Induced pluripotent stem cells from a spinal muscular atrophy patient View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2009-01-15

AUTHORS

Allison D. Ebert, Junying Yu, Ferrill F. Rose, Virginia B. Mattis, Christian L. Lorson, James A. Thomson, Clive N. Svendsen

ABSTRACT

Spinal muscular atrophy is one of the most common inherited forms of neurological disease leading to infant mortality. Patients have selective loss of lower motor neurons resulting in muscle weakness, paralysis and often death. Although patient fibroblasts have been used extensively to study spinal muscular atrophy, motor neurons have a unique anatomy and physiology which may underlie their vulnerability to the disease process. Here we report the generation of induced pluripotent stem cells from skin fibroblast samples taken from a child with spinal muscular atrophy. These cells expanded robustly in culture, maintained the disease genotype and generated motor neurons that showed selective deficits compared to those derived from the child's unaffected mother. This is the first study to show that human induced pluripotent stem cells can be used to model the specific pathology seen in a genetically inherited disease. As such, it represents a promising resource to study disease mechanisms, screen new drug compounds and develop new therapies. More... »

PAGES

277

Journal

TITLE

Nature

ISSUE

7227

VOLUME

457

Related Patents

  • Substantially Pure Human Retinal Progenitor, Forebrain Progenitor, And Retinal Pigment Epithelium Cell Cultures And Methods Of Making The Same
  • Induced Pluripotent Stem Cells Produced With Oct3/4, Klf4 And Sox2
  • Modified Polynucleotides For The Production Of Secreted Proteins
  • Compositions And Methods For Generation Of Human Epithelial Stem Cells
  • Engineered Nucleic Acids Encoding A Modified Erythropoietin And Their Expression
  • Simplified Basic Media For Human Pluripotent Cell Culture
  • Models For Parkinson's Disease Studies
  • Protein-Induced Pluripotent Cell Technology And Uses Thereof
  • Modified Polynucleotides For The Production Of Biologics And Proteins Associated With Human Disease
  • Modified Polynucleotides For Treating Galactosylceramidase Protein Deficiency
  • Modified Polynucleotides Encoding Granulysin
  • Substrates And Methods For Culturing Stem Cells
  • Methods And Compositions For Treating Neurological Disorders
  • Modified Nucleosides, Nucleotides, And Nucleic Acids, And Uses Thereof
  • Rna Preparations Comprising Purified Modified Rna For Reprogramming Cells
  • Modified Polynucleotides Encoding Cited4
  • Modified Polynucleotides For The Production Of Nuclear Proteins
  • Modified Polynucleotides Encoding Septin-4
  • Compositions And Methods For Reprogramming Eukaryotic Cells
  • A Protein-Induced Pluripotent Cell Technology Uses Thereof
  • Modified Polynucleotides For Treating Protein Deficiency
  • Engineered Nucleic Acids And Methods Of Use Thereof
  • Modified Polynucleotides Encoding Apoptosis Inducing Factor 1
  • Delivery And Formulation Of Engineered Nucleic Acids
  • Cell Compositions Derived From Dedifferentiated Reprogrammed Cells
  • Methods And Platforms For Drug Discovery Using Induced Pluripotent Stem Cells
  • Rna Preparations Comprising Purified Modified Rna For Reprogramming Cells
  • Modified Polynucleotides For The Production Of Proteins Associated With Human Disease
  • Delivery And Formulation Of Engineered Nucleic Acids
  • Rna Preparations Comprising Purified Modified Rna For Reprogramming Cells
  • Engineered Nucleic Acids And Methods Of Use Thereof
  • Modified Polynucleotides Encoding Copper Metabolism (Murr1) Domain Containing 1
  • Analysis Of Compounds For Pain And Sensory Disorders
