ATP drives lamina propria TH17 cell differentiation View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2008-10-09

AUTHORS

Koji Atarashi, Junichi Nishimura, Tatsuichiro Shima, Yoshinori Umesaki, Masahiro Yamamoto, Masaharu Onoue, Hideo Yagita, Naoto Ishii, Richard Evans, Kenya Honda, Kiyoshi Takeda

ABSTRACT

Interleukin (IL)-17-producing CD4(+) T lymphocytes (T(H)17 cells) constitute a subset of T-helper cells involved in host defence and several immune disorders. An intriguing feature of T(H)17 cells is their selective and constitutive presence in the intestinal lamina propria. Here we show that adenosine 5'-triphosphate (ATP) that can be derived from commensal bacteria activates a unique subset of lamina propria cells, CD70(high)CD11c(low) cells, leading to the differentiation of T(H)17 cells. Germ-free mice exhibit much lower concentrations of luminal ATP, accompanied by fewer lamina propria T(H)17 cells, compared to specific-pathogen-free mice. Systemic or rectal administration of ATP into these germ-free mice results in a marked increase in the number of lamina propria T(H)17 cells. A CD70(high)CD11c(low) subset of the lamina propria cells expresses T(H)17-prone molecules, such as IL-6, IL-23p19 and transforming-growth-factor-beta-activating integrin-alphaV and -beta8, in response to ATP stimulation, and preferentially induces T(H)17 differentiation of co-cultured naive CD4(+) T cells. The critical role of ATP is further underscored by the observation that administration of ATP exacerbates a T-cell-mediated colitis model with enhanced T(H)17 differentiation. These observations highlight the importance of commensal bacteria and ATP for T(H)17 differentiation in health and disease, and offer an explanation of why T(H)17 cells specifically present in the intestinal lamina propria. More... »

PAGES

808

References to SciGraph publications

  • 2006-05. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells in NATURE
  • 2006-05. Transforming growth factor-β induces development of the TH17 lineage in NATURE
  • 2007-09. IL-6 programs TH-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways in NATURE IMMUNOLOGY
  • 2006-08. P2X receptors as cell-surface ATP sensors in health and disease in NATURE
  • 2003-01. Intestinal IgA synthesis: regulation of front-line body defences in NATURE REVIEWS IMMUNOLOGY
  • 2008-05-29. A microbial symbiosis factor prevents intestinal inflammatory disease in NATURE
  • 2001-04. Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria in NATURE IMMUNOLOGY
  • 2000-11. CD27 is required for generation and long-term maintenance of T cell immunity in NATURE IMMUNOLOGY
  • 2007-09-20. Loss of integrin αvβ8 on dendritic cells causes autoimmunity and colitis in mice in NATURE
  • 2007-10. Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin 17–producing T cell responses in NATURE IMMUNOLOGY
  • 2007-07. IL-21 initiates an alternative pathway to induce proinflammatory TH17 cells in NATURE
  • 2007-07. Essential autocrine regulation by IL-21 in the generation of inflammatory T cells in NATURE
  • 2006-06. TGF-β, a 'double agent' in the immune pathology war in NATURE IMMUNOLOGY
  • 2007-08. Extracellular ATP triggers and maintains asthmatic airway inflammation by activating dendritic cells in NATURE MEDICINE
  • 2007-04. TH-17 cells in the circle of immunity and autoimmunity in NATURE IMMUNOLOGY
  • Journal

