        "id": "sg:person.01012642467.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01012642467.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Francis Crick Institute", 
          "id": "https://www.grid.ac/institutes/grid.451388.3", 
          "name": [
            "Division of Molecular Structure, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ramos", 
        "givenName": "Andres", 
        "id": "sg:person.01347671131.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01347671131.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ospedale San Martino", 
          "id": "https://www.grid.ac/institutes/grid.410345.7", 
          "name": [
            "Istituto Nazionale per la Ricerca sul Cancro (IST), Largo R. Benzi, 10; 16132 Genova, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gherzi", 
        "givenName": "Roberto", 
        "id": "sg:person.0637341244.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0637341244.90"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of California, San Diego", 
          "id": "https://www.grid.ac/institutes/grid.266100.3", 
          "name": [
            "Howard Hughes Medical Institute, Department and School of Medicine, University of California, San Diego, 9500 Gilman Drive, Room 345, La Jolla, California 92093-0648, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rosenfeld", 
        "givenName": "Michael G.", 
        "id": "sg:person.01063476055.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01063476055.19"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.molcel.2005.10.021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000465592"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00197809", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001469691", 
          "https://doi.org/10.1007/bf00197809"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00197809", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001469691", 
          "https://doi.org/10.1007/bf00197809"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.c800108200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001921959"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.1540407", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002090828"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m208954200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003032873"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/dev.00160", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004134452"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.str.2007.03.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005637968"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1725", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005845651", 
          "https://doi.org/10.1038/ng1725"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1725", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005845651", 
          "https://doi.org/10.1038/ng1725"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrm2632", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009902558", 
          "https://doi.org/10.1038/nrm2632"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2005.01.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010338150"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1522-2683()22:6<1224::aid-elps1224>3.0.co;2-i", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010805726"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1522-2683()22:6<1224::aid-elps1224>3.0.co;2-i", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010805726"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-07-2462", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012811329"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.embor.7400509", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016029106"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.embor.7400509", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016029106"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(01)00578-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019561667"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nsmb1250", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023067946", 
          "https://doi.org/10.1038/nsmb1250"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0506654102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023841510"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.1444406", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025405827"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2199-8-28", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027768228", 
          "https://doi.org/10.1186/1471-2199-8-28"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0263-7855(96)00009-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028069795"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pbio.0050005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028517126"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb1759", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028865043", 
          "https://doi.org/10.1038/ncb1759"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0509333103", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029486532"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkn509", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032139422"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.200603008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034924310"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng2003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036221931", 
          "https://doi.org/10.1038/ng2003"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng2003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036221931", 
          "https://doi.org/10.1038/ng2003"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1261/rna.2322506", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036696023"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.20.11.3951-3964.2000", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036740979"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/emboj/cdf582", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038040167"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.11.8.1023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041137808"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tcb.2006.12.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043767584"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tcb.2008.07.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044009500"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1997", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044012298", 
          "https://doi.org/10.1038/nrc1997"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1997", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044012298", 
          "https://doi.org/10.1038/nrc1997"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2008.10.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046485773"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2008.09.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047698038"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1261/rna.1155108", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048224171"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.febslet.2004.10.023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048801242"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/biostatistics/2.2.183", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048829539"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2004.05.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053692317"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1154040", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062457451"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074642264", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2009-06", 
    "datePublishedReg": "2009-06-01", 
    "description": "Consistent with the role of microRNAs (miRNAs) in down-regulating gene expression by reducing the translation and/or stability of target messenger RNAs, the levels of specific miRNAs are important for correct embryonic development and have been linked to several forms of cancer. However, the regulatory mechanisms by which primary miRNAs (pri-miRNAs) are processed first to precursor miRNAs (pre-miRNAs) and then to mature miRNAs by the multiprotein Drosha and Dicer complexes, respectively, remain largely unknown. The KH-type splicing regulatory protein (KSRP, also known as KHSRP) interacts with single-strand AU-rich-element-containing mRNAs and is a key mediator of mRNA decay. Here we show in mammalian cells that KSRP also serves as a component of both Drosha and Dicer complexes and regulates the biogenesis of a subset of miRNAs. KSRP binds with high affinity to the terminal loop of the target miRNA precursors and promotes their maturation. This mechanism is required for specific changes in target mRNA expression that affect specific biological programs, including proliferation, apoptosis and differentiation. These findings reveal an unexpected mechanism that links KSRP to the machinery regulating maturation of a cohort of miRNAs that, in addition to its role in promoting mRNA decay, independently serves to integrate specific regulatory programs of protein expression.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/nature08025", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2537607", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2493864", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2491863", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2774697", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2634766", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.5146404", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.3634121", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2764234", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0090-0028", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "7249", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "459"
      }
    ], 
    "name": "The RNA-binding protein KSRP promotes the biogenesis of a subset of microRNAs", 
    "pagination": "1010", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "010af6e7fe16735cca837a6505bc70c960c241f3e136735e878fad1acd4a8721"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "19458619"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0410462"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/nature08025"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1000219429"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/nature08025", 
      "https://app.dimensions.ai/details/publication/pub.1000219429"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T09:18", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000339_0000000339/records_109487_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/nature08025"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nature08025'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nature08025'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nature08025'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nature08025'


 

This table displays all metadata directly associated to this object as RDF triples.