  • In Vitro Differentiation Of Pluripotent Stem Cells To Pancreatic Endoderm Cells (Pec) And Endocrine Cells
  • Simplified Basic Media For Human Pluripotent Cell Culture
  • Human Blood-Brain Endothelial Cells Derived From Pluripotent Stem Cells And Blood-Brain Barrier Model Thereof
  • Identification Of Compounds That Disperse Tdp-43 Inclusions
  • Making And Using In Vitro-Synthesized Ssrna For Introducing Into Mammalian Cells To Induce A Biological Or Biochemical Effect
  • Engineered Nucleic Acids And Methods Of Use Thereof
  • Formulation And Delivery Of Plga Microspheres
  • Compositions And Methods For Reprogramming Eukaryotic Cells
  • Modified Polynucleotides Encoding Basic Helix-Loop-Helix Family Member E41
  • Modified Polynucleotides For The Production Of Proteins
  • Engineered Nucleic Acids And Methods Of Use Thereof
  • Engineered Nucleic Acids And Methods Of Use Thereof
  • Modified Polynucleotides For The Production Of Oncology-Related Proteins And Peptides
  • Simplified Basic Media For Human Pluripotent Cell Culture
  • Method Of Screening For Substances Capable Of Promoting Induction Of Induced Pluripotent Stem Cells
  • Engineered Nucleic Acids And Methods Of Use Thereof
  • Modified Polynucleotides For The Production Of G-Csf
  • Modified Nucleosides, Nucleotides, And Nucleic Acids, And Uses Thereof
  • Engineered Nucleic Acids And Methods Of Use Thereof
  • Terminally Modified Rna
  • Methods And Platforms For Drug Discovery
  • Induced Pluripotent Stem Cells And Uses Thereof
  • Functional Genomics Assay For Characterizing Pluripotent Stem Cell Utility And Safety
  • Methods And Platforms For Drug Discovery
  • Methods, Systems And Compositions Relating To Cell Conversion Via Protein-Induced In-Vivo Cell Reprogramming
  • Modified Polynucleotides For The Production Of Cosmetic Proteins And Peptides
  • Making And Using In Vitro-Synthesized Ssrna For Introducing Into Mammalian Cells To Induce A Biological Or Biochemical Effect
  • In Vivo Production Of Proteins
  • Modified Polynucleotides Encoding Siah E3 Ubiquitin Protein Ligase 1
  • Programming And Reprogramming Of Cells
  • Modified Polynucleotides Encoding Hepatitis A Virus Cellular Receptor 2
  • Dlin-Kc2-Dma Lipid Nanoparticle Delivery Of Modified Polynucleotides
  • Modified Polynucleotides For The Production Of Secreted Proteins
  • Rna Preparations Comprising Purified Modified Rna For Reprogramming Cells
  • Modified Polynucleotides For The Production Of Proteins
  • Method For Producing A Protein Of Interest In A Primate
  • Rna Preparations Comprising Purified Modified Rna For Reprogramming Cells
  • Modified Nucleosides, Nucleotides, And Nucleic Acids, And Uses Thereof
  • Cell Compositions Derived From Dedifferentiated Reprogrammed Cells
  • Cell Compositions Derived From Dedifferentiated Reprogrammed Cells
  • Modified Polynucleotides For The Production Of Cytoplasmic And Cytoskeletal Proteins
  • Modified Polynucleotides For The Production Of Cytoplasmic And Cytoskeletal Proteins
  • Modified Polynucleotides Encoding Aquaporin-5
  • Modified Polynucleotides For The Production Of Proteins Associated With Blood And Lymphatic Disorders
  • Modified Polynucleotides Encoding Aryl Hydrocarbon Receptor Nuclear Translocator
  • Modified Polynucleotides For The Production Of Proteins Associated With Blood And Lymphatic Disorders
  • Modified Nucleosides, Nucleotides, And Nucleic Acids, And Uses Thereof
  • Diagnostic Methods For Neuronal Disorders
  • Rna Preparations Comprising Purified Modified Rna For Reprogramming Cells
  • Split Dose Administration
  • Modified Polynucleotides For The Production Of Biologics And Proteins Associated With Human Disease
  • Formulation And Delivery Of Plga Microspheres
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nature07677

