Sensing voltage across lipid membranes View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2008-12-18

AUTHORS

Kenton J. Swartz

ABSTRACT

The detection of electrical potentials across lipid bilayers by specialized membrane proteins is required for many fundamental cellular processes such as the generation and propagation of nerve impulses. These membrane proteins possess modular voltage-sensing domains, a notable example being the S1-S4 domains of voltage-activated ion channels. Ground-breaking structural studies on these domains explain how voltage sensors are designed and reveal important interactions with the surrounding lipid membrane. Although further structures are needed to understand the conformational changes that occur during voltage sensing, the available data help to frame several key concepts that are fundamental to the mechanism of voltage sensing. More... »

PAGES

891

References to SciGraph publications

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nature07620

    DOI

    http://dx.doi.org/10.1038/nature07620

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1032258745

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/19092925


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