    TITLE

    Nature

    ISSUE

    7214

    VOLUME

    455

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nature07240

    DOI

    http://dx.doi.org/10.1038/nature07240

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1039390173

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/18716618


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Immunology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adenosine Triphosphate", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "CD11c Antigen", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "CD27 Ligand", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Differentiation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cells, Cultured", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Colitis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Disease Models, Animal", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Feces", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Germ-Free Life", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Immunoglobulin A", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Interleukin-17", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mucous Membrane", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Receptors, Purinergic P2", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "T-Lymphocytes, Helper-Inducer", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Osaka University", 
              "id": "https://www.grid.ac/institutes/grid.136593.b", 
              "name": [
                "Laboratory of Immune Regulation, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Atarashi", 
            "givenName": "Koji", 
            "id": "sg:person.0727663606.09", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0727663606.09"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Osaka University", 
              "id": "https://www.grid.ac/institutes/grid.136593.b", 
              "name": [
                "Laboratory of Immune Regulation, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nishimura", 
            "givenName": "Junichi", 
            "id": "sg:person.01305407424.39", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01305407424.39"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Yakult Central Institute", 
              "id": "https://www.grid.ac/institutes/grid.433815.8", 
              "name": [
                "Yakult Central Institute for Microbiological Research, Yaho 1796, Kunitachi, Tokyo 186-8650, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Shima", 
            "givenName": "Tatsuichiro", 
            "id": "sg:person.01266644330.79", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01266644330.79"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Yakult Central Institute", 
              "id": "https://www.grid.ac/institutes/grid.433815.8", 
              "name": [
                "Yakult Central Institute for Microbiological Research, Yaho 1796, Kunitachi, Tokyo 186-8650, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Umesaki", 
            "givenName": "Yoshinori", 
            "id": "sg:person.0731443130.12", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0731443130.12"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Osaka University", 
              "id": "https://www.grid.ac/institutes/grid.136593.b", 
              "name": [
                "Laboratory of Immune Regulation, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan", 
                "WPI Immunology Frontier Research Center, Osaka University, Osaka 565-0871, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yamamoto", 
            "givenName": "Masahiro", 
            "id": "sg:person.014065572104.87", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014065572104.87"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Yakult Central Institute", 
              "id": "https://www.grid.ac/institutes/grid.433815.8", 
              "name": [
                "Yakult Central Institute for Microbiological Research, Yaho 1796, Kunitachi, Tokyo 186-8650, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Onoue", 
            "givenName": "Masaharu", 
            "id": "sg:person.0774756424.47", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774756424.47"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Juntendo University", 
              "id": "https://www.grid.ac/institutes/grid.258269.2", 
              "name": [
                "Department of Immunology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yagita", 
            "givenName": "Hideo", 
            "id": "sg:person.0750313520.04", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0750313520.04"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Tohoku University", 
              "id": "https://www.grid.ac/institutes/grid.69566.3a", 
              "name": [
                "Department of Microbiology and Immunology, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ishii", 
            "givenName": "Naoto", 
            "id": "sg:person.01104100314.35", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104100314.35"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Leicester", 
              "id": "https://www.grid.ac/institutes/grid.9918.9", 
              "name": [
                "Department of Cell Physiology and Pharmacology, Henry Wellcome Building 2/59b, University of Leicester, Leicester LE1 9HN, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Evans", 
            "givenName": "Richard", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Osaka University", 
              "id": "https://www.grid.ac/institutes/grid.136593.b", 
              "name": [
                "Laboratory of Immune Regulation, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan", 
                "WPI Immunology Frontier Research Center, Osaka University, Osaka 565-0871, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Honda", 
            "givenName": "Kenya", 
            "id": "sg:person.01315560470.25", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01315560470.25"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Osaka University", 
              "id": "https://www.grid.ac/institutes/grid.136593.b", 
              "name": [
                "Laboratory of Immune Regulation, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan", 
                "WPI Immunology Frontier Research Center, Osaka University, Osaka 565-0871, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Takeda", 
            "givenName": "Kiyoshi", 
            "id": "sg:person.011177325272.67", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011177325272.67"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/ni1488", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002269423", 
              "https://doi.org/10.1038/ni1488"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.20071094", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002414981"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature07008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006761326", 
              "https://doi.org/10.1038/nature07008"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.180.3.1609", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006778911"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.immunol.25.022106.141557", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007584658"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri982", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008440265", 
              "https://doi.org/10.1038/nri982"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri982", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008440265", 
              "https://doi.org/10.1038/nri982"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.immunol.25.022106.141634", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008705322"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/80877", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008751219", 