    DOI

    http://dx.doi.org/10.1038/nature07677

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1036115204

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/19098894


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Neurosciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Differentiation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Lineage", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Separation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cells, Cultured", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cellular Reprogramming", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Child", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Fibroblasts", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Expression Regulation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Models, Biological", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Motor Neurons", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Muscular Atrophy, Spinal", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Pluripotent Stem Cells", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Skin", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Survival of Motor Neuron 1 Protein", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "University of Wisconsin\u2013Madison", 
              "id": "https://www.grid.ac/institutes/grid.14003.36", 
              "name": [
                "The Waisman Center, and,", 
                "The Stem Cell and Regenerative Medicine Center, University of Wisconsin-Madison, 1500 Highland Avenue, Madison, Wisconsin 53705, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ebert", 
            "givenName": "Allison D.", 
            "id": "sg:person.01206237660.54", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01206237660.54"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Wisconsin\u2013Madison", 
              "id": "https://www.grid.ac/institutes/grid.14003.36", 
              "name": [
                "The Genome Center and Wisconsin National Primate Research Center, University of Wisconsin-Madison, 425 Henry Mall, Madison, Wisconsin 53706, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yu", 
            "givenName": "Junying", 
            "id": "sg:person.01336707071.84", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01336707071.84"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Missouri", 
              "id": "https://www.grid.ac/institutes/grid.134936.a", 
              "name": [
                "Department of Veterinary Pathobiology, Bond Life Sciences Center, University of Missouri, 1201 Rollins Road, Columbia, Missouri 65211, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rose", 
            "givenName": "Ferrill F.", 
            "id": "sg:person.01124535157.03", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01124535157.03"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Missouri", 
              "id": "https://www.grid.ac/institutes/grid.134936.a", 
              "name": [
                "Department of Veterinary Pathobiology, Bond Life Sciences Center, University of Missouri, 1201 Rollins Road, Columbia, Missouri 65211, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mattis", 
            "givenName": "Virginia B.", 
            "id": "sg:person.01353200547.83", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01353200547.83"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Missouri", 
              "id": "https://www.grid.ac/institutes/grid.134936.a", 
              "name": [
                "Department of Veterinary Pathobiology, Bond Life Sciences Center, University of Missouri, 1201 Rollins Road, Columbia, Missouri 65211, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lorson", 
            "givenName": "Christian L.", 
            "id": "sg:person.01274273361.30", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274273361.30"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Wisconsin\u2013Madison", 
              "id": "https://www.grid.ac/institutes/grid.14003.36", 
              "name": [
                "The Stem Cell and Regenerative Medicine Center, University of Wisconsin-Madison, 1500 Highland Avenue, Madison, Wisconsin 53705, USA", 
                "The Genome Center and Wisconsin National Primate Research Center, University of Wisconsin-Madison, 425 Henry Mall, Madison, Wisconsin 53706, USA", 
                "Department of Anatomy, University of Wisconsin-Madison, 1300 University Avenue Madison, Wisconsin 53706, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Thomson", 
            "givenName": "James A.", 
            "id": "sg:person.012266000337.10", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012266000337.10"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Wisconsin\u2013Madison", 
              "id": "https://www.grid.ac/institutes/grid.14003.36", 
              "name": [
                "The Waisman Center, and,", 
                "The Stem Cell and Regenerative Medicine Center, University of Wisconsin-Madison, 1500 Highland Avenue, Madison, Wisconsin 53705, USA", 
                "Department of Anatomy, University of Wisconsin-Madison, 1300 University Avenue Madison, Wisconsin 53706, USA", 
                "Department of Neurology, University of Wisconsin-Madison, 600 North Highland Avenue, Madison, Wisconsin 53792, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Svendsen", 
            "givenName": "Clive N.", 
            "id": "sg:person.01204472636.82", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01204472636.82"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1523/jneurosci.1637-06.2006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000754992"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(00)80368-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005088934"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.94.18.9920", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005488001"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/3030", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005515285", 
              "https://doi.org/10.1038/3030"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/3030", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005515285", 
              "https://doi.org/10.1038/3030"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/0883073807305667", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007473987"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/0883073807305667", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007473987"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt1063", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008046577", 
              "https://doi.org/10.1038/nbt1063"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt1063", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008046577", 
              "https://doi.org/10.1038/nbt1063"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.3967-05.2006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008258462"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/hmg/ddi131", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010053463"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2007.11.019", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010904856"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/19.2.185", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011853799"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature06534", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011992920", 
