CtIP-BRCA1 modulates the choice of DNA double-strand-break repair pathway throughout the cell cycle View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2009-05

AUTHORS

Maximina H. Yun, Kevin Hiom

ABSTRACT

The repair of DNA double-strand breaks (DSBs) is tightly regulated during the cell cycle. In G1 phase, the absence of a sister chromatid means that repair of DSBs occurs through non-homologous end-joining or microhomology-mediated end-joining (MMEJ). These pathways often involve loss of DNA sequences at the break site and are therefore error-prone. In late S and G2 phases, even though DNA end-joining pathways remain functional, there is an increase in repair of DSBs by homologous recombination, which is mostly error-free. Consequently, the relative contribution of these different pathways to DSB repair in the cell cycle has a large influence on the maintenance of genetic integrity. It has remained unknown how DSBs are directed for repair by different, potentially competing, repair pathways. Here we identify a role for CtIP (also known as RBBP8) in this process in the avian B-cell line DT40. We establish that CtIP is required not only for repair of DSBs by homologous recombination in S/G2 phase but also for MMEJ in G1. The function of CtIP in homologous recombination, but not MMEJ, is dependent on the phosphorylation of serine residue 327 and recruitment of BRCA1. Cells expressing CtIP protein that cannot be phosphorylated at serine 327 are specifically defective in homologous recombination and have a decreased level of single-stranded DNA after DNA damage, whereas MMEJ remains unaffected. Our data support a model in which phosphorylation of serine 327 of CtIP as cells enter S phase and the recruitment of BRCA1 functions as a molecular switch to shift the balance of DSB repair from error-prone DNA end-joining to error-free homologous recombination. More... »

