Structure of the connexin 26 gap junction channel at 3.5 Å resolution View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2009-04

AUTHORS

Shoji Maeda, So Nakagawa, Michihiro Suga, Eiki Yamashita, Atsunori Oshima, Yoshinori Fujiyoshi, Tomitake Tsukihara

ABSTRACT

Gap junctions consist of arrays of intercellular channels between adjacent cells that permit the exchange of ions and small molecules. Here we report the crystal structure of the gap junction channel formed by human connexin 26 (Cx26, also known as GJB2) at 3.5 A resolution, and discuss structural determinants of solute transport through the channel. The density map showed the two membrane-spanning hemichannels and the arrangement of the four transmembrane helices of the six protomers forming each hemichannel. The hemichannels feature a positively charged cytoplasmic entrance, a funnel, a negatively charged transmembrane pathway, and an extracellular cavity. The pore is narrowed at the funnel, which is formed by the six amino-terminal helices lining the wall of the channel, which thus determines the molecular size restriction at the channel entrance. The structure of the Cx26 gap junction channel also has implications for the gating of the channel by the transjunctional voltage. More... »

PAGES

597

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature07869

DOI

http://dx.doi.org/10.1038/nature07869

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1022476406

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19340074


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