              "https://doi.org/10.1038/80877"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2006.01.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009201806"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm1617", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011740301", 
              "https://doi.org/10.1038/nm1617"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1102901", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013124540"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/j.gastro.2007.08.032", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015598312"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature06110", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016233292", 
              "https://doi.org/10.1038/nature06110"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1087262", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016599907"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/physrev.00015.2002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019362040"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1511", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021626925", 
              "https://doi.org/10.1038/ni1511"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni0407-345", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024255218", 
              "https://doi.org/10.1038/ni0407-345"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.20061308", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033164618"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature05970", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035445598", 
              "https://doi.org/10.1038/nature05970"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04753", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037247321", 
              "https://doi.org/10.1038/nature04753"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04753", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037247321", 
              "https://doi.org/10.1038/nature04753"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature05969", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037682433", 
              "https://doi.org/10.1038/nature05969"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0016-5085(03)00665-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038715248"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0016-5085(03)00665-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038715248"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04886", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041626860", 
              "https://doi.org/10.1038/nature04886"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04886", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041626860", 
              "https://doi.org/10.1038/nature04886"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04886", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041626860", 
              "https://doi.org/10.1038/nature04886"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04886", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041626860", 
              "https://doi.org/10.1038/nature04886"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04754", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043278106", 
              "https://doi.org/10.1038/nature04754"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04754", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043278106", 
              "https://doi.org/10.1038/nature04754"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04754", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043278106", 
              "https://doi.org/10.1038/nature04754"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2004-05-1718", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043750989"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni0606-557", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044131812", 
              "https://doi.org/10.1038/ni0606-557"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni0606-557", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044131812", 
              "https://doi.org/10.1038/ni0606-557"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2006.07.035", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046724496"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/86373", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049106469", 
              "https://doi.org/10.1038/86373"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/86373", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049106469", 
              "https://doi.org/10.1038/86373"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.20070590", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049529095"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077227717", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077227717", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082883629", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083338619", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2008-10-09", 
        "datePublishedReg": "2008-10-09", 
        "description": "Interleukin (IL)-17-producing CD4(+) T lymphocytes (T(H)17 cells) constitute a subset of T-helper cells involved in host defence and several immune disorders. An intriguing feature of T(H)17 cells is their selective and constitutive presence in the intestinal lamina propria. Here we show that adenosine 5'-triphosphate (ATP) that can be derived from commensal bacteria activates a unique subset of lamina propria cells, CD70(high)CD11c(low) cells, leading to the differentiation of T(H)17 cells. Germ-free mice exhibit much lower concentrations of luminal ATP, accompanied by fewer lamina propria T(H)17 cells, compared to specific-pathogen-free mice. Systemic or rectal administration of ATP into these germ-free mice results in a marked increase in the number of lamina propria T(H)17 cells. A CD70(high)CD11c(low) subset of the lamina propria cells expresses T(H)17-prone molecules, such as IL-6, IL-23p19 and transforming-growth-factor-beta-activating integrin-alphaV and -beta8, in response to ATP stimulation, and preferentially induces T(H)17 differentiation of co-cultured naive CD4(+) T cells. The critical role of ATP is further underscored by the observation that administration of ATP exacerbates a T-cell-mediated colitis model with enhanced T(H)17 differentiation. These observations highlight the importance of commensal bacteria and ATP for T(H)17 differentiation in health and disease, and offer an explanation of why T(H)17 cells specifically present in the intestinal lamina propria.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/nature07240", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1018957", 
            "issn": [
              "0090-0028", 
              "1476-4687"
            ], 
            "name": "Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "7214", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "455"
          }
        ], 
        "name": "ATP drives lamina propria TH17 cell differentiation", 
        "pagination": "808", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "bba2bd26a559ba3cd2c5a8e5e65f03413493d0403d4888127feafb58464d66f3"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "18716618"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "0410462"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/nature07240"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1039390173"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/nature07240", 
          "https://app.dimensions.ai/details/publication/pub.1039390173"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T19:45", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8681_00000425.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/nature07240"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nature07240'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nature07240'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nature07240'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nature07240'