PAGES

460

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature07955

DOI

http://dx.doi.org/10.1038/nature07955

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1000929920

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19357644


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Avian Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "B-Lymphocytes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "BRCA1 Protein", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carrier Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Cycle", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chickens", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cisplatin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Breaks, Double-Stranded", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Repair", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "G1 Phase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "G2 Phase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nuclear Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phosphorylation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phosphoserine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Recombination, Genetic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "S Phase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "X-Rays", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "MRC Laboratory of Molecular Biology", 
          "id": "https://www.grid.ac/institutes/grid.42475.30", 
          "name": [
            "Division of Protein and Nucleic Acid Chemistry, MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yun", 
        "givenName": "Maximina H.", 
        "id": "sg:person.01226743632.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01226743632.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "MRC Laboratory of Molecular Biology", 
          "id": "https://www.grid.ac/institutes/grid.42475.30", 
          "name": [
            "Division of Protein and Nucleic Acid Chemistry, MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hiom", 
        "givenName": "Kevin", 
        "id": "sg:person.0646412745.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0646412745.05"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1158/0008-5472.can-05-3209", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005215932"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.24.21.9305-9316.2004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009622574"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.24.21.9478-9486.2004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013148122"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.13.20.2633", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022595499"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/emboj/17.18.5497", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023693632"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/emboj/cdg161", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026940213"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.200411083", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030064876"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature07215", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031468320", 
          "https://doi.org/10.1038/nature07215"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1627", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033214796", 
          "https://doi.org/10.1038/ng1627"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1627", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033214796", 
          "https://doi.org/10.1038/ng1627"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1206136", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035503266", 
          "https://doi.org/10.1038/sj.onc.1206136"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1206136", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035503266", 
          "https://doi.org/10.1038/sj.onc.1206136"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pgen.1000110", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037227223"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1098/rstb.2000.0755", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038293743"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.1381306", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041272178"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.273.39.25388", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044736605"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.25.9.3535-3542.2005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046879805"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0959-440x(99)00038-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050218605"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature02964", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050476890", 
          "https://doi.org/10.1038/nature02964"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature02964", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050476890", 
          "https://doi.org/10.1038/nature02964"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.23.23.8820-8828.2003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050671964"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0968-0004(98)01232-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050817136"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature06337", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051713472", 
          "https://doi.org/10.1038/nature06337"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074471852", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2009-05", 
    "datePublishedReg": "2009-05-01", 
    "description": "The repair of DNA double-strand breaks (DSBs) is tightly regulated during the cell cycle. In G1 phase, the absence of a sister chromatid means that repair of DSBs occurs through non-homologous end-joining or microhomology-mediated end-joining (MMEJ). These pathways often involve loss of DNA sequences at the break site and are therefore error-prone. In late S and G2 phases, even though DNA end-joining pathways remain functional, there is an increase in repair of DSBs by homologous recombination, which is mostly error-free. Consequently, the relative contribution of these different pathways to DSB repair in the cell cycle has a large influence on the maintenance of genetic integrity. It has remained unknown how DSBs are directed for repair by different, potentially competing, repair pathways. Here we identify a role for CtIP (also known as RBBP8) in this process in the avian B-cell line DT40. We establish that CtIP is required not only for repair of DSBs by homologous recombination in S/G2 phase but also for MMEJ in G1. The function of CtIP in homologous recombination, but not MMEJ, is dependent on the phosphorylation of serine residue 327 and recruitment of BRCA1. Cells expressing CtIP protein that cannot be phosphorylated at serine 327 are specifically defective in homologous recombination and have a decreased level of single-stranded DNA after DNA damage, whereas MMEJ remains unaffected. Our data support a model in which phosphorylation of serine 327 of CtIP as cells enter S phase and the recruitment of BRCA1 functions as a molecular switch to shift the balance of DSB repair from error-prone DNA end-joining to error-free homologous recombination.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/nature07955", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2756588", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0090-0028", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "7245", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "459"
      }
    ], 
    "name": "CtIP-BRCA1 modulates the choice of DNA double-strand-break repair pathway throughout the cell cycle", 
    "pagination": "460", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "046e54e5e2a6701a93153c98f10b8f838f78f80637a93f06ade6a6f8d9246fd7"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "19357644"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0410462"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/nature07955"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1000929920"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/nature07955", 
      "https://app.dimensions.ai/details/publication/pub.1000929920"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T09:08", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000338_0000000338/records_47960_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/nature07955"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nature07955'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nature07955'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nature07955'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nature07955'


 

This table displays all metadata directly associated to this object as RDF triples.