              "https://doi.org/10.1038/nature06534"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.96.11.6307", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012008673"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2008.01.015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012430287"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/nbdi.1996.0010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014276815"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0165-0270(98)00126-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015436666"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0960-8966(06)80015-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017402430"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/71709", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018131147", 
              "https://doi.org/10.1038/71709"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/71709", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018131147", 
              "https://doi.org/10.1038/71709"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1634/stemcells.2007-0368", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024465612"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0711983105", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024490582"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(95)90460-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024818119"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuron.2005.12.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026364199"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg1268", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029530973", 
              "https://doi.org/10.1038/nrg1268"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg1268", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029530973", 
              "https://doi.org/10.1038/nrg1268"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/hmg/6.8.1205", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037403639"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/biostatistics/4.2.249", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037543114"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1158799", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039463429"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/btl117", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040779948"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ana.10743", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042349528"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/hmg/ddg256", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042767881"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(90)90662-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043517258"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/hmg/9.3.333", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044079183"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(02)00835-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045218174"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(00)80367-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045954308"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/hmg/ddi078", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046024323"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2008.07.041", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047970638"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35049541", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048213623", 
              "https://doi.org/10.1038/35049541"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35049541", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048213623", 
              "https://doi.org/10.1038/35049541"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1151526", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048905674"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng0797-265", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051068967", 
              "https://doi.org/10.1038/ng0797-265"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1074962", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062446833"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/01.wnl.0000201929.56928.13", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064347901"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/01.wnl.0000201929.56928.13", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064347901"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/01.wnl.0000201929.56928.13", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064347901"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.16-13-04069.1996", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1082938445"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gr.7.4.339", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083074536"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2009-01-15", 
        "datePublishedReg": "2009-01-15", 
        "description": "Spinal muscular atrophy is one of the most common inherited forms of neurological disease leading to infant mortality. Patients have selective loss of lower motor neurons resulting in muscle weakness, paralysis and often death. Although patient fibroblasts have been used extensively to study spinal muscular atrophy, motor neurons have a unique anatomy and physiology which may underlie their vulnerability to the disease process. Here we report the generation of induced pluripotent stem cells from skin fibroblast samples taken from a child with spinal muscular atrophy. These cells expanded robustly in culture, maintained the disease genotype and generated motor neurons that showed selective deficits compared to those derived from the child's unaffected mother. This is the first study to show that human induced pluripotent stem cells can be used to model the specific pathology seen in a genetically inherited disease. As such, it represents a promising resource to study disease mechanisms, screen new drug compounds and develop new therapies.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/nature07677", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2527575", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2681732", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2437470", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2683942", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2559858", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1018957", 
            "issn": [
              "0090-0028", 
              "1476-4687"
            ], 
            "name": "Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "7227", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "457"
          }
        ], 
        "name": "Induced pluripotent stem cells from a spinal muscular atrophy patient", 
        "pagination": "277", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "ac0a051162938297f06158e5674af8988d4265d99b23cc2e54c9fa41ec69f76c"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "19098894"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "0410462"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/nature07677"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1036115204"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/nature07677", 
          "https://app.dimensions.ai/details/publication/pub.1036115204"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T01:47", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8700_00000425.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/nature07677"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nature07677'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nature07677'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nature07677'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nature07677'