     

    This table displays all metadata directly associated to this object as RDF triples.

    331 TRIPLES      21 PREDICATES      78 URIs      38 LITERALS      27 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/nature07240 schema:about N00181154ff06491f9df5be1f5607966d
    2 N10412c93535646d69e05c81efdc4f2dd
    3 N1f705c7cd9a24bc4a9f1013c76e6ffd7
    4 N241f421eefb443d18cf645d19e418da0
    5 N4a066d7ab68345ffb722b04aacda624c
    6 N4ccc4e7667a04250806183f1a74faa15
    7 N4f892cf058fd4deebd2dca20d6c4afd3
    8 N7767f7d413c541e295275534573252ee
    9 N7a45e4b2676349638380bec7a2f77c89
    10 N844ce83140aa427c907c18af7eeba4c0
    11 N8f909cb3adea4a72a734dad83f91b53e
    12 N9dd46cc1018e4d04ab38a2120548665d
    13 Nb4e23f3e676f4d58a2dca309a3c87b0a
    14 Nb7ab95bfc46e40babe25ef7cd098d387
    15 Nc49809aaf22a41a889443e9c51e6bda7
    16 Nc8ec6fb02c574a19abc430f8191c221a
    17 Nfa7bc9317746403d9edfbf5c55efa394
    18 Nfc2b3bde561d413483f00fc8f2bd2631
    19 anzsrc-for:11
    20 anzsrc-for:1107
    21 schema:author Ne6ebd7c0b46a4938886fe8028535fb70
    22 schema:citation sg:pub.10.1038/80877
    23 sg:pub.10.1038/86373
    24 sg:pub.10.1038/nature04753
    25 sg:pub.10.1038/nature04754
    26 sg:pub.10.1038/nature04886
    27 sg:pub.10.1038/nature05969
    28 sg:pub.10.1038/nature05970
    29 sg:pub.10.1038/nature06110
    30 sg:pub.10.1038/nature07008
    31 sg:pub.10.1038/ni0407-345
    32 sg:pub.10.1038/ni0606-557
    33 sg:pub.10.1038/ni1488
    34 sg:pub.10.1038/ni1511
    35 sg:pub.10.1038/nm1617
    36 sg:pub.10.1038/nri982
    37 https://app.dimensions.ai/details/publication/pub.1077227717
    38 https://app.dimensions.ai/details/publication/pub.1082883629
    39 https://app.dimensions.ai/details/publication/pub.1083338619
    40 https://doi.org/10.1016/j.cell.2006.07.035
    41 https://doi.org/10.1016/j.immuni.2006.01.001
    42 https://doi.org/10.1016/s0016-5085(03)00665-6
    43 https://doi.org/10.1053/j.gastro.2007.08.032
    44 https://doi.org/10.1084/jem.20061308
    45 https://doi.org/10.1084/jem.20070590
    46 https://doi.org/10.1084/jem.20071094
    47 https://doi.org/10.1126/science.1087262
    48 https://doi.org/10.1126/science.1102901
    49 https://doi.org/10.1146/annurev.immunol.25.022106.141557
    50 https://doi.org/10.1146/annurev.immunol.25.022106.141634
    51 https://doi.org/10.1152/physrev.00015.2002
    52 https://doi.org/10.1182/blood-2004-05-1718
    53 https://doi.org/10.4049/jimmunol.180.3.1609
    54 schema:datePublished 2008-10-09
    55 schema:datePublishedReg 2008-10-09
    56 schema:description Interleukin (IL)-17-producing CD4(+) T lymphocytes (T(H)17 cells) constitute a subset of T-helper cells involved in host defence and several immune disorders. An intriguing feature of T(H)17 cells is their selective and constitutive presence in the intestinal lamina propria. Here we show that adenosine 5'-triphosphate (ATP) that can be derived from commensal bacteria activates a unique subset of lamina propria cells, CD70(high)CD11c(low) cells, leading to the differentiation of T(H)17 cells. Germ-free mice exhibit much lower concentrations of luminal ATP, accompanied by fewer lamina propria T(H)17 cells, compared to specific-pathogen-free mice. Systemic or rectal administration of ATP into these germ-free mice results in a marked increase in the number of lamina propria T(H)17 cells. A CD70(high)CD11c(low) subset of the lamina propria cells expresses T(H)17-prone molecules, such as IL-6, IL-23p19 and transforming-growth-factor-beta-activating integrin-alphaV and -beta8, in response to ATP stimulation, and preferentially induces T(H)17 differentiation of co-cultured naive CD4(+) T cells. The critical role of ATP is further underscored by the observation that administration of ATP exacerbates a T-cell-mediated colitis model with enhanced T(H)17 differentiation. These observations highlight the importance of commensal bacteria and ATP for T(H)17 differentiation in health and disease, and offer an explanation of why T(H)17 cells specifically present in the intestinal lamina propria.