314 TRIPLES      21 PREDICATES      80 URIs      32 LITERALS      20 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/nature08025 schema:about N3858c44e777647d99eb92a2bd3f91058
2 N57bbe0b524a8441ca1c5f6a5bbb3ce17
3 N5ff557a27f86481ea75ad7d15387a20b
4 N64ab88af7bb54d709b34216b38cb69b9
5 N6826e6506e0f47bab769e8fa286dc55f
6 N9e859348ba1c406799ad6c7807afa068
7 Nac682ed929f74dc9ac7587c033e593e2
8 Nb3fcab3f92ea4f1ab739f116b2a76503
9 Nba6b1927cf2c4a009ed320d51a5a9cdb
10 Nbc45931749744dc3ba55504f3c8abfd3
11 Ncc313adfe2bc44c292d43ee4afc9ba52
12 anzsrc-for:06
13 anzsrc-for:0601
14 schema:author N0db234e68f004456857107502daecf51
15 schema:citation sg:pub.10.1007/bf00197809
16 sg:pub.10.1038/ncb1759
17 sg:pub.10.1038/ng1725
18 sg:pub.10.1038/ng2003
19 sg:pub.10.1038/nrc1997
20 sg:pub.10.1038/nrm2632
21 sg:pub.10.1038/nsmb1250
22 sg:pub.10.1186/1471-2199-8-28
23 https://app.dimensions.ai/details/publication/pub.1074642264
24 https://doi.org/10.1002/1522-2683()22:6<1224::aid-elps1224>3.0.co;2-i
25 https://doi.org/10.1016/0263-7855(96)00009-4
26 https://doi.org/10.1016/j.cell.2005.01.014
27 https://doi.org/10.1016/j.febslet.2004.10.023
28 https://doi.org/10.1016/j.molcel.2004.05.002
29 https://doi.org/10.1016/j.molcel.2005.10.021
30 https://doi.org/10.1016/j.molcel.2008.09.014
31 https://doi.org/10.1016/j.molcel.2008.10.013
32 https://doi.org/10.1016/j.str.2007.03.006
33 https://doi.org/10.1016/j.tcb.2006.12.007
34 https://doi.org/10.1016/j.tcb.2008.07.007
35 https://doi.org/10.1016/s0092-8674(01)00578-5
36 https://doi.org/10.1038/sj.embor.7400509
37 https://doi.org/10.1073/pnas.0506654102
38 https://doi.org/10.1073/pnas.0509333103
39 https://doi.org/10.1074/jbc.c800108200
40 https://doi.org/10.1074/jbc.m208954200
41 https://doi.org/10.1083/jcb.200603008
42 https://doi.org/10.1093/biostatistics/2.2.183
43 https://doi.org/10.1093/emboj/cdf582
44 https://doi.org/10.1093/nar/gkn509
45 https://doi.org/10.1101/gad.11.8.1023
46 https://doi.org/10.1101/gad.1444406
47 https://doi.org/10.1101/gad.1540407
48 https://doi.org/10.1126/science.1154040
49 https://doi.org/10.1128/mcb.20.11.3951-3964.2000
50 https://doi.org/10.1158/0008-5472.can-07-2462
51 https://doi.org/10.1242/dev.00160
52 https://doi.org/10.1261/rna.1155108
53 https://doi.org/10.1261/rna.2322506
54 https://doi.org/10.1371/journal.pbio.0050005
55 schema:datePublished 2009-06
56 schema:datePublishedReg 2009-06-01
57 schema:description Consistent with the role of microRNAs (miRNAs) in down-regulating gene expression by reducing the translation and/or stability of target messenger RNAs, the levels of specific miRNAs are important for correct embryonic development and have been linked to several forms of cancer. However, the regulatory mechanisms by which primary miRNAs (pri-miRNAs) are processed first to precursor miRNAs (pre-miRNAs) and then to mature miRNAs by the multiprotein Drosha and Dicer complexes, respectively, remain largely unknown. The KH-type splicing regulatory protein (KSRP, also known as KHSRP) interacts with single-strand AU-rich-element-containing mRNAs and is a key mediator of mRNA decay. Here we show in mammalian cells that KSRP also serves as a component of both Drosha and Dicer complexes and regulates the biogenesis of a subset of miRNAs. KSRP binds with high affinity to the terminal loop of the target miRNA precursors and promotes their maturation. This mechanism is required for specific changes in target mRNA expression that affect specific biological programs, including proliferation, apoptosis and differentiation. These findings reveal an unexpected mechanism that links KSRP to the machinery regulating maturation of a cohort of miRNAs that, in addition to its role in promoting mRNA decay, independently serves to integrate specific regulatory programs of protein expression.