     

    This table displays all metadata directly associated to this object as RDF triples.

    326 TRIPLES      21 PREDICATES      86 URIs      37 LITERALS      26 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/nature07677 schema:about N10f57a0d439f477fa633ae5220e6a6c5
    2 N17414827690e4dbeb2afd8c7e9a1bb5d
    3 N17668e0a02cf48d08a98f97e88d2b680
    4 N1839f01fe9e04c59ac89be8e6efce80f
    5 N23263b00de5c4cfca0932b652da03d43
    6 N263e608b5c0c44168673a0457d21fd87
    7 N2b3d97beed6d417980b24a6a63d5a84d
    8 N3defc8a57f0b457e9a2d068510047360
    9 N47e781566dcb48a6bd7559edeb3647f9
    10 N4e3fbb1332714088beb5b7c65d2fb3d1
    11 N6010f4b89339436eba829a41c71d2486
    12 N85fdf571f39c407c8940b2dca4a84ccc
    13 N98d5673c07b644fba174f7f85b3b0ea7
    14 Na36c6bcdbf5947c59f1815d7c7ecfa41
    15 Nb2f02d29aa464ebdb07a8135aa71b392
    16 Nde6cdd34631247bb87cd0a96ab7b521a
    17 Ne360cfea9d4841e5a673db7885ce411b
    18 anzsrc-for:11
    19 anzsrc-for:1109
    20 schema:author Nc65351f08cf740a498ea96f95d907b9b
    21 schema:citation sg:pub.10.1038/3030
    22 sg:pub.10.1038/35049541
    23 sg:pub.10.1038/71709
    24 sg:pub.10.1038/nature06534
    25 sg:pub.10.1038/nbt1063
    26 sg:pub.10.1038/ng0797-265
    27 sg:pub.10.1038/nrg1268
    28 https://doi.org/10.1002/ana.10743
    29 https://doi.org/10.1006/nbdi.1996.0010
    30 https://doi.org/10.1016/0092-8674(90)90662-x
    31 https://doi.org/10.1016/0092-8674(95)90460-3
    32 https://doi.org/10.1016/j.cell.2007.11.019
    33 https://doi.org/10.1016/j.cell.2008.01.015
    34 https://doi.org/10.1016/j.cell.2008.07.041
    35 https://doi.org/10.1016/j.neuron.2005.12.001
    36 https://doi.org/10.1016/s0092-8674(00)80367-0
    37 https://doi.org/10.1016/s0092-8674(00)80368-2
    38 https://doi.org/10.1016/s0092-8674(02)00835-8
    39 https://doi.org/10.1016/s0165-0270(98)00126-5
    40 https://doi.org/10.1016/s0960-8966(06)80015-5
    41 https://doi.org/10.1073/pnas.0711983105
    42 https://doi.org/10.1073/pnas.94.18.9920
    43 https://doi.org/10.1073/pnas.96.11.6307
    44 https://doi.org/10.1093/bioinformatics/19.2.185
    45 https://doi.org/10.1093/bioinformatics/btl117
    46 https://doi.org/10.1093/biostatistics/4.2.249
    47 https://doi.org/10.1093/hmg/6.8.1205
    48 https://doi.org/10.1093/hmg/9.3.333
    49 https://doi.org/10.1093/hmg/ddg256
    50 https://doi.org/10.1093/hmg/ddi078
    51 https://doi.org/10.1093/hmg/ddi131
    52 https://doi.org/10.1101/gr.7.4.339
    53 https://doi.org/10.1126/science.1074962
    54 https://doi.org/10.1126/science.1151526
    55 https://doi.org/10.1126/science.1158799
    56 https://doi.org/10.1177/0883073807305667
    57 https://doi.org/10.1212/01.wnl.0000201929.56928.13
    58 https://doi.org/10.1523/jneurosci.16-13-04069.1996
    59 https://doi.org/10.1523/jneurosci.1637-06.2006
    60 https://doi.org/10.1523/jneurosci.3967-05.2006
    61 https://doi.org/10.1634/stemcells.2007-0368
    62 schema:datePublished 2009-01-15
    63 schema:datePublishedReg 2009-01-15
    64 schema:description Spinal muscular atrophy is one of the most common inherited forms of neurological disease leading to infant mortality. Patients have selective loss of lower motor neurons resulting in muscle weakness, paralysis and often death. Although patient fibroblasts have been used extensively to study spinal muscular atrophy, motor neurons have a unique anatomy and physiology which may underlie their vulnerability to the disease process. Here we report the generation of induced pluripotent stem cells from skin fibroblast samples taken from a child with spinal muscular atrophy. These cells expanded robustly in culture, maintained the disease genotype and generated motor neurons that showed selective deficits compared to those derived from the child's unaffected mother. This is the first study to show that human induced pluripotent stem cells can be used to model the specific pathology seen in a genetically inherited disease. As such, it represents a promising resource to study disease mechanisms, screen new drug compounds and develop new therapies.
    65 schema:genre research_article
    66 schema:inLanguage en
    67 schema:isAccessibleForFree true
    68 schema:isPartOf N5f587b61549a43358a048641947e817a
    69 Nd28fdb79c7db4c6a8c7e790c7e126b45
    70 sg:journal.1018957
    71 schema:name Induced pluripotent stem cells from a spinal muscular atrophy patient
    72 schema:pagination 277
    73 schema:productId N19f8487f76fe4692af52639eef27eb43
    74 N55b1115c5946404c9d0b17876ef742da
    75 N58e95eea711848a4ac849d6b657f69b2
    76 N8ffe25bfc0084ab3a9cfa8616b512811
    77 Na74937b2f42e46628688dae97444b4c2
    78 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036115204
    79 https://doi.org/10.1038/nature07677
    80 schema:sdDatePublished 2019-04-11T01:47
    81 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    82 schema:sdPublisher N0eea8ea119164675a0d98ea2d7c8bc43
    83 schema:url https://www.nature.com/articles/nature07677
    84 sgo:license sg:explorer/license/