225 TRIPLES      21 PREDICATES      70 URIs      41 LITERALS      29 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/nature07955 schema:about N0dda317e45d640938d5582da12c1e483
2 N15c6bbb6daee4eae9762ddb5180564b3
3 N1893a12f66724b4eb13efb328917e668
4 N1b51baece7c74f18aaeeb9058a9e03b6
5 N28380d6621ad4927b79d7c5edb3de0d9
6 N2fbd01ec889a4c3ba94f29fc068a813c
7 N334efa44f55c473e9957b76ae676f5bf
8 N431a3d89cfb04be889cd562a687bbfbd
9 N478c84d6cb534e9986ead5cd0f4285df
10 N6c28e075c37b423ea8193a5089f3f9c6
11 N70a491430f09425293317a34f05a1f02
12 N978846e73fc142359f8ff853bea290fc
13 N97e4016175f2431fadf2581c0257b1e4
14 N99d5de659f4a49398ee35eadd0b7dde4
15 Nb86f0de0a78240ac9d295303518aedff
16 Ne32e0f4ef3cb4ff9837353123d354dc2
17 Neb63558d76a24974a118329d8299f4bb
18 Nec326e3b0d13468e91bad1675acff580
19 Nec5f1b863d8e4f5f917f1ed97ac41100
20 Nf88791cee0234dbdb1799279957b2e2a
21 anzsrc-for:06
22 anzsrc-for:0604
23 schema:author Nc40d1417f9214cecb9ed7c9d5f1bd4f8
24 schema:citation sg:pub.10.1038/nature02964
25 sg:pub.10.1038/nature06337
26 sg:pub.10.1038/nature07215
27 sg:pub.10.1038/ng1627
28 sg:pub.10.1038/sj.onc.1206136
29 https://app.dimensions.ai/details/publication/pub.1074471852
30 https://doi.org/10.1016/s0959-440x(99)00038-x
31 https://doi.org/10.1016/s0968-0004(98)01232-8
32 https://doi.org/10.1074/jbc.273.39.25388
33 https://doi.org/10.1083/jcb.200411083
34 https://doi.org/10.1093/emboj/17.18.5497
35 https://doi.org/10.1093/emboj/cdg161
36 https://doi.org/10.1098/rstb.2000.0755
37 https://doi.org/10.1101/gad.13.20.2633
38 https://doi.org/10.1101/gad.1381306
39 https://doi.org/10.1128/mcb.23.23.8820-8828.2003
40 https://doi.org/10.1128/mcb.24.21.9305-9316.2004
41 https://doi.org/10.1128/mcb.24.21.9478-9486.2004
42 https://doi.org/10.1128/mcb.25.9.3535-3542.2005
43 https://doi.org/10.1158/0008-5472.can-05-3209
44 https://doi.org/10.1371/journal.pgen.1000110
45 schema:datePublished 2009-05
46 schema:datePublishedReg 2009-05-01
47 schema:description The repair of DNA double-strand breaks (DSBs) is tightly regulated during the cell cycle. In G1 phase, the absence of a sister chromatid means that repair of DSBs occurs through non-homologous end-joining or microhomology-mediated end-joining (MMEJ). These pathways often involve loss of DNA sequences at the break site and are therefore error-prone. In late S and G2 phases, even though DNA end-joining pathways remain functional, there is an increase in repair of DSBs by homologous recombination, which is mostly error-free. Consequently, the relative contribution of these different pathways to DSB repair in the cell cycle has a large influence on the maintenance of genetic integrity. It has remained unknown how DSBs are directed for repair by different, potentially competing, repair pathways. Here we identify a role for CtIP (also known as RBBP8) in this process in the avian B-cell line DT40. We establish that CtIP is required not only for repair of DSBs by homologous recombination in S/G2 phase but also for MMEJ in G1. The function of CtIP in homologous recombination, but not MMEJ, is dependent on the phosphorylation of serine residue 327 and recruitment of BRCA1. Cells expressing CtIP protein that cannot be phosphorylated at serine 327 are specifically defective in homologous recombination and have a decreased level of single-stranded DNA after DNA damage, whereas MMEJ remains unaffected. Our data support a model in which phosphorylation of serine 327 of CtIP as cells enter S phase and the recruitment of BRCA1 functions as a molecular switch to shift the balance of DSB repair from error-prone DNA end-joining to error-free homologous recombination.
48 schema:genre research_article
49 schema:inLanguage en
50 schema:isAccessibleForFree true
51 schema:isPartOf Nb8fd7c98fcf045ab829e8056dfc90594
52 Ncc1b824fda9f4469929f85966c64c1c0
53 sg:journal.1018957
54 schema:name CtIP-BRCA1 modulates the choice of DNA double-strand-break repair pathway throughout the cell cycle
55 schema:pagination 460
56 schema:productId N09c633ef5d6a422c8746e63c1fe5ab36
57 N515c30f73ce947ea9aec27fd5400e00a
58 N960d6836e96c4890bfd6de436ef159fb
59 Na26bded9070b4200b6ef219b8b782dd8
60 Ncc795d2a3bcd4e53ac1259e01b67c8df
61 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000929920
62 https://doi.org/10.1038/nature07955
