Cancer-related inflammation View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2008-07-01

AUTHORS

Alberto Mantovani, Paola Allavena, Antonio Sica, Frances Balkwill

ABSTRACT

The mediators and cellular effectors of inflammation are important constituents of the local environment of tumours. In some types of cancer, inflammatory conditions are present before a malignant change occurs. Conversely, in other types of cancer, an oncogenic change induces an inflammatory microenvironment that promotes the development of tumours. Regardless of its origin, 'smouldering' inflammation in the tumour microenvironment has many tumour-promoting effects. It aids in the proliferation and survival of malignant cells, promotes angiogenesis and metastasis, subverts adaptive immune responses, and alters responses to hormones and chemotherapeutic agents. The molecular pathways of this cancer-related inflammation are now being unravelled, resulting in the identification of new target molecules that could lead to improved diagnosis and treatment. More... »

PAGES

436-444

References to SciGraph publications

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  • Journal

    TITLE

    Nature

    ISSUE

    7203

    VOLUME

    454

    Clinical Trials linked to this publication

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nature07205

    DOI

    http://dx.doi.org/10.1038/nature07205

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1024729982

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/18650914


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    36 schema:description The mediators and cellular effectors of inflammation are important constituents of the local environment of tumours. In some types of cancer, inflammatory conditions are present before a malignant change occurs. Conversely, in other types of cancer, an oncogenic change induces an inflammatory microenvironment that promotes the development of tumours. Regardless of its origin, 'smouldering' inflammation in the tumour microenvironment has many tumour-promoting effects. It aids in the proliferation and survival of malignant cells, promotes angiogenesis and metastasis, subverts adaptive immune responses, and alters responses to hormones and chemotherapeutic agents. The molecular pathways of this cancer-related inflammation are now being unravelled, resulting in the identification of new target molecules that could lead to improved diagnosis and treatment.
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