Runx1 is required for the endothelial to haematopoietic cell transition but not thereafter View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2009-02-01

AUTHORS

Michael J. Chen, Tomomasa Yokomizo, Brandon M. Zeigler, Elaine Dzierzak, Nancy A. Speck

ABSTRACT

Blood linesHow the blood system forms during embryonic development is a topic of intensive research, in part because of the potential importance of the process for regenerative medicine. Two main theories have emerged to explain the formation of the haematopoietic stem cells that eventually populate the adult born marrow. One idea is that the haematopoietic stem cell and the endothelial lineage arise independently from the mesoderm; the other is that some haematopoietic and endothelial lineages derive from a specialized progenitor called a haemangioblast. Three papers in this issue unify the two theories. Both are correct: the haemangioblast does generate haematopoietic cells, but via a haemogenic endothelium intermediate. More... »

PAGES

887-891

Journal

TITLE

Nature

ISSUE

7231

VOLUME

457

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature07619

DOI

http://dx.doi.org/10.1038/nature07619

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1050657682

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19129762


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205 grid-institutes:None schema:alternateName Department of Biochemistry,
206 schema:name Department of Biochemistry,
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208 grid-institutes:grid.25879.31 schema:alternateName Present address: Abramson Family Cancer Research Institute and Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.
209 schema:name Department of Biochemistry,
210 Department of Genetics, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
211 Present address: Abramson Family Cancer Research Institute and Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.
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