58 schema:genre research_article
59 schema:inLanguage en
60 schema:isAccessibleForFree true
61 schema:isPartOf N55d8b3ba3449436f973046ec640eda3a
62 Nf5726cb5663f4a03bb338b53919bdb7e
63 sg:journal.1018957
64 schema:name The RNA-binding protein KSRP promotes the biogenesis of a subset of microRNAs
65 schema:pagination 1010
66 schema:productId N174eef6c79b945da981a2f1474e9c5e4
67 N3ec8eeacba1f49b29255313b284c565c
68 N441ffaf3aaba4a6b8cceecf4626de2b2
69 N605e3a4cf5514ab7b89b268bbc1bf977
70 N7fbbf9dcbdf54479a3f1da6d82ab94b5
71 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000219429
72 https://doi.org/10.1038/nature08025
73 schema:sdDatePublished 2019-04-11T09:18
74 schema:sdLicense https://scigraph.springernature.com/explorer/license/
75 schema:sdPublisher N4854e9c5eae3409b812e4a8414ecab02
76 schema:url https://www.nature.com/articles/nature08025
77 sgo:license sg:explorer/license/
78 sgo:sdDataset articles
79 rdf:type schema:ScholarlyArticle
80 N0db234e68f004456857107502daecf51 rdf:first sg:person.0617503470.71
81 rdf:rest N1c0d775fe0404cf3bf0e86dffd5f6ad9
82 N12b0cc8e70e9401eac4497c982eb5b4f rdf:first sg:person.0637341244.90
83 rdf:rest N1f855134f18c45d89445a06e967164a8
84 N174eef6c79b945da981a2f1474e9c5e4 schema:name nlm_unique_id
85 schema:value 0410462
86 rdf:type schema:PropertyValue
87 N1c0d775fe0404cf3bf0e86dffd5f6ad9 rdf:first sg:person.0740354470.90
88 rdf:rest Nacbd24e7c09c4aa1b1a9675effd31c87
89 N1f855134f18c45d89445a06e967164a8 rdf:first sg:person.01063476055.19
90 rdf:rest rdf:nil
91 N3858c44e777647d99eb92a2bd3f91058 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Cell Line
93 rdf:type schema:DefinedTerm
94 N3ec8eeacba1f49b29255313b284c565c schema:name doi
95 schema:value 10.1038/nature08025
96 rdf:type schema:PropertyValue
97 N414ea19fd756481b8bb6f9dfe1013912 rdf:first sg:person.01172432123.12
98 rdf:rest Nc7d8bb84875a4498905606d775496638
99 N441ffaf3aaba4a6b8cceecf4626de2b2 schema:name dimensions_id
100 schema:value pub.1000219429
101 rdf:type schema:PropertyValue
102 N4854e9c5eae3409b812e4a8414ecab02 schema:name Springer Nature - SN SciGraph project
103 rdf:type schema:Organization
104 N55d8b3ba3449436f973046ec640eda3a schema:volumeNumber 459
105 rdf:type schema:PublicationVolume
106 N57bbe0b524a8441ca1c5f6a5bbb3ce17 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Trans-Activators
108 rdf:type schema:DefinedTerm
109 N5ff557a27f86481ea75ad7d15387a20b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Mice
111 rdf:type schema:DefinedTerm
112 N605e3a4cf5514ab7b89b268bbc1bf977 schema:name readcube_id
113 schema:value 010af6e7fe16735cca837a6505bc70c960c241f3e136735e878fad1acd4a8721
114 rdf:type schema:PropertyValue
115 N64ab88af7bb54d709b34216b38cb69b9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Animals
117 rdf:type schema:DefinedTerm
118 N6826e6506e0f47bab769e8fa286dc55f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Ribonuclease III
120 rdf:type schema:DefinedTerm
121 N7fbbf9dcbdf54479a3f1da6d82ab94b5 schema:name pubmed_id
122 schema:value 19458619
123 rdf:type schema:PropertyValue
124 N9e859348ba1c406799ad6c7807afa068 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name RNA Processing, Post-Transcriptional