63 schema:sdDatePublished 2019-04-11T09:08
64 schema:sdLicense https://scigraph.springernature.com/explorer/license/
65 schema:sdPublisher N78b8cc8f5ac142138604d623b3d00ee2
66 schema:url https://www.nature.com/articles/nature07955
67 sgo:license sg:explorer/license/
68 sgo:sdDataset articles
69 rdf:type schema:ScholarlyArticle
70 N09c633ef5d6a422c8746e63c1fe5ab36 schema:name readcube_id
71 schema:value 046e54e5e2a6701a93153c98f10b8f838f78f80637a93f06ade6a6f8d9246fd7
72 rdf:type schema:PropertyValue
73 N0dda317e45d640938d5582da12c1e483 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
74 schema:name Nuclear Proteins
75 rdf:type schema:DefinedTerm
76 N15c6bbb6daee4eae9762ddb5180564b3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
77 schema:name Animals
78 rdf:type schema:DefinedTerm
79 N1893a12f66724b4eb13efb328917e668 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
80 schema:name S Phase
81 rdf:type schema:DefinedTerm
82 N1b51baece7c74f18aaeeb9058a9e03b6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
83 schema:name DNA Repair
84 rdf:type schema:DefinedTerm
85 N28380d6621ad4927b79d7c5edb3de0d9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
86 schema:name Avian Proteins
87 rdf:type schema:DefinedTerm
88 N2fbd01ec889a4c3ba94f29fc068a813c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
89 schema:name G1 Phase
90 rdf:type schema:DefinedTerm
91 N334efa44f55c473e9957b76ae676f5bf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Chickens
93 rdf:type schema:DefinedTerm
94 N431a3d89cfb04be889cd562a687bbfbd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Cell Line
96 rdf:type schema:DefinedTerm
97 N478c84d6cb534e9986ead5cd0f4285df schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Phosphorylation
99 rdf:type schema:DefinedTerm
100 N515c30f73ce947ea9aec27fd5400e00a schema:name doi
101 schema:value 10.1038/nature07955
102 rdf:type schema:PropertyValue
103 N5565ad4782004b57a4add18ef7ccc3d0 rdf:first sg:person.0646412745.05
104 rdf:rest rdf:nil
105 N6c28e075c37b423ea8193a5089f3f9c6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Humans
107 rdf:type schema:DefinedTerm
108 N70a491430f09425293317a34f05a1f02 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Carrier Proteins
110 rdf:type schema:DefinedTerm
111 N78b8cc8f5ac142138604d623b3d00ee2 schema:name Springer Nature - SN SciGraph project
112 rdf:type schema:Organization
113 N960d6836e96c4890bfd6de436ef159fb schema:name nlm_unique_id
114 schema:value 0410462
115 rdf:type schema:PropertyValue
116 N978846e73fc142359f8ff853bea290fc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Recombination, Genetic
118 rdf:type schema:DefinedTerm
119 N97e4016175f2431fadf2581c0257b1e4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name BRCA1 Protein
121 rdf:type schema:DefinedTerm
122 N99d5de659f4a49398ee35eadd0b7dde4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Cell Cycle
124 rdf:type schema:DefinedTerm
125 Na26bded9070b4200b6ef219b8b782dd8 schema:name pubmed_id
126 schema:value 19357644
127 rdf:type schema:PropertyValue
128 Nb86f0de0a78240ac9d295303518aedff schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name X-Rays
130 rdf:type schema:DefinedTerm
131 Nb8fd7c98fcf045ab829e8056dfc90594 schema:issueNumber 7245
132 rdf:type schema:PublicationIssue
133 Nc40d1417f9214cecb9ed7c9d5f1bd4f8 rdf:first sg:person.01226743632.21
134 rdf:rest N5565ad4782004b57a4add18ef7ccc3d0
135 Ncc1b824fda9f4469929f85966c64c1c0 schema:volumeNumber 459
136 rdf:type schema:PublicationVolume
137 Ncc795d2a3bcd4e53ac1259e01b67c8df schema:name dimensions_id
138 schema:value pub.1000929920
139 rdf:type schema:PropertyValue
140 Ne32e0f4ef3cb4ff9837353123d354dc2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name G2 Phase
142 rdf:type schema:DefinedTerm
143 Neb63558d76a24974a118329d8299f4bb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name B-Lymphocytes
145 rdf:type schema:DefinedTerm
146 Nec326e3b0d13468e91bad1675acff580 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name DNA Breaks, Double-Stranded
148 rdf:type schema:DefinedTerm
149 Nec5f1b863d8e4f5f917f1ed97ac41100 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Cisplatin
151 rdf:type schema:DefinedTerm
152 Nf88791cee0234dbdb1799279957b2e2a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Phosphoserine