    85 sgo:sdDataset articles
    86 rdf:type schema:ScholarlyArticle
    87 N0eea8ea119164675a0d98ea2d7c8bc43 schema:name Springer Nature - SN SciGraph project
    88 rdf:type schema:Organization
    89 N0f6e1624fd614fc7b301ae0beac4b0e4 rdf:first sg:person.01274273361.30
    90 rdf:rest Nfb8cf0812ebc462286907222ccc7aad6
    91 N10f57a0d439f477fa633ae5220e6a6c5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    92 schema:name Fibroblasts
    93 rdf:type schema:DefinedTerm
    94 N17414827690e4dbeb2afd8c7e9a1bb5d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    95 schema:name Motor Neurons
    96 rdf:type schema:DefinedTerm
    97 N17668e0a02cf48d08a98f97e88d2b680 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    98 schema:name Muscular Atrophy, Spinal
    99 rdf:type schema:DefinedTerm
    100 N1839f01fe9e04c59ac89be8e6efce80f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    101 schema:name Cell Separation
    102 rdf:type schema:DefinedTerm
    103 N19f8487f76fe4692af52639eef27eb43 schema:name nlm_unique_id
    104 schema:value 0410462
    105 rdf:type schema:PropertyValue
    106 N23263b00de5c4cfca0932b652da03d43 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    107 schema:name Models, Biological
    108 rdf:type schema:DefinedTerm
    109 N263e608b5c0c44168673a0457d21fd87 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    110 schema:name Male
    111 rdf:type schema:DefinedTerm
    112 N2b3d97beed6d417980b24a6a63d5a84d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    113 schema:name Humans
    114 rdf:type schema:DefinedTerm
    115 N38e41a538c86481ca6737c3f25583206 rdf:first sg:person.01336707071.84
    116 rdf:rest Nb21160fc74634bc1bf2e423dcc888883
    117 N3defc8a57f0b457e9a2d068510047360 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    118 schema:name Skin
    119 rdf:type schema:DefinedTerm
    120 N47e781566dcb48a6bd7559edeb3647f9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    121 schema:name Cells, Cultured
    122 rdf:type schema:DefinedTerm
    123 N4e3fbb1332714088beb5b7c65d2fb3d1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    124 schema:name Cellular Reprogramming
    125 rdf:type schema:DefinedTerm
    126 N55b1115c5946404c9d0b17876ef742da schema:name dimensions_id
    127 schema:value pub.1036115204
    128 rdf:type schema:PropertyValue
    129 N58e95eea711848a4ac849d6b657f69b2 schema:name pubmed_id
    130 schema:value 19098894
    131 rdf:type schema:PropertyValue
    132 N5f587b61549a43358a048641947e817a schema:issueNumber 7227
    133 rdf:type schema:PublicationIssue
    134 N6010f4b89339436eba829a41c71d2486 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    135 schema:name Survival of Motor Neuron 1 Protein
    136 rdf:type schema:DefinedTerm
    137 N67286a33ce204b7ead53a466598e9882 rdf:first sg:person.01353200547.83
    138 rdf:rest N0f6e1624fd614fc7b301ae0beac4b0e4
    139 N85fdf571f39c407c8940b2dca4a84ccc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    140 schema:name Child
    141 rdf:type schema:DefinedTerm
    142 N8ffe25bfc0084ab3a9cfa8616b512811 schema:name readcube_id
    143 schema:value ac0a051162938297f06158e5674af8988d4265d99b23cc2e54c9fa41ec69f76c
    144 rdf:type schema:PropertyValue
    145 N98d5673c07b644fba174f7f85b3b0ea7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    146 schema:name Gene Expression Regulation
    147 rdf:type schema:DefinedTerm
    148 Na36c6bcdbf5947c59f1815d7c7ecfa41 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    149 schema:name Cell Lineage
    150 rdf:type schema:DefinedTerm
    151 Na74937b2f42e46628688dae97444b4c2 schema:name doi
    152 schema:value 10.1038/nature07677
    153 rdf:type schema:PropertyValue
    154 Nb21160fc74634bc1bf2e423dcc888883 rdf:first sg:person.01124535157.03
    155 rdf:rest N67286a33ce204b7ead53a466598e9882
    156 Nb2f02d29aa464ebdb07a8135aa71b392 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    157 schema:name Cell Differentiation
    158 rdf:type schema:DefinedTerm
    159 Nc65351f08cf740a498ea96f95d907b9b rdf:first sg:person.01206237660.54
    160 rdf:rest N38e41a538c86481ca6737c3f25583206
    161 Nc6fafb93a4164d08a0cf99fd6d9371bf rdf:first sg:person.01204472636.82
    162 rdf:rest rdf:nil
    163 Nd28fdb79c7db4c6a8c7e790c7e126b45 schema:volumeNumber 457
    164 rdf:type schema:PublicationVolume
    165 Nde6cdd34631247bb87cd0a96ab7b521a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    166 schema:name Female
    167 rdf:type schema:DefinedTerm
    168 Ne360cfea9d4841e5a673db7885ce411b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    169 schema:name Pluripotent Stem Cells
    170 rdf:type schema:DefinedTerm
    171 Nfb8cf0812ebc462286907222ccc7aad6 rdf:first sg:person.012266000337.10
    172 rdf:rest Nc6fafb93a4164d08a0cf99fd6d9371bf
    173 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    174 schema:name Medical and Health Sciences
    175 rdf:type schema:DefinedTerm
    176 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