126 rdf:type schema:DefinedTerm
127 Na48c5922b65e41149ba57c050c40b9b5 rdf:first sg:person.01347671131.52
128 rdf:rest N12b0cc8e70e9401eac4497c982eb5b4f
129 Nac682ed929f74dc9ac7587c033e593e2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name MicroRNAs
131 rdf:type schema:DefinedTerm
132 Nacbd24e7c09c4aa1b1a9675effd31c87 rdf:first sg:person.014362222567.49
133 rdf:rest N414ea19fd756481b8bb6f9dfe1013912
134 Nb3fcab3f92ea4f1ab739f116b2a76503 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Humans
136 rdf:type schema:DefinedTerm
137 Nba6b1927cf2c4a009ed320d51a5a9cdb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name RNA-Binding Proteins
139 rdf:type schema:DefinedTerm
140 Nbc45931749744dc3ba55504f3c8abfd3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Cell Line, Tumor
142 rdf:type schema:DefinedTerm
143 Nc7d8bb84875a4498905606d775496638 rdf:first sg:person.01012642467.72
144 rdf:rest Na48c5922b65e41149ba57c050c40b9b5
145 Ncc313adfe2bc44c292d43ee4afc9ba52 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Cell Proliferation
147 rdf:type schema:DefinedTerm
148 Nf5726cb5663f4a03bb338b53919bdb7e schema:issueNumber 7249
149 rdf:type schema:PublicationIssue
150 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
151 schema:name Biological Sciences
152 rdf:type schema:DefinedTerm
153 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
154 schema:name Biochemistry and Cell Biology
155 rdf:type schema:DefinedTerm
156 sg:grant.2491863 http://pending.schema.org/fundedItem sg:pub.10.1038/nature08025
157 rdf:type schema:MonetaryGrant
158 sg:grant.2493864 http://pending.schema.org/fundedItem sg:pub.10.1038/nature08025
159 rdf:type schema:MonetaryGrant
160 sg:grant.2537607 http://pending.schema.org/fundedItem sg:pub.10.1038/nature08025
161 rdf:type schema:MonetaryGrant
162 sg:grant.2634766 http://pending.schema.org/fundedItem sg:pub.10.1038/nature08025
163 rdf:type schema:MonetaryGrant
164 sg:grant.2764234 http://pending.schema.org/fundedItem sg:pub.10.1038/nature08025
165 rdf:type schema:MonetaryGrant
166 sg:grant.2774697 http://pending.schema.org/fundedItem sg:pub.10.1038/nature08025
167 rdf:type schema:MonetaryGrant
168 sg:grant.3634121 http://pending.schema.org/fundedItem sg:pub.10.1038/nature08025
169 rdf:type schema:MonetaryGrant
170 sg:grant.5146404 http://pending.schema.org/fundedItem sg:pub.10.1038/nature08025
171 rdf:type schema:MonetaryGrant
172 sg:journal.1018957 schema:issn 0090-0028
173 1476-4687
174 schema:name Nature
175 rdf:type schema:Periodical
176 sg:person.01012642467.72 schema:affiliation https://www.grid.ac/institutes/grid.482245.d
177 schema:familyName Filipowicz
178 schema:givenName Witold
179 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01012642467.72
180 rdf:type schema:Person
181 sg:person.01063476055.19 schema:affiliation https://www.grid.ac/institutes/grid.266100.3
182 schema:familyName Rosenfeld
183 schema:givenName Michael G.
184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01063476055.19
185 rdf:type schema:Person
186 sg:person.01172432123.12 schema:affiliation https://www.grid.ac/institutes/grid.482245.d
187 schema:familyName Haase
188 schema:givenName Astrid D.