154 rdf:type schema:DefinedTerm
155 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
156 schema:name Biological Sciences
157 rdf:type schema:DefinedTerm
158 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
159 schema:name Genetics
160 rdf:type schema:DefinedTerm
161 sg:grant.2756588 http://pending.schema.org/fundedItem sg:pub.10.1038/nature07955
162 rdf:type schema:MonetaryGrant
163 sg:journal.1018957 schema:issn 0090-0028
164 1476-4687
165 schema:name Nature
166 rdf:type schema:Periodical
167 sg:person.01226743632.21 schema:affiliation https://www.grid.ac/institutes/grid.42475.30
168 schema:familyName Yun
169 schema:givenName Maximina H.
170 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01226743632.21
171 rdf:type schema:Person
172 sg:person.0646412745.05 schema:affiliation https://www.grid.ac/institutes/grid.42475.30
173 schema:familyName Hiom
174 schema:givenName Kevin
175 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0646412745.05
176 rdf:type schema:Person
177 sg:pub.10.1038/nature02964 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050476890
178 https://doi.org/10.1038/nature02964
179 rdf:type schema:CreativeWork
180 sg:pub.10.1038/nature06337 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051713472
181 https://doi.org/10.1038/nature06337
182 rdf:type schema:CreativeWork
183 sg:pub.10.1038/nature07215 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031468320
184 https://doi.org/10.1038/nature07215
185 rdf:type schema:CreativeWork
186 sg:pub.10.1038/ng1627 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033214796
187 https://doi.org/10.1038/ng1627
188 rdf:type schema:CreativeWork
189 sg:pub.10.1038/sj.onc.1206136 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035503266
190 https://doi.org/10.1038/sj.onc.1206136
191 rdf:type schema:CreativeWork
192 https://app.dimensions.ai/details/publication/pub.1074471852 schema:CreativeWork
193 https://doi.org/10.1016/s0959-440x(99)00038-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1050218605
194 rdf:type schema:CreativeWork
195 https://doi.org/10.1016/s0968-0004(98)01232-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050817136
196 rdf:type schema:CreativeWork
197 https://doi.org/10.1074/jbc.273.39.25388 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044736605
198 rdf:type schema:CreativeWork
199 https://doi.org/10.1083/jcb.200411083 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030064876
200 rdf:type schema:CreativeWork
201 https://doi.org/10.1093/emboj/17.18.5497 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023693632
202 rdf:type schema:CreativeWork
203 https://doi.org/10.1093/emboj/cdg161 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026940213
204 rdf:type schema:CreativeWork
205 https://doi.org/10.1098/rstb.2000.0755 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038293743
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1101/gad.13.20.2633 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022595499
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1101/gad.1381306 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041272178
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1128/mcb.23.23.8820-8828.2003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050671964
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1128/mcb.24.21.9305-9316.2004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009622574
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1128/mcb.24.21.9478-9486.2004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013148122
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1128/mcb.25.9.3535-3542.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046879805
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1158/0008-5472.can-05-3209 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005215932
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1371/journal.pgen.1000110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037227223
222 rdf:type schema:CreativeWork
223 https://www.grid.ac/institutes/grid.42475.30 schema:alternateName MRC Laboratory of Molecular Biology
224 schema:name Division of Protein and Nucleic Acid Chemistry, MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
225 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...