    177 schema:name Neurosciences
    178 rdf:type schema:DefinedTerm
    179 sg:grant.2437470 http://pending.schema.org/fundedItem sg:pub.10.1038/nature07677
    180 rdf:type schema:MonetaryGrant
    181 sg:grant.2527575 http://pending.schema.org/fundedItem sg:pub.10.1038/nature07677
    182 rdf:type schema:MonetaryGrant
    183 sg:grant.2559858 http://pending.schema.org/fundedItem sg:pub.10.1038/nature07677
    184 rdf:type schema:MonetaryGrant
    185 sg:grant.2681732 http://pending.schema.org/fundedItem sg:pub.10.1038/nature07677
    186 rdf:type schema:MonetaryGrant
    187 sg:grant.2683942 http://pending.schema.org/fundedItem sg:pub.10.1038/nature07677
    188 rdf:type schema:MonetaryGrant
    189 sg:journal.1018957 schema:issn 0090-0028
    190 1476-4687
    191 schema:name Nature
    192 rdf:type schema:Periodical
    193 sg:person.01124535157.03 schema:affiliation https://www.grid.ac/institutes/grid.134936.a
    194 schema:familyName Rose
    195 schema:givenName Ferrill F.
    196 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01124535157.03
    197 rdf:type schema:Person
    198 sg:person.01204472636.82 schema:affiliation https://www.grid.ac/institutes/grid.14003.36
    199 schema:familyName Svendsen
    200 schema:givenName Clive N.
    201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01204472636.82
    202 rdf:type schema:Person
    203 sg:person.01206237660.54 schema:affiliation https://www.grid.ac/institutes/grid.14003.36
    204 schema:familyName Ebert
    205 schema:givenName Allison D.
    206 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01206237660.54
    207 rdf:type schema:Person
    208 sg:person.012266000337.10 schema:affiliation https://www.grid.ac/institutes/grid.14003.36
    209 schema:familyName Thomson
    210 schema:givenName James A.
    211 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012266000337.10
    212 rdf:type schema:Person
    213 sg:person.01274273361.30 schema:affiliation https://www.grid.ac/institutes/grid.134936.a
    214 schema:familyName Lorson
    215 schema:givenName Christian L.
    216 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274273361.30
    217 rdf:type schema:Person
    218 sg:person.01336707071.84 schema:affiliation https://www.grid.ac/institutes/grid.14003.36
    219 schema:familyName Yu
    220 schema:givenName Junying
    221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01336707071.84
    222 rdf:type schema:Person
    223 sg:person.01353200547.83 schema:affiliation https://www.grid.ac/institutes/grid.134936.a
    224 schema:familyName Mattis
    225 schema:givenName Virginia B.
    226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01353200547.83
    227 rdf:type schema:Person
    228 sg:pub.10.1038/3030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005515285
    229 https://doi.org/10.1038/3030
    230 rdf:type schema:CreativeWork
    231 sg:pub.10.1038/35049541 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048213623
    232 https://doi.org/10.1038/35049541
    233 rdf:type schema:CreativeWork
    234 sg:pub.10.1038/71709 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018131147
    235 https://doi.org/10.1038/71709
    236 rdf:type schema:CreativeWork
    237 sg:pub.10.1038/nature06534 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011992920
    238 https://doi.org/10.1038/nature06534
    239 rdf:type schema:CreativeWork
    240 sg:pub.10.1038/nbt1063 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008046577
    241 https://doi.org/10.1038/nbt1063
    242 rdf:type schema:CreativeWork
    243 sg:pub.10.1038/ng0797-265 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051068967
    244 https://doi.org/10.1038/ng0797-265
    245 rdf:type schema:CreativeWork
    246 sg:pub.10.1038/nrg1268 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029530973
    247 https://doi.org/10.1038/nrg1268
    248 rdf:type schema:CreativeWork
    249 https://doi.org/10.1002/ana.10743 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042349528
    250 rdf:type schema:CreativeWork
    251 https://doi.org/10.1006/nbdi.1996.0010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014276815
    252 rdf:type schema:CreativeWork
    253 https://doi.org/10.1016/0092-8674(90)90662-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1043517258
    254 rdf:type schema:CreativeWork
    255 https://doi.org/10.1016/0092-8674(95)90460-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024818119
    256 rdf:type schema:CreativeWork
    257 https://doi.org/10.1016/j.cell.2007.11.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010904856
    258 rdf:type schema:CreativeWork
    259 https://doi.org/10.1016/j.cell.2008.01.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012430287
    260 rdf:type schema:CreativeWork
    261 https://doi.org/10.1016/j.cell.2008.07.041 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047970638
    262 rdf:type schema:CreativeWork