    57 schema:genre research_article
    58 schema:inLanguage en
    59 schema:isAccessibleForFree false
    60 schema:isPartOf N0c08a13eaae84e42b106659575c766ed
    61 N8f0e639119de4412956ae109fa0a07d0
    62 sg:journal.1018957
    63 schema:name ATP drives lamina propria TH17 cell differentiation
    64 schema:pagination 808
    65 schema:productId N14b35e60cac94fc1908337fde379a544
    66 N537892e799e94fc1a68e70cbf9127d42
    67 N88b5f8882cc746c1bfb030989fc7fb75
    68 Naef0b33001e3468cae165ba7a9e960ce
    69 Nf2743c0a4ed04f56acb2e790bb2cf595
    70 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039390173
    71 https://doi.org/10.1038/nature07240
    72 schema:sdDatePublished 2019-04-10T19:45
    73 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    74 schema:sdPublisher N75e084a1404c4423b86bf7ef043d99d6
    75 schema:url https://www.nature.com/articles/nature07240
    76 sgo:license sg:explorer/license/
    77 sgo:sdDataset articles
    78 rdf:type schema:ScholarlyArticle
    79 N00181154ff06491f9df5be1f5607966d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    80 schema:name Feces
    81 rdf:type schema:DefinedTerm
    82 N0c08a13eaae84e42b106659575c766ed schema:issueNumber 7214
    83 rdf:type schema:PublicationIssue
    84 N0d33a79b8d8a43f481c7be3fa9165349 rdf:first sg:person.01305407424.39
    85 rdf:rest N5d36ad9692cb47699b418eaa256d1a89
    86 N10412c93535646d69e05c81efdc4f2dd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    87 schema:name Receptors, Purinergic P2
    88 rdf:type schema:DefinedTerm
    89 N14b35e60cac94fc1908337fde379a544 schema:name readcube_id
    90 schema:value bba2bd26a559ba3cd2c5a8e5e65f03413493d0403d4888127feafb58464d66f3
    91 rdf:type schema:PropertyValue
    92 N1e580de50c5f4d62b004a6492562457d schema:affiliation https://www.grid.ac/institutes/grid.9918.9
    93 schema:familyName Evans
    94 schema:givenName Richard
    95 rdf:type schema:Person
    96 N1f705c7cd9a24bc4a9f1013c76e6ffd7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    97 schema:name Cells, Cultured
    98 rdf:type schema:DefinedTerm
    99 N241f421eefb443d18cf645d19e418da0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    100 schema:name Disease Models, Animal
    101 rdf:type schema:DefinedTerm
    102 N3a0055d8ae9b41769d23a9de34527e8c rdf:first sg:person.014065572104.87
    103 rdf:rest Nb999b3dd560d4867b97e64565d848bec
    104 N41083bcb8c0842c2b16f967c68dbc752 rdf:first sg:person.01315560470.25
    105 rdf:rest N90031dccb9764139b0d9290d101d2dd5
    106 N4a066d7ab68345ffb722b04aacda624c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    107 schema:name CD27 Ligand
    108 rdf:type schema:DefinedTerm
    109 N4ccc4e7667a04250806183f1a74faa15 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    110 schema:name Colitis
    111 rdf:type schema:DefinedTerm
    112 N4f892cf058fd4deebd2dca20d6c4afd3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    113 schema:name Interleukin-17
    114 rdf:type schema:DefinedTerm
    115 N537892e799e94fc1a68e70cbf9127d42 schema:name doi
    116 schema:value 10.1038/nature07240
    117 rdf:type schema:PropertyValue
    118 N5d36ad9692cb47699b418eaa256d1a89 rdf:first sg:person.01266644330.79
    119 rdf:rest N772674e01d9742429defa3e5f1dce2d3
    120 N75e084a1404c4423b86bf7ef043d99d6 schema:name Springer Nature - SN SciGraph project
    121 rdf:type schema:Organization
    122 N772674e01d9742429defa3e5f1dce2d3 rdf:first sg:person.0731443130.12
    123 rdf:rest N3a0055d8ae9b41769d23a9de34527e8c
    124 N7767f7d413c541e295275534573252ee schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    125 schema:name Germ-Free Life
    126 rdf:type schema:DefinedTerm
    127 N7a45e4b2676349638380bec7a2f77c89 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    128 schema:name Immunoglobulin A
    129 rdf:type schema:DefinedTerm
    130 N844ce83140aa427c907c18af7eeba4c0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    131 schema:name Cell Differentiation