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01172432123.12
190 rdf:type schema:Person
191 sg:person.01347671131.52 schema:affiliation https://www.grid.ac/institutes/grid.451388.3
192 schema:familyName Ramos
193 schema:givenName Andres
194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01347671131.52
195 rdf:type schema:Person
196 sg:person.014362222567.49 schema:affiliation https://www.grid.ac/institutes/grid.451388.3
197 schema:familyName Garcia-Mayoral
198 schema:givenName MariaFlor
199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014362222567.49
200 rdf:type schema:Person
201 sg:person.0617503470.71 schema:affiliation https://www.grid.ac/institutes/grid.266100.3
202 schema:familyName Trabucchi
203 schema:givenName Michele
204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617503470.71
205 rdf:type schema:Person
206 sg:person.0637341244.90 schema:affiliation https://www.grid.ac/institutes/grid.410345.7
207 schema:familyName Gherzi
208 schema:givenName Roberto
209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0637341244.90
210 rdf:type schema:Person
211 sg:person.0740354470.90 schema:affiliation https://www.grid.ac/institutes/grid.410345.7
212 schema:familyName Briata
213 schema:givenName Paola
214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0740354470.90
215 rdf:type schema:Person
216 sg:pub.10.1007/bf00197809 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001469691
217 https://doi.org/10.1007/bf00197809
218 rdf:type schema:CreativeWork
219 sg:pub.10.1038/ncb1759 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028865043
220 https://doi.org/10.1038/ncb1759
221 rdf:type schema:CreativeWork
222 sg:pub.10.1038/ng1725 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005845651
223 https://doi.org/10.1038/ng1725
224 rdf:type schema:CreativeWork
225 sg:pub.10.1038/ng2003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036221931
226 https://doi.org/10.1038/ng2003
227 rdf:type schema:CreativeWork
228 sg:pub.10.1038/nrc1997 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044012298
229 https://doi.org/10.1038/nrc1997
230 rdf:type schema:CreativeWork
231 sg:pub.10.1038/nrm2632 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009902558
232 https://doi.org/10.1038/nrm2632
233 rdf:type schema:CreativeWork
234 sg:pub.10.1038/nsmb1250 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023067946
235 https://doi.org/10.1038/nsmb1250
236 rdf:type schema:CreativeWork
237 sg:pub.10.1186/1471-2199-8-28 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027768228
238 https://doi.org/10.1186/1471-2199-8-28
239 rdf:type schema:CreativeWork
240 https://app.dimensions.ai/details/publication/pub.1074642264 schema:CreativeWork
241 https://doi.org/10.1002/1522-2683()22:6<1224::aid-elps1224>3.0.co;2-i schema:sameAs https://app.dimensions.ai/details/publication/pub.1010805726
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1016/0263-7855(96)00009-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028069795
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1016/j.cell.2005.01.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010338150
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1016/j.febslet.2004.10.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048801242
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1016/j.molcel.2004.05.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053692317
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1016/j.molcel.2005.10.021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000465592
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1016/j.molcel.2008.09.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047698038
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1016/j.molcel.2008.10.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046485773
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1016/j.str.2007.03.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005637968
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1016/j.tcb.2006.12.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043767584
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1016/j.tcb.2008.07.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044009500
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1016/s0092-8674(01)00578-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019561667
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1038/sj.embor.7400509 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016029106
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1073/pnas.0506654102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023841510
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1073/pnas.0509333103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029486532
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1074/jbc.c800108200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001921959
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1074/jbc.m208954200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003032873
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1083/jcb.200603008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034924310
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1093/biostatistics/2.2.183 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048829539
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1093/emboj/cdf582 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038040167
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1093/nar/gkn509 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032139422
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1101/gad.11.8.1023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041137808
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1101/gad.1444406 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025405827
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1101/gad.1540407 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002090828
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1126/science.1154040 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062457451
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1128/mcb.20.11.3951-3964.2000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036740979
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1158/0008-5472.can-07-2462 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012811329
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1242/dev.00160 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004134452
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1261/rna.1155108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048224171
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1261/rna.2322506 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036696023
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1371/journal.pbio.0050005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028517126
302 rdf:type schema:CreativeWork
303 https://www.grid.ac/institutes/grid.266100.3 schema:alternateName University of California, San Diego
304 schema:name Howard Hughes Medical Institute, Department and School of Medicine, University of California, San Diego, 9500 Gilman Drive, Room 345, La Jolla, California 92093-0648, USA
305 rdf:type schema:Organization
306 https://www.grid.ac/institutes/grid.410345.7 schema:alternateName Ospedale San Martino
307 schema:name Istituto Nazionale per la Ricerca sul Cancro (IST), Largo R. Benzi, 10; 16132 Genova, Italy
308 rdf:type schema:Organization
309 https://www.grid.ac/institutes/grid.451388.3 schema:alternateName The Francis Crick Institute
310 schema:name Division of Molecular Structure, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
311 rdf:type schema:Organization
312 https://www.grid.ac/institutes/grid.482245.d schema:alternateName Friedrich Miescher Institute
313 schema:name Friedrich Miescher Institute for Biomedical Research, PO Box 2543, 4002 Basel, Switzerland
314 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...