Adaptation of HIV-1 to human leukocyte antigen class I View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2009-02-25

AUTHORS

Yuka Kawashima, Katja Pfafferott, John Frater, Philippa Matthews, Rebecca Payne, Marylyn Addo, Hiroyuki Gatanaga, Mamoru Fujiwara, Atsuko Hachiya, Hirokazu Koizumi, Nozomi Kuse, Shinichi Oka, Anna Duda, Andrew Prendergast, Hayley Crawford, Alasdair Leslie, Zabrina Brumme, Chanson Brumme, Todd Allen, Christian Brander, Richard Kaslow, James Tang, Eric Hunter, Susan Allen, Joseph Mulenga, Songee Branch, Tim Roach, Mina John, Simon Mallal, Anthony Ogwu, Roger Shapiro, Julia G. Prado, Sarah Fidler, Jonathan Weber, Oliver G. Pybus, Paul Klenerman, Thumbi Ndung’u, Rodney Phillips, David Heckerman, P. Richard Harrigan, Bruce D. Walker, Masafumi Takiguchi, Philip Goulder

ABSTRACT

HIV a moving targetIn order to determine whether HIV is adapting to the human leukocyte antigen (HLA) alleles, such as HLA-B*57, B*57 and B*51, that mediate successful control of the virus, viral sequences and HLA types were analysed in more than 500 HIV-infected subjects drawn from North America, the Caribbean, Europe, Africa, Australasia and Asia. The results reveal that HIV is evolving at the population level in response to immune selection pressure. Whilst this does not indicate that HIV is necessarily 'winning' the evolutionary struggle against humans, it does suggest that successful HIV vaccines — like those against influenza — will need to keep pace with a changing immunological landscape. More... »

PAGES

641-645

Journal

TITLE

Nature

ISSUE

7238

VOLUME

458

Author Affiliations

  • Divisions of Viral Immunology and,
  • Centre for Clinical Immunology and Biomedical Statistics, Royal Perth Hospital and Murdoch University, Western Australia 6000, Australia
  • The James Martin 21st Century School, Peter Medawar Building for Pathogen Research, South Parks Road, Oxford OX1 3SY, UK
  • Department of Paediatrics,
  • Partners AIDS Research Center, Massachusetts General Hospital, 13th Street, Building 149, Charlestown, Boston, Massachusetts 02129, USA
  • AIDS Clinical Center, International Medical Center of Japan, 1-21-1 Toyama, Shinjuku-ku, Tokyo 162-8655, Japan
  • Fundació IrsiCaixa-HIVACAT, Hospital Germans Trias i Pujol, Badalona and Institucio Catalana de Recerca i Estudis Avancats (ICREA), Barcelona 08916, Spain
  • University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
  • Emory University Vaccine Center and Yerkes National Primate Research Center, Atlanta, Georgia 30329, USA
  • Zambia Emory HIV Research Project, and the Zambia Blood Transfusion Service, Lusaka, Zambia
  • Ladymeade Reference Unit, University of West Indies, Bridgetown BB11156, Barbados
  • Botswana-Harvard School of Public Health AIDS Initiative Partnership, Gaborone, Botswana
  • Division of Medicine, Wright Fleming Institute, Imperial College, St Mary’s Hospital, Norfolk Place, Paddington, London W2 1PG, UK
  • Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3SY, UK
  • HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban 4013, South Africa
  • BC Centre for Excellence in HIV/AIDS, Vancouver, British Columbia V6Z 1Y6, Canada
  • Miscrosoft Research, One Microsoft Way, Redmond, Washington 9805, USA
  • Howard Hughes Medical Institute, Chevy Chase, Maryland 20185, USA
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nature07746

    DOI

    http://dx.doi.org/10.1038/nature07746

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1041726315

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/19242411


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    500 Zambia Emory HIV Research Project, and the Zambia Blood Transfusion Service, Lusaka, Zambia
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    528 schema:name HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban 4013, South Africa
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    530 Partners AIDS Research Center, Massachusetts General Hospital, 13th Street, Building 149, Charlestown, Boston, Massachusetts 02129, USA
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    532 grid-institutes:grid.416553.0 schema:alternateName BC Centre for Excellence in HIV/AIDS, Vancouver, British Columbia V6Z 1Y6, Canada
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    538 Infectious Disease, Center for AIDS Research, Kumamoto University, 2-2-1 Honjo, Kumamoto 860-0811, Japan
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    540 grid-institutes:grid.4991.5 schema:alternateName Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3SY, UK
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