    132 rdf:type schema:DefinedTerm
    133 N88b5f8882cc746c1bfb030989fc7fb75 schema:name pubmed_id
    134 schema:value 18716618
    135 rdf:type schema:PropertyValue
    136 N8f0e639119de4412956ae109fa0a07d0 schema:volumeNumber 455
    137 rdf:type schema:PublicationVolume
    138 N8f909cb3adea4a72a734dad83f91b53e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    139 schema:name Female
    140 rdf:type schema:DefinedTerm
    141 N90031dccb9764139b0d9290d101d2dd5 rdf:first sg:person.011177325272.67
    142 rdf:rest rdf:nil
    143 N9dd46cc1018e4d04ab38a2120548665d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    144 schema:name Mucous Membrane
    145 rdf:type schema:DefinedTerm
    146 Naef0b33001e3468cae165ba7a9e960ce schema:name dimensions_id
    147 schema:value pub.1039390173
    148 rdf:type schema:PropertyValue
    149 Nb4e23f3e676f4d58a2dca309a3c87b0a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    150 schema:name T-Lymphocytes, Helper-Inducer
    151 rdf:type schema:DefinedTerm
    152 Nb7ab95bfc46e40babe25ef7cd098d387 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    153 schema:name Adenosine Triphosphate
    154 rdf:type schema:DefinedTerm
    155 Nb999b3dd560d4867b97e64565d848bec rdf:first sg:person.0774756424.47
    156 rdf:rest Nd220aa11cad24d5f86860c0aa8b5e65d
    157 Nbf297e0940ea4a12b544e3d926582c7c rdf:first N1e580de50c5f4d62b004a6492562457d
    158 rdf:rest N41083bcb8c0842c2b16f967c68dbc752
    159 Nc49809aaf22a41a889443e9c51e6bda7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    160 schema:name Mice
    161 rdf:type schema:DefinedTerm
    162 Nc8ec6fb02c574a19abc430f8191c221a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    163 schema:name CD11c Antigen
    164 rdf:type schema:DefinedTerm
    165 Nd220aa11cad24d5f86860c0aa8b5e65d rdf:first sg:person.0750313520.04
    166 rdf:rest Neea11247b96d4ebabc20f2131b23ed78
    167 Ne6ebd7c0b46a4938886fe8028535fb70 rdf:first sg:person.0727663606.09
    168 rdf:rest N0d33a79b8d8a43f481c7be3fa9165349
    169 Neea11247b96d4ebabc20f2131b23ed78 rdf:first sg:person.01104100314.35
    170 rdf:rest Nbf297e0940ea4a12b544e3d926582c7c
    171 Nf2743c0a4ed04f56acb2e790bb2cf595 schema:name nlm_unique_id
    172 schema:value 0410462
    173 rdf:type schema:PropertyValue
    174 Nfa7bc9317746403d9edfbf5c55efa394 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    175 schema:name Animals
    176 rdf:type schema:DefinedTerm
    177 Nfc2b3bde561d413483f00fc8f2bd2631 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    178 schema:name Male
    179 rdf:type schema:DefinedTerm
    180 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    181 schema:name Medical and Health Sciences
    182 rdf:type schema:DefinedTerm
    183 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
    184 schema:name Immunology
    185 rdf:type schema:DefinedTerm
    186 sg:journal.1018957 schema:issn 0090-0028
    187 1476-4687
    188 schema:name Nature
    189 rdf:type schema:Periodical
    190 sg:person.01104100314.35 schema:affiliation https://www.grid.ac/institutes/grid.69566.3a
    191 schema:familyName Ishii
    192 schema:givenName Naoto
    193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104100314.35
    194 rdf:type schema:Person
    195 sg:person.011177325272.67 schema:affiliation https://www.grid.ac/institutes/grid.136593.b
    196 schema:familyName Takeda
    197 schema:givenName Kiyoshi
    198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011177325272.67
    199 rdf:type schema:Person
    200 sg:person.01266644330.79 schema:affiliation https://www.grid.ac/institutes/grid.433815.8
    201 schema:familyName Shima
    202 schema:givenName Tatsuichiro
    203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01266644330.79
    204 rdf:type schema:Person
    205 sg:person.01305407424.39 schema:affiliation https://www.grid.ac/institutes/grid.136593.b
    206 schema:familyName Nishimura
    207 schema:givenName Junichi