    263 https://doi.org/10.1016/j.neuron.2005.12.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026364199
    264 rdf:type schema:CreativeWork
    265 https://doi.org/10.1016/s0092-8674(00)80367-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045954308
    266 rdf:type schema:CreativeWork
    267 https://doi.org/10.1016/s0092-8674(00)80368-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005088934
    268 rdf:type schema:CreativeWork
    269 https://doi.org/10.1016/s0092-8674(02)00835-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045218174
    270 rdf:type schema:CreativeWork
    271 https://doi.org/10.1016/s0165-0270(98)00126-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015436666
    272 rdf:type schema:CreativeWork
    273 https://doi.org/10.1016/s0960-8966(06)80015-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017402430
    274 rdf:type schema:CreativeWork
    275 https://doi.org/10.1073/pnas.0711983105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024490582
    276 rdf:type schema:CreativeWork
    277 https://doi.org/10.1073/pnas.94.18.9920 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005488001
    278 rdf:type schema:CreativeWork
    279 https://doi.org/10.1073/pnas.96.11.6307 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012008673
    280 rdf:type schema:CreativeWork
    281 https://doi.org/10.1093/bioinformatics/19.2.185 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011853799
    282 rdf:type schema:CreativeWork
    283 https://doi.org/10.1093/bioinformatics/btl117 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040779948
    284 rdf:type schema:CreativeWork
    285 https://doi.org/10.1093/biostatistics/4.2.249 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037543114
    286 rdf:type schema:CreativeWork
    287 https://doi.org/10.1093/hmg/6.8.1205 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037403639
    288 rdf:type schema:CreativeWork
    289 https://doi.org/10.1093/hmg/9.3.333 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044079183
    290 rdf:type schema:CreativeWork
    291 https://doi.org/10.1093/hmg/ddg256 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042767881
    292 rdf:type schema:CreativeWork
    293 https://doi.org/10.1093/hmg/ddi078 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046024323
    294 rdf:type schema:CreativeWork
    295 https://doi.org/10.1093/hmg/ddi131 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010053463
    296 rdf:type schema:CreativeWork
    297 https://doi.org/10.1101/gr.7.4.339 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083074536
    298 rdf:type schema:CreativeWork
    299 https://doi.org/10.1126/science.1074962 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062446833
    300 rdf:type schema:CreativeWork
    301 https://doi.org/10.1126/science.1151526 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048905674
    302 rdf:type schema:CreativeWork
    303 https://doi.org/10.1126/science.1158799 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039463429
    304 rdf:type schema:CreativeWork
    305 https://doi.org/10.1177/0883073807305667 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007473987
    306 rdf:type schema:CreativeWork
    307 https://doi.org/10.1212/01.wnl.0000201929.56928.13 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064347901
    308 rdf:type schema:CreativeWork
    309 https://doi.org/10.1523/jneurosci.16-13-04069.1996 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082938445
    310 rdf:type schema:CreativeWork
    311 https://doi.org/10.1523/jneurosci.1637-06.2006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000754992
    312 rdf:type schema:CreativeWork
    313 https://doi.org/10.1523/jneurosci.3967-05.2006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008258462
    314 rdf:type schema:CreativeWork
    315 https://doi.org/10.1634/stemcells.2007-0368 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024465612
    316 rdf:type schema:CreativeWork
    317 https://www.grid.ac/institutes/grid.134936.a schema:alternateName University of Missouri
    318 schema:name Department of Veterinary Pathobiology, Bond Life Sciences Center, University of Missouri, 1201 Rollins Road, Columbia, Missouri 65211, USA
    319 rdf:type schema:Organization
    320 https://www.grid.ac/institutes/grid.14003.36 schema:alternateName University of Wisconsin–Madison
    321 schema:name Department of Anatomy, University of Wisconsin-Madison, 1300 University Avenue Madison, Wisconsin 53706, USA
    322 Department of Neurology, University of Wisconsin-Madison, 600 North Highland Avenue, Madison, Wisconsin 53792, USA
    323 The Genome Center and Wisconsin National Primate Research Center, University of Wisconsin-Madison, 425 Henry Mall, Madison, Wisconsin 53706, USA
    324 The Stem Cell and Regenerative Medicine Center, University of Wisconsin-Madison, 1500 Highland Avenue, Madison, Wisconsin 53705, USA
    325 The Waisman Center, and,
    326 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...