    208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01305407424.39
    209 rdf:type schema:Person
    210 sg:person.01315560470.25 schema:affiliation https://www.grid.ac/institutes/grid.136593.b
    211 schema:familyName Honda
    212 schema:givenName Kenya
    213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01315560470.25
    214 rdf:type schema:Person
    215 sg:person.014065572104.87 schema:affiliation https://www.grid.ac/institutes/grid.136593.b
    216 schema:familyName Yamamoto
    217 schema:givenName Masahiro
    218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014065572104.87
    219 rdf:type schema:Person
    220 sg:person.0727663606.09 schema:affiliation https://www.grid.ac/institutes/grid.136593.b
    221 schema:familyName Atarashi
    222 schema:givenName Koji
    223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0727663606.09
    224 rdf:type schema:Person
    225 sg:person.0731443130.12 schema:affiliation https://www.grid.ac/institutes/grid.433815.8
    226 schema:familyName Umesaki
    227 schema:givenName Yoshinori
    228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0731443130.12
    229 rdf:type schema:Person
    230 sg:person.0750313520.04 schema:affiliation https://www.grid.ac/institutes/grid.258269.2
    231 schema:familyName Yagita
    232 schema:givenName Hideo
    233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0750313520.04
    234 rdf:type schema:Person
    235 sg:person.0774756424.47 schema:affiliation https://www.grid.ac/institutes/grid.433815.8
    236 schema:familyName Onoue
    237 schema:givenName Masaharu
    238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774756424.47
    239 rdf:type schema:Person
    240 sg:pub.10.1038/80877 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008751219
    241 https://doi.org/10.1038/80877
    242 rdf:type schema:CreativeWork
    243 sg:pub.10.1038/86373 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049106469
    244 https://doi.org/10.1038/86373
    245 rdf:type schema:CreativeWork
    246 sg:pub.10.1038/nature04753 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037247321
    247 https://doi.org/10.1038/nature04753
    248 rdf:type schema:CreativeWork
    249 sg:pub.10.1038/nature04754 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043278106
    250 https://doi.org/10.1038/nature04754
    251 rdf:type schema:CreativeWork
    252 sg:pub.10.1038/nature04886 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041626860
    253 https://doi.org/10.1038/nature04886
    254 rdf:type schema:CreativeWork
    255 sg:pub.10.1038/nature05969 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037682433
    256 https://doi.org/10.1038/nature05969
    257 rdf:type schema:CreativeWork
    258 sg:pub.10.1038/nature05970 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035445598
    259 https://doi.org/10.1038/nature05970
    260 rdf:type schema:CreativeWork
    261 sg:pub.10.1038/nature06110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016233292
    262 https://doi.org/10.1038/nature06110
    263 rdf:type schema:CreativeWork
    264 sg:pub.10.1038/nature07008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006761326
    265 https://doi.org/10.1038/nature07008
    266 rdf:type schema:CreativeWork
    267 sg:pub.10.1038/ni0407-345 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024255218
    268 https://doi.org/10.1038/ni0407-345
    269 rdf:type schema:CreativeWork
    270 sg:pub.10.1038/ni0606-557 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044131812
    271 https://doi.org/10.1038/ni0606-557
    272 rdf:type schema:CreativeWork
    273 sg:pub.10.1038/ni1488 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002269423
    274 https://doi.org/10.1038/ni1488
    275 rdf:type schema:CreativeWork
    276 sg:pub.10.1038/ni1511 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021626925
    277 https://doi.org/10.1038/ni1511
    278 rdf:type schema:CreativeWork
    279 sg:pub.10.1038/nm1617 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011740301
    280 https://doi.org/10.1038/nm1617
    281 rdf:type schema:CreativeWork
    282 sg:pub.10.1038/nri982 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008440265
    283 https://doi.org/10.1038/nri982
    284 rdf:type schema:CreativeWork
    285 https://app.dimensions.ai/details/publication/pub.1077227717 schema:CreativeWork
    286 https://app.dimensions.ai/details/publication/pub.1082883629 schema:CreativeWork
    287 https://app.dimensions.ai/details/publication/pub.1083338619 schema:CreativeWork
    288 https://doi.org/10.1016/j.cell.2006.07.035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046724496
    289 rdf:type schema:CreativeWork
    290 https://doi.org/10.1016/j.immuni.2006.01.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009201806
    291 rdf:type schema:CreativeWork
    292 https://doi.org/10.1016/s0016-5085(03)00665-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038715248
    293 rdf:type schema:CreativeWork
    294 https://doi.org/10.1053/j.gastro.2007.08.032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015598312
    295 rdf:type schema:CreativeWork
    296 https://doi.org/10.1084/jem.20061308 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033164618
    297 rdf:type schema:CreativeWork
    298 https://doi.org/10.1084/jem.20070590 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049529095
    299 rdf:type schema:CreativeWork
    300 https://doi.org/10.1084/jem.20071094 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002414981
    301 rdf:type schema:CreativeWork
    302 https://doi.org/10.1126/science.1087262 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016599907
    303 rdf:type schema:CreativeWork
    304 https://doi.org/10.1126/science.1102901 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013124540
    305 rdf:type schema:CreativeWork
    306 https://doi.org/10.1146/annurev.immunol.25.022106.141557 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007584658
    307 rdf:type schema:CreativeWork
    308 https://doi.org/10.1146/annurev.immunol.25.022106.141634 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008705322
    309 rdf:type schema:CreativeWork
    310 https://doi.org/10.1152/physrev.00015.2002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019362040
    311 rdf:type schema:CreativeWork
    312 https://doi.org/10.1182/blood-2004-05-1718 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043750989
    313 rdf:type schema:CreativeWork
    314 https://doi.org/10.4049/jimmunol.180.3.1609 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006778911
    315 rdf:type schema:CreativeWork
    316 https://www.grid.ac/institutes/grid.136593.b schema:alternateName Osaka University
    317 schema:name Laboratory of Immune Regulation, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan
    318 WPI Immunology Frontier Research Center, Osaka University, Osaka 565-0871, Japan
    319 rdf:type schema:Organization
    320 https://www.grid.ac/institutes/grid.258269.2 schema:alternateName Juntendo University
    321 schema:name Department of Immunology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan
    322 rdf:type schema:Organization
    323 https://www.grid.ac/institutes/grid.433815.8 schema:alternateName Yakult Central Institute
    324 schema:name Yakult Central Institute for Microbiological Research, Yaho 1796, Kunitachi, Tokyo 186-8650, Japan
    325 rdf:type schema:Organization
    326 https://www.grid.ac/institutes/grid.69566.3a schema:alternateName Tohoku University
    327 schema:name Department of Microbiology and Immunology, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan
    328 rdf:type schema:Organization
    329 https://www.grid.ac/institutes/grid.9918.9 schema:alternateName University of Leicester
    330 schema:name Department of Cell Physiology and Pharmacology, Henry Wellcome Building 2/59b, University of Leicester, Leicester LE1 9HN, UK
    331 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...